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WO2001087227A3 - Drug containing polymeric micelles - Google Patents

Drug containing polymeric micelles Download PDF

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Publication number
WO2001087227A3
WO2001087227A3 PCT/IB2001/001456 IB0101456W WO0187227A3 WO 2001087227 A3 WO2001087227 A3 WO 2001087227A3 IB 0101456 W IB0101456 W IB 0101456W WO 0187227 A3 WO0187227 A3 WO 0187227A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric micelles
drug containing
containing polymeric
micelles
therapeutic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/001456
Other languages
French (fr)
Other versions
WO2001087227A2 (en
Inventor
Jean-Christophe Leroux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labopharm Inc
Original Assignee
Labopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc filed Critical Labopharm Inc
Priority to EP01954286A priority Critical patent/EP1286643A2/en
Priority to AU2001276627A priority patent/AU2001276627A1/en
Publication of WO2001087227A2 publication Critical patent/WO2001087227A2/en
Anticipated expiration legal-status Critical
Publication of WO2001087227A3 publication Critical patent/WO2001087227A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel polymeric micelles which are pH and/or temperature sensitive, and which are used to increase potency of therapeutic agents, including anti tumor drugs.
PCT/IB2001/001456 2000-05-17 2001-05-15 Drug containing polymeric micelles Ceased WO2001087227A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01954286A EP1286643A2 (en) 2000-05-17 2001-05-15 Drug containing polymeric micelles
AU2001276627A AU2001276627A1 (en) 2000-05-17 2001-05-15 Drug containing polymeric micelles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57220100A 2000-05-17 2000-05-17
US09/572,201 2000-05-17

Publications (2)

Publication Number Publication Date
WO2001087227A2 WO2001087227A2 (en) 2001-11-22
WO2001087227A3 true WO2001087227A3 (en) 2002-11-28

Family

ID=24286790

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001456 Ceased WO2001087227A2 (en) 2000-05-17 2001-05-15 Drug containing polymeric micelles

Country Status (3)

Country Link
EP (1) EP1286643A2 (en)
AU (1) AU2001276627A1 (en)
WO (1) WO2001087227A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10046057B2 (en) 2012-09-24 2018-08-14 The Regents Of The University Of California Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
CN108347922B (en) * 2015-08-18 2021-03-16 巴斯夫欧洲公司 Agrochemical microcapsules with shells of polyvinyl alcohol and polyoxazoline

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
US7094810B2 (en) * 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
US6780428B2 (en) 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US7316816B2 (en) 2004-06-10 2008-01-08 Agency For Science Technology And Research Temperature and pH sensitive copolymers
US7727554B2 (en) * 2004-12-21 2010-06-01 Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center Sustained-release nanoparticle compositions and methods for using the same
WO2008004988A1 (en) * 2006-07-06 2008-01-10 Agency For Science, Technology And Research Thermally responsive micelles
US8703194B2 (en) 2007-11-02 2014-04-22 Agency For Science, Technology And Research Stimulus-responsive biodegradable polymers and methods of preparation
EP2620161A1 (en) 2008-05-13 2013-07-31 University of Washington Diblock copolymers and polynucleotide complexes thereof for delivery into cells
BRPI0911989A2 (en) 2008-05-13 2015-10-20 Phaserx Inc mycelic unions
KR20110026424A (en) * 2008-05-13 2011-03-15 유니버시티 오브 워싱톤 Polymer carrier
WO2010021770A1 (en) * 2008-08-22 2010-02-25 University Of Washington Heterogeneous polymeric micelles for intracellular delivery
ES2540767T3 (en) 2008-11-06 2015-07-13 University Of Washington Multi-block copolymers
JP2012507581A (en) 2008-11-06 2012-03-29 ユニヴァーシティ オブ ワシントン Bispecific intracellular delivery vehicle
US9593169B2 (en) 2008-12-08 2017-03-14 University Of Washington Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization
JP2010208955A (en) * 2009-03-06 2010-09-24 Makoto Yuasa Disease treatment drug
WO2011113616A1 (en) * 2010-03-19 2011-09-22 King Saud University A nanoparticle comprising a micelle formed by an amphiphilic block- copolymer and encapsulating a gadolinium complex
JP5848332B2 (en) 2010-05-14 2016-01-27 マリンクロッド エルエルシー Functional cross-linked nanostructures for optical contrast and therapy tandems
AU2014296278C1 (en) 2013-07-30 2023-02-02 Genevant Sciences Gmbh Block copolymers and their conjugates or complexes with oligonucleotides
JP2018509387A (en) 2015-01-21 2018-04-05 フェーズアールエックス インコーポレイテッド Methods, compositions, and systems for delivering therapeutic and diagnostic agents to cells
WO2017002114A1 (en) 2015-06-29 2017-01-05 Technion Research & Development Foundation Limited Amphiphilic polymers encapsulating therapeutically active agents, process of preparing same and use thereof
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
US11684584B2 (en) 2016-12-30 2023-06-27 Genevant Sciences Gmbh Branched peg molecules and related compositions and methods
CN115998713B (en) * 2023-01-17 2025-03-28 华中科技大学 Engineering modified tumor cell-derived microparticle drug-carrying preparation and preparation method thereof
CN118852545B (en) * 2024-06-27 2025-07-18 锐康九域(厦门)医药科技有限公司 Polymer carrier, pharmaceutical composition and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6322817B1 (en) * 1999-02-17 2001-11-27 Dabur Research Foundation Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6322817B1 (en) * 1999-02-17 2001-11-27 Dabur Research Foundation Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J. TAILLEFER ET AL.: "Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugs", JOURNAL OF PHARMACEUTICAL W SCIENCES, vol. 89, no. 1, January 2000 (2000-01-01), Washington (US), pages 52 - 62, XP002206433 *
J-C LEROUX ET AL.: "N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles", JOURNAL OF CONTROLLED RELEASE, vol. 72, no. 1-3, 14 May 2001 (2001-05-14), Amsterdam (NL), pages 71 - 84, XP004246437 *
M-C JONES ET AL.: "Polymeric micelles-a new generation of colloidal drug carriers", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 48, no. 2, 1 September 1999 (1999-09-01), Amsterdam (NL), pages 101 - 111, XP004257101 *
Sixth European Symposium on Controlled Drug Delivery; Noordwijk aan Zee, Netherlands; April 12-14, 2000 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10046057B2 (en) 2012-09-24 2018-08-14 The Regents Of The University Of California Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
CN108347922B (en) * 2015-08-18 2021-03-16 巴斯夫欧洲公司 Agrochemical microcapsules with shells of polyvinyl alcohol and polyoxazoline

Also Published As

Publication number Publication date
WO2001087227A2 (en) 2001-11-22
AU2001276627A1 (en) 2001-11-26
EP1286643A2 (en) 2003-03-05

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