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NO20001777L - Process for the preparation of substituted 4-phenyl-4-cyanocyclohexanecarboxylic acids - Google Patents

Process for the preparation of substituted 4-phenyl-4-cyanocyclohexanecarboxylic acids

Info

Publication number
NO20001777L
NO20001777L NO20001777A NO20001777A NO20001777L NO 20001777 L NO20001777 L NO 20001777L NO 20001777 A NO20001777 A NO 20001777A NO 20001777 A NO20001777 A NO 20001777A NO 20001777 L NO20001777 L NO 20001777L
Authority
NO
Norway
Prior art keywords
cyanocyclohexanecarboxylic
phenyl
acids
substituted
preparation
Prior art date
Application number
NO20001777A
Other languages
Norwegian (no)
Other versions
NO20001777D0 (en
Inventor
Kevin Webb
Wilford Mendelson
Jianhao Chen
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20001777D0 publication Critical patent/NO20001777D0/en
Publication of NO20001777L publication Critical patent/NO20001777L/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20001777A 1997-10-10 2000-04-06 Process for the preparation of substituted 4-phenyl-4-cyanocyclohexanecarboxylic acids NO20001777L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10
PCT/US1998/021061 WO1999018793A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (2)

Publication Number Publication Date
NO20001777D0 NO20001777D0 (en) 2000-04-06
NO20001777L true NO20001777L (en) 2000-05-03

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001777A NO20001777L (en) 1997-10-10 2000-04-06 Process for the preparation of substituted 4-phenyl-4-cyanocyclohexanecarboxylic acids

Country Status (30)

Country Link
EP (1) EP1043930A4 (en)
JP (1) JP2001519363A (en)
KR (1) KR100560038B1 (en)
CN (1) CN1192025C (en)
AP (1) AP1335A (en)
AR (1) AR015952A1 (en)
AU (1) AU741832B2 (en)
BG (1) BG104302A (en)
BR (1) BR9814064A (en)
CA (1) CA2305614A1 (en)
DZ (1) DZ2619A1 (en)
EA (1) EA003609B1 (en)
HU (1) HUP0003905A3 (en)
ID (1) ID25536A (en)
IL (1) IL135434A (en)
MA (1) MA24670A1 (en)
MY (1) MY122105A (en)
NO (1) NO20001777L (en)
NZ (1) NZ503759A (en)
OA (1) OA11347A (en)
PE (1) PE121599A1 (en)
PL (1) PL191974B1 (en)
SA (1) SA99191000A (en)
SK (1) SK4902000A3 (en)
TR (1) TR200000945T2 (en)
TW (1) TW440557B (en)
UA (1) UA67753C2 (en)
UY (2) UY25201A1 (en)
WO (1) WO1999018793A1 (en)
ZA (1) ZA989228B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
JP2003534238A (en) * 1999-12-15 2003-11-18 スミスクライン・ビーチャム・コーポレイション Salt of cis-4-cyano-4- [3- (cyclopentyloxy) -4-methoxyphenyl] cyclohexane-1-carboxylic acid.
ES2273804T3 (en) * 2000-01-26 2007-05-16 Smithkline Beecham Corporation CIS-LITHIUM-CYANO-4-3- (CYCLOPENTILOXI) -4-METOXYPHENYLCICLOHEXANOCARBOXYLATE MONOHIDRATE.
EP1265861A2 (en) 2000-03-16 2002-12-18 Inflazyme Pharmaceuticals, Ltd. Benzylated pde4 inhibitors
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
PL364135A1 (en) 2001-01-31 2004-12-13 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
EA200300622A1 (en) 2001-01-31 2003-12-25 Пфайзер Продактс Инк. DERIVATIVES OF AMIDES TIAZOLYL-, OXAZOLYL, PYRROLYL-AND IMIDAZOZYL ACID, USEFUL AS AN INHIBITORS OF PDE4 ISOFERMENT
DE60113731T2 (en) 2001-01-31 2006-06-29 Pfizer Products Inc., Groton ETHER DERIVATIVES SUITABLE AS INHIBITORS OF PDE4 ISOZYME
CN102491959B (en) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 Preparation method of oxirane derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
AU677776B2 (en) * 1992-04-02 1997-05-08 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
UY24882A1 (en) * 1997-02-12 2001-08-27 Smithkline Beecham Corp SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
ZA989228B (en) 1999-04-12
OA11347A (en) 2003-12-17
MY122105A (en) 2006-03-31
TW440557B (en) 2001-06-16
UA67753C2 (en) 2004-07-15
AR015952A1 (en) 2001-05-30
SA99191000A (en) 2005-12-03
HUP0003905A2 (en) 2001-03-28
IL135434A0 (en) 2001-05-20
EP1043930A4 (en) 2004-09-15
ID25536A (en) 2000-10-12
SK4902000A3 (en) 2000-11-07
AP1335A (en) 2004-11-29
KR100560038B1 (en) 2006-03-13
UY25524A1 (en) 2000-02-23
CA2305614A1 (en) 1999-04-22
CN1192025C (en) 2005-03-09
CN1275052A (en) 2000-11-29
NZ503759A (en) 2002-03-01
EA003609B1 (en) 2003-06-26
WO1999018793A1 (en) 1999-04-22
BR9814064A (en) 2000-09-26
AU9687498A (en) 1999-05-03
IL135434A (en) 2004-12-15
EA200000406A1 (en) 2000-10-30
AU741832B2 (en) 2001-12-13
UY25201A1 (en) 2001-08-27
AP2000001782A0 (en) 2000-06-30
TR200000945T2 (en) 2000-10-23
MA24670A1 (en) 1999-07-01
BG104302A (en) 2001-08-31
KR20010015709A (en) 2001-02-26
PE121599A1 (en) 2000-02-19
EP1043930A1 (en) 2000-10-18
PL339759A1 (en) 2001-01-02
HUP0003905A3 (en) 2002-01-28
NO20001777D0 (en) 2000-04-06
DZ2619A1 (en) 2003-03-08
JP2001519363A (en) 2001-10-23
PL191974B1 (en) 2006-07-31

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Legal Events

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