[go: up one dir, main page]

WO1996041595A1 - Procede et dispositif pour la culture d'un materiau de remplacement du tissu osseux - Google Patents

Procede et dispositif pour la culture d'un materiau de remplacement du tissu osseux Download PDF

Info

Publication number
WO1996041595A1
WO1996041595A1 PCT/DE1996/001024 DE9601024W WO9641595A1 WO 1996041595 A1 WO1996041595 A1 WO 1996041595A1 DE 9601024 W DE9601024 W DE 9601024W WO 9641595 A1 WO9641595 A1 WO 9641595A1
Authority
WO
WIPO (PCT)
Prior art keywords
bone
covering device
covering
template
centering pins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1996/001024
Other languages
German (de)
English (en)
Inventor
Axel Kirsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to BR9608365A priority Critical patent/BR9608365A/pt
Priority to AU58920/96A priority patent/AU5892096A/en
Priority to JP9502493A priority patent/JPH10510454A/ja
Priority to EP96915995A priority patent/EP0957831A1/fr
Publication of WO1996041595A1 publication Critical patent/WO1996041595A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2803—Bones for mandibular reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30451—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30907—Nets or sleeves applied to surface of prostheses or in cement
    • A61F2002/30909—Nets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30971—Laminates, i.e. layered products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4648—Means for culturing bone graft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4649—Bone graft or bone dowel harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00357—Wound bandages implanted wound fillings or covers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00407—Coating made of titanium or of Ti-based alloys

Definitions

  • the invention relates to a method for growing bone substitute material, in which a bone cavity freed from periosteum is covered by means of a covering device having a covering membrane, preferably made of biodegradable material, which can be fastened to the bone and is covered with respect to the soft tissue surrounding the bone , whereupon a breeding chamber thus created will grow through the bone from the bone, and a device for carrying out this method.
  • the procedure is such that the corresponding bone recess is covered against the surrounding soft tissue by means of a covering device, the covering device serving the purpose of protecting the bone recess against mechanical loads in order to prevent undisturbed bony growth of the bone building material guarantee, but also the purpose has to cover the bone recess in a substantially liquid-tight manner against the surrounding soft tissue in order to prevent the bone from growing in without bone.
  • covering devices such as covering membranes and the like are known, as are described, for example, in DE-OS 44 14 675, DE-OS 44 18 159, DE-PS 43 02 708 and DE-PS 43 02 709.
  • the covering devices can be attached to the bone by means of fastening nails, to name just one example, as they are mentioned, for example, in DE-PS 43 00 039.
  • the object of the invention is to create a method and a device of the generic type which ensure faster and better osseous filling of bone defects.
  • this object is achieved in a further development of the generic method in that the bone cavity is one of the final place of use of the Bone replacement material from different areas of a concavely curved bone, in particular the pelvic bone, is selected; that the periosteum is detached from the bone in the selected area; that the bone is opened, in particular drilled, at least at one point within the selected area to produce a bleeding connection between the bone tissue and the bone cavity defined by the selected area; that the covering device is then attached to the bone while covering the bone cavity; that the periosteum along with adjacent soft tissue is then brought into contact with the covering device; that after the ingrowth of the bone material in the growth chamber, the covering device is exposed; that the covering device and the grown bone substitute material are then removed from the bone cavity; and that finally the cultured bone substitute material is inserted into a bone recess to be finally filled with it.
  • a support grid covered with the cover membrane such as perforated titanium sheet, titanium grid or the like, is used as the covering device.
  • the invention also proposes that the covering device be at least partially inserted into the bone with its peripheral edge and thereby fastened to the bone.
  • the bone surface facing the growth chamber is covered with a separating grid, such as perforated titanium sheet or the like.
  • a separating grid is mechanically firmly connected to the peripheral edge of the covering device to form a breeding capsule containing the breeding chamber; and that the removal of the cultured bone substitute material from the bone cavity is accomplished by removing the growth capsule formed from the covering device and the separating grid.
  • the growth chamber is shaped in accordance with the anatomical requirements at the final place of use of the bone replacement material to be grown, and is preferably designed to be convex at least with respect to the bone cavity.
  • the invention provides that the region of the bone, which is possibly only provisionally selected, is initially covered with an essentially rigid template, such as titanium sheet template or the like, which corresponds to the shape of the covering device to be used later and which has at least three centering bores for receiving Has centering pins; that then, if necessary after optimizing the position of the template to the shape of the bone, centering pins are introduced into the bone through the centering holes, which protrude beyond the template on the side facing away from the bone; that the template is then removed; that instead of the template, the cover device adapted to its shape is placed on the bone, the cover device being centered by the centering pins which engage in the centering holes of the template; and that the covering device is then attached to the bone.
  • an essentially rigid template such as titanium sheet template or the like, which corresponds to the shape of the covering device to be used later and which has at least three centering bores for receiving Has centering pins
  • the loading the cover device is fixed by means of fastening rings or caps which can be placed on the ends of the centering pins which pass through the guide openings.
  • fastening rings or caps are glued to the centering pin.
  • the invention also proposes that the mounting rings or caps are welded to the centering pins.
  • Another embodiment of the invention proposes that the fastening rings or caps are screwed to the centering pins.
  • centering pins made of biodegradable material such as polylactide or the like, are used.
  • the device according to the invention for carrying out the method with a covering device, preferably having a covering membrane consisting of biodegradable material, which can be fastened to the peripheral edge of a bone cavity, is characterized in that the covering device is directed towards the area surrounding the bone cavity Bone has bent inlet edge.
  • the device according to the invention for carrying out the method can be characterized by a separating grid, such as perforated titanium sheet or the like, which can be mechanically connected to the peripheral edge of the covering device.
  • the invention is further characterized by a template corresponding to the shape of the covering device for receiving centering pins, the covering device has guide openings corresponding to the centering bores.
  • the centering pins consist of biodegradable material.
  • Another embodiment of the invention provides that the covering device can be fastened to the bone by means of fastening rings or caps that can be attached to the centering pins.
  • fastening rings or caps can be glued to the centering pins.
  • the invention provides that the fastening rings or caps can be welded to the centering pins.
  • the invention also provides that the fastening rings or caps can be screwed to the centering pins.
  • the invention is based on the surprising finding that it is possible to provide a sufficient amount of bone substitute material produced by the body's own bone substitute material without undue intervention in the place of use of the bone substitute material, by placing it in one place in a bone cavity, so to speak, of course is cultivated, which does not cause discomfort to the person to be treated.
  • the inner cavity of the pelvic bone is particularly suitable for this, since here the growth chamber to be formed is already limited on one side by a concave surface, namely the inner surface of the pelvic bone.
  • a breeding chamber can then be formed by means of the covering device, which interfered with growth of bone substitute material in a period of, for example, six to eight months.
  • FIG. 1 shows an embodiment of a template that can be used in the device according to the invention in contact with a pelvic bone in plan view;
  • FIG. 2 shows the template from FIG. 1 in an enlarged illustration, likewise in a plan view corresponding to FIG. 1;
  • FIG. 4 shows a section corresponding to FIG. 3 through a covering device of a device according to the invention
  • FIG. 5 shows a section corresponding to FIG. 4 through an exemplary embodiment of a covering device according to the invention on an enlarged scale
  • FIG. 6 shows a section corresponding to FIG. 4 through a modified exemplary embodiment of a covering device according to the invention.
  • FIG. 7 a section corresponding to FIG. 6 through a further embodiment a covering device according to the invention.
  • a template 12 made of curved titanium sheet, is placed there on the concave inner surface of a pelvic bone 10 facing the front of the body. It is temporarily held on the pelvic bone 10 by three centering pins 14, 16, 18, which are made of biodegradable material, namely polylactide in the exemplary embodiment shown, and in bores previously made in the pelvic bones 10, which will be explained in more detail below are let in.
  • Fig. 2 shows the relationships shown in Fig. 1 on an enlarged scale. It can be seen in particular that the template 12 is shaped in accordance with the curvature of a jawbone, as can also be seen from the sectional view according to FIG. 3.
  • FIG. 3 shows that a fastening hole 20 has been made in the pelvic bone 10, into which the centering pin 16 is inserted.
  • the template 12 has a centering bore 22, through which the centering pin 16 projects, with its free end located above in FIG. 3 projecting over the template 12.
  • FIG. 3 shows how, instead of the template 12 from FIG. 3, a cover device 24, which is curved and shaped in accordance with the template, is placed on the pelvic bone 10 and has a guide opening 26 which is penetrated by the centering pin 16.
  • a fastening cap 28 is glued onto the end of the centering pin 16 facing away from the pelvic bone 10, which cap, together with the further centering pins etc. 1 and 2 are shown, on which pelvic bone 10 holds firmly.
  • the cover device 24 has a support grid 30 made of titanium sheet and a continuous cover membrane 32 made of biodegradable material, namely polylactide, reference being made to DE-OS 44 14 675 for further explanation because of the structure of the cover device 24 in this regard reference is made in its entirety to the additional description of the invention.
  • a growth chamber 34 formed by the pelvic bone 10 and by the covering device 24 is already filled with ingrown bone substitute material 36 in FIG. 4.
  • Fig. 5 shows the cover device 24 of Fig. 4 in an enlarged view with webs 38, 40 of the support grid 30.
  • the cover membrane 32 is with the support grid 30 e.g. glued or welded or in the manner known from DE-OS 44 14 675 generated in situ on the support grid.
  • the method according to the invention is carried out, for example, using the device elements according to FIGS. 1 to 5 as follows:
  • a template 12 is formed from titanium sheet or selected from a larger supply of sample templates.
  • the concave inner surface of the pelvic bone 10 is then surgically exposed in some areas, the periosteum being lifted off.
  • the pelvic bone 10 is then damaged in the selected area to be covered by the template 12, for example by making small bores, so that bleeding occurs from the inside of the pelvic bone 10 into the area to be covered later by the covering device 24, ie into the growth chamber 34 (FIG. 4).
  • the stencil 12 is arranged on the concave inner surface of the pelvic bone 10 by gently pushing it back and forth in such a way that the peripheral edge of the convexly curved stencil 12 facing the pelvic bone 10 optimally contacts the inner surface of the pelvic bone 10 results. Then the fastening holes 20 are introduced into the pelvic bones 10 through the centering bores 22 provided in the template, whereupon the centering pins 14, 16, 18 are let into the fastening bores 20 which have been produced in the pelvic bones 10. The template 12 is then removed, so that the three centering pins 14, 16, 18 now protrude from the pelvic bone 10.
  • the covering device 24 shaped according to the template 12 is placed on the pelvic bone 10 in the selected area instead of the template 12, the centering pins 14, 16, 18 ensuring optimal positioning and centering of the covering device 24.
  • the cover membrane 32 may advantageously be located on the inside of the support grid 30 of the cover device 24 facing the support grid 30 instead of on the outside selected in FIG. 4, that is to say on the side facing away from the pelvic bone 10 .
  • a fastening cap 28 is placed on each of the centering pins 14, 16, 18 passing through the guide openings 26 of the covering device 24 and, in the exemplary embodiment shown, glued to the relevant centering pin.
  • the covering device 24 is now firmly attached in the manner attached to the pelvic bone 10 that the breeding chamber 34 compared to the surrounding soft tissue to be thought of in FIG. 4, in particular the previously detached periosteum, which is now brought into contact with the covering device 24 again with the remaining soft tissue against the Soft tissue is essentially liquid-impermeable, so that non-osseous ingrowth of soft tissue into the growth chamber 34 is prevented.
  • the bone replacement material 36 now grows in the breeding chamber 34, which, due to the meaningful shape of the covering device 24, roughly corresponds to the shape of a bone recess, for example in the jaw bone, which is to be filled with the bone replacement material .
  • the surgeon removes the covering device 24 together with the grown bone replacement material 36, the centering pins 14, 16, 18, since they consist of biodegradable material, can remain in the pelvic bone if necessary.
  • the bone substitute material 36 is used in the usual way to fill a bone recess to be treated, wherein a covering device, preferably consisting of a support grid and covering membrane, can be used again, as is the case, for example, in DE-OS 44 14 675 is known.
  • the treatment is particularly favorable because the bone substitute material already has approximately the shape of the bone to be treated, so that practically only joints or relatively small areas have to be re-grown with bone material, granular material being used for this purpose if necessary Bone replacement material of synthetic form, in particular based on hydroxylapatite, can be used in a known manner.
  • the Cover device 24 here also consisting of support grid 30 and cover membrane 32, in this case attached to the inner surface of support grid 30 facing cultivation chamber 34, has a circumferential inlet edge 42 bent in the direction of pelvic bone 10, which leads into a corresponding groove of the pelvic bone 10, which was previously milled in by the surgeon, is embedded.
  • the cultivation chamber 34 is closed particularly reliably with respect to the surrounding soft tissue, as a result of which perfect growth and cultivation of the bone replacement material 36 is promoted.
  • a separating grid 42 which, like the support grid 30, can be made of titanium sheet, bears against the inner surface of the pelvic bone 10 facing the growth chamber 34.
  • the peripheral edge of the separating grid 42 is mechanically firmly connected to the peripheral edge of the concavely shaped supporting grid 30 of the covering device 24.
  • the cover device 24 and the separating grid 42 form a cultivation chamber 34 which is "mechanically” closed on all sides, but from the pelvic bone 10 through the grid openings of the separating grid 42, which currently has no covering membrane, to Growth of the bone replacement material 36 necessary bleeding is guaranteed.
  • the entire capsule, which consists of the separating grid 42 and the covering device 24 is detached from the pelvic bone 10.
  • the separating grid 42 can be used as a guide for a surgical tool, such as a chisel or the like, so that the grown bone replacement material 36 can be detached from the pelvic bone 10 in a particularly gentle manner.
  • the covering device 24 naturally Loan also in other ways than can be attached to the pelvic bone 10 by means of the fastening caps 20 placed on the centering pins 14, 16, 18, in particular if no template 12 is used at all.
  • the covering device 24 can be fastened, for example, in the manner known from DE-PS 43 00 039 by means of corresponding fastening nails or the like.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)
  • Dental Prosthetics (AREA)

Abstract

L'invention a pour objet un procédé pour la culture d'un matériau de remplacement du tissu osseux, selon lequel une cavité osseuse débarrassée du périoste est recouverte par le tissu mou entourant l'os, au moyen d'un dispositif de recouvrement pouvant être fixé à l'os et présentant une membrane de recouvrement formée de préférence par un matériau biodégradable, après quoi une chambre de culture ainsi créée est traversée par un croissance osseuse en provenance de l'os, caractérisé en ce que: on choisit comme cavité osseuse une région d'un os concave, en particulier de l'os du bassin, différente de l'emplacement définitif d'utilisation du matériau de remplacement; le périoste est détaché de l'os dans la région choisie; l'os dans la région choisie est ouvert, en particulier foré, en au moins un emplacement, en vue d'obtenir une liaison permettant un écoulement sanguin entre le tissu osseux et la cavité osseuse déterminée par la région choisie; le dispositif de recouvrement est ensuite fixé à l'os pour recouvrir la cavité; le périoste avec le tissu mou voisin est ensuite appliqué sur le dispositif de recouvrement; après croissance du matériau osseux dans la chambre de culture, le dispositif de recouvrement est libéré, après quoi ce dispositif et le matériau de remplacement du tissu osseux cultivé sont retirés de la cavité osseuse; et enfin, le matériau de remplacement du tissu osseux cultivé est inséré dans une cavité osseuse à remplir définitivement de ce matériau. L'invention concerne en outre un dispositif pour la mise en ÷uvre de ce procédé.
PCT/DE1996/001024 1995-06-08 1996-06-04 Procede et dispositif pour la culture d'un materiau de remplacement du tissu osseux Ceased WO1996041595A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BR9608365A BR9608365A (pt) 1995-06-08 1996-06-04 Processo e dispositivo para o cultivo de material de substituição de ossos
AU58920/96A AU5892096A (en) 1995-06-08 1996-06-04 Process and device for the culture of bone replacement mater ial
JP9502493A JPH10510454A (ja) 1995-06-08 1996-06-04 骨補充材料の培養方法およびその装置
EP96915995A EP0957831A1 (fr) 1995-06-08 1996-06-04 Procede et dispositif pour la culture d'un materiau de remplacement du tissu osseux

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19520864.1 1995-06-08
DE1995120864 DE19520864C2 (de) 1995-06-08 1995-06-08 Vorrichtung zum Züchten von Knochenersatzmaterial

Publications (1)

Publication Number Publication Date
WO1996041595A1 true WO1996041595A1 (fr) 1996-12-27

Family

ID=7763877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/001024 Ceased WO1996041595A1 (fr) 1995-06-08 1996-06-04 Procede et dispositif pour la culture d'un materiau de remplacement du tissu osseux

Country Status (6)

Country Link
EP (1) EP0957831A1 (fr)
JP (1) JPH10510454A (fr)
AU (1) AU5892096A (fr)
BR (1) BR9608365A (fr)
DE (1) DE19520864C2 (fr)
WO (1) WO1996041595A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000510017A (ja) * 1996-05-10 2000-08-08 ジェイ． メドフ，ロバート 移植材料拘束装置
CN105214138A (zh) * 2015-10-09 2016-01-06 华中科技大学 一种基于仿生矿化钙磷纳米颗粒微图案化的人工仿生骨膜及其制备方法
CN107624059A (zh) * 2015-05-08 2018-01-23 瑞欧斯股份有限公司 用于覆盖和/或重建骨缺损部位的装置和骨缺损部位的覆盖装置的套接件的制造方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19911326A1 (de) * 1999-03-15 2000-09-28 Fege Wolfgang Vorrichtung zum Züchten von menschlichem oder tierischem Gewebe
ITBS20030028A1 (it) * 2003-03-13 2004-09-14 Physioplant S R L Microchiodo e metodo per la sua utilizzazione nel fissaggio di una membrana protettiva ad uso odontoiatrico.
NL2002742C2 (en) * 2009-04-09 2010-10-12 Univ Delft Tech Mechanical device for tissue regeneration.
CA2790242C (fr) 2010-02-19 2016-04-19 Reoss Gmbh Dispositif pour le recouvrement et/ou la reconstruction d'un defaut d'un os, et son procede de fabrication
DE102013112619A1 (de) 2013-11-15 2015-05-21 Marc Michael Sabbagh Knochenaugmentat

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014404A1 (fr) * 1990-03-21 1991-10-03 Titanbron I Åhus AB Procede et dispositif servant a ancrer efficacement un implant, et procede et dispositif favorisant la croissance du tissu osseux
EP0504103A1 (fr) * 1991-03-11 1992-09-16 Institut Straumann Ag Moyen pour attacher et maintenir une couverture sur un os de la mâchoire
DE4223153A1 (de) * 1991-07-15 1993-01-21 Straumann Inst Ag Zur befestigung eines zahnersatzes am kiefer dienendes implantat
EP0574091A2 (fr) * 1992-06-11 1993-12-15 Innovations B.V. Dental Elément barrière biorésorbable
WO1994003121A1 (fr) * 1992-08-05 1994-02-17 Guidor Ab Element chirurgical et procede de regeneration selective des tissus
DE4302709C1 (de) * 1993-02-01 1994-07-28 Kirsch Axel Abdeckeinrichtung mit Abdeckmembran
WO1996012446A1 (fr) * 1994-10-25 1996-05-02 Guidor Ab Procede et dispositif de croissance de tissu osseux

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4300039C1 (de) * 1993-01-04 1994-06-09 Imz Fertigung Vertrieb Befestigungsnagel und Setzwerkzeug hierfür
DE4302708C2 (de) * 1993-02-01 1995-06-01 Kirsch Axel Abdeckmembran
DE4414675C1 (de) * 1994-04-27 1995-09-28 Kirsch Axel Abdeckeinrichtung für Knochendefektstellen und Verfahren zu deren Herstellung
DE4418159C1 (de) * 1994-05-25 1995-09-14 Eberle Medizintech Elemente Stützgitter

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014404A1 (fr) * 1990-03-21 1991-10-03 Titanbron I Åhus AB Procede et dispositif servant a ancrer efficacement un implant, et procede et dispositif favorisant la croissance du tissu osseux
EP0504103A1 (fr) * 1991-03-11 1992-09-16 Institut Straumann Ag Moyen pour attacher et maintenir une couverture sur un os de la mâchoire
DE4223153A1 (de) * 1991-07-15 1993-01-21 Straumann Inst Ag Zur befestigung eines zahnersatzes am kiefer dienendes implantat
EP0574091A2 (fr) * 1992-06-11 1993-12-15 Innovations B.V. Dental Elément barrière biorésorbable
WO1994003121A1 (fr) * 1992-08-05 1994-02-17 Guidor Ab Element chirurgical et procede de regeneration selective des tissus
DE4302709C1 (de) * 1993-02-01 1994-07-28 Kirsch Axel Abdeckeinrichtung mit Abdeckmembran
WO1996012446A1 (fr) * 1994-10-25 1996-05-02 Guidor Ab Procede et dispositif de croissance de tissu osseux

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000510017A (ja) * 1996-05-10 2000-08-08 ジェイ． メドフ，ロバート 移植材料拘束装置
CN107624059A (zh) * 2015-05-08 2018-01-23 瑞欧斯股份有限公司 用于覆盖和/或重建骨缺损部位的装置和骨缺损部位的覆盖装置的套接件的制造方法
CN105214138A (zh) * 2015-10-09 2016-01-06 华中科技大学 一种基于仿生矿化钙磷纳米颗粒微图案化的人工仿生骨膜及其制备方法
US9821087B2 (en) 2015-10-09 2017-11-21 Huazhong University Of Science And Technology Bio-artificial periosteum based on micropatterning of biomimetic mineralized calcium-phosphorus nanoparticles and method for manufacturing the same

Also Published As

Publication number Publication date
JPH10510454A (ja) 1998-10-13
DE19520864A1 (de) 1996-12-12
EP0957831A1 (fr) 1999-11-24
DE19520864C2 (de) 1999-07-29
BR9608365A (pt) 1998-12-15
AU5892096A (en) 1997-01-09

Similar Documents

Publication Publication Date Title
DE4223153C2 (de) Zur Befestigung eines Zahnersatzes am Kiefer dienendes Implantat
DE60110735T2 (de) Knochentransplantatformendes Führungsinstrument
DE4400188C2 (de) Implantate zum Verschließen eines Trommelfell-Lochs und Unterseitenkratzer für ein Trommelfell
DE60022590T2 (de) Befestigungsvorrichtung und -verfahren für ein Transplantat
DE69519737T2 (de) Chirurgisches instrument zur behandlung von urin-inkontinenz bei frauen
DE102010055433B4 (de) Knochenschraube und Vorrichtung zur Knochendistraktion
DE69533129T2 (de) Zahnimplantat
DE69323596T2 (de) Befestigungselement für Knochengewebe
DE2238071A1 (de) Einrichtung zur implantation von zahnersatz
DE69102086T2 (de) Dauereinsatzteil zur Belüftung des Mittelohrraumes.
DE2422383C2 (de) Künstliches Trommelfell
DE4105165C2 (fr)
EP0957831A1 (fr) Procede et dispositif pour la culture d'un materiau de remplacement du tissu osseux
DE102005032933A1 (de) Erfindung betreffend Implantate
WO2014040654A1 (fr) Set d'implant dentaire
EP1341490A1 (fr) Implant de remplacement de disque intervertebral partiel
WO2009137947A1 (fr) Procédé de fabrication d'un dispositif permettant la régénération dirigée de tissu osseux
DE19606057C2 (de) Metallisches Formteil für ein Knochenimplantat
EP4274515A1 (fr) Implant en plusieurs parties comprenant un élément de support et un élément fonctionnel
EP3087954B1 (fr) Système de transplant d'os maxillaire
DE102010023794B4 (de) Medizinisches, insbesondere zahnmedizinisches Substrat
DE10356920A1 (de) In einen menschlichen Kiefer endostal einschraubbares Dentalimplantat zur Aufnahme und Fixierung eines Zahnersatzes
DE3112868A1 (de) "zahnimplantat"
DE19619922A1 (de) Verfahren und Modell für die gelenkte Knochenregeneration
DE102007014267B4 (de) Set zur Erstellung eines Implantates zur Refixierung von Knochenfragmenten und/oder Sehnenansätzen

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1996915995

Country of ref document: EP

ENP Entry into the national phase

Ref country code: US

Ref document number: 1998 973695

Date of ref document: 19980225

Kind code of ref document: A

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: CA

WWP Wipo information: published in national office

Ref document number: 1996915995

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1996915995

Country of ref document: EP