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WO2001087227A3 - Methodes et compositions a base de micelles polymeres sensibles au ph, permettant d'augmenter la puissance d'agents therapeutiques - Google Patents

Methodes et compositions a base de micelles polymeres sensibles au ph, permettant d'augmenter la puissance d'agents therapeutiques Download PDF

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Publication number
WO2001087227A3
WO2001087227A3 PCT/IB2001/001456 IB0101456W WO0187227A3 WO 2001087227 A3 WO2001087227 A3 WO 2001087227A3 IB 0101456 W IB0101456 W IB 0101456W WO 0187227 A3 WO0187227 A3 WO 0187227A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric micelles
drug containing
containing polymeric
micelles
therapeutic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/001456
Other languages
English (en)
Other versions
WO2001087227A2 (fr
Inventor
Jean-Christophe Leroux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labopharm Inc
Original Assignee
Labopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc filed Critical Labopharm Inc
Priority to AU2001276627A priority Critical patent/AU2001276627A1/en
Priority to EP01954286A priority patent/EP1286643A2/fr
Publication of WO2001087227A2 publication Critical patent/WO2001087227A2/fr
Anticipated expiration legal-status Critical
Publication of WO2001087227A3 publication Critical patent/WO2001087227A3/fr
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouvelles micelles polymères, qui sont sensibles au pH et/ou à la température et qui sont utilisées afin d'augmenter la puissance d'agents thérapeutiques, notamment de médicaments antitumoraux.
PCT/IB2001/001456 2000-05-17 2001-05-15 Methodes et compositions a base de micelles polymeres sensibles au ph, permettant d'augmenter la puissance d'agents therapeutiques Ceased WO2001087227A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001276627A AU2001276627A1 (en) 2000-05-17 2001-05-15 Drug containing polymeric micelles
EP01954286A EP1286643A2 (fr) 2000-05-17 2001-05-15 Methodes et compositions a base de micelles polymeres sensibles au ph, permettant d'augmenter la puissance d'agents therapeutiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57220100A 2000-05-17 2000-05-17
US09/572,201 2000-05-17

Publications (2)

Publication Number Publication Date
WO2001087227A2 WO2001087227A2 (fr) 2001-11-22
WO2001087227A3 true WO2001087227A3 (fr) 2002-11-28

Family

ID=24286790

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001456 Ceased WO2001087227A2 (fr) 2000-05-17 2001-05-15 Methodes et compositions a base de micelles polymeres sensibles au ph, permettant d'augmenter la puissance d'agents therapeutiques

Country Status (3)

Country Link
EP (1) EP1286643A2 (fr)
AU (1) AU2001276627A1 (fr)
WO (1) WO2001087227A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10046057B2 (en) 2012-09-24 2018-08-14 The Regents Of The University Of California Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
CN108347922B (zh) * 2015-08-18 2021-03-16 巴斯夫欧洲公司 具有聚乙烯醇和聚噁唑啉的壳的农业化学微胶囊

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US7094810B2 (en) 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US7316816B2 (en) * 2004-06-10 2008-01-08 Agency For Science Technology And Research Temperature and pH sensitive copolymers
US7727554B2 (en) 2004-12-21 2010-06-01 Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center Sustained-release nanoparticle compositions and methods for using the same
US20100159508A1 (en) * 2006-07-06 2010-06-24 Agency For Science, Technology And Research Thermally responsive micelles
US8703194B2 (en) 2007-11-02 2014-04-22 Agency For Science, Technology And Research Stimulus-responsive biodegradable polymers and methods of preparation
WO2009140429A2 (fr) 2008-05-13 2009-11-19 University Of Washington Ensembles micelles
CA2724105C (fr) 2008-05-13 2017-09-05 University Of Washington Copolymeres diblocs et complexes polynucleotidiques pour administration dans des cellules
CN102065902A (zh) * 2008-05-13 2011-05-18 华盛顿大学 聚合物载体
EP2331069A4 (fr) * 2008-08-22 2011-10-26 Univ Washington Micelles polymères hétérogènes pour administration intracellulaire
WO2010054266A2 (fr) 2008-11-06 2010-05-14 University Of Washington Copolymères multiséquencés
CA2742955A1 (fr) 2008-11-06 2010-05-14 University Of Washington Vehicules d'administration intracellulaire bispecifique
EP2373715A4 (fr) 2008-12-08 2014-12-03 Univ Washington Polymères à fonction oméga, copolymères séquencés à fonction de jonction, bioconjugués polymères et polymérisation d'extension de chaîne radicalaire
JP2010208955A (ja) * 2009-03-06 2010-09-24 Makoto Yuasa 疾患治療薬
EP2547369B1 (fr) * 2010-03-19 2017-04-19 King Saud University Nanoparticule comprenant une micelle formée par un copolymère séquencé amphiphile et encapsulant un complexe de gadolinium
IL223022A0 (en) 2010-05-14 2013-02-03 Texas A & M Univ Sys Functional, cross-linked nanostructures for tandem optical imaging and therapy
AU2014296278C1 (en) 2013-07-30 2023-02-02 Genevant Sciences Gmbh Block copolymers and their conjugates or complexes with oligonucleotides
CN107530436B (zh) 2015-01-21 2022-03-29 菲泽尔克斯公司 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统
WO2017002114A1 (fr) 2015-06-29 2017-01-05 Technion Research & Development Foundation Limited Polymères amphiphiles encapsulant des agents thérapeutiquement actifs, leur procédé de préparation et utilisation associée
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
WO2018126084A1 (fr) 2016-12-30 2018-07-05 Phaserx, Inc. Molécules de peg ramifié, compositions et procédés associés
CN115998713B (zh) * 2023-01-17 2025-03-28 华中科技大学 工程化改造肿瘤细胞来源微颗粒载药制剂及其制备方法
CN118852545B (zh) * 2024-06-27 2025-07-18 锐康九域(厦门)医药科技有限公司 一种聚合物载体和药物组合物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6322817B1 (en) * 1999-02-17 2001-11-27 Dabur Research Foundation Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6322817B1 (en) * 1999-02-17 2001-11-27 Dabur Research Foundation Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J. TAILLEFER ET AL.: "Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugs", JOURNAL OF PHARMACEUTICAL W SCIENCES, vol. 89, no. 1, January 2000 (2000-01-01), Washington (US), pages 52 - 62, XP002206433 *
J-C LEROUX ET AL.: "N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles", JOURNAL OF CONTROLLED RELEASE, vol. 72, no. 1-3, 14 May 2001 (2001-05-14), Amsterdam (NL), pages 71 - 84, XP004246437 *
M-C JONES ET AL.: "Polymeric micelles-a new generation of colloidal drug carriers", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 48, no. 2, 1 September 1999 (1999-09-01), Amsterdam (NL), pages 101 - 111, XP004257101 *
Sixth European Symposium on Controlled Drug Delivery; Noordwijk aan Zee, Netherlands; April 12-14, 2000 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10046057B2 (en) 2012-09-24 2018-08-14 The Regents Of The University Of California Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
CN108347922B (zh) * 2015-08-18 2021-03-16 巴斯夫欧洲公司 具有聚乙烯醇和聚噁唑啉的壳的农业化学微胶囊

Also Published As

Publication number Publication date
EP1286643A2 (fr) 2003-03-05
WO2001087227A2 (fr) 2001-11-22
AU2001276627A1 (en) 2001-11-26

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