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WO2000066590A3 - Tetracyclic progesterone receptor modulator compounds and methods - Google Patents

Tetracyclic progesterone receptor modulator compounds and methods Download PDF

Info

Publication number
WO2000066590A3
WO2000066590A3 PCT/US2000/011750 US0011750W WO0066590A3 WO 2000066590 A3 WO2000066590 A3 WO 2000066590A3 US 0011750 W US0011750 W US 0011750W WO 0066590 A3 WO0066590 A3 WO 0066590A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
progesterone receptor
methods
receptor modulator
tetracyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/011750
Other languages
French (fr)
Other versions
WO2000066590A2 (en
Inventor
Lin Zhi
Todd K Jones
Keith B Marschke
Christopher M Tegley
Andrew Fensome
Puwen Zhang
Jay E Wrobel
James P Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Ligand Pharmaceuticals Inc
Original Assignee
Ligand Pharmaceuticals Inc
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,353 external-priority patent/US6358947B1/en
Application filed by Ligand Pharmaceuticals Inc, American Home Products Corp filed Critical Ligand Pharmaceuticals Inc
Priority to MXPA01011294A priority Critical patent/MXPA01011294A/en
Priority to HK02104861.6A priority patent/HK1043788A1/en
Priority to EP00926495A priority patent/EP1175422A2/en
Priority to CA002371273A priority patent/CA2371273A1/en
Priority to JP2000615620A priority patent/JP2002543204A/en
Priority to AU45018/00A priority patent/AU4501800A/en
Publication of WO2000066590A2 publication Critical patent/WO2000066590A2/en
Publication of WO2000066590A3 publication Critical patent/WO2000066590A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Nonsteroidal compounds that are high affinity, high selectivity modulators for progesterone receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring progesterone receptor agonist, partial agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the progesterone receptor modulator compounds.
PCT/US2000/011750 1999-05-04 2000-05-01 Tetracyclic progesterone receptor modulator compounds and methods Ceased WO2000066590A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MXPA01011294A MXPA01011294A (en) 1999-05-04 2000-05-01 Tetracyclic progesterone receptor modulator compounds and methods.
HK02104861.6A HK1043788A1 (en) 1999-05-04 2000-05-01 Tetracyclic progesterone receptor modulator compounds and methods
EP00926495A EP1175422A2 (en) 1999-05-04 2000-05-01 Tetracyclic progesterone receptor modulator compounds and methods
CA002371273A CA2371273A1 (en) 1999-05-04 2000-05-01 Tetracyclic progesterone receptor modulator compounds and methods
JP2000615620A JP2002543204A (en) 1999-05-04 2000-05-01 Tetracyclic progesterone receptor modulatory compounds and methods
AU45018/00A AU4501800A (en) 1999-05-04 2000-05-01 Tetracyclic progesterone receptor modulator compounds and methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30461499A 1999-05-04 1999-05-04
US60/183,044 2000-04-19
US09/552,353 2000-04-19
US09/552,353 US6358947B1 (en) 1999-05-04 2000-04-19 Tetracyclic progesterone receptor modulator compounds and methods

Publications (2)

Publication Number Publication Date
WO2000066590A2 WO2000066590A2 (en) 2000-11-09
WO2000066590A3 true WO2000066590A3 (en) 2001-02-08

Family

ID=26974128

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/011750 Ceased WO2000066590A2 (en) 1999-05-04 2000-05-01 Tetracyclic progesterone receptor modulator compounds and methods

Country Status (6)

Country Link
EP (1) EP1175422A2 (en)
CN (1) CN1353717A (en)
AU (1) AU4501800A (en)
CA (1) CA2371273A1 (en)
HK (1) HK1043788A1 (en)
WO (1) WO2000066590A2 (en)

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JP2012520686A (en) 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション RNA interference-mediated inhibition of signal transduction transcription factor 6 (STAT6) gene expression using small interfering nucleic acids (siNA)
JP2012520683A (en) 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション RNA interference-mediated inhibition of connective tissue growth factor (CTGF) gene expression using small interfering nucleic acids (siNA)
JP2012521763A (en) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション RNA interference-mediated inhibition of signal transduction transcription factor 1 (STAT1) gene expression using small interfering nucleic acids (siNA)
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JP2012521762A (en) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション RNA interference-mediated inhibition of nerve growth factor β chain (NGFβ) gene expression using small interfering nucleic acids (siNA)
US20120010272A1 (en) 2009-03-27 2012-01-12 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Apoptosis Signal-Regulating Kinase 1 (ASK1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
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US20100273744A1 (en) 2009-04-24 2010-10-28 Paul Martin Gore Compounds
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US20120245171A1 (en) 2009-12-03 2012-09-27 Glaxo Group Limited Benzpyrazole derivatives as inhibitors of pi3 kinases
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019458A2 (en) * 1994-12-22 1996-06-27 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US5688808A (en) * 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019458A2 (en) * 1994-12-22 1996-06-27 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US5688808A (en) * 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
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US5693647A (en) * 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods

Also Published As

Publication number Publication date
EP1175422A2 (en) 2002-01-30
CA2371273A1 (en) 2000-11-09
HK1043788A1 (en) 2002-09-27
AU4501800A (en) 2000-11-17
CN1353717A (en) 2002-06-12
WO2000066590A2 (en) 2000-11-09

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