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UY26729A1 - Alquilaminas heterocíclicas como antagonistas de los receptores muscarínicos - Google Patents

Alquilaminas heterocíclicas como antagonistas de los receptores muscarínicos

Info

Publication number
UY26729A1
UY26729A1 UY26729A UY26729A UY26729A1 UY 26729 A1 UY26729 A1 UY 26729A1 UY 26729 A UY26729 A UY 26729A UY 26729 A UY26729 A UY 26729A UY 26729 A1 UY26729 A1 UY 26729A1
Authority
UY
Uruguay
Prior art keywords
antagonists
muscarinic receptors
compounds
alkylamines
heterocyclic
Prior art date
Application number
UY26729A
Other languages
English (en)
Inventor
Hans Maag
Antony Prince
Charles Alois Dvorak
David Bruce Repke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY26729A1 publication Critical patent/UY26729A1/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

Esta invención se refiere a compuestos que son generalmente antagonistas de los receptores muscarínicos M2/M3 y que están representados por la fórmula I en donde X, Y y Z son -O-, -S- o >N-R5, y los otros sustituyentes son tal como se definen en la especificación; o profármacos, isómeros individuales, mezclas racémicas o no-racémicas de isómeros, y sales o solvatos farmacéuticamente aceptables de los mismos. La invención además se refiere a las composiciones farmacéuticas que contienen dichos compuestos. Los procesos para su preparación y su utilidad para el tratamiento de enfermedades asociadas con anomalías en el músculo liso.
UY26729A 2000-05-25 2001-05-24 Alquilaminas heterocíclicas como antagonistas de los receptores muscarínicos UY26729A1 (es)

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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ302807B6 (cs) * 2000-05-25 2011-11-23 F. Hoffmann-La Roche Ag Substituovaný 1-aminoalkyllaktam, zpusob jeho prípravy a použití pro výrobu léciva a farmaceutická kompozice s jeho obsahem
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
AU2002345664C1 (en) 2001-06-11 2008-03-06 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
PL370765A1 (en) 2001-12-03 2005-05-30 F.Hoffmann-La Roche Ag 4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists
ATE381541T1 (de) 2001-12-03 2008-01-15 Hoffmann La Roche Aminotetralinderivate, antagonisten von muscarinrezeptoren
EP1546099B1 (en) 2002-07-08 2008-12-31 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo 3.1.0 hexane derivatives useful as muscarinic receptor antagonists
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089900A1 (en) 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
MX2007005306A (es) 2004-11-04 2007-06-11 Xenoport Inc Formas de dosis oral de liberacion sostenida de la prodroga gabapentina.
AU2006265639A1 (en) 2005-07-01 2007-01-11 Jenrin Discovery MAO-B inhibitors useful for treating obesity
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
MX2009011276A (es) * 2007-04-19 2010-01-15 Dong A Pharm Co Ltd Inhibidor de dpp-iv que incluye el grupo beta-amino, metodo para la preparacion del mismo y composicion farmaceutica que contiene el mismo para prevenir y tratar una diabetes o una obesidad.
TWI423967B (zh) * 2008-02-21 2014-01-21 Dainippon Sumitomo Pharma Co 醯胺衍生物及含有其之醫藥組合物
US8008291B2 (en) * 2008-02-29 2011-08-30 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists
CA2716256C (en) * 2008-02-29 2016-08-23 Mimetica Pty Ltd 3-substituted-1,4-diazepan-2-one melanocortin-5 receptor antagonists
US8138178B2 (en) * 2008-05-01 2012-03-20 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
KR20110050459A (ko) * 2008-07-25 2011-05-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
KR101354421B1 (ko) * 2008-07-28 2014-01-22 에프. 호프만-라 로슈 아게 케모카인 수용체의 다이아제판 및 피페라진 유도체 조절제
US8757092B2 (en) 2011-03-22 2014-06-24 Eco-Composites Llc Animal bedding and associated method for preparing the same
US9737047B2 (en) 2011-03-22 2017-08-22 Ccd Holdings Llc Method for the treatment, control, minimization, and prevention of bovine mastitis
MX370140B (es) * 2014-06-06 2019-12-03 Astellas Pharma Inc Derivado de 2-acilaminotiazol o sal del mismo.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3054794A (en) 1958-01-17 1962-09-18 Us Vitamin Pharm Corp Process for preparing 3-(aminoalkyl)-oxazolidine-2, 4-diones
US3354178A (en) 1965-04-09 1967-11-21 Sterling Drug Inc Nu-(4-amino-2-butynyl)-nu-alkylcarboxamides
US4065471A (en) 1965-04-09 1977-12-27 Sterling Drug Inc. N-(4-Amino-2-butynyl)imides
AT345806B (de) 1975-03-06 1978-10-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer substituierter arylalkylamine und deren salze
DD123741A5 (es) 1975-03-06 1977-01-12
US4087541A (en) 1975-03-06 1978-05-02 Boehringer Ingelheim Gmbh 2-(Aralkylaminoalkyl)phthalimidines
US4083407A (en) * 1977-02-07 1978-04-11 The Dow Chemical Company Spacer composition and method of use
US4490369A (en) 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
US4729994A (en) 1986-08-20 1988-03-08 Mcneilab, Inc. Benzothiazepine vasodilators having aralkyl substitution
DE3631013A1 (de) 1986-09-12 1988-03-24 Thomae Gmbh Dr K Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FI892362L (fi) 1988-06-01 1989-12-02 Eisai Co Ltd Buten- eller propensyraderivat.
US5177089A (en) 1988-06-01 1993-01-05 Eisai Co., Ltd. Butenoic or propenoic acid derivative
US5998452A (en) 1993-06-23 1999-12-07 Chugai Seiyaku Kabushiki Kaisha Benzene derivatives, compositions and methods for treating ischemic diseases
SE9303274D0 (sv) 1993-10-07 1993-10-07 Astra Ab Novel phenylethyl and phenylproplamines
RU2067579C1 (ru) * 1994-10-07 1996-10-10 Пермский фармацевтический институт 3-(2'-нафтоилметилен)-пиперазинон-2 и 1-n-фенил-3-фенацилиденпиперазинон-2, проявляющие противовоспалительную активность
US6319920B1 (en) * 1998-02-27 2001-11-20 Syntex (U.S.A.) Llc 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
CZ302807B6 (cs) * 2000-05-25 2011-11-23 F. Hoffmann-La Roche Ag Substituovaný 1-aminoalkyllaktam, zpusob jeho prípravy a použití pro výrobu léciva a farmaceutická kompozice s jeho obsahem

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EP1289965A1 (en) 2003-03-12
RU2241702C2 (ru) 2004-12-10
EP1289965B1 (en) 2005-10-26
US7361648B2 (en) 2008-04-22
WO2001090081A1 (en) 2001-11-29
ATE307806T1 (de) 2005-11-15
US20020004501A1 (en) 2002-01-10
ES2251517T3 (es) 2006-05-01
KR100544000B1 (ko) 2006-01-20
PL361282A1 (en) 2004-10-04
CN1178922C (zh) 2004-12-08
BR0111061A (pt) 2003-04-15
TWI306095B (en) 2009-02-11
CA2409841A1 (en) 2001-11-29
JP2003534330A (ja) 2003-11-18
NZ522411A (en) 2004-05-28
CZ302807B6 (cs) 2011-11-23
KR20030003763A (ko) 2003-01-10
JP4071000B2 (ja) 2008-04-02
US6667301B2 (en) 2003-12-23
IL152701A0 (en) 2003-06-24
DE60114413T2 (de) 2006-07-27
NO20025640L (no) 2003-01-22
HUP0302010A2 (hu) 2003-09-29
CA2409841C (en) 2009-04-14
YU88902A (sh) 2006-01-16
NO20025640D0 (no) 2002-11-22
AR028624A1 (es) 2003-05-14
CZ20024200A3 (cs) 2004-01-14
CN1430610A (zh) 2003-07-16
PL204753B1 (pl) 2010-02-26
US20060287293A1 (en) 2006-12-21
US20040087581A1 (en) 2004-05-06
AU1012202A (en) 2001-12-03
HRP20020904A2 (en) 2004-12-31
US7094778B2 (en) 2006-08-22
MXPA02011418A (es) 2003-04-25
PE20011325A1 (es) 2002-01-03
DE60114413D1 (de) 2005-12-01
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