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NO20025640L - Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptorantagonister - Google Patents

Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptorantagonister

Info

Publication number
NO20025640L
NO20025640L NO20025640A NO20025640A NO20025640L NO 20025640 L NO20025640 L NO 20025640L NO 20025640 A NO20025640 A NO 20025640A NO 20025640 A NO20025640 A NO 20025640A NO 20025640 L NO20025640 L NO 20025640L
Authority
NO
Norway
Prior art keywords
lactams
aminoalkyl
substituted
receptor antagonists
muscarinic receptor
Prior art date
Application number
NO20025640A
Other languages
English (en)
Other versions
NO20025640D0 (no
Inventor
Charles Alois Dvorak
Lawrence Emerson Fisher
Keena Lynn Green
Iii Ralph New Harris
Hans Maag
Anthony Prince
David Bruce Repke
Russell Stephen Stabler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20025640D0 publication Critical patent/NO20025640D0/no
Publication of NO20025640L publication Critical patent/NO20025640L/no

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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NO20025640A 2000-05-25 2002-11-22 Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptorantagonister NO20025640L (no)

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ATE381541T1 (de) 2001-12-03 2008-01-15 Hoffmann La Roche Aminotetralinderivate, antagonisten von muscarinrezeptoren
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US7361648B2 (en) 2008-04-22
WO2001090081A1 (en) 2001-11-29
ATE307806T1 (de) 2005-11-15
US20020004501A1 (en) 2002-01-10
ES2251517T3 (es) 2006-05-01
KR100544000B1 (ko) 2006-01-20
PL361282A1 (en) 2004-10-04
CN1178922C (zh) 2004-12-08
BR0111061A (pt) 2003-04-15
TWI306095B (en) 2009-02-11
CA2409841A1 (en) 2001-11-29
JP2003534330A (ja) 2003-11-18
NZ522411A (en) 2004-05-28
CZ302807B6 (cs) 2011-11-23
KR20030003763A (ko) 2003-01-10
JP4071000B2 (ja) 2008-04-02
US6667301B2 (en) 2003-12-23
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DE60114413T2 (de) 2006-07-27
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CA2409841C (en) 2009-04-14
YU88902A (sh) 2006-01-16
NO20025640D0 (no) 2002-11-22
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CZ20024200A3 (cs) 2004-01-14
CN1430610A (zh) 2003-07-16
PL204753B1 (pl) 2010-02-26
US20060287293A1 (en) 2006-12-21
US20040087581A1 (en) 2004-05-06
AU1012202A (en) 2001-12-03
HRP20020904A2 (en) 2004-12-31
US7094778B2 (en) 2006-08-22
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