UY25201A1 - METHOD FOR TREATING SUBSTITUTED 4-PHENYL-4-CYANOCICLOHEXANOIC ACID - Google Patents
METHOD FOR TREATING SUBSTITUTED 4-PHENYL-4-CYANOCICLOHEXANOIC ACIDInfo
- Publication number
- UY25201A1 UY25201A1 UY25201A UY25201A UY25201A1 UY 25201 A1 UY25201 A1 UY 25201A1 UY 25201 A UY25201 A UY 25201A UY 25201 A UY25201 A UY 25201A UY 25201 A1 UY25201 A1 UY 25201A1
- Authority
- UY
- Uruguay
- Prior art keywords
- cr4r5
- cyanociclohexanoic
- phenyl
- acid
- alkyl
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Esta invención se refiere a un método para preparar un compuesto de fórmula l, en la que R1 es (CR4R5)nC(O)O(CR4R5)mR6; (CR4R5)rR6, en que los restos alquilo pueden estar opcionalmente sustituidos con uno o más halogenos; X es YR2, halogeno, nitro, NH2, o formilamina; X2 es O o NR8; R3 es H, halogeno, alquilo, CH2NHC(O)C(O)NH2, alquilo sustituido con halo, ciclopropilo, etc; R' y R'' son independientemente H o C(O)OX, en que X es H o un catión metálico o amonio. Una composición de materia que comprende cis-4-ciano-4-3-ciclopentilloxi-4-metoxifenil)-r-1-ciclohexano-carboxilato de litio esencialmente puro.This invention relates to a method of preparing a compound of formula I, wherein R1 is (CR4R5) nC (O) O (CR4R5) mR6; (CR4R5) rR6, in which the alkyl moieties can be optionally substituted with one or more halogens; X is YR2, halogen, nitro, NH2, or formylamine; X2 is O or NR8; R3 is H, halogen, alkyl, CH2NHC (O) C (O) NH2, halo-substituted alkyl, cyclopropyl, etc; R 'and R' 'are independently H or C (O) OX, where X is H or a metal or ammonium cation. A composition of matter comprising essentially pure lithium cis-4-cyano-4-3-cyclopentilloxy-4-methoxyphenyl) -r-1-cyclohexane-carboxylate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6161397P | 1997-10-10 | 1997-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25201A1 true UY25201A1 (en) | 2001-08-27 |
Family
ID=22036929
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25201A UY25201A1 (en) | 1997-10-10 | 1998-10-07 | METHOD FOR TREATING SUBSTITUTED 4-PHENYL-4-CYANOCICLOHEXANOIC ACID |
| UY25524A UY25524A1 (en) | 1997-10-10 | 1999-05-25 | METHOD FOR PREPARING SUBSTITUTED 4-PHENYL4-CIANOCICLOHEXANOIC ACIDS |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25524A UY25524A1 (en) | 1997-10-10 | 1999-05-25 | METHOD FOR PREPARING SUBSTITUTED 4-PHENYL4-CIANOCICLOHEXANOIC ACIDS |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1043930A4 (en) |
| JP (1) | JP2001519363A (en) |
| KR (1) | KR100560038B1 (en) |
| CN (1) | CN1192025C (en) |
| AP (1) | AP1335A (en) |
| AR (1) | AR015952A1 (en) |
| AU (1) | AU741832B2 (en) |
| BG (1) | BG104302A (en) |
| BR (1) | BR9814064A (en) |
| CA (1) | CA2305614A1 (en) |
| DZ (1) | DZ2619A1 (en) |
| EA (1) | EA003609B1 (en) |
| HU (1) | HUP0003905A3 (en) |
| ID (1) | ID25536A (en) |
| IL (1) | IL135434A (en) |
| MA (1) | MA24670A1 (en) |
| MY (1) | MY122105A (en) |
| NO (1) | NO20001777L (en) |
| NZ (1) | NZ503759A (en) |
| OA (1) | OA11347A (en) |
| PE (1) | PE121599A1 (en) |
| PL (1) | PL191974B1 (en) |
| SA (1) | SA99191000A (en) |
| SK (1) | SK4902000A3 (en) |
| TR (1) | TR200000945T2 (en) |
| TW (1) | TW440557B (en) |
| UA (1) | UA67753C2 (en) |
| UY (2) | UY25201A1 (en) |
| WO (1) | WO1999018793A1 (en) |
| ZA (1) | ZA989228B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9920152D0 (en) * | 1999-08-25 | 1999-10-27 | Smithkline Beecham Plc | Novel process |
| WO2001043692A2 (en) * | 1999-12-15 | 2001-06-21 | Smithkline Beecham Corporation | SALTS OF Cis-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANE-1-CARBOXYLIC ACID |
| DZ3285A1 (en) * | 2000-01-26 | 2001-08-02 | Smithkline Beecham Corp | MONOHYDRATE CIS-LITHIUM-4-CYANO-4- (3- (CYCLOPENTYLOXY) -4METHOXYPHENYL) CYCLOHEXANECARBOXYLATE |
| US6555572B2 (en) | 2000-03-16 | 2003-04-29 | Inflazyme Pharmaceuticals Ltd. | Benzylated PDE4 inhibitors |
| WO2002060896A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
| PL364135A1 (en) | 2001-01-31 | 2004-12-13 | Pfizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| CA2436551A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes |
| CN102491959B (en) * | 2011-12-19 | 2015-03-25 | 江苏澄扬作物科技有限公司 | Preparation method of oxirane derivative |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4021478A (en) * | 1972-07-13 | 1977-05-03 | The Upjohn Company | Preparation of carboxylic acids from glycidonitriles with ionic lewis acids |
| MX9301943A (en) * | 1992-04-02 | 1994-08-31 | Smithkline Beecham Corp | COMPOUNDS. |
| US5524438A (en) * | 1994-12-15 | 1996-06-11 | United Technologies Corporation | Segmented bulkhead liner for a gas turbine combustor |
| UY24882A1 (en) * | 1997-02-12 | 2001-08-27 | Smithkline Beecham Corp | SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS |
| US6452022B1 (en) * | 1997-10-10 | 2002-09-17 | Smithkline Beecham Corporation | Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
-
1998
- 1998-07-10 UA UA2000041944A patent/UA67753C2/en unknown
- 1998-10-02 MA MA25278A patent/MA24670A1/en unknown
- 1998-10-07 AP APAP/P/2000/001782A patent/AP1335A/en active
- 1998-10-07 NZ NZ503759A patent/NZ503759A/en unknown
- 1998-10-07 JP JP2000515437A patent/JP2001519363A/en active Pending
- 1998-10-07 EA EA200000406A patent/EA003609B1/en not_active IP Right Cessation
- 1998-10-07 AR ARP980105002A patent/AR015952A1/en unknown
- 1998-10-07 SK SK490-2000A patent/SK4902000A3/en unknown
- 1998-10-07 KR KR1020007003742A patent/KR100560038B1/en not_active Expired - Fee Related
- 1998-10-07 UY UY25201A patent/UY25201A1/en not_active IP Right Cessation
- 1998-10-07 PL PL339759A patent/PL191974B1/en not_active IP Right Cessation
- 1998-10-07 CN CNB988100304A patent/CN1192025C/en not_active Expired - Fee Related
- 1998-10-07 HU HU0003905A patent/HUP0003905A3/en not_active Application Discontinuation
- 1998-10-07 ID IDW20000614A patent/ID25536A/en unknown
- 1998-10-07 AU AU96874/98A patent/AU741832B2/en not_active Ceased
- 1998-10-07 CA CA002305614A patent/CA2305614A1/en not_active Abandoned
- 1998-10-07 DZ DZ980229A patent/DZ2619A1/en active
- 1998-10-07 BR BR9814064-7A patent/BR9814064A/en not_active IP Right Cessation
- 1998-10-07 TR TR2000/00945T patent/TR200000945T2/en unknown
- 1998-10-07 EP EP98950965A patent/EP1043930A4/en not_active Withdrawn
- 1998-10-07 IL IL13543498A patent/IL135434A/en not_active IP Right Cessation
- 1998-10-07 WO PCT/US1998/021061 patent/WO1999018793A1/en not_active Ceased
- 1998-10-08 MY MYPI98004606A patent/MY122105A/en unknown
- 1998-10-09 ZA ZA989228A patent/ZA989228B/en unknown
- 1998-10-09 PE PE1998000955A patent/PE121599A1/en not_active Application Discontinuation
- 1998-12-01 TW TW087116680A patent/TW440557B/en not_active IP Right Cessation
-
1999
- 1999-01-26 SA SA99191000A patent/SA99191000A/en unknown
- 1999-05-25 UY UY25524A patent/UY25524A1/en not_active Application Discontinuation
-
2000
- 2000-04-05 BG BG104302A patent/BG104302A/en unknown
- 2000-04-06 NO NO20001777A patent/NO20001777L/en not_active Application Discontinuation
- 2000-04-07 OA OA1200000100A patent/OA11347A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 110 | Patent granted |
Effective date: 20100625 |
|
| VENC | Patent expired |
Effective date: 20181007 |