TR200000945T2 - Method for the preparation of substituted 4-phenyl-4-cyanocyclohexanoic acids - Google Patents
Method for the preparation of substituted 4-phenyl-4-cyanocyclohexanoic acidsInfo
- Publication number
- TR200000945T2 TR200000945T2 TR2000/00945T TR200000945T TR200000945T2 TR 200000945 T2 TR200000945 T2 TR 200000945T2 TR 2000/00945 T TR2000/00945 T TR 2000/00945T TR 200000945 T TR200000945 T TR 200000945T TR 200000945 T2 TR200000945 T2 TR 200000945T2
- Authority
- TR
- Turkey
- Prior art keywords
- phenyl
- substituted
- preparation
- group
- cyanocyclohexanoic
- Prior art date
Links
- XWFKZQVEYDVFTA-UHFFFAOYSA-N 4-cyano-4-phenylcyclohexane-1-carboxylic acid Chemical class C1CC(C(=O)O)CCC1(C#N)C1=CC=CC=C1 XWFKZQVEYDVFTA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910001507 metal halide Inorganic materials 0.000 abstract 1
- 150000005309 metal halides Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Bu bulus, bir formül (II): bilesigin bir grup I (a) ya da grup II (a) metal halidi ile, aprotik bir dipolar amid esasli solvent ve su vasitasi ile islenmesi ile, R' ya da R" 'nün en az birinin bir karboksil grubu oldugu asagidaki tipte bir bilesigin olusturulmasi ile ilgilidir.This invention is a formula (II): by treating the compound with a metal halide of a group I (a) or group II (a), with an aprotic dipolar amide-based solvent and water, at least R 'or R " It relates to the formation of a compound of the following type in which one is a carboxyl group.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6161397P | 1997-10-10 | 1997-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000945T2 true TR200000945T2 (en) | 2000-10-23 |
Family
ID=22036929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00945T TR200000945T2 (en) | 1997-10-10 | 1998-10-07 | Method for the preparation of substituted 4-phenyl-4-cyanocyclohexanoic acids |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1043930A4 (en) |
| JP (1) | JP2001519363A (en) |
| KR (1) | KR100560038B1 (en) |
| CN (1) | CN1192025C (en) |
| AP (1) | AP1335A (en) |
| AR (1) | AR015952A1 (en) |
| AU (1) | AU741832B2 (en) |
| BG (1) | BG104302A (en) |
| BR (1) | BR9814064A (en) |
| CA (1) | CA2305614A1 (en) |
| DZ (1) | DZ2619A1 (en) |
| EA (1) | EA003609B1 (en) |
| HU (1) | HUP0003905A3 (en) |
| ID (1) | ID25536A (en) |
| IL (1) | IL135434A (en) |
| MA (1) | MA24670A1 (en) |
| MY (1) | MY122105A (en) |
| NO (1) | NO20001777L (en) |
| NZ (1) | NZ503759A (en) |
| OA (1) | OA11347A (en) |
| PE (1) | PE121599A1 (en) |
| PL (1) | PL191974B1 (en) |
| SA (1) | SA99191000A (en) |
| SK (1) | SK4902000A3 (en) |
| TR (1) | TR200000945T2 (en) |
| TW (1) | TW440557B (en) |
| UA (1) | UA67753C2 (en) |
| UY (2) | UY25201A1 (en) |
| WO (1) | WO1999018793A1 (en) |
| ZA (1) | ZA989228B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9920152D0 (en) * | 1999-08-25 | 1999-10-27 | Smithkline Beecham Plc | Novel process |
| WO2001043692A2 (en) * | 1999-12-15 | 2001-06-21 | Smithkline Beecham Corporation | SALTS OF Cis-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANE-1-CARBOXYLIC ACID |
| DZ3285A1 (en) * | 2000-01-26 | 2001-08-02 | Smithkline Beecham Corp | MONOHYDRATE CIS-LITHIUM-4-CYANO-4- (3- (CYCLOPENTYLOXY) -4METHOXYPHENYL) CYCLOHEXANECARBOXYLATE |
| US6555572B2 (en) | 2000-03-16 | 2003-04-29 | Inflazyme Pharmaceuticals Ltd. | Benzylated PDE4 inhibitors |
| WO2002060896A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
| PL364135A1 (en) | 2001-01-31 | 2004-12-13 | Pfizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| CA2436551A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes |
| CN102491959B (en) * | 2011-12-19 | 2015-03-25 | 江苏澄扬作物科技有限公司 | Preparation method of oxirane derivative |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4021478A (en) * | 1972-07-13 | 1977-05-03 | The Upjohn Company | Preparation of carboxylic acids from glycidonitriles with ionic lewis acids |
| MX9301943A (en) * | 1992-04-02 | 1994-08-31 | Smithkline Beecham Corp | COMPOUNDS. |
| US5524438A (en) * | 1994-12-15 | 1996-06-11 | United Technologies Corporation | Segmented bulkhead liner for a gas turbine combustor |
| UY24882A1 (en) * | 1997-02-12 | 2001-08-27 | Smithkline Beecham Corp | SUBSTITUTED 4-PHENYL-4-CIANO-CYCLOHEXANOIC ACIDS |
| US6452022B1 (en) * | 1997-10-10 | 2002-09-17 | Smithkline Beecham Corporation | Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids |
-
1998
- 1998-07-10 UA UA2000041944A patent/UA67753C2/en unknown
- 1998-10-02 MA MA25278A patent/MA24670A1/en unknown
- 1998-10-07 AP APAP/P/2000/001782A patent/AP1335A/en active
- 1998-10-07 NZ NZ503759A patent/NZ503759A/en unknown
- 1998-10-07 JP JP2000515437A patent/JP2001519363A/en active Pending
- 1998-10-07 EA EA200000406A patent/EA003609B1/en not_active IP Right Cessation
- 1998-10-07 AR ARP980105002A patent/AR015952A1/en unknown
- 1998-10-07 SK SK490-2000A patent/SK4902000A3/en unknown
- 1998-10-07 KR KR1020007003742A patent/KR100560038B1/en not_active Expired - Fee Related
- 1998-10-07 UY UY25201A patent/UY25201A1/en not_active IP Right Cessation
- 1998-10-07 PL PL339759A patent/PL191974B1/en not_active IP Right Cessation
- 1998-10-07 CN CNB988100304A patent/CN1192025C/en not_active Expired - Fee Related
- 1998-10-07 HU HU0003905A patent/HUP0003905A3/en not_active Application Discontinuation
- 1998-10-07 ID IDW20000614A patent/ID25536A/en unknown
- 1998-10-07 AU AU96874/98A patent/AU741832B2/en not_active Ceased
- 1998-10-07 CA CA002305614A patent/CA2305614A1/en not_active Abandoned
- 1998-10-07 DZ DZ980229A patent/DZ2619A1/en active
- 1998-10-07 BR BR9814064-7A patent/BR9814064A/en not_active IP Right Cessation
- 1998-10-07 TR TR2000/00945T patent/TR200000945T2/en unknown
- 1998-10-07 EP EP98950965A patent/EP1043930A4/en not_active Withdrawn
- 1998-10-07 IL IL13543498A patent/IL135434A/en not_active IP Right Cessation
- 1998-10-07 WO PCT/US1998/021061 patent/WO1999018793A1/en not_active Ceased
- 1998-10-08 MY MYPI98004606A patent/MY122105A/en unknown
- 1998-10-09 ZA ZA989228A patent/ZA989228B/en unknown
- 1998-10-09 PE PE1998000955A patent/PE121599A1/en not_active Application Discontinuation
- 1998-12-01 TW TW087116680A patent/TW440557B/en not_active IP Right Cessation
-
1999
- 1999-01-26 SA SA99191000A patent/SA99191000A/en unknown
- 1999-05-25 UY UY25524A patent/UY25524A1/en not_active Application Discontinuation
-
2000
- 2000-04-05 BG BG104302A patent/BG104302A/en unknown
- 2000-04-06 NO NO20001777A patent/NO20001777L/en not_active Application Discontinuation
- 2000-04-07 OA OA1200000100A patent/OA11347A/en unknown
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