WO2001085068A1 - Partie d'endoprothese pour le remplacement d'articulations, utilisation et procede de fabrication de ladite partie - Google Patents
Partie d'endoprothese pour le remplacement d'articulations, utilisation et procede de fabrication de ladite partie Download PDFInfo
- Publication number
- WO2001085068A1 WO2001085068A1 PCT/EP2001/005070 EP0105070W WO0185068A1 WO 2001085068 A1 WO2001085068 A1 WO 2001085068A1 EP 0105070 W EP0105070 W EP 0105070W WO 0185068 A1 WO0185068 A1 WO 0185068A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- areas
- endoprosthesis
- osseoinductive
- osseointegrative
- osseoconductive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/34—Acetabular cups
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
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- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
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- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
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Definitions
- the present invention relates to an endoprosthesis part for the joint replacement, to the use of the endoprosthesis part according to the invention and to a production method for endoprosthesis parts according to the invention.
- endoprosthesis parts for artificial cement-free joint replacement have been manufactured using an inlay technique.
- Such an endoprosthesis part is e.g. in EP 0 743 050.
- a ceramic 1 nert in a metal bowl e.g. anchored from titanium.
- the ceramic insert has a spherical concavity to accommodate the ball head of a joint.
- the good tribological properties of the ceramic are used.
- the metal shell surrounding the ceramic insert takes on the task of bony integration of the endoprosthesis part in order to ensure good stability of the endoprosthesis part over several years. Due to the dynamic loading of the joint, however, the connection point between the ceramic and the metal shell is heavily loaded, which results in a reduced service life of the endoprosthesis part.
- endoprosthesis parts have been proposed which consist entirely of a ceramic and thus solve the problem of the connection between ceramic and metal.
- endoprosthesis parts have the disadvantage that the bony healing does not take place, or takes place only insufficiently, and therefore long-term stability of the endoprosthesis part cannot be guaranteed, which in turn results in the endoprosthesis part having a limited shelf life.
- an endoprosthesis part in particular an artificial acetabular cup or acetabular cup, is provided for the joint replacement, which body can absorb force areas, which are integrally formed with the body and which can absorb a force acting on the endoprosthesis part, in particular when inserting the endoprosthesis part into a bone osseointegrative and / or osseoinductive or osseoconductive areas, which enable bony ingrowth or osseointegration of the endoprosthesis part or stimulate or promote bone growth.
- the force absorption areas serve to e.g. absorb forces occurring when the endoprosthesis part is hammered into a prepared bone bed and thus essentially protect the osseointegrative and / or osseoinductive or osseoconductive areas from damage. Furthermore, the force absorption areas preferably ensure the primary stability of the endoprosthesis part within the bone in the first time after insertion.
- the osseointegrative and / or osseoinductive or osseoconductive areas promote the bony ingrowth of the endoprosthesis part and thereby enable good secondary stability, so that the prosthesis part is anchored in the long term.
- the body with the force absorption areas and the osseointegrative and / or osseoinductive or osseoconductive areas are preferably provided in a monoblock structure in the endoprosthesis part according to the invention. It has been found that junctions between different materials often represent a weak point in endoprosthesis parts. The life of the endoprosthesis part according to the invention can be increased by the monoblock structure.
- the endoprosthesis part according to the invention preferably has at least three force absorption areas, which enable a stable support of the endoprosthesis part.
- the force absorption areas are preferably distributed circumferentially on the endoprosthesis part, so that the forces e.g. be distributed evenly over the force absorption areas when inserting.
- the osseointegrative and / or osseoinductive or osseoconductive regions are arranged between two adjacent force absorption regions.
- Osseointegrative and / or osseoinductive or osseoconductive areas often have a low stability with respect to the pressure loads occurring during insertion and in the first time after insertion. These loads can be absorbed by the force absorption areas, whereby the osseointegrative and / or osseoinductive or osseoconductive areas are protected.
- the force absorption areas preferably project over the osseointegrative and / or osseoinductive or osseoconductive areas.
- the osseointegrative and / or osseoinductive or osseoconductive areas can additionally be protected against stresses occurring during insertion, the elastic properties of the bone in particular being exploited.
- the force absorption areas project by approximately 0.3 mm to 1 mm in relation to the osseointegrative and / or osseoinductive or osseoconductive areas. This range of values has proven to be particularly suitable for the difference in height between the force absorption areas and the osseointegrative and / or osseoinductive or osseoconductive areas.
- the force absorption areas preferably have, at least in part, a thread or thread areas formed thereon. This offers the advantage of an additional positive and frictional primary anchoring of the endoprosthesis part.
- devices for securing against rotation are provided on the force absorption areas, which essentially prevent the inserted endoprosthesis part from twisting.
- the endoprosthesis part can be prevented from rotating in the bone bearing in the first time after insertion before the secondary anchoring of the endoprosthesis part is formed by bone healing.
- the body of the endoprosthesis part preferably has good tribological properties on a side facing a joint. This enables an advantageous interaction of the endoprosthesis part with a joint counterpart to be achieved.
- the body and the force-absorbing areas are preferably formed from a hard ceramic.
- Hard ceramics on the one hand have very good tribological properties, on the other hand they are very resistant to pressure and shear forces. Furthermore, ceramics, when used as a raw material for endoprostheses, have very good Bjo compatibility. Furthermore, the joint counterpart is often also made of a hard ceramic.
- the advantageous tribological property of the hard ceramic can be further enhanced by the self-pairing of ceramic on ceramic.
- the osseointegrative and / or osseoinductive or osseoconductive regions are further preferably formed from a porous ceramic. Bone can grow very well into the pores of the porous ceramic, which enables good bony integration.
- the osseointegrative and / or osseoinductive or osseoconductive areas are preferably formed from a ceramic which has a porosity of approximately 10-70 vol.%, Preferably approximately 20-60 vol.%.
- the porosity of the ceramic on the outer circumference is preferably approximately 80% by volume and decreases radially in the direction of the body.
- the outer envelope of the force-absorbing areas preferably has essentially the shape of a hemisphere.
- a pole area of the substantially hemispherical outer envelope of the force-receiving areas is preferably flattened. This ensures a better fit of the endoprosthesis part.
- An equatorial region of the substantially hemispherical outer envelope of the force-absorbing regions is further preferably widened.
- a type of “clamping area” can preferably be formed, which enables the endoprosthesis part to fit more firmly in the bone bearing.
- the use of the endoprosthesis part according to the invention is further provided as a cementless anchored acetabular cup for receiving a corresponding hip joint head.
- Steps include:
- the body and the osseointegrative and / or osseoinductive or osseoconductive areas are preferably connected in a sandwich construction, the body and the force-absorbing areas integrally formed therewith being provided from a hard ceramic and the osseointegrative and / or osseoinductive or osseoconductive Porous ceramic areas are provided.
- the body and the force-absorbing areas formed in one piece from a hard ceramic and the osseointegrative and / or osseoinductive or osseoconductive areas from a porous ceramic are preferably provided, and the porosity of the osseointegrative and / or osseoinductive or osseoconductive is more preferred Areas created by providing meltable particles in the green body of the ceramic and subsequent melting of the particles.
- the osseointegrative and / or osseoinductive or osseoconductive areas are sprayed onto the body in the spaces between the force absorption areas.
- the osseointegrative and / or osseoinductive or osseoconductive areas are further preferably sprayed into the spaces between the force absorption areas by means of a titanium plasma spray process.
- the osseointegrative and / or osseoinductive or osseoconductive areas (4) are preferably formed by means of hydroxyapatite or bone morphogenic proteins (BMP), which is applied in the spaces between the force absorption areas (2).
- BMP bone morphogenic proteins
- Figure 1 is a plan view of a first embodiment of the endoprosthesis part according to the invention.
- Fig. 2 is a sectional view of the first embodiment along line A-A of Fig. 1;
- FIG. 3 shows a top view of a second embodiment of the endoprosthesis part according to the invention.
- FIG. 4 shows a top view of a third embodiment of the endoprosthesis part according to the invention.
- FIG. 5 shows a top view of a fourth embodiment of the endoprosthesis part according to the invention.
- Fig. 6 is a sectional view of the fourth embodiment along line A-A of Fig. 5;
- Fig. 7 is a sectional view of a fifth embodiment of the endoprosthesis part according to the invention along a line substantially corresponding to line A-A of Fig. 1;
- FIG. 8 is a sectional view of a sixth embodiment of the endoprosthesis part according to the invention along a line which essentially corresponds to line A-A of FIG. 1.
- Endoprosthesis parts for the artificial cement-free replacement of an acetabular cup are described.
- the invention can Endoprosthesis part can also be used for other joints, such as finger, ankle or knee joints
- Fig. 1 shows a plan view
- Fig. 2 shows a sectional view of a first embodiment of the endoprosthesis part according to the invention along line A-A in Fig. 1.
- the endoprosthesis part is manufactured in a monoblock structure, i.e. the endoprosthesis part is of uniform design. It therefore has essentially no connection areas, which often represent a weak point of endoprosthesis parts in conventional endoprosthesis parts.
- the endoprosthesis part has an essentially hemispherical body 6, force-absorbing areas 2 formed on the outer circumference of the body 6 and a multiplicity of osseointegrative and / or osseoinductive or osseoconductive areas (bone formation areas) 4.
- the body 6 essentially has the shape of a hollow hemisphere in order to reproduce the shape of an acetabular cup as advantageously as possible. However, a shape deviating from this is conceivable as long as appropriate contact with a joint counterpart is ensured.
- the body 6 can preferably be conical or frustoconical or parabolic.
- the inner concavity 8 is designed to receive a joint counterpart of a hip joint and to interact with it.
- the body 6 is preferably made of a hard ceramic, for example Al 2 O 3 or zirconium oxide ceramic, since hard ceramic has very good tribological properties. This is particularly advantageous, since a good interaction of the socket with the joint counterpart is achieved.
- the joint counterpart is also formed from a hard ceramic, the advantageous tribological properties of the hard ceramic can be reinforced by the self-pairing of ceramic on ceramic.
- the force absorption areas 2 are formed in one piece or unitary with the body 6, preferably made of a hard ceramic.
- the ceramic of the body 6 and the force absorption areas 2 is preferably essentially completely closed, ie the pores have a diameter which is less than 5 ⁇ m is.
- the ceramic used preferably corresponds to the standard ISO 6474 2nd Edition, 1994.
- the force absorption areas 2 can very well absorb the forces which occur when the endoprosthesis part is inserted as described below.
- at least three force-absorbing areas 2 are arranged on the circumference of the body 6 in a substantially uniform manner, which ensures a stable support of the endoprosthesis part.
- the endoprosthesis part is fixed cement-free in the bone bed. To do this, it must be press-fit or anchored using a thread described later (so-called screw socket).
- screw socket a thread described later
- the receiving area for the endoprosthesis part in the bone bearing is made somewhat smaller than the endoprosthesis part to be inserted and subsequently the endoprosthesis part is hammered into the bone bearing.
- the bone bearing preferably has an approximately 1-2 mm smaller diameter than the endoprosthesis part and is more preferably elliptical or oval.
- the undersizing of the bone bed ensures good primary stability of the endoprosthesis part in the first weeks and months after insertion, before a bony connection with the bone formation areas 4 can be formed.
- great pressure and shear forces occur due to the impact in the bone bearing, which are essentially absorbed by the force-absorbing areas 2.
- the force absorption areas 2 are formed in the arrangement described below. From a pole 14 to an equator or equatorial region 16 of the body 6, substantially strip-shaped force-absorbing regions 2 extend at regular intervals. Eight such strips are preferably provided. Furthermore, an essentially annular force receiving area 2 is formed around the equator 16 of the body 6 and an essentially circular force receiving area 2 is formed on or on the pole 14 of the body 6. The bone formation areas are in the spaces formed by the force absorption areas 2 4 trained. The space between the bone and the bone formation areas 4 can be bridged by bone formation.
- the force absorption areas 2 protrude in the radial direction with respect to the bone formation areas 4.
- the radius difference of the force absorption areas is preferably 2 and
- Bone formation areas 4 approx. 0.3 - 1 mm.
- the force absorption areas 2 come into contact with the prepared bone bearing first and can thus absorb the forces that occur and protect the sensitive bone formation areas 4 from damage or destruction.
- the force absorption areas 2 ensure the primary stability of the endoprosthesis part, which is achieved by the press-fit insertion of the endoprosthesis part. Due to the undersizing of the bone bearing, large pressure forces act on the endoprosthesis part even after insertion. These are preferably essentially absorbed by the force absorption areas 2 provided.
- the force absorption areas 2 can further serve to secure the rotation. When inserted, the force-absorbing areas 2 are pressed slightly into the bone bearing and twisting of the endoprosthesis part in the bone bearing can thus be substantially avoided.
- the bone formation areas 4 enable bony ingrowth (so-called secondary stability) and thus good long-term stability of the endoprosthesis part.
- the bone formation areas 4 grow through the blood path and after about 2 - 8 months, trabeculae form, which enable long-term stability of the endoprosthesis part.
- the bone formation regions 4 are preferably formed from a porous ceramic, into which the bone can grow well.
- the ceramic used more preferably has a porosity of 20-60% by volume. Alternatively, a decrease in the porosity from outside to inside can be provided in the radial direction, with preference a porosity of 80 vol.% on the outer circumference and a decrease to almost 0 vol.% is provided in the interior of the endoprosthesis part.
- materials that have good osseointegrative and / or osseoinductive or osseoconductive properties can also be used, such as titanium applied or applied using a titanium plasma spray, titanium melts, an applied or applied layer of hydroxyapatite or one or more bone morphogenic proteins (bone morphogenic proteins, BMP), and which, as described later, can be attached to the body 6 of the endoprosthesis part.
- Further materials are, for example, tricalcium phosphate, polylactic acid, polyglycolic acid, polycaprolactone and various photopolymers which contain bone-morphogenic proteins and a transforming growth factor ⁇ (TGF ⁇ ).
- TGF ⁇ transforming growth factor ⁇
- FIG 3 shows the top view of a second embodiment of the endoprosthesis part according to the invention.
- the force absorption areas 2 are designed in the form of rings which are concentric with the pole 14 of the endoprosthesis part.
- the bone formation areas 4 are in turn arranged between the force absorption areas 2.
- the force absorption areas 2 are designed in the form of circular areas which are preferably distributed substantially uniformly on the circumference of the endoprosthesis part.
- the force receiving areas 2 can also have other regular and / or irregular shapes, e.g. an elliptical shape.
- the force absorption areas 2 also serve to secure the rotation of the endoprosthesis part.
- rotation-securing devices are provided on or at the force-absorbing areas 2 in a further embodiment.
- 5 and 6 show a top view and a section of a fourth embodiment of the endoprosthesis part according to the invention, in which 2 additional triangular profile strips 12 are formed on the strip-shaped force-receiving areas. These additional protrusions 12 can penetrate even further into the bone bed and thus prevent rotation of the endoprosthesis part even more effectively.
- the profile strips 12 can also have other cross sections, for example rectangular, trapezoidal or semicircular.
- the rotational securing property of the force-absorbing areas 2 can be reinforced by projections, for example knobs, of different shapes.
- the outer envelope essentially has the shape of a hemisphere. It can preferably be provided, as shown in FIG. 7, that the pole 14 of the hemisphere is flattened by a few millimeters, essentially approximately 2-4% of the outside diameter. In this way, a better fit of the endoprosthesis part can be achieved. 7, so-called “clamping areas” can preferably be formed by widening the substantially hemispherical endoprosthesis part toward the equator 16 by a few millimeters. This ensures better primary stability of the endoprosthesis part by a clamping effect of the expanded areas 7, the equatorial region 16 is expanded continuously, and it is also conceivable to expand the equatorial region 16 in regions or steps.
- a sixth preferred embodiment of the endoprosthesis part according to the invention is described, which is anchored in the prepared bone bearing with the aid of threads.
- the outer circumference of the endoprosthesis part with the body 6 and / or the force-absorbing areas 2 is provided with one-piece threads or threaded areas 10.
- the threads 10 have an acute cross section. Threads with a rectangular, trapezoidal, round or sawtooth-shaped cross section would also be conceivable.
- the bony bearing must be prepared with appropriate taps. After the bone has been prepared accordingly, the endoprosthesis part can be screwed into the bone bed and thus firmly anchored.
- the threads 10, as positive and frictional elements, take over the primary anchoring of the endoprosthesis part in the bone bearing.
- the force absorption areas 2, in this case together with the thread 10, serve to absorb the forces that occur in the first time after the endoprosthesis part is inserted and thus to protect the sensitive bone formation areas 4.
- An embodiment would also be conceivable which has self-tapping threads or thread areas.
- the dimensions of the endoprosthesis part according to the invention correspond to the values customarily used. More specifically, the outer diameter of the endoprosthesis part is approximately 44 mm - 64 mm and the inner diameter corresponding to approximately 22 mm, 28 mm, 32 mm or 35 mm.
- the endoprosthesis part according to the invention is provided in a monoblock structure, i.e. the endoprosthesis part is of uniform design. It therefore has essentially no connection areas, which often represent a weak point of endoprosthesis parts in conventional endoprosthesis parts.
- the manufactured endoprosthesis part has a body 6 and force-absorbing areas 2 formed thereon in one piece a hard all-ceramic and bone formation areas 4 made of a porous ceramic.
- the endoprosthesis part is formed as a whole, ie all areas are manufactured at the same time.
- Al 2 O 3 and / or zirconium oxide is preferably used as the raw material for the production of the endoprosthesis part.
- the prepared and prepared raw materials are brought into the desired shape. This can be done, for example, in a casting or powder compaction process.
- the green body thus shaped is then dried and fired.
- the solidified form is then treated.
- meltable and / or burnable particles are provided in the green compact of the ceramic. These particles are melted out and / or burned out during or during the firing of the ceramic and leave voids which form a porosity.
- This manufacturing method is particularly advantageous if a change in the porosity in the endoprosthesis part in the radial direction as described above is desired.
- the body 6 is formed in a first step with the force-absorbing areas 2 formed thereon in one piece.
- the bone formation areas 4 are applied into the spaces between the force absorption areas 2 and connected accordingly, for example by hardening or sintering the ceramic.
- the body with the force-absorbing regions 2 formed thereon in one piece preferably consists of a hard all-ceramic, such as, for example, an Al 2 O 3 ceramic or zirconium oxide ceramic.
- the bone formation areas 4 again preferably consist of a porous ceramic.
- the bone formation regions 4 can further preferably have titanium or a titanium alloy which is sprayed on by means of a titanium plasma spray.
- the bone formation areas 4 can be formed by applying hydroxylapatite or BMP.
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU60280/01A AU6028001A (en) | 2000-05-08 | 2001-05-04 | Endoprosthesis part for use in joint replacement, use of the same and productionmethod therefor |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10022260A DE10022260C2 (de) | 2000-05-08 | 2000-05-08 | Endoprotheseteil für den Gelenkersatz, Verwendung des Endoprotheseteils und Herstellungsverfahren für Endoprotheseteile |
| DE10022260.9 | 2000-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001085068A1 true WO2001085068A1 (fr) | 2001-11-15 |
Family
ID=7641112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2001/005070 Ceased WO2001085068A1 (fr) | 2000-05-08 | 2001-05-04 | Partie d'endoprothese pour le remplacement d'articulations, utilisation et procede de fabrication de ladite partie |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU6028001A (fr) |
| DE (1) | DE10022260C2 (fr) |
| WO (1) | WO2001085068A1 (fr) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003059407A1 (fr) * | 2002-01-21 | 2003-07-24 | Straumann Holding Ag | Implants a surface modifiee |
| WO2008015290A1 (fr) * | 2006-08-04 | 2008-02-07 | Ceramtec Ag | Coque métallique à enveloppe extérieure poreuse, utilisée pour réduire les déformations de coque dans des cas d'ajustement serré |
| EP2149351A1 (fr) * | 2008-07-29 | 2010-02-03 | DERU GmbH | Composants d'endoprothèses |
| FR2938751A1 (fr) * | 2008-11-25 | 2010-05-28 | Othesio Implants | Implant cotyloidien pour prothese de hanche |
| DE102010028429A1 (de) * | 2010-04-30 | 2011-12-15 | Hans Grundei | Implantat als Knochenersatz mit einer seiner Oberfläche zumindest teilweise bedeckenden offenmaschigen, dreidimensionalen Raumnetzstruktur |
| RU2515754C1 (ru) * | 2013-02-13 | 2014-05-20 | Федеральное государственное бюджетное учреждение "Саратовский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения Российской Федерации (ФГБУ "СарНИИТО" Минздрава России) | Способ обезболивания после тотального эндопротезирования тазобедренного сустава при деформирующих коксартрозах |
| US8894717B2 (en) | 2009-04-24 | 2014-11-25 | Depuy International Limited | Surgical prostheses |
| RU2555121C1 (ru) * | 2014-08-05 | 2015-07-10 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Способ комбинированного продленного обезболивания при эндопротезировании тазобедренного сустава |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10159683A1 (de) * | 2001-11-30 | 2003-06-18 | Michael Gahlert | Dantalimplantat |
| DE102004004131A1 (de) * | 2004-01-28 | 2005-08-18 | Universität Duisburg-Essen | Hüftgelenkspfanne mit variablen Oberflächeneigenschaften |
| DE102017012229A1 (de) | 2017-10-19 | 2019-04-25 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Implantat |
| DE102017124483A1 (de) | 2017-10-19 | 2019-04-25 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Implantat |
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2001
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- 2001-05-04 AU AU60280/01A patent/AU6028001A/en not_active Abandoned
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| EP0743050A1 (fr) * | 1995-04-27 | 1996-11-20 | Howmedica France | Cotyle pour prothèse de hanche |
| US5658338A (en) * | 1995-09-29 | 1997-08-19 | Tullos; Hugh S. | Prosthetic modular bone fixation mantle and implant system |
| EP0806212A1 (fr) * | 1996-05-10 | 1997-11-12 | Matrix Medical B.V. | Dispositif pour l'incorporation et la délivrance d'agents bioactifs |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003059407A1 (fr) * | 2002-01-21 | 2003-07-24 | Straumann Holding Ag | Implants a surface modifiee |
| GB2401074A (en) * | 2002-01-21 | 2004-11-03 | Straumann Holding Ag | Surface-modified implants |
| GB2401074B (en) * | 2002-01-21 | 2006-02-22 | Straumann Holding Ag | Surface-modified implants |
| WO2008015290A1 (fr) * | 2006-08-04 | 2008-02-07 | Ceramtec Ag | Coque métallique à enveloppe extérieure poreuse, utilisée pour réduire les déformations de coque dans des cas d'ajustement serré |
| EP2149351A1 (fr) * | 2008-07-29 | 2010-02-03 | DERU GmbH | Composants d'endoprothèses |
| FR2938751A1 (fr) * | 2008-11-25 | 2010-05-28 | Othesio Implants | Implant cotyloidien pour prothese de hanche |
| US8894717B2 (en) | 2009-04-24 | 2014-11-25 | Depuy International Limited | Surgical prostheses |
| US8979939B2 (en) | 2009-04-24 | 2015-03-17 | Depuy International Limited | Surgical prostheses |
| DE102010028429A1 (de) * | 2010-04-30 | 2011-12-15 | Hans Grundei | Implantat als Knochenersatz mit einer seiner Oberfläche zumindest teilweise bedeckenden offenmaschigen, dreidimensionalen Raumnetzstruktur |
| RU2515754C1 (ru) * | 2013-02-13 | 2014-05-20 | Федеральное государственное бюджетное учреждение "Саратовский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения Российской Федерации (ФГБУ "СарНИИТО" Минздрава России) | Способ обезболивания после тотального эндопротезирования тазобедренного сустава при деформирующих коксартрозах |
| RU2555121C1 (ru) * | 2014-08-05 | 2015-07-10 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Способ комбинированного продленного обезболивания при эндопротезировании тазобедренного сустава |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6028001A (en) | 2001-11-20 |
| DE10022260A1 (de) | 2001-11-29 |
| DE10022260C2 (de) | 2002-06-06 |
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