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UY29632A1 - Derivados de pirazolopiridina como inhibidores del receptor b(beta)-adrenérgico cinasa 1 - Google Patents

Derivados de pirazolopiridina como inhibidores del receptor b(beta)-adrenérgico cinasa 1

Info

Publication number
UY29632A1
UY29632A1 UY29632A UY29632A UY29632A1 UY 29632 A1 UY29632 A1 UY 29632A1 UY 29632 A UY29632 A UY 29632A UY 29632 A UY29632 A UY 29632A UY 29632 A1 UY29632 A1 UY 29632A1
Authority
UY
Uruguay
Prior art keywords
inhibitors
beta
derivatives
pirazolopiridine
adrenérgico
Prior art date
Application number
UY29632A
Other languages
English (en)
Inventor
Dr Kurt Ritter
Dr Henning Steinhagen
Dr Jochen Huber
Dr Bernard Pirard
Dr Kirsten Bjergarde
Dr Marcel Patek
Drr Martin Smrcina
Dr Linli Wei
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of UY29632A1 publication Critical patent/UY29632A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a los derivados 6-amido sustituidos de pirazolopiridina de fórmula (I) útiles como inhibidores del receptor beta-adrenérgico cinasa 1 (BARK-1), a las composiciones que contienen dichos compuestos y a su utilización para el tratamietno y prevención de la insuficiencia cardíaca crónica, la hipertensión, isquemia de miocardio y de las infecciones por el virus de la hepatitis C (HCV) y para le prevención de la adicción a los opioides.
UY29632A 2005-06-27 2006-06-27 Derivados de pirazolopiridina como inhibidores del receptor b(beta)-adrenérgico cinasa 1 UY29632A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05013774 2005-06-27

Publications (1)

Publication Number Publication Date
UY29632A1 true UY29632A1 (es) 2007-01-31

Family

ID=35395578

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29632A UY29632A1 (es) 2005-06-27 2006-06-27 Derivados de pirazolopiridina como inhibidores del receptor b(beta)-adrenérgico cinasa 1

Country Status (30)

Country Link
US (1) US7910602B2 (es)
EP (1) EP1899333B1 (es)
JP (1) JP5010594B2 (es)
KR (1) KR20080020638A (es)
CN (1) CN101208340B (es)
AR (1) AR054514A1 (es)
AT (1) ATE423118T1 (es)
AU (1) AU2006264044A1 (es)
BR (1) BRPI0612320A2 (es)
CA (1) CA2611296A1 (es)
CY (1) CY1110464T1 (es)
DE (1) DE602006005242D1 (es)
DK (1) DK1899333T3 (es)
ES (1) ES2322197T3 (es)
HR (1) HRP20090244T2 (es)
IL (1) IL188381A0 (es)
MA (1) MA29498B1 (es)
MX (1) MX2007015829A (es)
MY (1) MY139016A (es)
NO (1) NO20080392L (es)
NZ (1) NZ564757A (es)
PL (1) PL1899333T3 (es)
PT (1) PT1899333E (es)
RS (1) RS50821B (es)
RU (1) RU2415855C2 (es)
SI (1) SI1899333T1 (es)
TW (1) TW200800982A (es)
UY (1) UY29632A1 (es)
WO (1) WO2007000241A1 (es)
ZA (1) ZA200709853B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200815438A (en) * 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
US20110009421A1 (en) * 2008-02-27 2011-01-13 Takeda Pharmaceutical Company Limited Compound having 6-membered aromatic ring
US9321787B2 (en) * 2011-07-07 2016-04-26 Sanofi Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
GB201410815D0 (en) * 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents
US12172995B2 (en) 2018-10-24 2024-12-24 Bristol-Myers Squibb Company Substituted indole and indazole compounds
US11998537B2 (en) 2018-10-24 2024-06-04 Bristol-Myers Squibb Company Substituted indole dimer compounds
ES2987832T3 (es) 2019-05-09 2024-11-18 Bristol Myers Squibb Co Compuestos de benzimidazolona sustituidos
KR20220075381A (ko) 2019-10-01 2022-06-08 브리스톨-마이어스 스큅 컴퍼니 치환된 비시클릭 헤테로아릴 화합물
WO2021067657A1 (en) 2019-10-04 2021-04-08 Bristol-Myers Squibb Company Substituted carbazole compounds
WO2024137671A1 (en) * 2022-12-20 2024-06-27 Exelixis, Inc. Compounds that inhibit pkmyt1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0765327B1 (en) * 1994-06-16 1999-07-21 Pfizer Inc. Pyrazolo and pyrrolopyridines
JP2002508324A (ja) * 1997-12-13 2002-03-19 ブリストル−マイヤーズ スクイブ カンパニー サイクリン依存性キナーゼ阻害剤としてのピラゾロ［３，４−ｂ］ピリジンの使用
JP2002020386A (ja) * 2000-07-07 2002-01-23 Ono Pharmaceut Co Ltd ピラゾロピリジン誘導体
WO2003068773A1 (en) * 2002-02-12 2003-08-21 Glaxo Group Limited Pyrazolopyridine derivatives
JP2005534713A (ja) * 2002-08-07 2005-11-17 三菱ウェルファーマ株式会社 ジヒドロピラゾロピリジン化合物
BRPI0407811A (pt) * 2003-02-27 2006-02-14 Uriach Y Compania S A J composto derivados de pirazolopiridina, processo para a preparação dos mesmos, composição farmacêutica e respectivos uso

Also Published As

Publication number Publication date
AU2006264044A1 (en) 2007-01-04
MX2007015829A (es) 2008-02-22
RS50821B (sr) 2010-08-31
TW200800982A (en) 2008-01-01
SI1899333T1 (sl) 2009-08-31
RU2008102970A (ru) 2009-08-10
HRP20090244T2 (hr) 2009-07-31
US7910602B2 (en) 2011-03-22
JP5010594B2 (ja) 2012-08-29
PL1899333T3 (pl) 2009-07-31
KR20080020638A (ko) 2008-03-05
AR054514A1 (es) 2007-06-27
HRP20090244T1 (en) 2009-06-30
PT1899333E (pt) 2009-04-23
CY1110464T1 (el) 2015-04-29
CN101208340B (zh) 2010-12-22
IL188381A0 (en) 2008-04-13
RU2415855C2 (ru) 2011-04-10
MY139016A (en) 2009-08-28
JP2008543957A (ja) 2008-12-04
EP1899333A1 (en) 2008-03-19
CA2611296A1 (en) 2007-01-04
ZA200709853B (en) 2008-12-31
BRPI0612320A2 (pt) 2010-11-09
DK1899333T3 (da) 2009-06-15
ES2322197T3 (es) 2009-06-17
DE602006005242D1 (de) 2009-04-02
WO2007000241A1 (en) 2007-01-04
MA29498B1 (fr) 2008-05-02
CN101208340A (zh) 2008-06-25
US20080227777A1 (en) 2008-09-18
ATE423118T1 (de) 2009-03-15
NZ564757A (en) 2009-12-24
NO20080392L (no) 2008-02-28
EP1899333B1 (en) 2009-02-18

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Legal Events

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Effective date: 20130128