[go: up one dir, main page]

WO2002016941A3 - A combinatorial method for rapid screening of drug delivery formulations - Google Patents

A combinatorial method for rapid screening of drug delivery formulations Download PDF

Info

Publication number
WO2002016941A3
WO2002016941A3 PCT/US2001/026473 US0126473W WO0216941A3 WO 2002016941 A3 WO2002016941 A3 WO 2002016941A3 US 0126473 W US0126473 W US 0126473W WO 0216941 A3 WO0216941 A3 WO 0216941A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
rapid screening
formulations
substance
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/026473
Other languages
French (fr)
Other versions
WO2002016941A2 (en
Inventor
Samir Mitragotri
Pankaj Karande
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Priority to US10/344,961 priority Critical patent/US20040023841A1/en
Priority to AU2001286725A priority patent/AU2001286725A1/en
Publication of WO2002016941A2 publication Critical patent/WO2002016941A2/en
Publication of WO2002016941A3 publication Critical patent/WO2002016941A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)

Abstract

This invention describes a novel method for rapid screening of formulations for drug delivery, which uses a high throughput array to screen multiple samples. This method monitors the depletion of a test substance from a donor well, the migration of the substance into a test membrane, and/or the migration of the substance through a membrane into a receptor well. It can be used to discover new formulations as well as to optimize the existing formulations for delivering drugs via transdermal, oral, or injectable routes.
PCT/US2001/026473 2000-08-23 2001-08-23 A combinatorial method for rapid screening of drug delivery formulations Ceased WO2002016941A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/344,961 US20040023841A1 (en) 2001-08-23 2001-08-23 Combinatorial method for rapid screening of drug delivery formulations
AU2001286725A AU2001286725A1 (en) 2000-08-23 2001-08-23 A combinatorial method for rapid screening of drug delivery formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22745300P 2000-08-23 2000-08-23
US60/227,453 2000-08-23

Publications (2)

Publication Number Publication Date
WO2002016941A2 WO2002016941A2 (en) 2002-02-28
WO2002016941A3 true WO2002016941A3 (en) 2003-01-03

Family

ID=22853172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026473 Ceased WO2002016941A2 (en) 2000-08-23 2001-08-23 A combinatorial method for rapid screening of drug delivery formulations

Country Status (2)

Country Link
AU (1) AU2001286725A1 (en)
WO (1) WO2002016941A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7788701A (en) 2000-07-14 2002-01-30 Transform Pharmaceuticals Inc System and method for optimizing tissue barrier transfer of compounds
US6852526B2 (en) 2000-07-14 2005-02-08 Transform Pharmaceuticals, Inc. Transdermal assay with magnetic clamp
US7172859B2 (en) 2000-07-14 2007-02-06 Transform Pharmaceuticals, Inc. System and method for optimizing tissue barrier transfer of compounds
US7449307B2 (en) 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
EP1556501A4 (en) * 2002-10-28 2009-04-08 Transform Pharmaceuticals Inc Transdermal assay with magnetic clamp
CA2530407A1 (en) * 2003-07-23 2005-02-03 The Regents Of The University Of California Penetration enhancer combinations for transdermal delivery
US20050065062A1 (en) * 2003-09-24 2005-03-24 3M Innovative Properties Company Method of formulating a pharmaceutical composition
US7635452B2 (en) * 2003-09-24 2009-12-22 3M Innovative Properties Company System, kit, and method for measuring membrane diffusion
CN103323496B (en) * 2013-05-24 2018-12-18 中国人民解放军第二五一医院 High-throughput percutaneous corrosion and absorption detecting plate
CN103308564A (en) * 2013-06-03 2013-09-18 拉芳家化股份有限公司 Method for detecting percutaneous absorption efficiency of active component of cosmetic
CN113514370B (en) * 2021-04-14 2024-09-27 广州呼吸药物工程技术有限公司 Unidirectional permeability device and method for measuring drug-carrying non-vascular stent drug

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260210A (en) * 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TANG HUA ET AL: "Theoretical description of transdermal transport of hydrophilic permeants: Application to low-frequency sonophoresis.", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 90, no. 5, May 2001 (2001-05-01), pages 545 - 568, XP001096081, ISSN: 0022-3549 *

Also Published As

Publication number Publication date
AU2001286725A1 (en) 2002-03-04
WO2002016941A2 (en) 2002-02-28

Similar Documents

Publication Publication Date Title
WO2002016941A3 (en) A combinatorial method for rapid screening of drug delivery formulations
WO2003000018A3 (en) Dopamine agonist formulations for enhanced central nervous system delivery
CY1110260T1 (en) SOLID PHARMACEUTICAL COMPOSITIONS CONTAINING AN S1P RELATIVE RECEPTORS AND A SUGAR ALCOHOL
WO2001027611A3 (en) Multiplex cytokine analysis
WO2003051302A3 (en) Methods and compositions for treatment of central nervous system disorders
DK1208095T3 (en) Dibenzopyrans as glucocorticoid receptor antagonists for the treatment of diabetes
WO2004054542A3 (en) Oral drug delivery system comprising high viscosity liquid carrier materials
FR2822827B1 (en) NOVEL N- (ARYLSULFONYL) BETA-AMINOACIDS DERIVATIVES COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THEIR PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
NO20081198L (en) Procedure for Predicting or Monitoring a Patient's Response to a Drug Targeted at an ErbB Receptor
WO2000066590A3 (en) Tetracyclic progesterone receptor modulator compounds and methods
WO2004073634A3 (en) Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists
WO2003062241A8 (en) Fused heterocyclic succinimidecompounds and analogs thereof, modulators of nuclear hormone receptor function
NO20052496D0 (en) Selected CGRP antagonists, methods for their preparation and use thereof as drugs.
MA28342A1 (en) NOVEL AZABICYCLIC DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DK1695709T3 (en) Crystalline gamma-form of ivabradine hydrochloride, process for its preparation and pharmaceutical compositions containing it
WO2003025137A3 (en) Sweet taste receptors
WO2001000875A3 (en) Novel methods and products for arrayed microsphere analysis
DK1267833T3 (en) Pharmaceutical compositions and processes for their preparation
MXPA03011898A (en) gamma-SECRETASE IN VITRO.
FR2872164B1 (en) QUINOLINE-4-SUBSTITUTED DERIVATIVES, PROCESS AND PREPARATION INTERMEDIATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
DK1098891T3 (en) Polycyclic thiazolidin-2-ylidene amines, process for their preparation and their use as drugs
AU6435700A (en) Cyclic peptidomimetic urokinase receptor antagonists
DK1265904T3 (en) Positive Allosteric AMPA Receptor Modulators, Methods for Preparing and Using Them as Drugs
WO2006028810A3 (en) Method of wound healing using a2b adenosine receptor antagonists
Takahashi et al. Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 10344961

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP