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WO2001091577A1 - Aliment solide et prevention des maladies des onglons chez les bovins - Google Patents

Aliment solide et prevention des maladies des onglons chez les bovins Download PDF

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Publication number
WO2001091577A1
WO2001091577A1 PCT/JP2000/003486 JP0003486W WO0191577A1 WO 2001091577 A1 WO2001091577 A1 WO 2001091577A1 JP 0003486 W JP0003486 W JP 0003486W WO 0191577 A1 WO0191577 A1 WO 0191577A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
solid feed
biotin
solidifying agent
hoof
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2000/003486
Other languages
English (en)
Japanese (ja)
Inventor
Takayoshi Matsuki
Eiichi Ohashi
Ryo Saito
Keiichiro Suzuki
Yasuyuki Suzuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Zenyaku Kogyo Co Ltd
Original Assignee
Nippon Zenyaku Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zenyaku Kogyo Co Ltd filed Critical Nippon Zenyaku Kogyo Co Ltd
Priority to JP2001587599A priority Critical patent/JP4714398B2/ja
Priority to PCT/JP2000/003486 priority patent/WO2001091577A1/fr
Priority to CNB008197911A priority patent/CN1267015C/zh
Publication of WO2001091577A1 publication Critical patent/WO2001091577A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/40—Mineral licks, e.g. salt blocks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to a solid feed and a method for preventing hoof disease in cattle.
  • hoof disease in livestock is a disease that is said to have the greatest economic loss after mastitis and reproductive problems. Livestock suffers from severe stress when they suffer from hoof disease, and this stress is thought to hinder livestock productivity such as loss of body weight and milk yield and milk quality, resulting in increased economic loss.
  • Piotin is a sulfur-containing water-soluble vitamin that functions as a coenzyme for carboxylase, is involved in gluconeogenesis, fatty acid synthesis, amino acid catabolism, and bacterial propionate synthesis, and produces keratin in relation to hoof strength. It has the effect of promoting.
  • biotin In addition to biotin, nutrients such as vitamin A, vitamin D, zinc, copper, manganese, methionine, cystine, essential fatty acids, phosphorus, and calcium are required for epithelial cell differentiation and keratin production. It is believed that the deficiency prevents normal hoof formation. In particular, biotin and zinc are considered to be important factors that are likely to be in short supply. The supply of biotin to dairy and beef cattle reduces the incidence of sole ulcers and heel erosions, a type of hoof disease.
  • bovine saliva is originally made of baking soda that has a buffering effect, and if it is possible to promote bovine salivary secretion, it will prevent rumen acidosis.
  • As one method for effectively secreting saliva it has been confirmed by the inventors that the amount of saliva increases by eating a mineral block agent or the like.
  • the present inventors have conducted repeated studies on a method for efficiently taking biotin into the body, and as a result, formed a solid feed containing biotin and other hoof components, and a rumen pH regulator, and formed a solid feed.
  • the present invention was found to be able to increase the utilization rate of biotin, make it possible to supply biotin economically by feeding it, and at the same time, to prevent rumenacidosis and to effectively prevent hoof disease, thereby completing the present invention.
  • the present invention relates to a method of mixing and solidifying biotin, a hoof component, and a solidifying agent, or a method of mixing biotin, a hoof component, a rumen pH regulator, and a solidifying agent. It is solidified by solidification.
  • the biotin used in the solid feed may be a powder, granule or solution such as d-biotin, and may contain about 0.05 to 0.1% by weight of biotin.
  • At least one of the components constituting the hoof can be selected and used as nutrients such as vitamin A, vitamin D, zinc, copper, manganese, methionine, cystine, essential fatty acids, phosphorus, and calcium. It can contain about 0.01 to 20% by weight.
  • Various organic acids such as citric acid, malic acid, and acetic acid, and sodium bicarbonate can be used alone or as a mixture as a rumen pH adjuster. If the amount of cattle licking solid feed per cow per day is 50 g, the amount that maintains the pH in the rumen after feeding at 6.5 or more, for example, about sodium hydrogen carbonate It can contain 40 to 60% by weight.
  • Salt can be used as the solidifying agent, and can contain, for example, about 80 to 99% by weight of salt.
  • salt As the solidifying agent, salt, magnesium salt and molasses can be used.
  • salt is 30 to 45% by weight
  • magnesium salt is 0.1 to 1.0% by weight
  • molasses is about 0.4 to 2%. 8% by weight.
  • the solidifying agents include one or more liquid molasses such as molasses or corn steeper, one or more metal oxides, inorganic acids, inorganic salts, organic acids, and organic acids.
  • a mixture with one or more acids or salts selected from the group consisting of acid salts can be used.
  • one or more molasses or a liquid feed such as corn steep liquor 30 to 9 7% by weight, one or more metal oxides 2 to 35% by weight, one or more acids selected from the group consisting of inorganic acids, inorganic acid salts, organic acids, and organic acid salts May contain from 1 to 35% by weight of salts.
  • the solidifying agent adjusts at least one of corn steep liquor and fish soluble, and at least one of magnesium chloride and calcium chloride, and if necessary, a small amount of water and pH to 3 to 9.
  • PH adjusting solution, and phosphoric acid for example, containing at least one of corn steep liquor and fish soy liquor, and at least one of magnesium chloride and calcium chloride. It may contain from 5 to 20% by weight, if necessary a small amount of water, a rumen PH regulator to adjust the pH to 3 to 9, and 0.2 to 15.0% by weight of phosphoric acid. (three Reference: Patent No. 2096413)
  • the following methods can be used to solidify the solid feed.
  • salt When salt is used as the solidifying agent, a mixture of salt, piotin, and other hoof constituents is mixed with 80 to 98% by weight of salt, 0.005 to 0.
  • salt, magnesium salt, and molasses are used as the solidifying agent
  • a mixture of dietary salts and magnesium salts, molasses, biotin, and hoof components, and a rumen pH adjuster are also mixed. 30% to 45% by weight of salt, 0.1% to 1.0% by weight of magnesium salt, about 0.4% to 2.8% by weight of molasses, 0.005% to 0.1% by weight of biotin, Combine the hoof component about 0.01 to 20% by weight, the rumen pH adjuster 10 to 60% by weight, and press pressure 550i;
  • liquid feeds such as one or more molasses or corn steeper, one or more metal oxides, inorganic acids, inorganic acid salts, organic acids, and organic acids are used as solidifying agents.
  • liquid feed such as one or more molasses or corn steep liquor 30 to 97 weight %, 1 or
  • At least one of corn steep liquor and fish soluble, and at least magnesium chloride and calcium chloride should be added to the solidifying agent. If a mixture consisting of one and, if necessary, a minimum of water is added to adjust the pH to 3 to 9 and phosphoric acid, use corn steep liquor and fish soy liquor. Adjust at least one of magnesium chloride and calcium chloride to 0.5 to 20% by weight, if necessary, a small amount of water, and adjust the pH to 3 to 9 with a lumen pH adjuster After mixing with 0.005 to 0.1% by weight of pyotin, about 0.01 to 20% by weight of hoof constituents, and 10 to 60% by weight of a rumen pH adjuster, phosphoric acid was added. It is solidified by adding 2 to 15.0% by weight to form a double salt.
  • the solidified solid feed can prevent cattle hoof disease by allowing the cow to lick it freely between meals.
  • the amount of licking at this time was about 35 g, and the daily supply of biotin was about 3.5 mg.
  • commercially available feed additives containing biotin dust, product name “Nail Up”; manufactured by Rochevitamine Japan Co., Ltd .; 400 mg of vitamin E 10, OOOrag, d-Piotin, 3,600 mg of organic zinc, Meteonin (7,200 mg) was fed to cattle.
  • the feed additive equivalent to 1 Omg or more in terms of daily biotin intake (1 Per head per day
  • the amount of licking at this time was about 18 g, and the amount of supply of biotin described by 1 was about 1.8 mg.
  • a commercially available feed additive containing piotin (powder, product name "Nail Up”; Roche Vitamin Japan
  • the method of feeding cows a solid feed containing biotin increases the amount of biotin taken up by the cows and increases the cost of biomass. It is possible to increase the utilization rate of hottin.
  • licking solid feed promotes salivary secretion, and a rumen pH regulator prevents the decrease of rumen pH in the rumen, preventing rumen acidosis and preventing bacteria in the rumen. It is considered that by increasing the amount of produced biotin, the blood concentration of biotin was further increased, thereby effectively preventing cattle hoof disease.
  • FIG. 1 is a graph showing the state in which the ratio of cows with hoof disease when the solid feed prepared in Example 5 was licked by cattle was lower than that in the same period of the previous year.
  • FIG. 3 is a graph showing the state in which the percentage of milk fat increased when cows licked the solid feed prepared in Example 5, and FIG. 3 shows the steps taken when cows licked the solid feed prepared in Example 6.
  • Fig. 4 is a graph showing the change in milk yield when the solid feed prepared in Example 6 was licked by a cow, and Fig. 4 is a graph showing the change in milk yield.
  • FIG. 6 is a graph showing a state in which the blood biotin concentration was significantly increased when cattle licked the solid feed prepared in Example 8, and FIG.
  • Fig. 7 is a graph showing an increase in blood biotin concentration at the second month of the salary when administered. 4 is a graph showing the effect of adjusting pH in rumen by feeding by licking.
  • Example 1 98% by weight of salt, 0.1% by weight of piotin, 0.25% by weight of inorganic zinc, 0.05% by weight of manganese, 0.1% by weight of manganese, 0.1% by weight of organic zinc, 0.2% by weight of methionine.
  • Vitamin A 2 After mixing 0.1000 wt% of iron and 0.12 wt% of iron, 0.15 wt% of copper and 0.015 wt% of selenium, 0.015 wt% of selenium and vitamin E2,000 IU, press pressure The mixture was squeezed with a hydraulic press of 750 t and solidified to produce a solid mixed feed. The prepared solid feed had sufficient physical properties to make cows lick.
  • a solid feed was prepared by mixing 0.2% by weight and 50% by weight of sodium bicarbonate, and squeezing and solidifying the mixture with a hydraulic press having a pressing pressure of 650t. The prepared solid feed had sufficient physical properties to make cows lick.
  • a solid feed was prepared by mixing 0.1% by weight and 50% by weight of sodium bicarbonate and pressing the mixture using a hydraulic press with a press pressure of 65Ot to solidify.
  • a solid feed was prepared by mixing 0.1% by weight and 50% by weight of sodium bicarbonate and pressing the mixture using a hydraulic press with a press pressure of 65Ot to solidify.
  • the prepared solid feed was licked by 699 cows from 7 farms for about 6 months, and it improved foot disease and related diseases and increased milk yield compared to 488 unpaid controls.
  • the postpartum accident rate was reduced, and the milk fat percentage was increased.
  • the amount of licking at this time was about 34 g per animal per day on average. Calculated from the amount of food taken, the daily supply of biotin was about 3.4 mg.
  • the prepared solid feed was fed to 2 dairy cows, 1 2 6 cattle, for 3 months.
  • the number of lame cows decreased, the hooves became stiff, and the blood biotin concentration increased significantly (Fig. 5).
  • the amount of licking was about 35 g / animal / day.
  • the daily supply of biotin was about 3.5 mg.
  • feed additives containing piotin powder, product name “Nail-up”; manufactured by Roche Vitamin Japan Co., Ltd .; 10,000 kg of vitamin E, 400 mg of d-biotin, 3,600 mg of organic zinc, 3,600 mg of methionine was fed to cattle, and in order to increase the concentration of blood biotin, the feed supplement equivalent to 1 Omg or more (1 day) was converted to the daily intake of biotin. Per animal, “nail up” 25 g or more) was required.
  • the blood biotin concentration was about 50 pg / m from the initial 302 pg / m1 to 3488 pg / m1. 1 (Fig. 6).
  • the amount of licking at this time was about 18 g per animal per day on average, and the daily supply of biotin was calculated to be about 1.8 mg.
  • feed additives containing biotin dust, product name “Nail Up”; manufactured by Roche Vitamin Japan Co., Ltd .; 10,000 kg of vitamin E, 400 mg of d-biotin, 3,600 mg of organic zinc, Methionine 7,200 mg
  • feed supplementation equivalent to 1 mg or more of daily dietary intake of dietary supplements was required.
  • a solid feed was prepared by mixing 0.1% by weight and 50% by weight of sodium bicarbonate and pressing the mixture with a hydraulic press having a press pressure of 65Ot to solidify.
  • the free feeding of the biotin-containing solid feed of the present invention by a cow allows easy intake of biotin and hoof components into the body, increases the utilization of biotin, and enhances saliva and rumen secreted by feeding.
  • By adding an H regulator rumen acidosis can be prevented and it can be used effectively for the prevention of hoof disease in cattle.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un aliment solide contenant de la biotine, des composants d'onglons, et un agent régulateur du pH du rumen, solidifiés à l'aide d'un solidifiant. Lorsqu'ils lèchent cet aliment solide contenant de la biotine, les bovins absorbent une dose élevée de celle-ci dans leur organisme, ce qui permet de prévenir l'acidose du rumen et les maladies des onglons.
PCT/JP2000/003486 2000-05-31 2000-05-31 Aliment solide et prevention des maladies des onglons chez les bovins Ceased WO2001091577A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001587599A JP4714398B2 (ja) 2000-05-31 2000-05-31 固形飼料及び牛の蹄病予防方法
PCT/JP2000/003486 WO2001091577A1 (fr) 2000-05-31 2000-05-31 Aliment solide et prevention des maladies des onglons chez les bovins
CNB008197911A CN1267015C (zh) 2000-05-31 2000-05-31 固化块状饲料及其用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2000/003486 WO2001091577A1 (fr) 2000-05-31 2000-05-31 Aliment solide et prevention des maladies des onglons chez les bovins

Publications (1)

Publication Number Publication Date
WO2001091577A1 true WO2001091577A1 (fr) 2001-12-06

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PCT/JP2000/003486 Ceased WO2001091577A1 (fr) 2000-05-31 2000-05-31 Aliment solide et prevention des maladies des onglons chez les bovins

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CN (1) CN1267015C (fr)
WO (1) WO2001091577A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103609856A (zh) * 2013-11-18 2014-03-05 四川铁骑力士实业有限公司 一种母猪蹄部保健的饲料添加剂及其使用方法
JP2016525371A (ja) * 2013-07-30 2016-08-25 ベネミルク オーワイＢｅｎｅｍｉｌｋ Ｏｙ 反芻動物用ミネラル舐食組成物およびこれを作成および使用する方法
US20160317500A1 (en) * 2013-12-13 2016-11-03 Dsm Ip Assets B.V. Novel use of biotin and natural essential oils for bovine animals for the prevention and treatment of ketosis

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102113637B (zh) * 2010-12-17 2013-07-17 沈阳农业大学 一种耐气候型牛促繁殖营养舔砖的生产方法
CN102068454B (zh) * 2011-01-13 2012-04-25 王之盛 一种预防瘤胃酸中毒的缓释调控剂及其制备方法
CN102763776B (zh) * 2012-07-27 2013-12-11 太仓安佑生物科技有限公司 一种促进种畜蹄部健康的功能性饲料
CN103892057B (zh) * 2012-12-26 2015-12-23 内蒙古伊利实业集团股份有限公司 预防高产奶牛蹄病的1%饲料添加剂及其制备方法与应用
CN104664121A (zh) * 2013-12-02 2015-06-03 内蒙古伊利实业集团股份有限公司 一种奶牛饲料添加剂
CN106260591A (zh) * 2016-08-08 2017-01-04 广汉隆达饲料有限公司 一种改善奶牛蹄部健康的组合物
CN106666126A (zh) * 2016-12-23 2017-05-17 上海光明荷斯坦牧业有限公司 一种预防牛瘤胃酸中毒的舔砖及其制作方法

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JPS6075240A (ja) * 1983-09-29 1985-04-27 Nippon Zenyaku Kogyo Kk 家畜用固形飼料及びその製造法
JPS623745A (ja) * 1985-06-28 1987-01-09 Toyo Jozo Co Ltd ブロツク状飼料およびそれを用いる飼育法
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JPH09172980A (ja) * 1995-12-28 1997-07-08 Ajinomoto Co Inc 新規リン酸アミノ酸複合塩及び水溶性高分子を含有する反すう動物用飼料添加組成物
EP0937706A1 (fr) * 1995-12-28 1999-08-25 Ajinomoto Co., Inc. Sel composite d'acide phosphorique et d'acide amine comprenant des metaux polyvalents, et compositions d'additif nutritionnel pour ruminants

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JPS623745A (ja) * 1985-06-28 1987-01-09 Toyo Jozo Co Ltd ブロツク状飼料およびそれを用いる飼育法
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016525371A (ja) * 2013-07-30 2016-08-25 ベネミルク オーワイＢｅｎｅｍｉｌｋ Ｏｙ 反芻動物用ミネラル舐食組成物およびこれを作成および使用する方法
CN103609856A (zh) * 2013-11-18 2014-03-05 四川铁骑力士实业有限公司 一种母猪蹄部保健的饲料添加剂及其使用方法
US20160317500A1 (en) * 2013-12-13 2016-11-03 Dsm Ip Assets B.V. Novel use of biotin and natural essential oils for bovine animals for the prevention and treatment of ketosis
US10952991B2 (en) 2013-12-13 2021-03-23 Dsm Ip Assets B.V. Use of biotin and natural essential oils for bovine animals for the prevention and treatment of ketosis
US11478455B2 (en) 2013-12-13 2022-10-25 Dsm Ip Assets B.V. Use of biotin and natural essential oils for bovine animals for the prevention and treatment of ketosis

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CN1267015C (zh) 2006-08-02
JP4714398B2 (ja) 2011-06-29
CN1454057A (zh) 2003-11-05

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