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US20070208252A1 - Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses - Google Patents

Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses Download PDF

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Publication number
US20070208252A1
US20070208252A1 US11/436,892 US43689206A US2007208252A1 US 20070208252 A1 US20070208252 A1 US 20070208252A1 US 43689206 A US43689206 A US 43689206A US 2007208252 A1 US2007208252 A1 US 2007208252A1
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working device
sensor
lumen
subject
extender
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US11/436,892
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Joshua Makower
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Acclarent Inc
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Acclarent Inc
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Publication date
Priority claimed from US10/829,917 external-priority patent/US7654997B2/en
Priority claimed from US10/912,578 external-priority patent/US7361168B2/en
Priority claimed from US10/944,270 external-priority patent/US20060004323A1/en
Priority claimed from US11/037,548 external-priority patent/US7462175B2/en
Priority claimed from US11/116,118 external-priority patent/US7720521B2/en
Priority to US11/436,892 priority Critical patent/US20070208252A1/en
Application filed by Acclarent Inc filed Critical Acclarent Inc
Assigned to ACCLARENT, INC. reassignment ACCLARENT, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MAKOWER, JOSHUA
Priority to PCT/US2007/011474 priority patent/WO2007136589A2/fr
Priority to US11/804,308 priority patent/US10188413B1/en
Priority to US11/804,309 priority patent/US8932276B1/en
Publication of US20070208252A1 publication Critical patent/US20070208252A1/en
Priority to US12/949,708 priority patent/US20110060214A1/en
Priority to US14/464,948 priority patent/US20140364725A1/en
Priority to US15/083,826 priority patent/US11065061B2/en
Priority to US16/212,864 priority patent/US11020136B2/en
Priority to US16/532,681 priority patent/US20200022718A1/en
Abandoned legal-status Critical Current

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Definitions

  • the present invention relates generally to medical devices, systems and methods and more particularly to methods and devices for performing image guided interventional procedures to treat disorders of the paranasal sinuses, ears, nose or throat (ENT).
  • ENT paranasal sinuses, ears, nose or throat
  • New devices, systems and techniques are being developed for the treatment of sinusitis and other disorders of the ear, nose, throat and paranasal sinuses.
  • various catheters, guidewires and other devices useable to perform minimally invasive, minimally traumatic ear, nose and throat surgery have been described in U.S. patent applications Ser. No. 10/829,917 entitled “Devices, Systems and Methods for Diagnosing and Treating Sinusitis and Other Disorders of the Ears, Nose and/or Throat,” Ser. No. 10/912,578 entitled “Implantable Device and Methods for Delivering Drugs and Other Substances to Treat Sinusitis and Other Disorders,” Ser. No.
  • a dilation catheter e.g., a balloon catheter or other type of dilator
  • FTSI Flexible Transnasal Sinus Intervention
  • a dilation catheter e.g., a balloon catheter or other type of dilator
  • the dilation catheter is then used to dilate the ostium or other anatomical structures to facilitate natural drainage from the sinus cavity.
  • a tubular guide may be initially inserted through the nose and advanced to a position near the sinus ostium and a guidewire may then be advanced through the tubular guide and into the affected paranasal sinus.
  • the dilation catheter may then be advanced over the guidewire and through the tubular guide to a position where its dilator (e.g., balloon) is positioned within the sinus ostium.
  • the dilator e.g., balloon
  • the dilator is then expanded causing the ostium to dilate.
  • dilation of the ostium may fracture, move or remodel bony structures that surround or are adjacent to the ostium.
  • irrigation solution and/or therapeutic agents may be infused through a lumen of the dilation catheter and/or other working devices (e.g., guidewires, catheters, cannula, tubes, dilators, balloons, substance injectors, needles, penetrators, cutters, debriders, microdebriders, hemostatic devices, cautery devices, cryosurgical devices, heaters, coolers, scopes, endoscopes, light guides, phototherapy devices, drills, rasps, saws, etc.) may be advanced through the tubular guide and/or over the guidewire to deliver other therapy to the sinus or adjacent tissues during the same procedure in which the FTSI is carried out.
  • working devices e.g., guidewires, catheters, cannula, tubes, dilators, balloons, substance injectors, needles, penetrators, cutters, debriders, microdebriders, hemostatic devices, cautery devices, cryosurgical devices, heaters, coolers, scopes, endoscopes, light
  • FTSI in FTSI procedures, structures and passageways other than sinus ostia may be dilated using the tools described above, tissue may be resected or ablated, bone may be restructured, drugs or drug delivery systems may be deployed, etc., as described in the documents incorporated here by reference.
  • FTSI will generally used to refer broadly to all of those procedures, not just dilation of sinus ostia.
  • IGS Image guided surgery
  • a digital tomographic scan e.g., a CT or MRI scan
  • the operative field e.g., the nasal cavities and paranasal sinuses
  • a specially programmed computer is then used to convert the digital tomographic scan data into a digital map.
  • sensors mounted on the surgical instruments send data to the computer indicating the position of each surgical instrument.
  • the computer correlates the data received from the instrument-mounted sensors with the digital map that was created from the preoperative tomographic scan.
  • One or more image(s) is/are then displayed on a monitor showing the tomographic scan along with an indicator (e.g., cross hairs or an illuminated dot) of the real time position of each surgical instrument.
  • an indicator e.g., cross hairs or an illuminated dot
  • a typical IGS surgery system of the prior art includes a) a computer work station, b) a video monitor, c) one or more surgical instruments having sensors mounted thereon, d) a localizer and e) a sensor tracking system.
  • the sensor(s) mounted on the surgical instruments and the corresponding tracing system may be optical, electromagnetic or electromechanical.
  • the localizer functions to localize or “register” the preoperative tomographic image data with the real time physical positioning of the patient's body during surgery.
  • the sensor tracking system serves to track the position of each sensor equipped surgical instrument during the surgery and to communicate such information to the computer workstation.
  • optical navigation elements e.g., infrared light emitting LEDs or passive markers
  • Camera(s) is/are positioned to receive light emitted or reflected from the navigation elements.
  • An optical IGS system that is useable in ENT and sinus surgery is the LandmarX Evolutions ENT II Image Guidance System available from Medtronic Xomed Surgical Products, Inc., Jacksonville, Fla.
  • Other optical IGS systems useable in ENT surgery include the VectorVision® system and Kolibri® system available from BrainLAB, Inc., Westchester, Ill.
  • a sensor assembly known as a STARLINKTM Universal Instrument Adapter
  • a plurality of passive markers in the nature of reflective members is positioned at spaced apart locations on the navigation element assembly.
  • An infrared light source and cameras are positioned to receive light reflected from the passive markers located on the navigation element assembly.
  • a computer then receives input from the cameras and uses software tracking algorithms to determine the real time position of the instrument within the subject's body based on the relative spatial positions of the passive markers.
  • the instrument's current position is then displayed on a monitor along with stored tomographic images, thereby enabling the operator to monitor the position and movement of the instrument relative to anatomical structures of interest.
  • radiofrequency electromagnetic sensors e.g., electromagnetic coils
  • a transmitter is positioned near the operative field.
  • the transmitter transmits signals that are received by the instrument-mounted sensors.
  • the tracking system detects variations in the electromagnetic field caused by the movement of the instrument-mounted sensors relative to the transmitter. Examples of commercially available electromagnetic IGS systems that have been used in ENT and sinus surgery include the ENTrak plusTM and InstaTrak ENTTM systems available from GE Medical Systems, Salt Lake City, Utah.
  • electromagnetic image guidance systems that may be modified for use in accordance with the present invention include but are not limited to those available from Surgical Navigation Technologies, Inc., Louiville, Colo., Biosense-Webster, Inc., Diamond Bar, Calif. and Calypso Medical Technologies, Inc., Seattle, Wash.
  • Electromechanical systems have not been widely used in ENT or sinus surgery.
  • Registration is the process of matching two sets of data (i.e., the preoperative tomographic scan data and the intraoperative patient body position data) so that the image displayed on the monitor will accurately show the position(s) of the surgical instrument(s) relative to the locations of anatomical structures shown on the tomographic scan.
  • a number of different registration strategies have been used, including intrinsic strategies as well as extrinsic strategies.
  • fiducial registration The registration strategy most widely used in sinus surgery and other ENT procedures is an intrinsic registration strategy known as anatomical fiducial registration.
  • a number of fiducial markers are placed at specific anatomical locations on the patient's body during the preoperative tomographic scan and during the surgical procedure. These fiducial markers are typically positioned on the patient's head or face at locations that correspond to specific anatomical landmarks within the ears, nose and/or throat.
  • the fiducial markers may be mounted on a head set or frame that is worn by the patient or the fiducial markers may be affixed directly to the patient's body (e.g., by adhesive attachment to the skin, anchoring into bone, etc.).
  • the sinus surgery or other ENT procedure is performed.
  • the fiducial markers must remain in fixed position on or in the patient's body until after the surgery has been completed.
  • IGS systems that use fiducial markers mounted on or in the patient's body allow for free movement and repositioning of the patient's head during surgery.
  • image guidance systems When applied to functional endoscopic sinus surgery (FESS) the use of image guidance systems allows the surgeon to achieve more precise movement and positioning of the surgical instruments than can be achieved by viewing through an endoscope alone. This is so because a typical endoscopic image is a spatially limited, two dimensional, line-of-sight view.
  • image guidance systems provides a real time, three dimensional view of all of the anatomy surrounding the operative field, not just that which is actually visible in the spatially limited, two dimensional, direct line-of-sight endoscopic view.
  • One shortcoming of the prior art IGS systems used in sinus surgery and other ENT procedures is that the sensors have been mounted on proximal portions of the instruments (e.g., on the handpiece of the instrument) such that the sensors remain outside of the patient's body during the surgical procedure. Because these prior art surgical instruments were of rigid, pre-shaped construction, the proximally mounted sensors could be used to accurately indicate to real time position of the distal tip of the instrument. However, in the new FTSI procedures and other new ENT procedures that use flexible and/or malleable catheters and instruments, it is no longer suitable to mount the sensors on proximal portions of the surgical instruments such that the sensors remain outside of the body. Rather, it will be necessary to mount or integrate the sensors at the distal tips of the instruments and/or at other locations on portions of the instruments that are actually inserted into the patient's body, thereby allowing for flexibility or malleability of the instrument shaft.
  • the present invention provides new sensor-equipped devices that are useable to perform image guided FTSI procedures as well as a variety of other image guided ENT procedures. Additionally, the present invention provides improvements and modifications to the prior art IGS systems and methods to facilitate the performance of image guided FTSI and other image ENT procedures with minimal or less iatrogenic trauma to and/or alteration of anatomical structures that are not involved in the disorder being treated.
  • the present invention generally provides methods, systems and devices for performing image guided FTSI procedures as well as other image guided procedures for the treatment of sinusitis and other disorders of the paranasal sinuses, ears, nose and/or throat.
  • a method and system for performing an image guided treatment procedure to treat a disease or disorder of an ear, nose, throat or a paranasal sinus in a human or animal subject e.g., guidewires, catheters, cannula, tubes, dilators, balloons, substance injectors, needles, penetrators, cutters, debriders, microdebriders, hemostatic devices, cautery devices, cryosurgical devices, heaters, coolers, scopes, endoscopes, light guides, phototherapy devices, drills, rasps, saws, etc.
  • a working device e.g., guidewires, catheters, cannula, tubes, dilators, balloons, substance injectors, needles, penetrators, cutters, debriders, microdebriders, hemostatic devices, cautery devices, cryosurgical devices, heaters, coolers, scopes, endoscopes, light guides, phototherapy devices, drills, rasps, saws, etc.
  • a sensor is positioned on or in the portion of the working device that becomes inserted into the ear, nose, throat or paranasal sinus of the subject.
  • An image guidance system is used to determine the location of the sensor when the sensor is positioned within an ear, nose, throat or paranasal sinus of the subject, thereby providing a real time indication of the positioning and movement of the working device during the treatment procedure.
  • a preoperative tomographic scan (e.g., a CT scan, MRI scan, PET scan, 3 dimensional fluoroscopy such as FluoroCT, etc.) may be obtained and the image guidance system may be programmed to display the tomographic images on a video monitor along with a real time indication (e.g., cross hairs, an illuminated dot, etc.) of the location of the working device relative to the anatomical structures shown on the tomographic image.
  • a real time indication e.g., cross hairs, an illuminated dot, etc.
  • an endoscope or intranasal camera may additionally be used to provide a direct line-of-sight video image through the nasal cavity.
  • Such direct line-of-sight video image may be displayed on a separate monitor or may be integrated with the tomographic image data to provide a single monitor display combining 1) the real time line-of-sight video image, 2) indicia (e.g., dotted lines) depicting anatomical structures that are hidden from view on the real time line-of-sight video image and 3) indicia of instrument position provided by the image guidance system.
  • the indicia of instrument position may consist of a single indicator (e.g., cross hairs or a dot) indicating the current position of the working device within the subject's body.
  • the indicia of instrument position may consist of a series of marks (e.g., a sharp dot followed by a series of phantom dots) indicating the path of prior or future advancement or movement of the working device.
  • the working device may optionally include a rotation indicator (e.g., an accelerometer) and the image guidance system may be further programmed to sense and indicate the rotational orientation of the working device within the subject's body.
  • sensor-equipped working devices e.g., guidewires, catheters, cannula, tubes, dilators, balloons, substance injectors, needles, penetrators, cutters, debriders, microdebriders, hemostatic devices, cautery devices, cryosurgical devices, heaters, coolers, scopes, endoscopes, light guides, phototherapy devices, drills, rasps, saws, etc.
  • image guided FTSI procedures e.g., guidewires, catheters, cannula, tubes, dilators, balloons, substance injectors, needles, penetrators, cutters, debriders, microdebriders, hemostatic devices, cautery devices, cryosurgical devices, heaters, coolers, scopes, endoscopes, light guides, phototherapy devices, drills, rasps, saws, etc.
  • These image guided working devices of the present invention generally comprise an elongate shaft that is insertable through the nose to a location within a paranasal sinus, ear, nose or throat of the subject and one or more sensor(s) is/are positioned on or in the device at a location that becomes inserted into the subject's body during the procedure.
  • a sensor may be located at the distal tip of the device.
  • sensor(s) may be located at other locations on the shaft of the device, such as at the location of a particular working element (e.g., a dilator, balloon, substance injector, needle, penetrator, cutter, debrider, microdebrider, hemostatic device, cautery device, cryosurgical device, heater, cooler, scope, lense, port, endoscope, light guide, phototherapy device, drill, rasp, saw, etc.).
  • a particular working element e.g., a dilator, balloon, substance injector, needle, penetrator, cutter, debrider, microdebrider, hemostatic device, cautery device, cryosurgical device, heater, cooler, scope, lense, port, endoscope, light guide, phototherapy device, drill, rasp, saw, etc.
  • the shaft of the working device proximal to the sensor(s) may be flexible or malleable.
  • Such flexibility or malleability may allow the working device to be advanced though tortuous regions of the intra nasal anatomy and/or to be positioned behind obstructive anatomical structure(s) (e.g., behind the uncinate process) without traumatizing or requiring removal or surgical modification of the obstructive anatomical structure(s).
  • obstructive anatomical structure(s) e.g., behind the uncinate process
  • a system of working devices specifically useable to perform an image guided FTSI procedure generally comprises a flexible guidewire that is advanceable into the ostium of a paranasal sinus and a dilation catheter that is advanceable over the guidewire and useable to dilate the ostium of the paranasal sinus.
  • a sensor is located on a portion of the guidewire and/or dilation catheter that becomes positioned within the subject's body.
  • the sensor communicates with the image guidance system to provide real time indicia of the position of the guidewire and/or dilation catheter such that the operator may precisely position the dilator within the desired sinus ostium without the need for obtaining direct line-of-sight endoscope view of that sinus ostium.
  • the system may additionally comprise a tubular guide through which the guidewire and/or dilation catheter may be advanced.
  • the tubular guide may be rigid, flexible or malleable and may be specifically configured to be advanced through the nose to a position within or near the ostium of the affected paranasal sinus.
  • fiducial marker devices may be precisely and reproducibly positioned within the mouth of a human subject.
  • these fiducial marker devices may incorporate brackets, projection of other configurational attributes for mounting of a transmitter useable in conjunction with an electromagnetic image guidance system.
  • a single sensor is mounted on a working device that is inserted into the body (e.g., into a paranasal sinus, and a plurality of transmitters are positioned outside of the subject's body such that the device-mounted sensor will receive signals from at least 3 transmitters, thereby enabling a computer within the image guidance system to compute (e.g., triangulate) the three dimensional position of the sensor within the subject's body.
  • a system that is useable to perform a procedure in which a working device is inserted to a position within an ear, nose, throat or paranasal sinus of a human or animal subject.
  • such system comprises a) a working device that has a proximal end and a distal end, said working device being insertable into an ear, nose, throat or paranasal sinus of a human or animal subject and useable to facilitate performance of a diagnostic or therapeutic procedure; b) an extender that is attachable to the proximal end of the working device; c) a marker assembly that is attachable to or part of the extender, said marker assembly comprising a plurality of active or passive markers; and d) an image guidance system that is adapted to receive signals from the sensors and to determine, on the basis of said signals, the current position of the working device within the subject's body.
  • the working device may have a lumen through which a second working device may be inserted or through which a fluid or substance may be infused.
  • the extender may also have a lumen that becomes substantially continuous with the working device lumen to facilitate delivery of such second working device or substance.
  • the marker assembly may be attachable to and detachable from the extender by way of a clamp or other connector apparatus. Still further in accordance with the invention, there is provided a method for image guided performance of a treatment procedure to treat a disease or disorder of an ear, nose, throat or a paranasal sinus in a human or animal subject.
  • Such method generally comprises the steps of a) providing a working device that is useable to carry out or facilitate at least a portion of said treatment procedure, said working device having a distal end that becomes inserted into the subject's body and a proximal end that remains outside of the subjects body; b) providing an extension member that is attachable to the proximal end of the working device; c) providing a marker assembly that comprises a plurality of markers, said marker assembly being attachable to the extension member; c) providing an image guidance system that is useable to determine the location of the working device within the ear, nose, throat or paranasal sinus of the subject on the basis of signals received from the markers of the marker assembly; d) attaching the extension member to the proximal end of the working device; e) attaching the marker assembly to the extension member; g) inserting the distal end of the working device into the subject's body; and h) using the image guidance system to detect the position of the working device within the subject's body on the basis of signals received
  • FIG. 1 is a side view of a sensor-equipped guidewire of the present invention.
  • FIG. 1A is an enlarged cut-away view of the distal end of the sensor-equipped guidewire of FIG. 1 .
  • FIG. 2A is a perspective view of a sensor-equipped guide tube of the present invention.
  • FIG. 2B is a perspective view of another sensor-equipped guide tube of the present invention.
  • FIG. 3 is a schematic perspective view of a sensor-equipped working device useable to perform a therapeutic or diagnostic procedure within an ear, nose, throat or paranasal sinus.
  • FIG. 4 is a perspective view of a sensor-equipped dilation catheter of the present invention.
  • FIG. 4A is a partial cut away view of a first embodiment of a sensor equipped balloon dilation catheter of the present invention.
  • FIG. 4B is a cross sectional view through line 4 B- 4 B of FIG. 4A .
  • FIG. 4C is a partial cut away view of a second embodiment of a sensor equipped balloon dilation catheter of the present invention.
  • FIG. 4D is a cross sectional view through line 4 D- 4 D of FIG. 4C .
  • FIG. 4E is a partial cut away view of a third embodiment of a sensor equipped balloon dilation catheter of the present invention.
  • FIG. 4F is a cross sectional view through line 4 F- 4 F of FIG. 4E .
  • FIG. 4G is a partial cut away view of a fourth embodiment of a sensor equipped balloon dilation catheter of the present invention.
  • FIG. 4H is a cross sectional view through line 4 H- 4 H of FIG. 4G .
  • FIG. 4I is a partial cut away view of a fifth embodiment of a sensor equipped balloon dilation catheter of the present invention.
  • FIG. 4J is a cross sectional view through line 4 J- 4 J of FIG. 4I .
  • FIG. 5 is a perspective view of a sensor-equipped sub-selective sheath of the present invention.
  • FIG. 5A is a cross sectional view through line 5 A- 5 A of FIG. 5 .
  • FIG. 6 is a side view of a sensor equipped penetrator of the present invention.
  • FIG. 7A shows a human subject undergoing a preoperative tomographic scan while wearing a head frame having fiducial anatomical markers thereon.
  • FIG. 7B is a schematic showing of data from the preoperative tomographic scan being loaded into the computer workstation of the image guidance system in accordance with this invention.
  • FIG. 7C shows an example of the image guidance system being used to provide a single image display (which may or may not incorporate superimposed data or indicia from multiple sources).
  • FIG. 7D an example of the image guidance system being used to provide separate displays of multiple images.
  • FIG. 7E shows the human subject positioned on the operating table and wearing the head frame having fiducial anatomical markers and a transmitter thereon.
  • FIG. 8 is a schematic depiction of an electromagnetic field having a sensor equipped working device of the present invention positioned therein.
  • FIG. 8A is a perspective view of one embodiment of a localizer apparatus mountable transmitter having one or more transmitter locations.
  • FIG. 8B is a perspective view of another embodiment of a localizer apparatus mountable transmitter having three transmitter locations.
  • FIG. 8C is a perspective view of another embodiment of a localizer apparatus mountable transmitter having three transmitter locations.
  • FIG. 9 shows the human subject positioned on the operating table during performance of an image guided interventional procedures using sensor equipped device(s) of the present invention.
  • FIG. 9A is a schematic showing of a video monitor displaying indicia of the path of advancement or movement of a sensor equipped working device in accordance with the present invention.
  • FIG. 10A shows a first orthogonal view of an anatomical image with indicators of the current position of the distal tip of a working device and indicia of the path of advancement of that working device, as seen on a video monitor screen during performance of a procedure according to this invention.
  • FIG. 10B shows a second orthogonal view of the procedure shown in FIG. 10A as viewed on a separate video monitor screen during performance of a procedure according to this invention.
  • FIGS. 11A-11C show examples of direct line-of-sight endoscopic images with superimposed indicia indicating the positions of anatomical structure(s) and/or apparatus that are hidden from view on the line-of-sight endoscopic images, as viewed on video monitors during performance of procedures according to this invention.
  • FIG. 12 shows a sensor-equipped working device of the present invention that is additionally equipped with a rotation sensor to indicate the rotational orientation of the device while it is positioned within a subject's body.
  • FIGS. 13A and 13B are schematic showings of examples of anatomical images viewed on a video monitor with indicia of the current position and prior path of advancement of an image guided working device shown in relation to a) adjacent anatomical structures and b) “keep in” and/or “keep out” zones that have been delineated to assist the operator in safely and correctly performing the procedure.
  • FIG. 14A is a top perspective view of a first embodiment of a fiducial marker mouthpiece according to the present invention.
  • FIG. 14B is a side perspective view of the fiducial marker mouthpiece of FIG. 14 A .
  • FIG. 15A is a top perspective view of a second embodiment of a fiducial marker mouthpiece according to the present invention.
  • FIG. 15B is a side perspective view of the fiducial marker mouthpiece of FIG. 15 A .
  • FIG. 15 C is a front view of the mouth of a human subject having the fiducial marker mouthpiece of FIGS. 15A and 15B in its operative position.
  • FIG. 16 is a partial cut-away side view of a sensor equipped guidewire of the present invention attached to a cable/connector assembly of the present invention.
  • FIG. 17 is a partial cut-away side view of a sensor equipped working device of the present invention having a cable/connector assembly of the present invention attached thereto.
  • FIG. 18 is an exploded view of a system of the present invention that includes a tubular guide working device, an extension that is attachable to the proximal end of the tubular guide working device and a navigation elements assembly that is attachable to the extender to facilitate tracking of the working device by an IGS system.
  • FIG. 19 is a fully assembled view of the device of FIG. 18 along with an IGS system useable therewith.
  • FIGS. 1-6 and 11 show examples of sensor equipped working devices of the present invention.
  • FIGS. 7A-17 show various components and operational aspects of an image guidance system of the present invention and its use in conjunction with the sensor equipped working devices of the present invention.
  • FIGS. 1 and 1 A show a sensor equipped guidewire 10 that may be inserted through a nostril (with or without a guide tube or guide catheter) and advanced to a desired location within a paransal sinus, ear, nose or throat.
  • This sensor-equipped guidewire 10 comprises an elongate flexible body 12 having a proximal end PE and a distal end DE.
  • the elongate body 12 comprises a core member 19 which may be solid or tubular.
  • the core member 19 is tubular and comprises stainless steel hypotube.
  • an outer member 18 such as a helical strand or wire may be wound or otherwise disposed about the core member 19 , as is well known in the art of guidewire manufacturing.
  • a distal tip member 15 formed of electrically insulating material e.g., plastic
  • electrically insulating material e.g., plastic
  • any appropriate means such as adhesive (e.g., epoxy), mechanical innerlocking, frictional fit, etc.
  • An electromagnetic sensor 16 e.g., an electromagnetic coil
  • an electrically insulating cylindrical cover 17 e.g. a plastic sheath, plastic shrink wrap, etc
  • cover 17 may be substantially flush with the adjacent outer surface of the outer member 18 , if present, as shown in FIG. 1A .
  • sensor leads 14 may extend from the electromagnetic sensor coil 16 , through the lumen of the core member 19 and to or out of the proximal end PE of the guidewire 10 .
  • a connector 21 e.g., a jack located on the proximal end PE of the guidewire 10 may be configured to connect to a corresponding connector 27 (e.g., a plug) located on one end of a cable 25 .
  • a connector 23 on the other end of the cable 25 is then connectable to an image guidance system that is programmed for use in combination with such guidewire, as described more fully herebelow.
  • the guidewire's proximal connector 21 may be connected to another types of cable/connector assembly 400 as shown in FIGS. 16 and 17 and described herebelow.
  • the sensor 16 may be in wireless communication with an image guidance system, as explained more fully hereblow.
  • the outer helical wire wrap 18 may formed of wire, a plastic strand, a helically cut metal or plastic tube, or any other suitable material.
  • the guidewire 10 may be constructed such that at least a distal portion of the outer member 18 or other outer material (e.g., helically cut tube) may be made of substantially nonferromagnetic material and may extend over the sensor 16 such that the sensor is disposed within a substantially nonferromagnetic portion of the outer member 18 .
  • the sensor leads 14 may then extend through the outer member 18 .
  • the senor 16 need not necessarily be longitudinally aligned with or disposed about the longitudinal axis of the device. Rather, the sensor may be disposed transversely within the device or in any other suitable attitude, position or alignment.
  • a crossmember may extend transversely across such lumen or cavity and the sensor 16 may be disposed about such crossmember (e.g., an electromagnetic coil may be wound about the cross member).
  • Such construction may allow for better selectivity and control of the magnetic permeability of the material lying under and/or over the sensor 16 and may allow for a more robust design and construction of certain devices.
  • Examples of commercially available image guidance systems that may be modified and programmed for use in connection with this sensor equipped guidewire 10 , as well as the other sensor equipped working devices described in this patent application, include the ENTrak PlusTM and InstaTrak ENTTM systems available from GE Medical Systems, Salt Lake City, Utah as well as systems available from Surgical Navigation Technologies, Inc., Louisville, Colo., Biosense-Webster, Inc., Diamond Bar, Calif. and Calypso Medical Technologies, Inc., Seattle, Wash.
  • the guidewire body 12 and any proximal connector 21 may be small enough in diameter to allow the desired catheter(s) and/or other devices(s) to be advanced over the guidewire body 12 and any proximal connector 21 .
  • FIGS. 2A and 2B show examples of sensor equipped tubular guides 20 a , 20 b that may be inserted through a nostril (with or without a guidewire) and advanced to a desired location within a paranasal sinus, ear, nose or throat. All of portions of tubular guides of the present invention may be rigid, flexible or malleable. In the particular examples shown in FIGS.
  • the tubular guides 20 a , 20 b are substantially rigid and preformed to a specific shape to facilitate advancement of the tubular guide 20 a or 20 b to locations that are immediately adjacent to the ostia of paranasal sinuses such that working devices such as dilation catheters and the like may be advanced through the tubular guide 20 a or 20 b and into or through the adjacent sinus ostium.
  • FIG. 2A shows an example of a tubular guide 20 a that is configured for use in accessing the ostium of a maxillary sinus of a human subject.
  • This tubular guide 20 a comprises a substantially straight proximal portion 22 a and a curved distal portion 24 a .
  • a Luer hub 28 a is mounted on the proximal end PE of the proximal portion 20 a .
  • a sensor 16 such as an n electromagnetic sensor coil, is positioned on the curved distal portion 24 a .
  • Wire leads 14 may extend from the electromagnetic sensor coil 16 , though the proximal portion 22 a and out of the proximal end PE of the tubular guide 20 a , as shown, for attachment of the tubular guide 20 a to an image guidance system that is programmed for use in combination with such guidewire as described more fully herebelow.
  • the proximal portion 22 a comprises stainless steel hypotube of approximately 0.040 inch to approximately 0.200 inch outer diameter. It will be appreciated that in embodiments where stainless steel or other metal is used, such metal will be separated from the sensor 16 by insulating material(s) and/or sufficient distance to avoid any affect that the meal may have on the accuracy or function of the sensor 16 .
  • a plastic tube formed of rigid plastic e.g., pebax, polyurethane, etc
  • This protruding portion of the plastic tube is then plastically deformed (e.g., thermally formed) to the desired curvature, thereby forming the curved distal portion 24 a of the tubular guide 20 a .
  • the sensor 16 comprises a coil that is wound about or positioned about the outer surface of the curved distal portion 24 a of the tube.
  • a plastic film or other electrically insulating cover may be heat shrunk or otherwise disposed and secured about the electromagnetic sensor 16 to provide a smooth outer surface in the area where the electromagnetic sensor 16 is mounted.
  • the electromagnetic sensor 16 may be mounted at or near the distal tip of the tubular guide 20 a to permit the associated image guidance system to monitor the real time position of the distal tip of the guide 20 a .
  • Wire leads 14 may extend from the electromagnetic sensor 16 , through or along the distal portion 24 a , through or along the proximal portion and out of the proximal end PE of the tubular guide 20 a , as shown.
  • the plastic tube that extends through the metal hypotube and protrudes thereform to form the curved distal portion 14 a may have a large working lumen as well as one or two additional lumens through which the wire leads 14 may pass.
  • the wire leads 14 may pass along the outer surface of the distal portion 24 a , the through the lumen of the hupotube, between the outer surface of the inner plastic tube and inner surface of the outer hypotube.
  • the distal portion 24 a is substantially rigid and is preformed to a curve of from approximately 70 degrees through approximately 135 degrees, so as to be useable for accessing the ostium of a maxillary sinus without requiring substantial cutting or surgical modification of the uncinate process or other normal anatomical structures within the nose.
  • the distal portion 24 a may be malleable (e.g., a malleable metal, polymer or metal-polymer composite) so that the operator may shape the distal portion 24 a as desired, depending on the particular sinus ostium or other location to be accessed, anatomical irregularities of the subject, etc. So long as the electromagnetic sensor coil 16 is located distal to any curve(s) introduced in the malleable distal segment, the introduction of such custom made curve(s) will not require any recalibration or otherwise hamper the ability of the image guidance system to sense the position of the distal end of the tubular guide 20 a .
  • malleable e.g., a malleable metal, polymer or metal-polymer composite
  • this tubular guide 20 a is inserted through the subject's nostril, either alone, over a previously inserted guidewire or with a guidewire pre-inserted into the lumen of the tubular guide 20 a .
  • the tubular guide 20 a is then advanced through the medial meatus and rotated to cause the curve of the distal portion 24 a to pass over the uncinate process such that the open distal end DE of the tubular guide 20 a is positioned adjacent to and in substantial alignment with the ostium of the maxillary sinus.
  • the tubular guide 20 b shown in FIG. 2B may be constructed and used in the same manner as the tubular guide 20 a of FIG. 2A except that the curved distal portion 24 b has a less severe curvature than the distal portion of the 24a of the guide shown in FIG. 2A .
  • the distal portion 24 b is substantially rigid and is preformed to a curve of from approximately 30 degrees through approximately 90 degrees, thereby being useable for accessing the ostia of frontal sinuses.
  • tubular guides 20 a , 20 b shown in FIGS. 2A and 2B are merely examples of the many shapes and configurations in which tubular guides of the present invention may be configured to accesses specific locations within the nose, paranasal sinuses, Eustacian tubes, etc. Additionally, it is to be appreciated that any of the guidewires 10 , tubular guides 20 a , 20 b or other working devices 30 of this invention may be steerable, bendable, malleable or capable of being articulated.
  • FIG. 3 shows a generic example of a sensor-equipped working device 30 of the present invention.
  • This device 30 comprises an elongate shaft 32 , a sensor 16 , a working element 36 and wires 14 that extend from the sensor 16 through the shaft 32 and out of the proximal end PE of the device 30 .
  • the outer diameter of the working device 30 may be less than the inner diameter of a sensor-equipped tubular guide 20 a or 20 b or other tubular guide such that the working device 30 may be advanced through a tubular guide to a desired location where treatment is to be applied.
  • the working device 30 may have a guidewire lumen extending through or adjacent to the shaft 32 such that the working device 30 may be advanced over a sensor-equipped guidewire 10 or other guide member to a desired location where the treatment is to be applied.
  • the senor 16 comprises a coil that is wound about or positioned about the outer surface of shaft 32 a known distance from the distal end DE of the device 30 .
  • the spatial relationship of the sensor 16 to the distal end DE will remain constant and, thus, the position of the distal end DE of the device 30 may be determined and displayed on a video screen on the basis of the sensed location of the sensor 16 .
  • one or more sensors may be positioned in known spatial relation to the working element so as to provide the ability to determine and display the real time location of the working element on the basis of the sensed location of the sensor(s) 16 .
  • the senor comprises a wire coil
  • such coil may be positioned within or wound about the outer surface of the elongate shaft 32 .
  • a plastic film or other electrically insulating cover e.g, an outer skin
  • Wire leads 14 may extend from the sensor 16 , through the shaft 32 to facilitate connection of the sensor 16 to an image guidance console (e.g., a computer workstation) as described herein.
  • the wire leads 14 may pass along the outer surface of the shaft 32 and may be secured by adhesive, a surrounding wrap, sheath or skin, etc.
  • wire leads 14 or the sensor 16 itself may be connected directly, indirectly through an intervening apparatus (e.g., a cable, self-calibrating instrument system or other intervening apparatus) or by wireless connection to the console 76 and/or computer 78 .
  • an intervening apparatus e.g., a cable, self-calibrating instrument system or other intervening apparatus
  • such self-calibrating instrument system may comprise a sensor-equipped distal instrument attached to a proximal handpiece.
  • the instrument system would be initially calibrated by touching the sensor-equipped distal instrument to fiducial markers. Once the instrument system was calibrated, the sensor-equipped distal instrument could be exchanged for other sensor-equipped distal instruments without requiring the user to recalibrate the instrument system. Instead, the instrument system would self calibrate by means of the proximal handpiece reading calibration information embedded electronically in a tag on the distal instrument.
  • the working element 36 may be positioned at a location between the proximal end PE and distal end DE, as shown in the example of FIG. 3 .
  • the working element 36 may be positioned at or on the distal end DE of the device 30 , depending on the mode of action and intended use of the working element.
  • the working element 36 may perform or facilitate any type of therapeutic or diagnostic function. Examples of working elements 36 that may be used include but are not limited to: dilators, balloons, substance injectors, needles, penetrators, cutters, debriders, microdebriders, hemostatic devices, cautery devices, cryosurgical devices, heaters, coolers, scopes, lenses, ports, endoscopes, light guides, phototherapy devices, drills, rasps, saws, etc.
  • any working device 30 of this invention may include a guide member 37 , such as a flexible, malleable or rigid wire or other elongate member, that extends from the distal end DE of the device, as shown in phantom in FIG. 3 .
  • This guide member 37 may be tapered or nontapered.
  • the guide member 37 will typically be smaller in diameter than the body 32 of the working device 30 such that the guide member may be easily advanced through an ostium of other anatomical opening, thereby facilitating or “guiding” placement of the body 32 of the device 30 in a position adjacent to that ostium or opening and/or thereby facilitating or guiding further advancement of the body 32 of the device 30 through that ostium or opening.
  • FIGS. 4-4J show some specific examples of sensor equipped working devices in the nature of dilation catheters (e.g., balloon catheters) for dilation of the ostia of paranasal sinuses or other anatomical or pathological structures.
  • FIGS. 4-4B show an embodiment of a sensor equipped dilation catheter 40 a comprising a shaft 42 comprising a single, multi-lumen tube, a proximal Luer hub 48 , a balloon 46 , sensor(s) 16 and sensor leads 14 . While any number of sensors 16 may be used, the example shown in FIGS. 4-4B incorporates two (2) sensors 16 , wherein one sensor 16 is located near the proximal end of the balloon 46 and the other sensor 16 is located near the distal end of the balloon 46 .
  • a through lumen 94 extends from the bore of the proximal Luer hub 48 , through the shaft 42 and terminates distally in a distal end opening.
  • This through lumen 94 may be used for fluid infusion/aspiration and/or for guidewire passage.
  • Lead lumens 98 also extend through the shaft 42 and the sensor leads 14 extend through such lead lumens 98 .
  • An inflation/deflation lumen 96 extends from a sidearm port 49 on the proximal hub 48 , through the shaft 42 and terminates in an aperture 91 within the balloon 46 to facilitate inflation and deflation of the balloon 46 .
  • the balloon will typically be formed of a relatively non-compliant material such as polyethylene teraphthalate (PET) or nylon of a thickness and density that renders the balloon capable of withstanding inflation pressures of up to approximately 25 atmospheres.
  • PET polyethylene teraphthalate
  • the balloon 46 may have a straight cylindrical side wall with tapered ends, as shown, and if the balloon 46 is so constructed, the sensors 16 may be positioned directly beneath the proximal and distal ends of the straight cylindrical mid-portion MP of the balloon 46 as seen in FIG. 4A . As explained more fully herebelow, this catheter 40 may be advanced to a position where the deflated balloon 46 is positioned within a stenotic ostium of a paranasal sinus with the distal sensor 16 on one side of the ostium and the proximal sensor 16 on the other side of the ostium.
  • FIGS. 4C and 4D show another way in which a sensor equipped dilation catheter 40 b may be constructed.
  • the catheter 40 b differs from that shown in FIGS. 4-4B because its shaft 104 comprises an outer tube 100 and an inner tube 102 .
  • the inner tube 102 extends through the outer tube 100 and protrudes out of the distal end of the outer tube 100 by a fixed distance.
  • the sensors 16 are mounted on the outer tube 100 at spaced apart locations such that one sensor 16 is directly beneath the proximal end of the straight walled midportion MP of the balloon 46 and the other sensor 16 is directly beneath the distal end of the straight walled midportion MP of the balloon 46 .
  • the outer tube 100 has a main through lumen 106 and two lead lumens 108 through which the sensor leads 14 extend.
  • the inner tube 102 has a through lumen 103 which may be used as a guidewire lumen and/or an infusion/aspiration lumen or for other purposes.
  • the outer diameter of the inner tube 102 is smaller than the inner diameter of the outer tube 100 such that a space exists to allow balloon inflation fluid to be infused into or removed from the balloon 46 through the lumen of the outer tube 100 .
  • This embodiment of the dilation catheter 40 shown in FIGS. 4C-4D may be positioned and used to dilate the ostium of a paranasal sinus in the same manner as that described above with respect to the embodiment of FIG
  • FIGS. 4E and 4F show yet another way in which a sensor equipped dilation catheter 40 c may be constructed.
  • the catheter 40 c has a shaft 114 that comprises an outer tube 100 a and an inner tube 102 a , wherein the outer tube 100 a terminates near the longitudinal midpoint of the balloon 46 and the inner tube 102 a extends through the outer tube 100 a and protrudes out of the distal end of the outer tube 100 a by a fixed distance.
  • the proximal sensor 16 is positioned on the outer tube 100 a at a location that is directly beneath the proximal end of the straight walled midportion MP of the balloon 46 and the other sensor 16 is positioned on the inner tube 102 a at a location that is directly beneath the distal end of the straight walled midportion MP of the balloon 46 .
  • the outer tube 100 a has a main through lumen 106 a and one lead lumen 120 through which the sensor leads 14 from the proximal sensor 16 extend.
  • the inner tube 102 a has a through lumen 103 a which may be used as a guidewire lumen and/or an infusion/aspiration lumen.
  • the outer diameter of the inner tube 102 a is smaller than the inner diameter of the lumen 106 a of outer tube 100 a such that a space exists to allow balloon inflation fluid to be infused into or removed from the balloon 46 through the lumen 106 a of outer tube 100 a.
  • the sensor leads 14 from the distal sensor 16 extend along the outer surface of the inner tube 102 a , as shown, and may be secured to the outer surface of the inner tube 102 a by any suitable means such as adhesive, clips, bands, sheathing, shrink wrapping, etc. It is to be appreciated, however, that in any of the embodiments, any of the sensor leads 14 may extend outside of, within or through a lumen of any portion of the catheter shaft, as may be desirable or expedient for manufacturing or operative purposes and/or to minimize electrical interference and optimize signal transmission.
  • FIGS. 4G and 4H show another way in which a sensor equipped dilation catheter 40 d may be constructed. In this example, like the example shown in FIGS.
  • the catheter 40 d has a shaft 126 that comprises an outer tube 100 b and an inner tube 102 b .
  • the outer tube 100 b terminates near the longitudinal midpoint of the balloon 46 and the inner tube 102 b extends through the outer tube 100 b and protrudes out of the distal end of the outer tube 100 b by a fixed distance.
  • the proximal sensor 16 is positioned on the outer tube 100 b at a location that is directly beneath the proximal end of the straight walled midportion MP of the balloon 46 and the other sensor 16 is positioned on the inner tube 102 b at a location that is directly beneath the distal end of the straight walled midportion MP of the balloon 46 .
  • the outer tube 100 b has a main through lumen 106 b and one lead lumen 126 through which the sensor leads 14 from the proximal sensor 16 extend.
  • the inner tube 102 b has a through lumen 103 b which may be used as a guidewire lumen and/or an infusion/aspiration lumen.
  • the outer diameter of the inner tube 102 b is smaller than the inner diameter of the outer tube 100 b such that a space exists to allow balloon inflation fluid to be infused into or removed from the balloon 46 through the lumen 106 b of the outer tube 100 b .
  • a second lead lumen 128 is formed in the wall of the inner tube 102 b and the wire leads 14 from the distal sensor 16 extend through such second lead lumen 128 , as shown.
  • FIGS. 4I and 4J show yet another way in which a sensor equipped dilation catheter 40 e may be constructed.
  • the shaft 136 comprises an outer tube 100 c that terminates within the proximal region of the balloon 46 and the inner tube 102 c extends through the outer tube 100 c such that it protrudes out of the distal end of the outer tube 100 c by a fixed distance.
  • both the proximal and distal sensors 16 are positioned on the inner tube 102 c .
  • the proximal sensor 16 is positioned on the inner tube 100 c at a location that is directly beneath the proximal end of the straight walled midportion MP of the balloon 46 and a distal sensor 16 is positioned on the inner tube 102 c at a location that is directly beneath the distal end of the straight walled midportion MP of the balloon 46 .
  • the outer tube 100 c has a main through lumen 106 c through which the inner tube 102 c extends.
  • the inner tube 102 c has a through lumen 103 c which may be used as a guidewire lumen and/or an infusion/aspiration lumen and two lead lumens 142 , 144 through which the sensor leads 14 from the proximal and distal sensors 16 extend.
  • the outer diameter of the inner tube 102 c is smaller than the inner diameter of the lumen 106 c of outer tube 100 c such that a space exists to allow balloon inflation fluid to be infused into or removed from the balloon 46 through the lumen 106 c of outer tube 100 c.
  • balloons 46 shown in FIGS. 4-4J are straight walled cylindrical balloons having tapered ends, it is to be appreciated that various other shapes and configurations of balloons may be employed in any embodiments of the dilation catheter 40 .
  • one or more depressions or indentations e.g., an annular depression or groove
  • examples of balloons having such depressions or indentations are described in U.S. patent application Ser. Nos. 10/829,917, 10/944,270 and 11/037,548, which are expressly incorporated herein by reference.
  • sensors 16 may be positioned at many other locations other than those shown in these examples.
  • sensor(s) may be located in the center of the balloon 46 or other working element and/or elsewhere on or in the catheter shaft within the balloon 46 or other working element and/or distal to the balloon 46 or other working element and/or proximal to the balloon 46 or other dilator and/or within the wall(s) of the balloon 46 or other dilator.
  • the shaft of the device e.g., the catheter body
  • the shaft of the device need not be of coaxial (e.g., tube within a tube) design, but alternatively may be a single catheter body having a plurality of lumens.
  • a catheter shaft having four lumens may be used.
  • One lumen may serve as a guidewire/working lumen
  • one lumen may serve as a balloon 46 inflation/deflation lumen
  • the other two lumens may serve as passageways for the sensor leads 14 .
  • a fixed guide tip and/or sensor 16 may be located at the distal end DE of the device.
  • the balloon 46 may be replaced by other types of dilators or expandable structures, such as expandable mesh cages and the like.
  • the balloon 46 or other dilator may be coated, textured, equipped with injection ports or otherwise equipped and/or constructed to deliver additional treatment(s) in addition to the primary anatomical dilation.
  • the balloon 46 may be coated with or may comprise a drug or any other substance (e.g., a hemostatic agent or a substance that deters scarring or adhesion formation) that will transfer onto or into the tissue contacted by the balloon. Examples of balloons having such additional treatment delivering capabilities are described in U.S. patent application Ser. Nos. 10/912,578 and 11/037,548, which are expressly incorporated herein by reference.
  • a stent or other radially expandable implantable device may be mounted on the exterior of the balloon 46 or other dilator such that, when the balloon 46 is inflated (or when any other type of dilator is expanded) the stent or other radially expandable implantable device will be expanded and will remain within the body after the balloon has been deflated (or the other type of dilator contracted) and the dilation catheter 40 removed.
  • Examples of stents and other radially expandable implantable devices that may be used in conjunction with these sensor equipped dilation catheters 40 are described in U.S. patent application Ser. Nos. 10/829,917; 10/912,578; 10/944,270 and 11/037,548, which are expressly incorporated herein by reference.
  • the sheath 50 shown in FIGS. 5 and 5 A comprises an elongate tubular body 52 having a Luer hub 54 on its proximal end PE and a sensor 16 , such as an electromagnetic coil located at some desired location, such as at or near the distal end DE of the tubular body 52 .
  • a main lumen 216 extends through the tubular body 52 in communication and direct alignment with the bore of the Luer hub 54 .
  • a separate lead lumen 56 also extends through the tubular body 52 .
  • Sensor lead wires 14 extend through such lead lumen 56 and out of the proximal hub 54 such that the lead wires 14 may be connected to the computer of an image guidance system as described more fully herebelow.
  • the inner diameter D 1 of the sheath lumen 216 will be large enough to allow a guidewire 10 and/or working device 30 , 40 , 60 to be advanced through the lumen 216 of the subselective sheath 50 and/or the outer diameter D 2 of the tubular body 52 will be small enough to advance through a tubular guide 20 a , 20 b .
  • the tubular body 52 of the subselective sheath 50 may be formed of a polymer such as Pebax, polyimide, high density polyethylene (HDPE), low density polyethylene (LDPE), blends of HDPE/LDPE, etc. and may have a wall thickness from approximately 0.001 inches through approximately 0.050 inches.
  • a lubricious liner or coating may be disposed within the main lumen 216 to facilitate sliding of guidewires or working devices therethrough.
  • the penetrator 60 comprises a solid or hollow elongate body 62 (e.g., a plastic or stainless steel rod or hypotube of approximately 14 gage through approximately 27 gage having a sharp tip 64 at its distal end DE.
  • a sensor 16 such as an electromagnetic coil, is positioned at a desired location on the penetrator, such as at or near its distal end DE. In some embodiments a sensor coil may be wrapped about the elongate body 62 .
  • a notch or depression may be formed in the elongate body to accommodate such coil wrap and a covering, such as a plastic coating, sleeve, shrink wrap, etc. may be disposed about the coil, thereby providing a smooth outer surface and deterring direct contact of the sensor coil with body fluids or tissues.
  • Sensor lead wires 14 extend through the elongate body 62 exiting near its proximal end PE such that they may be connected to the computer of an image guidance system as described more fully herebelow.
  • any of the sensor equipped working devices may incorporate biocompatible outer layers or coatings of lubricious material to facilitate smooth advancement of the device through the nasal anatomy, unless the inclusion of such coating would render the device unusable for its intended purpose.
  • any of the sensor equipped working devices may incorporate a vibrator or other movement imparting apparatus to cause vibration, reciprocation, vacillation or other movement of the working device to facilitate passage of the working device through tight or tortuous anatomical passages, unless the inclusion of such vibrator or other movement imparting apparatus would render the device unusable for its intended purpose.
  • any of the sensor equipped working devices may incorporate internal guidewire lumens for over-the-wire use or rapid exchange type guidewire lumens (e.g., tubes, split lumens or rails on that extend along a portion of the outer wall of the catheter) to facilitate rapid device and/or guidewire exchange during the procedure, unless the inclusion of such guidewire lumen would render the working device unusable for its intended purpose.
  • guidewire lumens e.g., tubes, split lumens or rails on that extend along a portion of the outer wall of the catheter
  • such rapid exchange guidewire lumen may have a length of from about 0.5 cm through about 10 cm.
  • the guidewire lumen may have a distal aperture at the distal end of the device and a proximal aperture located less than 10 cm proximal to the distal aperture.
  • the sensor equipped working devices of the present invention may be used in conjunction with an image guidance system to perform a variety of image guided procedures for the treatment of sinusitis or other disorders of the paranasal sinuses, ears, nose or throat.
  • An example of an electromagnetic image guidance system is shown in FIGS. 7-9 .
  • This image guidance system comprises a localizer apparatus 70 and a console 76 that includes a computer workstation 78 and a video monitor 80 .
  • the video monitor 80 may be used in a single screen mode 80 a to single screen image or in split screen mode 80 b to simultaneously display 2 or more images.
  • the localizer apparatus 70 which in this example comprises a headset, has positioning projections 71 that are configured to rest on or to insert within the ear canals and on either side of the bridge of the subject's nose such that each time the localizer apparatus 70 is worn by the subject it will remain in the same substantially fixed position relative to the subject's paranasal sinuses and intranasal anatomy, even when the subject's head is turned or moved about.
  • Two or more radiopaque fiducial markers 72 are mounted at fixed locations on either side of the portion of the localizer apparatus 70 that resides over the subject's forehead, as shown. Also, as seen in FIGS.
  • the localizer apparatus 70 is adapted to have a transmitter assembly 75 mounted at a specific location in the center of the portion of the localizer apparatus 70 that resides over the subject's forehead.
  • the transmitter assembly 75 has one or more transmitter locations or sites 73 which emit electrical signals that are sensed by the sensor(s) 16 located on the working devices that will later be inserted into the subjects nose.
  • a single transmitter 75 a having single or plural (e.g., one, two, three or more) transmitter site(s) 73 may be used.
  • the transmitter 71 a may emit a variable signal from the single transmitter site 73 to create a non-uniform electromagnetic field such that the position of a single sensor 16 may be determined within that electromagnetic field. If three (3) or more transmitter sites 73 are used, the transmitter 75 a may emit separate signals through each transmitter site 73 such that the location of an individual sensor 16 may be determined by a process of triangulation, similar to the manner in which GPS technology is used to determine the positions of objects on the earth's surface. In this regard, FIGS.
  • transmitters 75 b , 75 c show alternative transmitters 75 b , 75 c , each of which has three (3) transmitter sites 73 at spaced apart locations which may be used for real time triangulation of the position of a single electromagnetic coil sensor 16 located on a working device 10 , 20 a , 20 b , 30 , 40 , 60 , etc.
  • These transmitters 75 a , 75 b are constructed such that the transmission sites 73 are positioned on arm members 79 a , 79 b that emanate or extend from a central post 77 , such arm members 75 a , 75 b being configured and positioned so as to provided the needed signal transmission while not obstructing the surgeon's access to the operative field.
  • the subject is initially placed in a CT scanner S while wearing the localizer apparatus 70 (without the transmitter 75 mounted thereon).
  • a pre-procedure CT scan of the head is obtained using a protocol that is compatible with the image guidance system to be used.
  • the CT scan data is down-loaded onto a transfer disc 82 .
  • the pre-procedure CT scan may be used for planning of the procedure.
  • anatomical structures of interest e.g., ostia and sinuses
  • desired instrument trajectories may be plotted (e.g., the surgeon may plan the trajectory on which a curved penetrator 60 will be advanced to create openings in or between the ethmoid air cells) and “keep out” areas may be defined (e.g., skull base, posterior/superior wall of sphenoid near pituitary, orbital floor, facial nerves, etc.)
  • the CT scan data is uploaded from the transfer disc 82 into the computer 78 of the image guidance system.
  • the localizer apparatus 70 is again placed on the subject's head and a transmitter 75 is attached to the localizer apparatus 70 .
  • the positioning projections 71 are placed in the same locations as during the pre-procedure CT scan, thereby ensuring that the localizer apparatus 70 and its fiducial markers 72 are in the same positions relative to the subject's head as they were during the pre-procedure CT scan.
  • the transmitter 75 is connected to the computer 78 .
  • the computer 78 then initiates and performs a localization protocol to accomplish the “registration” process whereby the positions of the fiducial markers 72 are used to correlate the stored CT scan data with the subject's current body position.
  • Such localization protocol may require the physician to touch the tip of a sensor equipped working device 30 or a non-sterile sensor equipped localization wand to each fiducial marker and signaling to the computer 78 when such is accomplished, thereby enabling the computer to correlate the current positions of each fiducial marker 72 within the electromagnetic field with the position of that fiducial marker 72 on the stored CT scan images.
  • the sensor equipped tubular guide 20 may be initially inserted into the subject's nose and the sensor lead wires 14 of the tubular guide 20 connected to the console 76 .
  • the sensor equipped tubular guide 20 may be pre-calibrated at the point of manufacture.
  • Calibration details e.g., length of instrument, position of sensor relative to distal tip, baseline output from additional sensors, etc.
  • Calibration details may be stored in an electronically readable medium (e.g., a read-only tag) on or in each working device 30 such that, when each working device 30 is connected to the console 76 or a precalibrated handpiece, the computer 78 will read the calibration tag and will cause the image guidance system to self-calibrate accordingly.
  • the sensor(s) 16 of the tubular guide 20 receive signals from the transmitter site(s) 76 and in turn send signals to the computer 78 .
  • the computer 78 uses such signals to determine the position of the sensor(s) 16 and/or the position of a desired portion (e.g., the distal tip) of the tubular guide 20 within the patient's body.
  • the computer 78 also causes an indicator of the position of the sensor 16 and/or desired portion of the tubular guide 20 to appear on the video monitor 80 relative to the CT scan image displayed on the monitor 80 .
  • the computer 78 will cause the displayed CT scan image to scroll from cross section to cross section, thereby providing real time monitoring of the anatomical structures in the area of the sensor 16 and/or desired portion of the tubular guide 20 .
  • the physician advances the tubular guide 20 to a position where its distal tip is adjacent to (and in substantial alignment with) a sinus ostium or other structure to be treated by a working device 30 .
  • a non-sensor equipped or sensor equipped guidewire may then be advanced through the tubular guide 20 into or through the sinus ostium or other area to be treated by the working device 30 .
  • the guidewire may be initially inserted within the lumen of the tubular guide 20 and may be advanced along with the tubular guide 20 .
  • the tubular guide 20 may be inserted first and the guidewire may subsequently be advanced through the lumen of the tubular guide 20 .
  • a sensor equipped guidewire 10 is used.
  • the sensor lead wires 14 of the sensor equipped guidewire 14 are attached to the console 76 and the computer 78 performs the self-calibration in the same manner as described above.
  • the guidewire is advanced as the sensor(s) 16 on the guidewire 10 receive signals from the transmitter site(s) 76 and in turn the sensor(s) 16 send signals to the computer 78 .
  • the computer 78 uses such signals to determine the position of the guidewire's sensor 16 and/or a desired location on the guidewire 10 (e.g., its distal tip).
  • the computer 78 also causes an indicator of the position of the sensor 16 and/or desired portion of the guidewire 10 to appear on the video monitor 80 relative to the CT scan image displayed on the monitor 80 .
  • the monitor 80 will display indicators of the positions of both the tubular guide 10 and guidewire 20 .
  • the indicator of tubular guide 20 position may be deactivated so that it no longer appears on the monitor 80 and the only device position indicator appearing will then be that of the guidewire 10 .
  • the position indicators may be color coded or otherwise made to be distinguishable from one another.
  • the surgeon or system must choose which device is the “master” (the device whose movement controls the position of the cross hairs and therefore which image slices are displayed) and which device is the “reference” (ie, its relative position is displayed, but movement of this device does not move the cross hairs or change which image slices are displayed.
  • the guidewire 10 could be equipped with a plurality of sensors 16 , such that a primary sensor 16 is located at or near the distal tip and one or more secondary sensors are located along the shaft of the guidewire 10 .
  • the primary sensor 10 could remain active while the secondary sensors could be actuated and deactuated on demand. This would enable the physician to confirm that a sufficient amount of the guidewire 10 has been advanced into or past a particular anatomical location (e.g., confirm that enough of the guidewire 10 has been advanced into and coiled within a paranasal sinus.
  • the sensor equipped working device 30 is inserted over the guidewire 10 .
  • the tubular guide 20 may remain in place and the sensor equipped working device 30 will be inserted over the guidewire 10 and through the tubular guide 20 , as shown in the example of FIG. 9 .
  • the tubular guide 20 may be removed leaving the guidewire 10 in place and the working device 30 may then be inserted over the guidewire 10 alone.
  • the sensor lead wires 14 of the sensor equipped working device 30 are attached to the console 76 .
  • the computer 78 performs a self-calibration as described above.
  • the sensor equipped working device 30 is advanced over the guidewire 10 .
  • the computer 78 receives signals from the transmitter site(s) 76 and sensor(s) 16 on the working device 30 .
  • the computer 78 will cause one or more indicator(s) of the position of the working device 30 to appear on the video monitor 80 relative to the CT scan image displayed on the monitor 80 .
  • the physician may advance the working device 30 to a precise location within the body where its working element 36 is operatively positioned within the sinus ostium or other area to be treated.
  • a one or more sensor(s) 16 may be positioned on the working device 30 so as to delineate or mark the location of its working element 36 (e.g., sensors may be located at the proximal and distal ends of a dilation balloon or a single sensor may be positioned a known distance form the distal tip of a penetrator), thereby facilitating precise positioning of the working element 36 relative to the sinus ostium or other anatomical area to be treated by the working element 36 .
  • the monitor 80 may display indicators of the positions of some or all of those other devices along with the indicator of the position of the working device 30 .
  • the position indicator(s) of the other devices may be deactivated or caused not to be displayed on the video monitor 80 so that only the position of the working device 30 is visible.
  • the position indicator for the working device 30 may be displayed simultaneously with position indications of the other indwelling sensor equipped devices (e.g. tubular guide 20 and guidewire 10 ) and the position indicators for each of the separate devices may be color coded or otherwise distinguishable from one another when viewed on the monitor 80 .
  • more than one working device 30 may be used. Accordingly, in such procedures, after one working device has been used to deliver a desired treatment or portion of a treatment (e.g., a balloon used to dilate the ostium of a paranasal sinus), that first working device may be removed, leaving the guidewire 30 in place. Thereafter, another working device 30 may then be advanced over the guidewire 30 and used to deliver another stage of the treatment to the same location. Or, the guidewire 10 may be moved to a different location and another working device 30 (or even the same working device 30 ) may then be used to deliver a treatment to a different treatment location. This may be repeated numerous times with various different types of working devices 30 .
  • a desired treatment or portion of a treatment e.g., a balloon used to dilate the ostium of a paranasal sinus
  • a first working device 30 in the form of a balloon dilation catheter 40 may be advanced over the guidewire 10 , used to dilate the ostium of a paranasal sinus and then removed, leaving the guidewire 10 in place.
  • a second working device in the form of a penetrator 60 may be advanced over the guidewire 10 into the paranasal sinus and used to puncture a mucocele, mucocyst or other vesicle located on the wall of the sinus or elsewhere. The penetrator 60 may then be removed leaving the guidewire 10 in place.
  • another working device 30 in the form of a tube or sheath 50 may be advanced over the guidewire 30 and used to lavage (e.g., wash out) the sinus.
  • the tube or sheath 50 may be removed, leaving the guidewire 10 in place, and yet another working device in the nature of a substance eluting implant delivery catheter may be advanced over the guidewire 10 and used to place a substance eluting implant (e.g., a therapeutic implant as described in incorporated U.S. patent application Ser. Nos. 10/829,917 and 10/912,578) in or near the affected paranasal sinus.
  • the guidewire 30 and the tubular guide 20 if it remains at that point
  • the guidewire 30 may be withdrawn and removed from the subject's nasal cavity.
  • the computer 78 may be programmed to display on the video monitor 80 not only an indicator 94 of the current position of a sensor equipped device 10 , 20 , 30 , 40 , 50 , 60 , 220 but also path indicator(s) 97 (e.g., ghosts, dotted lines, etc.) indicating the prior positions (e.g., the path of advancement) of that sensor equipped device 10 , 20 , 30 , 40 , 50 , 60 , 220 such that the device's path of advancement or retraction can be visualized on the monitor 80 .
  • path indicator(s) 97 e.g., ghosts, dotted lines, etc.
  • some distance measurement markings 95 may also be displayed to allow the physician to easily determine the relative distance by which a sensor equipped device 10 , 20 , 30 , 40 , 50 , 60 , 220 is advanced or retracted.
  • the computer 78 may optionally be programmed to display path indicator(s) 97 indicating a planned path of device advancement that is intended to be followed.
  • the computer 78 may be programmed such that, as a sensor equipped device 30 is advanced or moved over a particular path, that path may be converted into a different type of indicia (e.g., a solid or color coded line) and displayed on the video monitor 80 .
  • a sensor equipped device 30 e.g., a solid or color coded line
  • the tip of a sensor-equipped working device 30 could be advanced, passed or swept over an anatomical surface or boundary and the computer 78 could then cause the monitor 80 to display an indication (e.g., a solid or colored line) delineating or demarcating that anatomical surface or boundary.
  • This aspect of the invention could be used, for example, to provide on the displayed video image an outline of the inner surface of a paranasal sinus.
  • this aspect of the invention could be used intraoperatively to provide a current image of the shape of an anatomical structure that is being modified in the procedure (e.g., the shape of the nasal septum during a septoplasty procedure intended to straighten the septum).
  • the surgeon could trace with the distal tip of the sensor-equipped device the boundary of anatomical structures to be “erased” from the displayed images.
  • the device so the present invention may include one or more radiopaque markers or radiographically visible region(s) to facilitate their use with fluoroscopy or x-ray.
  • the computer 78 of the image guidance system may be programmed to accept operator input as to points or locations along a path of device advancement that should be tagged or flagged on the displayed image and/or on a recorded image maintained as a record of the procedure. These tags can then be correlated with the image guidance system so that as the physician reviews the case on the CT, the endoscopic images are linked and being “flown through” as well.
  • an endoscope 84 within the subject's body to obtain an endoscopic image that may be viewed separately or concurrently with the pre-procedure scan images and indicia of device position indicators 97 , 97 , 95 provided on the video monitor 80 .
  • the endoscope 84 may or may not be equipped with sensor(s) 16 to allow its position to be monitored by the image guidance system.
  • Standard endoscopes used during functional endoscopic sinus surgery may be used for this purpose, including but not limited to the Karl Storz Hopkins II rigid scope (7210AA) and the Karl Storz Flexible Rhino-Laryngoscope (11101RP) which are available commercially from Karl Storz Endoscopy—America, Culver City, Calif.
  • the sensor(s) mounted on the endoscope will provide a real time indication of the position of the endoscope 84 within the subject's body.
  • another sensor equipped guidewire 10 or device 30 may be inserted into the endoscope 84 to provide an indication of the endoscope's location within the body.
  • a non-sensor equipped endoscope 84 such as a flexible endoscope (e.g., Karl Storz Flexible Rhino-Laryngoscope (11101RP), Karl Storz Endoscopy—America, Culver City, Calif.), may be used and a sensor equipped guidewire 10 may be inserted into (e.g., “parked” within) the working lumen of that endoscope 84 .
  • the sensor(s) 16 on the guidewire will provide to the computer indicia of the position of the endoscope 84 as it is navigated through the anatomy.
  • an indicator of the position of an endoscope 84 (or any other device into which the sensor equipped guidewire 10 may be inserted) may be displayed on the image guidance system monitor 80 , even though that endoscope 84 (or other device) is not itself equipped with a sensor 16 .
  • a window or signal transitionable region may be formed in the endoscope to allow the sensor(s) on the guidewire 10 to receive signals from the transmitter 75 , or the portion of the guidewire 10 on which the sensor(s) is/are located my protrude out of an opening in the endoscope to allow the sensor(s) on the guidewire 10 to receive signals from the transmitter 75 .
  • this procedure is useable not only with endoscopes 84 , but also with any other devices into which a sensor-equipped guidewire 10 may be inserted.
  • a sensor equipped guidewire 10 may be inserted into a needle and used to guide the needle to a desired submucosal position where it is desired to deliver a substance (e.g., a drug or other therapeutic substance) or implant.
  • the visual image obtained from the endoscope 84 may be displayed on a monitor that is separate from the image guidance system monitor 80 (e.g., on a separate endoscopic tower commonly used with endoscopes during FESS).
  • the endoscopic image may be displayed on the image guidance system monitor 80 interchangeably with the pre-procedure scan images and indicia of device position indicators 97 , 97 , 95 (e.g., such that the physician may switch back and forth between a real time, line-of-sight image provided by the endoscope 84 and the pre-procedure scan images and device position indicators 97 , 97 , 95 provided by the image guidance system.
  • the image guidance system may incorporate two separate monitors 80 , one of which displays a real time, line-of-sight image provided by the endoscope 84 and the other of which displays the pre-procedure scan images and device position indicators 97 , 97 , 95 provided by the image guidance system.
  • the image guidance system may incorporate a single monitor 80 that is operable in split screen mode such that one portion of the monitor screen displays a real time, line-of-sight image provided by the endoscope 84 and another portion of the monitor screen displays the pre-procedure scan images and device position indicators 97 , 97 , 95 provided by the image guidance system.
  • the computer 78 of the image guidance system may be programmed to combine or integrate a real time, line-of-sight image that is received from the endoscope 84 with the stored pre-procedure scan images or with computer models that have been derived from the pre-procedure scan images and loaded into the image guidance system computer 78 .
  • FIGS. 10A and 10B show one example of the manner in which an endoscopic image may be used in conjunction with CT scan images to provide unique displays and images to the physician.
  • a standard rigid endoscope is used.
  • a vasoconstricting agent e.g., cocaine, ephedrine, etc.
  • the endoscope 84 is then inserted into the nares and positioned to view the medial meatus MM, which is an open passageway adjacent to the middle turbinate MT.
  • the uncinate process UP is a rigid structure that protrudes from the lateral wall of the nose, near the anterior end of the middle turbinate, preventing the endoscope 84 from viewing structures that lie behind the uncinate process UP.
  • Such structures include the ethmoid bulla and an opening called the hiatus semilunaris as well as the ostium of the maxillary sinus which drains into the hiatus semilunaris.
  • the computer 78 of the image guidance system has used the stored CT scan data to integrate, into the displayed endoscopic image, an anatomical structure indicator 202 (e.g., a dotted line or other demarcation) showing the position of an anatomical structure of interest that is hidden from view of the endoscope 84 by the protruding uncinate process UP and/or portions of the midal turbinate MT.
  • anatomical structure indicator 202 is in the form of a generally circular dotted line showing the perimeter of the maxillary sinus ostium MO.
  • a flexible sensor equipped working device 30 is being advanced through the medial meatus MM, around the intact uncinate process UP and into the maxillary ostium MO, as indicated by a device position indicator 94 and advancement path indicators 95 .
  • a separate video screen displays a sagital tomographic image of the maxillary ostium MO based on the pre-procedure CT scan images that are stored in the computer 78 of the image guidance system.
  • the computer 78 is programmed to cause an indicator 94 b of the position of the distal end of the working device 30 relative to the maxillary ostium MO.
  • the indicator 94 b is a circle, but any suitable marking or demarcation may be used.
  • This view shown in FIG. 10B aids the physician in advancing the distal end of the working device 30 through the maxillary ostium MO, without having to incise or remove the uncinate process UP.
  • the computer 78 may be programmed to use the distal tip of the guidewire 10 or any other location on any other working device 30 as a “virtual viewpoint” from which a virtual endoscopic view is created from the pre-procedure CT scan images and displayed on the monitor 80 .
  • an endoscope 84 having an electromagnetic sensor 16 thereon may be advanced though a portion for the subject's body while the image guidance system computer 78 receives and uses signals received from the sensor 16 on the endoscope 84 to determine the position of the endoscope within the subject's body, stores endoscopic images received from the endoscope and correlates the stored endoscopic images with locations within the subject's body. Thereafter, the operator may request an endoscopic image obtained from a specified location within the subject's body and the computer 78 may display on the video monitor 84 the stored endoscopic image obtained at the selected location.
  • the selected location may be the current location of a working device 30 within the subject's body.
  • a working device 30 that has an electromagnetic sensor 16 thereon may be positioned within the subject's body, the computer 78 may determine the position of the working device based on signals received from the sensor on the working device 30 and the computer 78 may display on the video monitor a stored endoscopic image that was previously obtained from the current location of the working device 30 . In this manner, the operator is provided with an endoscopic image of the anatomy near the working device even though the working device may not be equipped with an endoscope. In other cases, this system and method may be used to compare a real time endoscopic image to a previously stored endoscopic image.
  • an endoscope 84 having a sensor 16 thereon may be positioned within the subject's body and used to obtain a real time endoscopic image.
  • the computer 78 may use signals received from the sensor 16 on the endoscope 84 to determine its real time position and to display a real time endoscopic image obtained from the endoscope currently positioned within the body and ii) a stored endoscopic image that was previously obtained at the same location where the endoscope 84 is currently positioned.
  • the real time and stored endoscopic images may be displayed side by side (e.g., on separate screens or using a split screen on a single monitor 84 . This technique may be used, for example, to compare a post-operative or intra-operative endoscopic image to a previously obtained pre-operative endoscopic image for the purpose of assessing efficacy, changes, etc.
  • the computer 78 of the image guidance system may also be programmed to display on the image guidance system monitor 80 and/or on a separate endoscopic monitor, one or more virtual images generated from the stored CT scan data and/or the device position data received from the sensor(s) 16 .
  • virtual images of ostia, bones and portions of devices e.g., inflated balloons
  • FIGS. 11A-11C Examples of this are shown in FIGS. 11A-11C .
  • FIG. 11A shows an image obtained from an endoscope 84 wherein an image guided dilation catheter 40 having a dilation balloon 46 has been advanced partially through an anatomical opening 209 and the balloon has been inflated.
  • the computer 78 is programmed to use the information received from the sensor(s) on this balloon dilation catheter 40 to superimpose or otherwise display on the endoscopic image a virtual image (e.g., dotted line) 208 representing the portion of the inflated balloon 46 that is hidden from actual view of the endoscope.
  • a virtual image e.g., dotted line
  • FIG. 11B shows an image obtained from an endoscope 84 viewing an anatomical structure AS within the body.
  • This particular anatomical structure AS is made up of bone covered with mucous membrane or other soft tissue, as is typical of structures located within the nose and paranasal sinuses.
  • An ostium OS or opening is formed in the anatomical structure AS, as shown.
  • the computer 78 is programmed to use information from the stored pre-procedure CT scan data to superimpose or otherwise display, on the endoscopic image, virtual images (e.g., dotted lines) 210 showing the edges of the bones that underlie the anatomical structure AS and ostium OS being viewed by the endoscope 84 .
  • virtual images e.g., dotted lines
  • FIG. 11C shows an image obtained from an endoscope 84 positioned within the middle meatus MM, anterior to the uncinate process UP.
  • the computer 78 is programmed to use information from the stored pre-procedure CT scan data to superimpose or otherwise display, on the endoscopic image, virtual images (e.g., dotted lines) 214 showing the maxillary ostium MO and openings into the ethmoid air cells EO, which are hidden from the endoscope's view by the uncinate process UP.
  • virtual images e.g., dotted lines
  • the ability to view virtual images 214 of the maxillary ostium MO and/or openings into ethmoid air cells EO may enable the physician to advance flexible or curved devices (e.g., the guidewires, catheters, penetrators and any other working devices 30 ) into or through those openings MO, EO to perform treatment procedures directed at the maxillary sinuses and/or ethmoid air cells without requiring removal or surgical modification of the protruding uncinate process UP.
  • An example of a procedure for dilation the maxillary ostium and/or delivering other treatment to the maxillary sinus is described above.
  • Various other procedures may be performed to treat or ablate the ethmoid air cells.
  • Some examples of the types of procedures that may be performed to treat and/or ablate the ethmoid air cells include those described in U.S.
  • any of the working devices 10 , 20 , 30 , 40 , 50 , 60 of the present invention may include, in addition to one or more of the image guidance system sensors 16 , one or more other sensors or movement indicators that may provide further information regarding the 3 dimensional position and/or orientation of the device 10 , 20 , 30 , 40 , 50 , 60 .
  • the types of other sensors or movement indication apparatus include, for example, accelerometers, strain gages (for flexible instruments), pitch/roll sensors, and capacitive sensors.
  • a working device 220 e.g., a guidewire, catheter, cannula, tube, dilator, balloon, substance injector, needle, penetrator, cutter, debrider, microdebrider, hemostatic device, cautery device, cryosurgical device, heater, cooler, scope, endoscope, light guide, phototherapy device, drill, rasp, saw, etc.
  • a working element 36 e.g., a dilator, balloon, injector, light delivery lens, endoscopic lens, cutter, opening, port, heater, cooler, probe, or other treatment delivering apparatus or structure.
  • All or portion(s) of the shaft 222 may be rigid, flexible or malleable.
  • An accelerometer 228 is mounted on one side of the hub 226 , as shown. This accelerometer 228 sends signals to the computer 78 indicating rotational movement of the device 220 .
  • the computer 78 is programmed to process those signals and to provide, on the basis of those signals, an indicator of the current rotational orientation of the device 220 within the subject's body.
  • the device may be inserted into the subject's nostril with a specific maker (not shown) or structure (e.g., one or more wings 227 ) of the device 220 in specific radial orientation (e.g., such that the wings 227 on the hub 226 extend vertically up and down—at the 12 o'clock and 6 o'clock positions).
  • a foot pedal or button on the console 76 may be depressed to cause the computer 78 to identify the current position of the accelerometer 228 as the “zero” or starting position. Thereafter, any clockwise or counterclockwise rotation of the device 220 will cause signals to be sent from the accelerometer 228 to the computer 78 and the computer will cause indicia of such rotational movement of the device 220 to be shown on the monitor 80 or elsewhere.
  • the present invention is also useable to aid the operator in maintaining the operative instruments within predefined areas of the subject's body (e.g., “keep in zones”) and/or to avoid advancing operative instruments into other predefined areas of the subject's body (e.g., “keep out zones”). Examples of this are shown in FIGS. 13A and 13B .
  • the computer 78 may be programmed to display indicia (e.g., shaded and unshaded areas) demarcating keep out zones 90 and a keep in zone 92 .
  • the intended keep in zone(s) and keep out zone(s) may be electronically marked on the CT scan images during the physician's pre-procedure planning. As shown in FIG.
  • device position indicators 94 and path indicators 95 will appear only within the keep in zone 92 and no alarm (e.g., visual or audible alarm) will be provided to the operator.
  • the device position indicator 94 will appear in the keep in zone 92 and, optionally, the computer 78 may be programmed to cause an alarm (e.g., visual or audible alarm) to be provided to the operator.
  • the transmitter assembly 75 need not be mounted on a localizer apparatus 70 or otherwise affixed to the subject's head. Instead, in such cases, it may be possible for just the fiducial markers 72 to be affixed to the subject's body while the transmitter assembly 75 and fiducial markers 72 may be mounted on or within the operating table, on a nearby IV pole, on or in a fluoroscopic c-arm or elsewhere near the subject's body.
  • image guided ENT procedures including many FTSI procedures
  • the transmitter assembly 75 and fiducial markers 72 may be mounted on a localizer apparatus 70 or otherwise affixed to subject's body such that after the fiducial markers 72 have been used to perform the initial localization/registration protocol, the transmitter sites 73 will subsequently move in fixed spatial relationship to the subject's head.
  • a localizer apparatus 70 as shown in FIGS. 7E and 9 may be used for this purpose.
  • such headset may be uncomfortable for an unanesthetized subject and/or may be an unwelcome or non-sterile obstacle located near the operative field during the procedure.
  • the present invention provides other head attachment devices that may be used to attach the fiducial markers 72 and transmitter(s) 75 to the subject's head during the pre-procedure CT scan and also during the procedure.
  • these head attachment devices may comprise adhesive patches that contain the fiducial markers 72 and to which the transmitter 75 is attachable.
  • a mouthpiece may be used as a head affixation device. Examples of such mouthpieces 240 , 240 a are shown in FIGS. 14A-15C .
  • a dental mouthpiece 242 is formed of silicon or other plastic.
  • This mouthpiece 242 may be configured based on an impression of the subject's teeth such that the positioning of the mouthpiece 242 will be reproducible from wearing to wearing.
  • the methods for making mouthpieces 242 of this type are well known and such mouthpieces are sometimes worn by athletes who play contact sports and by some individuals who tend gnash or grind their teeth during sleep.
  • Radiopaque fiducial markers 244 such as metal articles, are mounted at locations on the mouthpiece 242 , as shown.
  • fiducial markers 72 may be located on the buccal sides of the mouthpiece 242 so as to be easily accessible during the localization/registration protocol where it may be necessary for a sensor equipped device 30 or a sensor equipped wand to be touched against or placed in juxtaposition to each fiducial marker 72 .
  • a transmitter assembly 75 mounting location is provided on the mouthpiece such that the transmitter 75 may be attached to the mouthpiece 242 at a predetermined, reproducible position.
  • the embodiment 240 a shown in FIGS. 15A-15C is the same as that shown in FIGS. 14A and 14B except that it includes a transmitter mounting member 244 that is attached to the front of the mouthpiece 242 .
  • the transmitter assembly 75 may be attached to this transmitter mounting member 244 .
  • a plurality of transmitter locations or sites 73 may be at spaced apart locations along the transmitter mounting member 73 to facilitate determination (e.g., by triangulation) of the position of a single sensor 16 positioned within the subject's ears, nose, throat or paranasal sinuses.
  • FIGS. 16 and 17 show examples of a cable connector assembly 400 that may be used in connection with any of the sensor equipped devices of the present invention, as well a other sensor equipped devices, to facilitate transmission of signal(s) between the sensor equipped device and an image guidance system, console 76 and/or computer 78 .
  • This cable/connector assembly 400 comprises a cable 402 one end of which is connected to the sensor equipped device and the other end of which terminates in a connector 402 .
  • the sensor leads 14 extend through the cable 402 to connector 404 .
  • a corresponding connector 406 is mounted on the image guidance system console 76 or computer 78 .
  • the connectors 404 , 406 may comprise multi-pin connectors as shown, or any other suitable type of connector.
  • the connectors 404 , 406 may transmit either information or signals in addition to signals from the sensor(s) mounted on the device.
  • the sensor equipped device and/or connector 402 may contain a PROM, memory chip or other storage medium that holds magnetic or digitally encoded information relating to the device (e.g., calibration information, information relating the position of a sensor 16 to the distal end DE of the device, information relating the position of the sensor 16 to a working element on the device, information relating to the length, diameter or other sizing of the device, information as to the type of device (e.g., balloon catheter, guidewire, penetrator, cutter, tubular guide, etc.) being employed or numerous other types of information).
  • the type of device e.g., balloon catheter, guidewire, penetrator, cutter, tubular guide, etc.
  • That other information may be transmitted through certain prongs, pins, channels or other contact points in the connectors 404 , 406 while the signals form the sensor(s) is/are transmitted through other prongs, pins, channels or other contact points in the connectors 404 , 406 . transmitted to the image guidance system console 76 and/or computer 78 and the connectors 404 , 406 .
  • an optional handpiece 408 may be attached to the end of the cable 402 opposite the connector 404 .
  • Such handpiece may perform the dual function of 1) connecting the cable 402 to the sensor equipped device and 2) providing a handpiece that the operator may use to manipulate, torque or otherwise move the device.
  • the proximal end of a sensor equipped guidewire 10 as shown in FIGS. 1-1A and described above is inserted into a bore of the handpiece 408 causing the connector 21 on the proximal end of the guidewire body 12 to engage a corresponding connector (not seen in FIG. 16 ) located within the handpiece 408 .
  • signals from the guidewire's sensor 16 will travel from the guidewire 10 , through cable 402 , to cable connector 404 and into console/computer connector 406 , thereby providing communication between the guidewire 10 and the image guidance system console 76 and/or computer 78 .
  • the handpiece may be disengaged from the proximal end of the guidewire to permit such advancement of another device over the guidewire.
  • the cable 402 may be connected directly to the proximal portion of a sensor equipped device.
  • the cable 402 is attached to the proximal hub 38 of a working device 30 that is equipped with a working element 36 and sensor 16 , as shown in FIG. 3 and described hereabove.
  • the attachment of the cable 402 to the working device 30 may be permanent or disconnectable.
  • a plug and jack arrangement may be used to allow the cable 402 to be volitionally connected to and disconnected form the device 30 .
  • the image guidance components (e.g., markers and/or sensors) need not be integrated into or attached to the device at the time of manufacture. Rather, in some embodiments, the image guidance components may be attachable to a working device (e.g., guidewire, guide catheter, balloon catheter, lavage catheter, needle, electrosurgical probe, stent delivery catheter, substance eluting implant delivery catheter, debrider, seeker, cannula, tube, dilator, balloon, substance injector, penetrator, cutter, debrider, microdebrider, hemostatic device, cautery device, cryosurgical device, heater, cooler, scope, endoscope, phototherapy device, drill, rasp, saw, punch, forceps and laser, etc.) at the time of the procedure.
  • a working device e.g., guidewire, guide catheter, balloon catheter, lavage catheter, needle, electrosurgical probe, stent delivery catheter, substance eluting implant delivery catheter, debrider, seeker, cannula, tube, dilator, balloon, substance inject
  • FIGS. 18-19 show an example wherein an extender 500 is attached to the proximal end of a working device 502 and an optical navigation element assembly 506 is attached by way of clamp 504 to the extender 500 .
  • an optical IGS system 508 such as the VectorVision® ENT image guidance system (available from BrainLAB AG, Westchester, Ill.) or LandmarX® image guidance system (available from Medtronic Xomed Surgical Products, Inc., Jacksonville, Fla.), may be used to monitor the position of the working device within a subject's body.
  • VectorVision® ENT image guidance system available from BrainLAB AG, Westchester, Ill.
  • LandmarX® image guidance system available from Medtronic Xomed Surgical Products, Inc., Jacksonville, Fla.
  • the working device 502 comprises a tubular guide having a curved distal end DE, a female Luer connector 510 on its proximal end and a lumen extending therethrough.
  • This tubular guide working device 502 is similar to the tubular guides 20 a and 20 b shown in FIGS. 2A and 2B , except that this tubular guide working device 502 does not incorporate any sensor 16 or wire leads 14 .
  • the extender 500 comprises a substantially cylindrical elongate body 514 having a lumen that extends longitudinally therethrough, a male Luer connector 516 on its distal end and a female Luer connector 518 on its proximal end.
  • the male Luer connector 516 on the distal end of extender 500 is connectable to the female Luer connector 510 on the proximal end of the tubular guide working device 502 .
  • the lumen of the extender 500 is substantially continuous with the lumen of the tubular guide working device 502 such that other working devices (e.g., guidewires, balloon catheters, lavage catheters, needles, electrosurgical probes, stent delivery catheters and substance eluting implant delivery catheters, debriders, seekers, cannulae, tubes, dilators, balloons, substance injectors, penetrators, cutters, debriders, microdebriders, hemostatic devices, cautery devices, cryosurgical devices, heaters, coolers, scopes, endoscopes, phototherapy devices, drills, rasps, saws, punches, forceps and lasers, etc.) may be inserted into the proximal end PE of the extender 500 and advanced through the extender 500 , through the tubular guide working
  • the extender 500 may perform other optional functions. For example, prior to or after the clamp 530 has been attached to the extender 500 , the extender 500 may be used as a handle to facilitate grasping and control of the tubular guide working device 502 .
  • the tubular guide working device 502 has a curve 520 formed near its distal end.
  • the angle A of such curve may range from 0 to about 110 degrees.
  • all or part of this tubular guide working device 502 may be made of plastically deformable or malleable material such that the operator may customize the shape of this device 502 before or during the procedure.
  • the navigation element assembly 506 comprises a hub member 522 , a plurality of radiating arms 524 that extend radially from the hub member 522 and a plurality of active or passive navigation elements 526 attached to the radiating arms 524 .
  • active optical navigation elements include light emitters, such as light emitting diodes (LEDs).
  • passive optical navigation elements include reflective members (e.g., spheres) that reflect light, such as infrared light emitted from one or more infrared light sources located in proximity to the device.
  • the bottom end of the hub member 522 is configured to be received by or otherwise attached to the clamp 504 .
  • the bottom end of the hub member 522 is received within an upstanding sleeve portion 528 of clamp 504 and a locking pin 530 is used to hold the navigation element assembly 506 in substantially fixed rotational position relative to the clamp 504 .
  • the body portion 532 of clamp 504 is designed to fit upon and frictionally engage the cylindrical body 514 of the extender 500 such that the clamp 504 and navigation element assembly 506 will be firmly attached to the extender and, thus, will be held in substantially fixed position relative to the extender 500 and the tubular guide working device 502 to which the extender 500 has been attached.
  • the extender 500 in some embodiments can have features to enhance the attachment of the navigation element assembly to the extender in substantially fixed rotational position such as knurling, indentations, etc.
  • One commercially available example of a navigation element assembly 506 and clamp 504 having the general configuration shown in FIGS. 18 and 19 is the STARLINKTM Universal Instrument Adapter manufactured by BrainLAB, Inc., Westchester, Ill.
  • FIGS. 18 and 19 show an embodiment where the navigation element assembly 506 is attachable to and detachable from the extender 500 , it is to be appreciated that, in some other embodiments of this invention, the clamp 504 and/or navigation element assembly 506 may be integrated into or pre-attached to the extender 500 .
  • a clamp or other fitting designed to receive and attach the navigation element assembly 506 may be molded into or pre-attached to the extender 500 .
  • all or part of the navigation element assembly 506 (e.g., with or without inclusion of the active or passive navigation elements 526 ) may be molded into or pre-attached to the extender 500 .
  • the IGS system 508 generally comprises a monitor 534 and one or more camera(s) 538 . Additionally, when the navigation elements 525 are passive (e.g., reflective) rather than active (e.g., light emitting), the IGS system 508 may further comprise one or more light emitter(s) 536 (e.g., infrared lamps) which emit light that is reflected by the passive markers 526 . Additionally, the IGS system incorporates a computing device (e.g., a computer or microprocessor) that is loaded with software for calibration and tracking of the distal end DE of tubular guide working device 502 and/or other working devices within the subject's body.
  • a computing device e.g., a computer or microprocessor
  • a user interface may also be provided to enable the user to enter parameters or information into the system 508 .
  • the computing device 540 may be programmed with software that includes a database containing design parameters (e.g., length, curvature/shape, etc.) for a number of tubular guides and/or other working devices to which the extender 500 may be attached.
  • the user interface device is used to enter or detect the particular type of working device.
  • the user enters the type of guide device 100 (e.g. a maxillary sinus ostium access guide device) in the surgical navigation system.
  • the software in the surgical navigation system then calibrates the position and/or orientation of the distal tip of guide device 100 to navigational unit 118 , and hence to the surgical navigation system.
  • the male Luer connector on the distal end of the extender 500 is firmly attached to the female Luer connector 510 on the proximal end of the tubular guide working device 502 .
  • the navigation element assembly 506 is attached to the clamp 504 and the clamp 504 is firmly mounted on the extender 500 , as described above.
  • Stored anatomical images, such as CT scan images are displayed on the monitor 534 of the IGS system 508 .
  • a facemask or other headgear containing fiducial markers may have been worn by the subject as the CT scan images (or other anatomical images) are obtained and the locations of the fiducial markers on the scanned images may then be used for purposes of registration in accordance with the instructions provided by the manufacturer of the IGS system.
  • headgear containing fiducial markers examples include those devices shown in FIGS. 7E, 9 and 14 A- 15 C of this application as well as those devices commercially available as the Reference Headband/Reference Star (BrainLAB, Inc., Westchester, Ill.) and the FramelockTM kit (Medtronic Xomed Surgical Products, Inc., Jacksonville, Fla.)
  • the subject may not have worn fiducial markers during the prior CT scan (or other anatomical imaging procedure) and, instead, an alternative calibration technique may be used.
  • the position and/or the trajectory of the distal end DE of the tubular guide working device 502 may be calibrated to the surgical navigation system using an anatomical landmark of the patient's body.
  • a device such as the Z-Touch® Registration System (BrainLAB, Inc., Westchester, Ill.) may be used.
  • Z-Touch® Registration System is a special laser pointer that allows the VectorVision® IGS system to utilize the surface anatomy of the subject's face and head to calculate an advanced surface-matching algorithm and calibrate the system to the patient's scan.
  • the position of the distal tip of guide device 100 may be calibrated to the surgical navigation system using a calibration device such as VectorVision® ENT ICM4 Instrument Calibration Tool (Brainlab, Inc., Westchester, Ill.) that comprises one or more fiducial markers used for calibration purposes.
  • the distal end DE of the tubular guide working device 502 may be inserted trans-nasally and advanced to a position where the distal end DE is in alignment with or adjacent to a desired treatment sight, such as the ostium of a paranasal sinus.
  • a second working device e.g., guidewire, guide catheter, balloon catheter, lavage catheter, needle, electrosurgical probe, stent delivery catheter, substance eluting implant delivery catheter, debrider, seeker, cannula, tube, dilator, balloon, substance injector, penetrator, cutter, debrider, microdebrider, hemostatic device, cautery device, cryosurgical device, heater, cooler, scope, endoscope, phototherapy device, drill, rasp, saw, punch, forceps and laser, etc.
  • a second working device e.g., guidewire, guide catheter, balloon catheter, lavage catheter, needle, electrosurgical probe, stent delivery catheter, substance eluting implant delivery catheter, debrider, seeker, cannula, tube, dilator, balloon, substance injector, penetrator, cutter, debrider, microdebrider, hemostatic device, cautery device, cryosurgical device, heater, cooler, scope, endoscope, phototherapy device, drill, rasp, saw, punch, forcep
  • One such therapeutic function would be to dilate an opening of a paranasal sinus by a) using the IGS system to position the distal end DE of the tubular guide working device 502 adjacent to or in alignment with the opening of the paranasal sinus, b) advancing a dilation catheter through the extender 500 and through the tubular guide working device 500 and into the opening of the paranasal sinus and c) using the dilation catheter to dilate the opening of the paransal sinus. Additionally or alternatively, fluids or substances may be infused through the extender 500 and through the tubular guide working device 502 for purposes of lavage, imaging or treatment delivery.
  • FluoroCT is a relatively new technology in which a C-arm type three-dimensional (3D) imaging device (e.g., the ISO-C3D available from Siemens Medical Systems) is used to obtain a fluoroscopic computed tomogram. Because these C-arm devices may be mobile, Fluoro CT scans may be obtained intraoperatively and immediately postoperatively, as well as preoperatively. In some cases, FluoroCT may be used to obtain the pre-procedure imaging data stored in the image guidance system computer 78 . Additionally, in some cases, one or more FluoroCT scans may be obtained during or after the procedure and data sets from such intraoperative or postoperative FluoroCT scans may be loaded into the computer 78 .
  • 3D three-dimensional
  • the computer 78 may be programmed to use such FluoroCT scan data to update the previously stored imaging data that has been obtained by traditional CT, MRI, FluoroCT or other means, thereby adjusting the stored anatomical image data to show changes to the anatomy that have occurred subsequent to the pre-operative scan. Additionally or alternatively, the computer may be programmed 78 to display the newly added FluoroCT data in addition to or in comparison with other images based on the preoperative scan, thereby allowing the surgeon to compare the current (e.g., intraoperative or postoperative) anatomy to the preoperative anatomy.
  • the current e.g., intraoperative or postoperative
  • the computer 78 of the image guidance system may be programmed with a number of optional programs (e.g., software bundles) to provide additional or different features.
  • optional programs e.g., software bundles
  • the following are non-limiting examples of some of the optional capabilities that may be programmed into the computer 78 :
  • the computer 78 may, in some embodiments, be programmed to automatically suggest path(s) of advancement or vector(s) along which a desired device (e.g., a sensor equipped working device 30 ) may be advanced to reach a desired location (e.g., the ostium of a particular paranasal sinus, the ethnoid air cells, a site of infection, a bulla, a mucocele, a mucocyst, etc.)
  • the suggested path(s) of advancement or vector(s) may be selected based on operator-input criteria (e.g., least complex path, least tortuous path, least traumatic path, safest path, etc.)
  • the computer 78 may cause indicia of such desired path(s) or vector(s) (e.g., dotted lines) to appear on the video monitor 80 in relation to the displayed anatomical CT and/or endoscopic images.
  • the computer 78 may, in some embodiments, be programmed to display not only the anatomical structures that are adjacent to or near the current position of a sensor equipped working device 30 , but also anatomical structures that are located ahead on one or more path(s) on which the device 30 may be advanced from its current position to reach its target position.
  • the computer 78 may cause the monitor 80 to display 1) a tomographic section or other anatomical image of the area in which the working device 30 is currently located (the “current location image”) and 2) one or more other tomographic sections or other images showing anatomical structures that lie ahead on one or more intended path(s) of advancement (the “path ahead image(s)).
  • the current location image and the path ahead image(s) may be displayed simultaneously (e.g., on separate monitors, on a split screen monitor or on a single screen where with one image is inset within a larger image).
  • current location image and the path ahead image(s) may be displayed one at a time such that the operator may switch back and forth between the current location image and the path ahead image(s).
  • the computer 78 may, in some embodiments, be programmed to take the stored pre-procedure imaging scan data and compare it to subsequently input a post-procedural or intra-operative imaging scan data such that the effects or anatomical changes caused by the procedure may be assessed.
  • the computer 78 may, in some embodiments, be programmed to provide a turn indicator (e.g., an audible signal or visual indicator shown on the monitor screen) to indicate the direction that a guidewire 10 or other sensor equipped working device 30 should be turned to navigate toward a desired target location.
  • a turn indicator e.g., an audible signal or visual indicator shown on the monitor screen
  • the computer 78 may, in some embodiments, be programmed to utilize the stored anatomical image data (e.g., CT scan data) to provides prompts or suggestions of 1) anatomical structures or pathological lesions that may be amenable to a particular treatment and/or 2) optimal or suggested locations and/or rotational orientations in which working device(s) 30 may be placed in order to effect a particular treatment and/or 3) the optimal or suggested size or dimensions of the working device(s) 30 to be used (e.g., for regions marked in red a 6 mm balloon diameter is suggested and for regions marked in blue a 7 mm balloon is suggested).
  • CT scan data e.g., CT scan data
  • the computer 78 may, in some embodiments, be programmed to provide a simulated result of a particular procedure before the procedure is actually performed.
  • the ability to generate a simulated result may be particularly advantageous in cases where it is not feasible for the physician to actually view the area being treated and, thus, is unable to make a visual assessment of such area as may be needed to arrive at an accurate prediction of the likely therapeutic and/or untoward results of a proposed treatment or maneuver.
  • the console 76 and computer 78 may be adapted to receive operator input of the particular diameter (or other dimensions/characteristics) of a dilator balloon that the physician proposes to use for dilation of a particular passageway.
  • the computer 78 will be programmed with software that it will use to provide a simulated view of what that passageway would look like after it has been dilated by that proposed balloon and what submucosal, adjacent or hidden anatomical structures would likely be compressed or otherwise affected by such dilation procedure, if the procedure were actually performed using a balloon having the proposed diameter, dimensions and/or characteristics.
  • the computer 78 may, in some embodiments, be programmed to provide a simulated view of a particular device that is positioned within the subject's body.
  • the computer 78 may be programmed with device information (e.g., the dimensions, shape and appearance of the device) and, after tracking the trajectory of a the sensor 16 mounted on that device through the anatomy, the computer 78 may generate and display on the monitor 80 , a “virtual” image of the device as it is positioned relative to the adjacent anatomy.
  • This aspect of the invention may provide to the operator some “feel” for the relative 3 dimensional size and position of the device within the body.
  • the computer 78 may, in some embodiments, be programmed to provide a simulated view from a vantage point on a device that has been inserted into the subject's body. For example, the computer 78 may cause the monitor to display a forward looking view from the distal tip of an advancing guidewire as if the operator were sitting on the distal tip of the guidewire and looking forward at the anatomy as the guidewire is advanced.
  • any working device 30 may incorporate endoscopic components (e.g., fiber optic light guide, fiber optic image transmission bundle, lenses, etc.) as well as other working elements 36 .
  • the working device 30 may comprise an on board endoscope that is useable to view some or all of the procedure wherein that working device 30 is employed.
  • any working device 30 may be inserted or incorporated into an endoscope such that the endoscope may be used to view some or all of the procedure wherein that working device 30 is employed.
  • the locations of the sensor(s) 16 and transmitter(s) 75 or transmitter sites 73 may be switched.
  • one or more transmitter sites 73 may be located on a transmitter equipped device (e.g., a guidewire, tubular guide, sheath, dilation catheter or other device having a working element as described herein) and one or more sensors 16 may be located on a localizer apparatus 70 such as a localizer frame or headset.
  • the use of the sensor equipped working devices 30 and methods of the present invention may serve a number of purposes and may provide a number of advantages over the prior art.
  • the use of such image guided devices and methods may permit very precise positioning and movement of devices within the subject's body, thereby improving the safety of the procedure, causing less trauma or unnecessary iatrogenic tissue modification, requiring less use of fluoroscopy or x-ray and hence less radiation exposure to the subject or the operator(s), etc.

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US11/436,892 2004-04-21 2006-05-17 Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses Abandoned US20070208252A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US11/436,892 US20070208252A1 (en) 2004-04-21 2006-05-17 Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
PCT/US2007/011474 WO2007136589A2 (fr) 2006-05-17 2007-05-10 Systèmes et procédés pour effectuer des interventions guidées par des images dans les oreilles, le nez, la gorge et les sinus paranasaux
US11/804,309 US8932276B1 (en) 2004-04-21 2007-05-16 Shapeable guide catheters and related methods
US11/804,308 US10188413B1 (en) 2004-04-21 2007-05-16 Deflectable guide catheters and related methods
US12/949,708 US20110060214A1 (en) 2004-04-21 2010-11-18 Systems and Methods for Performing Image Guided Procedures Within the Ear, Nose, Throat and Paranasal Sinuses
US14/464,948 US20140364725A1 (en) 2004-04-21 2014-08-21 Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
US15/083,826 US11065061B2 (en) 2004-04-21 2016-03-29 Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
US16/212,864 US11020136B2 (en) 2004-04-21 2018-12-07 Deflectable guide catheters and related methods
US16/532,681 US20200022718A1 (en) 2004-04-21 2019-08-06 Deflectable guide catheters and related methods

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10/829,917 US7654997B2 (en) 2004-04-21 2004-04-21 Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US10/912,578 US7361168B2 (en) 2004-04-21 2004-08-04 Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders
US10/944,270 US20060004323A1 (en) 2004-04-21 2004-09-17 Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US11/037,548 US7462175B2 (en) 2004-04-21 2005-01-18 Devices, systems and methods for treating disorders of the ear, nose and throat
US11/116,118 US7720521B2 (en) 2004-04-21 2005-04-26 Methods and devices for performing procedures within the ear, nose, throat and paranasal sinuses
US11/436,892 US20070208252A1 (en) 2004-04-21 2006-05-17 Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses

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US10/912,587 Continuation-In-Part US7057079B2 (en) 2002-02-08 2004-08-06 Method of synthesizing alkenone compounds
US11/116,118 Continuation-In-Part US7720521B2 (en) 2004-04-21 2005-04-26 Methods and devices for performing procedures within the ear, nose, throat and paranasal sinuses

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US11/804,308 Continuation-In-Part US10188413B1 (en) 2004-04-21 2007-05-16 Deflectable guide catheters and related methods
US12/949,708 Continuation US20110060214A1 (en) 2004-04-21 2010-11-18 Systems and Methods for Performing Image Guided Procedures Within the Ear, Nose, Throat and Paranasal Sinuses
US14/464,948 Continuation US20140364725A1 (en) 2004-04-21 2014-08-21 Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses

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US14/464,948 Abandoned US20140364725A1 (en) 2004-04-21 2014-08-21 Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
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US20140364725A1 (en) 2014-12-11
US11065061B2 (en) 2021-07-20
US20160270863A1 (en) 2016-09-22
US20110060214A1 (en) 2011-03-10

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