TW200800982A - Pyrazolopyridine derivatives as inhibitors of β-adrenergic receptor kinase 1 - Google Patents

Pyrazolopyridine derivatives as inhibitors of β-adrenergic receptor kinase 1

Info

Publication number: TW200800982A
Authority: TW; Taiwan
Prior art keywords: inhibitors; adrenergic receptor; receptor kinase; pyrazolopyridine derivatives; prevention
Prior art date: 2005-06-27

Application number

TW095122584A

Other languages

English (en)

Inventor

Henning Steinhagen

Jochen Huber

Kurt Ritter

Bernard Pirard

Kirsten Bjergarde

Marcel Patek

Martin Smrcina

Linli Wei

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-27

Filing date

2006-06-23

Publication date

2008-01-01

2006-06-23 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2008-01-01 Publication of TW200800982A publication Critical patent/TW200800982A/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Virology (AREA)
Psychiatry (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TW095122584A 2005-06-27 2006-06-23 Pyrazolopyridine derivatives as inhibitors of β-adrenergic receptor kinase 1 TW200800982A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05013774		2005-06-27

Publications (1)

Publication Number	Publication Date
TW200800982A true TW200800982A (en)	2008-01-01

Family

ID=35395578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095122584A TW200800982A (en)	2005-06-27	2006-06-23	Pyrazolopyridine derivatives as inhibitors of β-adrenergic receptor kinase 1

Country Status (30)

Country	Link
US (1)	US7910602B2 (zh)
EP (1)	EP1899333B1 (zh)
JP (1)	JP5010594B2 (zh)
KR (1)	KR20080020638A (zh)
CN (1)	CN101208340B (zh)
AR (1)	AR054514A1 (zh)
AT (1)	ATE423118T1 (zh)
AU (1)	AU2006264044A1 (zh)
BR (1)	BRPI0612320A2 (zh)
CA (1)	CA2611296A1 (zh)
CY (1)	CY1110464T1 (zh)
DE (1)	DE602006005242D1 (zh)
DK (1)	DK1899333T3 (zh)
ES (1)	ES2322197T3 (zh)
HR (1)	HRP20090244T2 (zh)
IL (1)	IL188381A0 (zh)
MA (1)	MA29498B1 (zh)
MX (1)	MX2007015829A (zh)
MY (1)	MY139016A (zh)
NO (1)	NO20080392L (zh)
NZ (1)	NZ564757A (zh)
PL (1)	PL1899333T3 (zh)
PT (1)	PT1899333E (zh)
RS (1)	RS50821B (zh)
RU (1)	RU2415855C2 (zh)
SI (1)	SI1899333T1 (zh)
TW (1)	TW200800982A (zh)
UY (1)	UY29632A1 (zh)
WO (1)	WO2007000241A1 (zh)
ZA (1)	ZA200709853B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200815438A (en) *	2006-06-13	2008-04-01	Bayer Schering Pharma Ag	Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
US20110009421A1 (en) *	2008-02-27	2011-01-13	Takeda Pharmaceutical Company Limited	Compound having 6-membered aromatic ring
US9321787B2 (en) *	2011-07-07	2016-04-26	Sanofi	Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring
US8889730B2 (en)	2012-04-10	2014-11-18	Pfizer Inc.	Indole and indazole compounds that activate AMPK
US9394285B2 (en)	2013-03-15	2016-07-19	Pfizer Inc.	Indole and indazole compounds that activate AMPK
GB201410815D0 (en) *	2014-06-17	2014-07-30	Ucb Biopharma Sprl And Katholieke Universiteit Leuven	Therapeutic agents
US12172995B2 (en)	2018-10-24	2024-12-24	Bristol-Myers Squibb Company	Substituted indole and indazole compounds
US11998537B2 (en)	2018-10-24	2024-06-04	Bristol-Myers Squibb Company	Substituted indole dimer compounds
ES2987832T3 (es)	2019-05-09	2024-11-18	Bristol Myers Squibb Co	Compuestos de benzimidazolona sustituidos
KR20220075381A (ko)	2019-10-01	2022-06-08	브리스톨-마이어스 스큅 컴퍼니	치환된 비시클릭 헤테로아릴 화합물
WO2021067657A1 (en)	2019-10-04	2021-04-08	Bristol-Myers Squibb Company	Substituted carbazole compounds
WO2024137671A1 (en) *	2022-12-20	2024-06-27	Exelixis, Inc.	Compounds that inhibit pkmyt1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0765327B1 (en) *	1994-06-16	1999-07-21	Pfizer Inc.	Pyrazolo and pyrrolopyridines
JP2002508324A (ja) *	1997-12-13	2002-03-19	ブリストル−マイヤーズスクイブカンパニー	サイクリン依存性キナーゼ阻害剤としてのピラゾロ［３，４−ｂ］ピリジンの使用
JP2002020386A (ja) *	2000-07-07	2002-01-23	Ono Pharmaceut Co Ltd	ピラゾロピリジン誘導体
WO2003068773A1 (en) *	2002-02-12	2003-08-21	Glaxo Group Limited	Pyrazolopyridine derivatives
JP2005534713A (ja) *	2002-08-07	2005-11-17	三菱ウェルファーマ株式会社	ジヒドロピラゾロピリジン化合物
BRPI0407811A (pt) *	2003-02-27	2006-02-14	Uriach Y Compania S A J	composto derivados de pirazolopiridina, processo para a preparação dos mesmos, composição farmacêutica e respectivos uso

2006
- 2006-06-13 BR BRPI0612320-1A patent/BRPI0612320A2/pt not_active IP Right Cessation
- 2006-06-13 RS RSP-2009/0165A patent/RS50821B/sr unknown
- 2006-06-13 PL PL06754324T patent/PL1899333T3/pl unknown
- 2006-06-13 PT PT06754324T patent/PT1899333E/pt unknown
- 2006-06-13 JP JP2008518660A patent/JP5010594B2/ja not_active Expired - Fee Related
- 2006-06-13 HR HR20090244T patent/HRP20090244T2/xx unknown
- 2006-06-13 EP EP06754324A patent/EP1899333B1/en active Active
- 2006-06-13 ES ES06754324T patent/ES2322197T3/es active Active
- 2006-06-13 KR KR1020077030289A patent/KR20080020638A/ko not_active Withdrawn
- 2006-06-13 NZ NZ564757A patent/NZ564757A/en not_active IP Right Cessation
- 2006-06-13 SI SI200630284T patent/SI1899333T1/sl unknown
- 2006-06-13 CA CA002611296A patent/CA2611296A1/en not_active Abandoned
- 2006-06-13 DK DK06754324T patent/DK1899333T3/da active
- 2006-06-13 MX MX2007015829A patent/MX2007015829A/es active IP Right Grant
- 2006-06-13 WO PCT/EP2006/005649 patent/WO2007000241A1/en not_active Ceased
- 2006-06-13 AU AU2006264044A patent/AU2006264044A1/en not_active Abandoned
- 2006-06-13 CN CN200680023397XA patent/CN101208340B/zh not_active Expired - Fee Related
- 2006-06-13 AT AT06754324T patent/ATE423118T1/de not_active IP Right Cessation
- 2006-06-13 DE DE602006005242T patent/DE602006005242D1/de active Active
- 2006-06-13 RU RU2008102970/04A patent/RU2415855C2/ru not_active IP Right Cessation
- 2006-06-23 TW TW095122584A patent/TW200800982A/zh unknown
- 2006-06-23 AR ARP060102721A patent/AR054514A1/es not_active Application Discontinuation
- 2006-06-26 MY MYPI20063009A patent/MY139016A/en unknown
- 2006-06-27 UY UY29632A patent/UY29632A1/es not_active Application Discontinuation
2007
- 2007-11-15 ZA ZA200709853A patent/ZA200709853B/xx unknown
- 2007-11-30 MA MA30441A patent/MA29498B1/fr unknown
- 2007-12-20 US US11/961,282 patent/US7910602B2/en not_active Expired - Fee Related
- 2007-12-24 IL IL188381A patent/IL188381A0/en unknown
2008
- 2008-01-21 NO NO20080392A patent/NO20080392L/no not_active Application Discontinuation
2009
- 2009-05-11 CY CY20091100501T patent/CY1110464T1/el unknown

Also Published As

Publication number	Publication date
AU2006264044A1 (en)	2007-01-04
MX2007015829A (es)	2008-02-22
RS50821B (sr)	2010-08-31
SI1899333T1 (sl)	2009-08-31
RU2008102970A (ru)	2009-08-10
HRP20090244T2 (hr)	2009-07-31
US7910602B2 (en)	2011-03-22
JP5010594B2 (ja)	2012-08-29
PL1899333T3 (pl)	2009-07-31
KR20080020638A (ko)	2008-03-05
AR054514A1 (es)	2007-06-27
HRP20090244T1 (en)	2009-06-30
PT1899333E (pt)	2009-04-23
UY29632A1 (es)	2007-01-31
CY1110464T1 (el)	2015-04-29
CN101208340B (zh)	2010-12-22
IL188381A0 (en)	2008-04-13
RU2415855C2 (ru)	2011-04-10
MY139016A (en)	2009-08-28
JP2008543957A (ja)	2008-12-04
EP1899333A1 (en)	2008-03-19
CA2611296A1 (en)	2007-01-04
ZA200709853B (en)	2008-12-31
BRPI0612320A2 (pt)	2010-11-09
DK1899333T3 (da)	2009-06-15
ES2322197T3 (es)	2009-06-17
DE602006005242D1 (de)	2009-04-02
WO2007000241A1 (en)	2007-01-04
MA29498B1 (fr)	2008-05-02
CN101208340A (zh)	2008-06-25
US20080227777A1 (en)	2008-09-18
ATE423118T1 (de)	2009-03-15
NZ564757A (en)	2009-12-24
NO20080392L (no)	2008-02-28
EP1899333B1 (en)	2009-02-18

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