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WO1998000172A3 - Compositions et methodes modifiant la biodistribution d'agents biologiques - Google Patents

Compositions et methodes modifiant la biodistribution d'agents biologiques Download PDF

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Publication number
WO1998000172A3
WO1998000172A3 PCT/US1997/010766 US9710766W WO9800172A3 WO 1998000172 A3 WO1998000172 A3 WO 1998000172A3 US 9710766 W US9710766 W US 9710766W WO 9800172 A3 WO9800172 A3 WO 9800172A3
Authority
WO
WIPO (PCT)
Prior art keywords
biodistribution
methods
altering
compositions
biological agents
Prior art date
Application number
PCT/US1997/010766
Other languages
English (en)
Other versions
WO1998000172A2 (fr
Inventor
Thomas Porter
Patrick L Iversen
Original Assignee
Univ Nebraska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nebraska filed Critical Univ Nebraska
Priority to AT97932228T priority Critical patent/ATE260677T1/de
Priority to CA002258882A priority patent/CA2258882C/fr
Priority to DE69727958T priority patent/DE69727958T2/de
Priority to JP50420598A priority patent/JP4201348B2/ja
Priority to EP97932228A priority patent/EP0938341B1/fr
Publication of WO1998000172A2 publication Critical patent/WO1998000172A2/fr
Publication of WO1998000172A3 publication Critical patent/WO1998000172A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention porte sur une nouvelle composition pharmaceutique améliorée et sur une méthode d'administration d'agents thérapeutiques pouvant s'utiliser avec divers agents thérapeutiques et permettre d'administrer une substance thérapeutique ou diagnostique en des sites spécifique. On peut donc utiliser des doses plus faibles ou obtenir une efficacité plus grande avec des médicaments atteignant traditionnellement les sites cibles ou obtenir de meilleurs résultats avec des agents tels que les oligonucléotides et les polynucléotides handicapés par des problèmes de biodistribution.
PCT/US1997/010766 1996-06-28 1997-06-20 Compositions et methodes modifiant la biodistribution d'agents biologiques WO1998000172A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT97932228T ATE260677T1 (de) 1996-06-28 1997-06-20 Zusammenstellungen und verfahren zur änderung der bioverteilung von biologischen agentien
CA002258882A CA2258882C (fr) 1996-06-28 1997-06-20 Compositions et methodes modifiant la biodistribution d'agents biologiques
DE69727958T DE69727958T2 (de) 1996-06-28 1997-06-20 Zusammensetzungen und Verfahren zur Änderung der Bioverteilung von biologischen Agentien
JP50420598A JP4201348B2 (ja) 1996-06-28 1997-06-20 生物学的薬剤の体内分布を改変させるための組成物および方法
EP97932228A EP0938341B1 (fr) 1996-06-28 1997-06-20 Compositions et methodes modifiant la biodistribution d'agents biologiques

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/670,999 US5849727A (en) 1996-06-28 1996-06-28 Compositions and methods for altering the biodistribution of biological agents
US08/670,999 1996-06-28

Publications (2)

Publication Number Publication Date
WO1998000172A2 WO1998000172A2 (fr) 1998-01-08
WO1998000172A3 true WO1998000172A3 (fr) 1998-05-14

Family

ID=24692746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/010766 WO1998000172A2 (fr) 1996-06-28 1997-06-20 Compositions et methodes modifiant la biodistribution d'agents biologiques

Country Status (7)

Country Link
US (5) US5849727A (fr)
EP (1) EP0938341B1 (fr)
JP (2) JP4201348B2 (fr)
AT (1) ATE260677T1 (fr)
CA (1) CA2258882C (fr)
DE (1) DE69727958T2 (fr)
WO (1) WO1998000172A2 (fr)

Cited By (8)

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US6884407B1 (en) 1996-09-11 2005-04-26 Bristol-Myers Squibb Pharma Company Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
US6998107B2 (en) 1991-04-05 2006-02-14 Bristol-Myers Squibb Pharma Comapany Composition comprising low density microspheres
US7078015B2 (en) 1989-12-22 2006-07-18 Imarx Therapeutics, Inc. Ultrasound imaging and treatment
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US7105151B2 (en) 1997-06-18 2006-09-12 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7329402B2 (en) 1995-06-07 2008-02-12 Imarx Pharmaceutical Corp. Methods of imaging and treatment
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US7612033B2 (en) 1994-11-29 2009-11-03 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell

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US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
US5849727A (en) * 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
CN1234742A (zh) 1996-10-28 1999-11-10 奈科姆成像有限公司 诊断和/或治疗剂的改进或与其相关的改进
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
WO1998018498A2 (fr) * 1996-10-28 1998-05-07 Marsden, John, Christopher Ameliorations apportees a des agents diagnostiques et/ou therapeutiques ou les concernant
ES2264159T3 (es) * 1996-10-28 2006-12-16 Amersham Health As Mejoras en/o relacionadas con agentes de diagnostico/terapeuticos.
US6261537B1 (en) * 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
EP0991427A2 (fr) * 1996-10-28 2000-04-12 Marsden, John Christopher Ameliorations apportees a des agents diagnostiques et/ou therapeutiques ou les concernant
CN1238700A (zh) * 1996-10-28 1999-12-15 奈科姆成像有限公司 诊断和/或治疗剂的改进或与其相关的改进
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US5849727A (en) 1998-12-15
DE69727958T2 (de) 2005-04-07
US20040013662A1 (en) 2004-01-22
ATE260677T1 (de) 2004-03-15
JP4201348B2 (ja) 2008-12-24
US6117858A (en) 2000-09-12
US6537814B1 (en) 2003-03-25
US7115583B2 (en) 2006-10-03
CA2258882C (fr) 2009-03-17
CA2258882A1 (fr) 1998-01-08
JP2009029810A (ja) 2009-02-12
US20040057946A1 (en) 2004-03-25
EP0938341A2 (fr) 1999-09-01
WO1998000172A2 (fr) 1998-01-08
US7198949B2 (en) 2007-04-03
EP0938341B1 (fr) 2004-03-03
JP2000515499A (ja) 2000-11-21
DE69727958D1 (de) 2004-04-08

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