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WO2001037804A3 - Preservation and formulation of bioactive materials - Google Patents

Preservation and formulation of bioactive materials Download PDF

Info

Publication number
WO2001037804A3
WO2001037804A3 PCT/US2000/032071 US0032071W WO0137804A3 WO 2001037804 A3 WO2001037804 A3 WO 2001037804A3 US 0032071 W US0032071 W US 0032071W WO 0137804 A3 WO0137804 A3 WO 0137804A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
bioactive materials
preservation
formulation
vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/032071
Other languages
French (fr)
Other versions
WO2001037804A2 (en
Inventor
Victor Bronshtein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universal Preservation Technologies Inc
Original Assignee
Universal Preservation Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universal Preservation Technologies Inc filed Critical Universal Preservation Technologies Inc
Priority to AU20461/01A priority Critical patent/AU2046101A/en
Priority to US10/130,840 priority patent/US7153472B1/en
Publication of WO2001037804A2 publication Critical patent/WO2001037804A2/en
Publication of WO2001037804A3 publication Critical patent/WO2001037804A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

This invention relates to formulations comprising biological samples preserved as dry glassy powders and hydrophobic carriers, the formulations being adapted for the long-term storage and delivery of the bioactive materials, in particular viral and bacterial vaccines, vectors and cells, at ambient or higher temperatures, and to methods for preparing these formulations.
PCT/US2000/032071 1999-11-22 2000-11-22 Preservation and formulation of bioactive materials Ceased WO2001037804A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU20461/01A AU2046101A (en) 1999-11-22 2000-11-22 Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers
US10/130,840 US7153472B1 (en) 2000-11-22 2000-11-22 Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16678399P 1999-11-22 1999-11-22
US60/166,783 1999-11-22

Publications (2)

Publication Number Publication Date
WO2001037804A2 WO2001037804A2 (en) 2001-05-31
WO2001037804A3 true WO2001037804A3 (en) 2001-11-22

Family

ID=22604686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032071 Ceased WO2001037804A2 (en) 1999-11-22 2000-11-22 Preservation and formulation of bioactive materials

Country Status (2)

Country Link
AU (1) AU2046101A (en)
WO (1) WO2001037804A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666844B2 (en) 1999-04-16 2010-02-23 Novo Nordisk A/S Dry mouldable drug formulation

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6623762B2 (en) * 2001-02-16 2003-09-23 Cambridge Biostability Ltd. Composition and method for controlled release injections
US7135180B2 (en) * 2002-04-11 2006-11-14 Medimmune Vaccines, Inc. Preservation of bioactive materials by freeze dried foam
GB0408199D0 (en) * 2004-04-13 2004-05-19 Cambridge Biostability Ltd Liquids containing suspended sugar glass particles
KR20070009639A (en) * 2004-04-13 2007-01-18 캠브리지 바이오스테빌리티 리미티드 Liquid containing suspended glass particles
US9744227B2 (en) * 2004-06-02 2017-08-29 Universal Stabilization Technologies, Inc. Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof
WO2013188626A2 (en) * 2012-06-15 2013-12-19 Dow Global Technologies Llc Probiotic-containing particles having improved probiotic stability when in aqueous formulations
EP4026568A1 (en) 2015-04-17 2022-07-13 CureVac Real Estate GmbH Lyophilization of rna
EP3297682B1 (en) 2015-05-20 2021-07-14 CureVac AG Dry powder composition comprising long-chain rna
CN107635587A (en) 2015-05-20 2018-01-26 库瑞瓦格股份公司 Include long-chain RNA dry powder compositions
CN107897170A (en) * 2017-11-17 2018-04-13 南京普维康生物科技有限公司 A kind of buccal swab DNA preservation solution and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002240A1 (en) * 1996-07-15 1998-01-22 Universal Preservation Technologies, Inc. Preservation by foam formation
WO1998016250A1 (en) * 1996-10-16 1998-04-23 Alza Corporation Stable protein and nucleic acid formulations using non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity
WO1998041188A2 (en) * 1997-03-18 1998-09-24 Quadrant Holdings Cambridge Limited Stable particle in liquid formulations

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002240A1 (en) * 1996-07-15 1998-01-22 Universal Preservation Technologies, Inc. Preservation by foam formation
US5766520A (en) * 1996-07-15 1998-06-16 Universal Preservation Technologies, Inc. Preservation by foam formation
WO1998016250A1 (en) * 1996-10-16 1998-04-23 Alza Corporation Stable protein and nucleic acid formulations using non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity
WO1998041188A2 (en) * 1997-03-18 1998-09-24 Quadrant Holdings Cambridge Limited Stable particle in liquid formulations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666844B2 (en) 1999-04-16 2010-02-23 Novo Nordisk A/S Dry mouldable drug formulation

Also Published As

Publication number Publication date
AU2046101A (en) 2001-06-04
WO2001037804A2 (en) 2001-05-31

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