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UY24499A1 - Nuevos derivados de 2-(3h)-oxazolona - Google Patents

Nuevos derivados de 2-(3h)-oxazolona

Info

Publication number
UY24499A1
UY24499A1 UY24499A UY24499A UY24499A1 UY 24499 A1 UY24499 A1 UY 24499A1 UY 24499 A UY24499 A UY 24499A UY 24499 A UY24499 A UY 24499A UY 24499 A1 UY24499 A1 UY 24499A1
Authority
UY
Uruguay
Prior art keywords
oxazolone
group
alkyl
compound
formula
Prior art date
Application number
UY24499A
Other languages
English (en)
Inventor
Duran Carles Puig
Noguera Ferran Pujol
Forner Dolors Fernandez
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8294266&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY24499(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of UY24499A1 publication Critical patent/UY24499A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de 2-(3H)-oxazolona de fórmula (I) (figura 1) en donde: R1 es un grupo alquilo o NR4R5, en donde R4 y R5 son cada uno independientemente H o un grupo alquilo o bencilo; R2 es un grupo naftilo, tetrahidronaftilo, o un grupo fenilo no sustituido o fenilo sustituido, siendo los substituyentes seleccionados de 1 a 3 átomos de halógeno o grupos alquilo, hidroxi, alcoxi, o trifluorometilo; y R3 es H o un grupo alquilo. Ejemplo no limitante: 3-(4-fluorofenil)-4-(4-metilsulfonilfenil)-2-(3H)-oxazolona. Además se describe una composición farmacéutica que comprende, como ingrediente activo al compuesto de fórmula l, y un excipiente o diluyente farmacéuticamente aceptable. El uso del compuesto en la fabricación de un medicamento para el tratamiento del dolor, fiebre o inflamación, para inhibir la contracción del músculo liso inducida por protanoides, o para la prevención del cáncer colorectal.
UY24499A 1996-03-21 1997-03-21 Nuevos derivados de 2-(3h)-oxazolona UY24499A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009600685A ES2125161B1 (es) 1996-03-21 1996-03-21 Nuevos derivados de 2-(3h)-oxazolona.

Publications (1)

Publication Number Publication Date
UY24499A1 true UY24499A1 (es) 1997-04-02

Family

ID=8294266

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24499A UY24499A1 (es) 1996-03-21 1997-03-21 Nuevos derivados de 2-(3h)-oxazolona

Country Status (29)

Country Link
US (1) US6869968B1 (es)
EP (1) EP0888316B1 (es)
JP (1) JP3810091B2 (es)
KR (1) KR100496395B1 (es)
CN (1) CN1110488C (es)
AR (1) AR006340A1 (es)
AT (1) ATE197294T1 (es)
AU (1) AU713811B2 (es)
BR (1) BR9708141A (es)
CA (1) CA2249420A1 (es)
CO (1) CO4780046A1 (es)
CZ (1) CZ294963B6 (es)
DE (1) DE69703437T2 (es)
DK (1) DK0888316T3 (es)
ES (2) ES2125161B1 (es)
GR (1) GR3035096T3 (es)
ID (1) ID16778A (es)
IL (1) IL126206A (es)
NO (1) NO311761B1 (es)
NZ (1) NZ331901A (es)
PE (1) PE42898A1 (es)
PL (1) PL188722B1 (es)
PT (1) PT888316E (es)
RU (1) RU2194043C2 (es)
TW (1) TW426674B (es)
UA (1) UA52645C2 (es)
UY (1) UY24499A1 (es)
WO (1) WO1997034882A1 (es)
ZA (1) ZA972203B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125161B1 (es) 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
FR2753449B1 (fr) * 1996-09-13 1998-12-04 Union Pharma Scient Appl Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique
ES2131015B1 (es) * 1997-09-12 2000-03-01 Almirall Prodesfarma Sa Nuevos derivados de 2-(3h)-oxazolona, procedimientos para su preparacion y su empleo en composiciones farmaceuticas.
ES2154561B1 (es) * 1998-09-25 2001-12-01 Almirall Prodesfarma Sa Derivados de 2-fenilpiran-4-ona.
ES2168895A1 (es) * 1999-03-26 2002-06-16 Almirall Prodesfarma Sa Derivados de 2-fenilpiran-4-ona.
CO5261556A1 (es) 1999-12-08 2003-03-31 Pharmacia Corp Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico
CA2393724A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
CA2492066A1 (en) 2002-06-28 2004-01-08 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
ES2215474B1 (es) 2002-12-24 2005-12-16 J. URIACH & CIA S.A. Nuevos derivados de fosforamida.
ES2213485B1 (es) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
DE602004002832T2 (de) 2003-05-07 2007-06-06 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
CN1309717C (zh) * 2003-06-03 2007-04-11 李小虎 4－芳基－5h－噻吩－2－酮衍生物、其制法和用途
RU2270673C1 (ru) * 2004-08-17 2006-02-27 Государственное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" (ГОУ ВПО СибГМУ) Способ реабилитации больных после операции на щитовидной железе
JP2010516679A (ja) * 2007-01-19 2010-05-20 マリンクロット インコーポレイテッド 診断用および治療用シクロオキシゲナーゼ−２結合リガンド
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3578671A (en) * 1967-11-06 1971-05-11 Wyeth John & Brother Ltd Oxazoles
US4632930A (en) * 1984-11-30 1986-12-30 E. I. Du Pont De Nemours And Company Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives
ZW19786A1 (en) * 1985-10-17 1988-05-18 Hoffmann La Roche Heterocyclic compounds
US4866182A (en) 1988-02-18 1989-09-12 Merrell Dow Pharmaceuticals Inc. Cardiotonic alkanoyl and aroyl oxazolones
US5380738A (en) 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
DE4435547A1 (de) 1994-10-05 1996-04-11 Bayer Ag Sulfonylaminocarbonyltriazolinone mit über Sauerstoff und Schwefel gebundenen Substituenten
JP2636819B2 (ja) 1994-12-20 1997-07-30 日本たばこ産業株式会社 オキサゾール系複素環式芳香族化合物
ES2125161B1 (es) 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
FR2753449B1 (fr) 1996-09-13 1998-12-04 Union Pharma Scient Appl Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique

Also Published As

Publication number Publication date
CZ294963B6 (cs) 2005-04-13
PT888316E (pt) 2001-02-28
BR9708141A (pt) 1999-07-27
AR006340A1 (es) 1999-08-25
PE42898A1 (es) 1998-08-12
PL328915A1 (en) 1999-03-01
ZA972203B (en) 1997-09-25
GR3035096T3 (en) 2001-03-30
JP2000506876A (ja) 2000-06-06
MX9701944A (es) 1998-06-30
NO984325D0 (no) 1998-09-17
AU713811B2 (en) 1999-12-09
UA52645C2 (uk) 2003-01-15
ATE197294T1 (de) 2000-11-15
CZ297998A3 (cs) 1999-02-17
KR100496395B1 (ko) 2005-09-27
NO984325L (no) 1998-11-23
ES2125161B1 (es) 1999-11-16
PL188722B1 (pl) 2005-04-29
HK1015371A1 (en) 1999-10-15
DK0888316T3 (da) 2000-11-27
CN1218459A (zh) 1999-06-02
CN1110488C (zh) 2003-06-04
RU2194043C2 (ru) 2002-12-10
EP0888316B1 (en) 2000-11-02
TW426674B (en) 2001-03-21
IL126206A (en) 2001-06-14
ES2151254T3 (es) 2000-12-16
CA2249420A1 (en) 1997-09-25
NO311761B1 (no) 2002-01-21
DE69703437T2 (de) 2001-03-08
ES2125161A1 (es) 1999-02-16
CO4780046A1 (es) 1999-05-26
WO1997034882A1 (en) 1997-09-25
ID16778A (id) 1997-11-13
JP3810091B2 (ja) 2006-08-16
KR20000064727A (ko) 2000-11-06
NZ331901A (en) 1999-10-28
IL126206A0 (en) 1999-05-09
DE69703437D1 (de) 2000-12-07
EP0888316A1 (en) 1999-01-07
AU2289397A (en) 1997-10-10
US6869968B1 (en) 2005-03-22

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Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20170321