WO2002060432A1 - Hypoglycemic agent - Google Patents

Hypoglycemic agent Download PDF

Info

Publication number: WO2002060432A1
Authority: WO; WIPO (PCT)
Prior art keywords: complex; hypoglycemic agent; acids; diabetes; health food
Prior art date: 2001-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

PCT/JP2002/000549

Other languages

English (en)

French (fr)

Inventor

Yoshitane Kojima

Hiromu Sakurai

Yutaka Yoshikawa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Japan Science and Technology Agency

Original Assignee

Japan Science and Technology Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-31

Filing date

2002-01-25

Publication date

2002-08-08

2002-01-25 Application filed by Japan Science and Technology Corp filed Critical Japan Science and Technology Corp

2002-01-25 Priority to US10/470,786 priority Critical patent/US7226935B2/en

2002-01-25 Priority to KR10-2003-7009991A priority patent/KR20030076635A/ko

2002-01-25 Priority to EP02716383A priority patent/EP1364647A4/en

2002-01-25 Priority to CA002436425A priority patent/CA2436425A1/en

2002-08-08 Publication of WO2002060432A1 publication Critical patent/WO2002060432A1/ja

2003-07-31 Anticipated expiration legal-status Critical

2006-12-01 Priority to US11/607,223 priority patent/US20070155655A1/en

2006-12-04 Priority to US11/633,899 priority patent/US20070155657A1/en

2006-12-04 Priority to US11/633,870 priority patent/US20070155656A1/en

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/315—Zinc compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Furan Compounds (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)

PCT/JP2002/000549 2001-01-13 2002-01-25 Hypoglycemic agent Ceased WO2002060432A1 (en)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
US10/470,786 US7226935B2 (en)	2001-01-31	2002-01-25	Hypoglycemic agent
KR10-2003-7009991A KR20030076635A (ko)	2001-01-31	2002-01-25	혈당강하제
EP02716383A EP1364647A4 (en)	2001-01-31	2002-01-25	HYPOGLYCEMIC AGENT
CA002436425A CA2436425A1 (en)	2001-01-31	2002-01-25	Hypoglycemic agent
US11/607,223 US20070155655A1 (en)	2001-01-31	2006-12-01	Hypoglycemic agent
US11/633,899 US20070155657A1 (en)	2001-01-13	2006-12-04	Hypoglycemic agent
US11/633,870 US20070155656A1 (en)	2001-01-31	2006-12-04	Hypoglycemic agent

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2001024532		2001-01-31
JP2001-024532		2001-01-31
JP2001373289A JP2003040784A (ja)	2001-01-31	2001-12-06	血糖降下剤
JP2001-373289		2001-12-06

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
US11/047,206 Division US20050130880A1 (en)	2001-01-13	2005-01-28	Hypoglycemic agent

Publications (1)

Publication Number	Publication Date
WO2002060432A1 true WO2002060432A1 (en)	2002-08-08

Family

ID=26608699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2002/000549 Ceased WO2002060432A1 (en)	2001-01-13	2002-01-25	Hypoglycemic agent

Country Status (7)

Country	Link
US (5)	US7226935B2 (ja)
EP (5)	EP1900367A3 (ja)
JP (1)	JP2003040784A (ja)
KR (1)	KR20030076635A (ja)
CN (1)	CN1536994A (ja)
CA (1)	CA2436425A1 (ja)
WO (1)	WO2002060432A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004035065A1 (ja) *	2002-10-18	2004-04-29	Arita, Junichi	血糖降下作用を有する亜鉛含有物
JP2004201675A (ja) *	2002-12-10	2004-07-22	Arita Junichi	糖尿病予防効果を有する亜鉛高含有食品
US7557088B2 (en)	2006-03-28	2009-07-07	Neopro Labs, Llc	Methods and compositions for treating conditions
US7704955B2 (en)	2004-11-24	2010-04-27	Neopro Pain, Inc.	Methods and compositions for modulating conditions in both mammals and plants
US8217141B2 (en)	2007-05-17	2012-07-10	Neopro Labs, Llc	Crystalline and amorphous forms of peptide
US11021514B2 (en)	2016-06-01	2021-06-01	Athira Pharma, Inc.	Compounds
US11492374B2 (en)	2020-06-25	2022-11-08	Humanwell Pharmaceutical US	Peptides for treatment of medical disorders
US12215173B2 (en)	2019-08-07	2025-02-04	HUMANWELL PHARMACEUTICAL US, Inc.	Kappa opioid receptor peptide amide ligands

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003040784A (ja) *	2001-01-31	2003-02-13	Japan Science & Technology Corp	血糖降下剤
WO2004037169A2 (en) *	2002-10-18	2004-05-06	Merck & Co., Inc.	Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US8114445B2 (en) *	2008-11-07	2012-02-14	Reliv International Inc.	Dietary supplement for promoting wellness and weight loss and methods of administering the same
CN106928085A (zh) *	2017-01-22	2017-07-07	陕西师范大学	一种l‑茶氨酸锌螯合物及制备方法和含该螯合物的茶饮料及制备方法
CN106889616B (zh) *	2017-01-22	2020-08-04	陕西师范大学	一种l-茶氨酸铁螯合物及制备方法和含该螯合物的速溶茶粉及制备方法
CN106866451A (zh) *	2017-01-22	2017-06-20	陕西师范大学	一种l‑茶氨酸硒螯合物及制备方法和含该螯合物的含片及制备方法
CN108714206A (zh) *	2018-05-01	2018-10-30	张奉明	一种产后调理的花胶弹性蛋白肽组合物及其制备方法
BR112023018676A2 (pt)	2021-03-18	2023-10-10	Seagen Inc	Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco

Citations (12)

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JPS5338630A (en) *	1976-09-17	1978-04-08	Riishiyu Pharm Corp	Composition comprising zinc based composite vitamins and mineral
JPS5455712A (en) *	1977-10-12	1979-05-04	Nippon Kayaku Co Ltd	Double salt of halogenated methylmethionine sulfonium and zinc halide, and its preparation
JPS61282317A (ja) *	1985-06-06	1986-12-12	Toyo Jozo Co Ltd	骨代謝促進剤
WO1987001281A1 (en) *	1985-08-27	1987-03-12	Glyzinc Pharmaceuticals Limited	Zinc glycerolate complex and additions for pharmaceutical applications
WO1987004622A1 (en) *	1986-02-06	1987-08-13	Albion Laboratories, Inc.	Amino acid chelated compositions for delivery to specific biological tissue sites
EP0256645A2 (en) *	1986-07-03	1988-02-24	Albion International, Inc.	Preparation of pharmaceutical grade pure acid chelates
JPH061720A (ja) *	1992-06-16	1994-01-11	Res Inst For Prod Dev	抗炎、抗潰瘍剤
EP0658568A1 (en) *	1993-12-09	1995-06-21	Eli Lilly And Company	Glucagon-like insulinotropic peptides, compositions and methods
EP0755917A1 (fr) *	1995-07-26	1997-01-29	L'oreal	Dérivés de N,N'-di(aralkyl) N,N'-di(Carboxyalkyl) alkylène di- ou triamine et de N-(aralkyl) N'-(carboxyalkyl) N,N'-di (carboxyalkyl) alkylène di- ou triamine et utilisation en pharmacie et en cosmétique
US5948388A (en) *	1998-06-12	1999-09-07	Soft Gel Technologies, Inc.	Chewable softgel oral hygiene product
US5962517A (en) *	1997-01-31	1999-10-05	Murad; Howard	Pharmaceutical compositions and methods for treating acne
WO2001039769A1 (en) *	1999-11-30	2001-06-07	Japan Science And Technology Corporation	Hypoglycemics comprising organic zinc (ii) complexes

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2001
- 2001-12-06 JP JP2001373289A patent/JP2003040784A/ja active Pending
2002
- 2002-01-25 US US10/470,786 patent/US7226935B2/en not_active Expired - Fee Related
- 2002-01-25 EP EP07009993A patent/EP1900367A3/en not_active Withdrawn
- 2002-01-25 EP EP07009990A patent/EP1900366A3/en not_active Withdrawn
- 2002-01-25 WO PCT/JP2002/000549 patent/WO2002060432A1/ja not_active Ceased
- 2002-01-25 EP EP07009991A patent/EP1905438A3/en not_active Withdrawn
- 2002-01-25 CA CA002436425A patent/CA2436425A1/en not_active Abandoned
- 2002-01-25 CN CNA02804391XA patent/CN1536994A/zh active Pending
- 2002-01-25 EP EP02716383A patent/EP1364647A4/en not_active Withdrawn
- 2002-01-25 EP EP07009992A patent/EP1897541A3/en not_active Withdrawn
- 2002-01-25 KR KR10-2003-7009991A patent/KR20030076635A/ko not_active Ceased
2005
- 2005-01-28 US US11/047,206 patent/US20050130880A1/en not_active Abandoned
2006
- 2006-12-01 US US11/607,223 patent/US20070155655A1/en not_active Abandoned
- 2006-12-04 US US11/633,899 patent/US20070155657A1/en not_active Abandoned
- 2006-12-04 US US11/633,870 patent/US20070155656A1/en not_active Abandoned

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5338630A (en) *	1976-09-17	1978-04-08	Riishiyu Pharm Corp	Composition comprising zinc based composite vitamins and mineral
JPS5455712A (en) *	1977-10-12	1979-05-04	Nippon Kayaku Co Ltd	Double salt of halogenated methylmethionine sulfonium and zinc halide, and its preparation
JPS61282317A (ja) *	1985-06-06	1986-12-12	Toyo Jozo Co Ltd	骨代謝促進剤
WO1987001281A1 (en) *	1985-08-27	1987-03-12	Glyzinc Pharmaceuticals Limited	Zinc glycerolate complex and additions for pharmaceutical applications
WO1987004622A1 (en) *	1986-02-06	1987-08-13	Albion Laboratories, Inc.	Amino acid chelated compositions for delivery to specific biological tissue sites
EP0256645A2 (en) *	1986-07-03	1988-02-24	Albion International, Inc.	Preparation of pharmaceutical grade pure acid chelates
JPH061720A (ja) *	1992-06-16	1994-01-11	Res Inst For Prod Dev	抗炎、抗潰瘍剤
EP0658568A1 (en) *	1993-12-09	1995-06-21	Eli Lilly And Company	Glucagon-like insulinotropic peptides, compositions and methods
EP0755917A1 (fr) *	1995-07-26	1997-01-29	L'oreal	Dérivés de N,N'-di(aralkyl) N,N'-di(Carboxyalkyl) alkylène di- ou triamine et de N-(aralkyl) N'-(carboxyalkyl) N,N'-di (carboxyalkyl) alkylène di- ou triamine et utilisation en pharmacie et en cosmétique
US5962517A (en) *	1997-01-31	1999-10-05	Murad; Howard	Pharmaceutical compositions and methods for treating acne
US5948388A (en) *	1998-06-12	1999-09-07	Soft Gel Technologies, Inc.	Chewable softgel oral hygiene product
WO2001039769A1 (en) *	1999-11-30	2001-06-07	Japan Science And Technology Corporation	Hypoglycemics comprising organic zinc (ii) complexes

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Title
ABUFARAG, A. ET AL.: "Zinc complexes of the ligand dipicolylglycine", INORG. CHEM., vol. 34, no. 8, 1995, pages 2207 - 2216, XP002950791 *
HEMMERLE, H. ET AL.: "Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate tetraslocase", J. MED. CHEM., vol. 40, no. 2, 1997, pages 137 - 145, XP002950792 *
See also references of EP1364647A4 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004035065A1 (ja) *	2002-10-18	2004-04-29	Arita, Junichi	血糖降下作用を有する亜鉛含有物
JP2004201675A (ja) *	2002-12-10	2004-07-22	Arita Junichi	糖尿病予防効果を有する亜鉛高含有食品
US8530432B2 (en)	2004-11-24	2013-09-10	Neopro Labs, Llc	Methods and compositions for treating conditions
US7704955B2 (en)	2004-11-24	2010-04-27	Neopro Pain, Inc.	Methods and compositions for modulating conditions in both mammals and plants
US7851448B2 (en)	2004-11-24	2010-12-14	Neopro Labs, Llc	Methods for modulating activities in plants
US7858586B2 (en)	2004-11-24	2010-12-28	Neopro Labs, Llc	Method of treating condition in animal
US8492159B2 (en)	2004-11-24	2013-07-23	Neopro Pain, Inc.	Methods and compositions for treating conditions
US7557088B2 (en)	2006-03-28	2009-07-07	Neopro Labs, Llc	Methods and compositions for treating conditions
US8217141B2 (en)	2007-05-17	2012-07-10	Neopro Labs, Llc	Crystalline and amorphous forms of peptide
US11021514B2 (en)	2016-06-01	2021-06-01	Athira Pharma, Inc.	Compounds
US12421276B2 (en)	2016-06-01	2025-09-23	Athira Pharma, Inc.	Methods of treating neurodegenerative disease with substituted n-hexanoic-l-tyrosine-l-isoleucine-(6)-aminohexanoic amide analogues
US12215173B2 (en)	2019-08-07	2025-02-04	HUMANWELL PHARMACEUTICAL US, Inc.	Kappa opioid receptor peptide amide ligands
US11492374B2 (en)	2020-06-25	2022-11-08	Humanwell Pharmaceutical US	Peptides for treatment of medical disorders

Also Published As

Publication number	Publication date
JP2003040784A (ja)	2003-02-13
EP1905438A2 (en)	2008-04-02
EP1905438A3 (en)	2008-07-02
CA2436425A1 (en)	2002-08-08
US20070155657A1 (en)	2007-07-05
CN1536994A (zh)	2004-10-13
EP1897541A2 (en)	2008-03-12
EP1900366A2 (en)	2008-03-19
EP1900366A3 (en)	2008-06-25
EP1900367A2 (en)	2008-03-19
EP1900367A3 (en)	2008-07-02
US20050130880A1 (en)	2005-06-16
EP1897541A3 (en)	2008-05-28
EP1364647A1 (en)	2003-11-26
US20070155655A1 (en)	2007-07-05
EP1364647A4 (en)	2006-04-05
US7226935B2 (en)	2007-06-05
US20040077620A1 (en)	2004-04-22
US20070155656A1 (en)	2007-07-05
KR20030076635A (ko)	2003-09-26

Publication	Publication Date	Title
WO2002060432A1 (en)	2002-08-08	Hypoglycemic agent
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