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UA98928C2 - 1,4-дигидропиридинконденсированные гетероциклы, способ их получения, применения и композиция, которая содержит их - Google Patents

1,4-дигидропиридинконденсированные гетероциклы, способ их получения, применения и композиция, которая содержит их

Info

Publication number
UA98928C2
UA98928C2 UAA200802146A UAA200802146A UA98928C2 UA 98928 C2 UA98928 C2 UA 98928C2 UA A200802146 A UAA200802146 A UA A200802146A UA A200802146 A UAA200802146 A UA A200802146A UA 98928 C2 UA98928 C2 UA 98928C2
Authority
UA
Ukraine
Prior art keywords
dihydropyridine
preparing
same
compositions containing
fused heterocycles
Prior art date
Application number
UAA200802146A
Other languages
English (en)
Ukrainian (uk)
Inventor
Жак Может
Анил Наир
Нина Ма
Кирстен Бьергард
Брюно Филош-Ромм
Одиль Ангуйан-Бонифас
Серж Миньяни
Жан-Кристоф Карри
Франсуа Клерк
Эрве Мину
Лоран Шио
Сесиль Комбо
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of UA98928C2 publication Critical patent/UA98928C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Изобретение касается 1,4-дигидропиридинконденсированных гетероциклов, способа их получения, применения и композиций, которые содержат их.Изобретение касается замещенных дигидропиридинконденсированных гетероциклов, которые можно использовать для лечения ракового заболевания, особенно для предотвращения деления раковых клеток.Данные соединения действуют как ингибиторы киназ А и/или В.Формула (I)(I).
UAA200802146A 2005-07-20 2006-07-18 1,4-дигидропиридинконденсированные гетероциклы, способ их получения, применения и композиция, которая содержит их UA98928C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05291558A EP1746097B1 (en) 2005-07-20 2005-07-20 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

Publications (1)

Publication Number Publication Date
UA98928C2 true UA98928C2 (ru) 2012-07-10

Family

ID=35510894

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200802146A UA98928C2 (ru) 2005-07-20 2006-07-18 1,4-дигидропиридинконденсированные гетероциклы, способ их получения, применения и композиция, которая содержит их

Country Status (37)

Country Link
US (1) US8163768B2 (ru)
EP (2) EP1746097B1 (ru)
JP (2) JP2009501778A (ru)
KR (1) KR101286796B1 (ru)
CN (1) CN101243087B (ru)
AR (1) AR054845A1 (ru)
AT (2) ATE455115T1 (ru)
AU (1) AU2006273692B8 (ru)
BR (1) BRPI0614002A2 (ru)
CA (1) CA2615700C (ru)
CR (1) CR9663A (ru)
CY (1) CY1109964T1 (ru)
DE (1) DE602005018911D1 (ru)
DK (1) DK1746097T3 (ru)
DO (1) DOP2006000175A (ru)
EA (1) EA016815B1 (ru)
EC (1) ECSP078062A (ru)
ES (1) ES2339676T3 (ru)
HN (1) HN2008000088A (ru)
HR (1) HRP20100195T1 (ru)
IL (1) IL188861A0 (ru)
MA (1) MA29634B1 (ru)
MX (1) MX2008000902A (ru)
MY (1) MY148617A (ru)
NO (1) NO20080831L (ru)
NZ (1) NZ592766A (ru)
PE (2) PE20100718A1 (ru)
PL (1) PL1746097T3 (ru)
PT (1) PT1746097E (ru)
RS (1) RS51351B (ru)
SI (1) SI1746097T1 (ru)
TN (1) TNSN08020A1 (ru)
TW (1) TWI386411B (ru)
UA (1) UA98928C2 (ru)
UY (1) UY29685A1 (ru)
WO (1) WO2007012972A2 (ru)
ZA (1) ZA200800542B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945535B1 (fr) * 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) * 2010-11-17 2012-05-18 Sanofi Aventis Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
CA2870339C (en) 2012-05-15 2020-06-02 Novartis Ag Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1
PL2861579T3 (pl) 2012-05-15 2018-07-31 Novartis Ag Pochodne benzamidu do hamowania aktywności ABL 1, ABL 2 i BCR-ABL 1
ES2665539T3 (es) 2012-05-15 2018-04-26 Novartis Ag Derivados de benzamida para inhibir la actividad de ABL1, ABL2 y BCR-ABL1
BR112014027181A2 (pt) 2012-05-15 2017-06-27 Novartis Ag derivados de benzamida para a inibição da atividade de abl1, abl2 e bcr-abl1
JP6321662B2 (ja) * 2012-10-12 2018-05-09 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. Ｇｓｋ３阻害剤およびその使用の方法
JP2017537940A (ja) * 2014-12-10 2017-12-21 マサチューセッツ インスティテュート オブ テクノロジー 増殖性疾患の処置に有用な融合１，３−アゾール誘導体
EP3291676B1 (en) 2015-04-30 2022-08-17 Memorial Sloan Kettering Cancer Center Mitragynine analogs and uses thereof
RU2619932C1 (ru) * 2015-11-25 2017-05-22 федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
US11180492B2 (en) 2016-01-15 2021-11-23 University Of Central Florida Research Foundation, Inc. Anti-parasitic compounds and uses thereof
BR112018016133A2 (pt) 2016-02-16 2019-01-02 Massachusetts Inst Technology aglutinantes de max como moduladores de myc e usos dos mesmos
US11203601B2 (en) 2017-04-05 2021-12-21 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
WO2018209030A1 (en) * 2017-05-12 2018-11-15 Rti International Diarylureas as cb1 allosteric modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE355841T1 (de) * 1997-12-13 2007-03-15 Bristol Myers Squibb Co Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer
EP1242422A1 (en) 1999-11-19 2002-09-25 Abbott Laboratories Tricyclic dihydropyrimidine potassium channel openers
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
JP2003525939A (ja) 2000-03-03 2003-09-02 アボット・ラボラトリーズ 三環式ジヒドロピラゾロン及び三環式ジヒドロイソオキサゾロンカリウムチャンネル開放剤
CN1630656A (zh) 2001-02-02 2005-06-22 三菱制药株式会社 二氢吡唑并吡啶化合物及其制药用途
FR2823854A1 (fr) 2001-04-18 2002-10-25 Centre Nat Rech Scient Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale
FR2825091B1 (fr) * 2001-05-23 2003-07-04 Servier Lab Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
SE0301371D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab New Compounds
CA2528938A1 (en) * 2003-06-13 2005-02-24 Zentaris Gmbh Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof

Also Published As

Publication number Publication date
BRPI0614002A2 (pt) 2011-03-01
UY29685A1 (es) 2007-02-28
AR054845A1 (es) 2007-07-18
HRP20100195T1 (hr) 2010-05-31
ATE455115T1 (de) 2010-01-15
ATE521611T1 (de) 2011-09-15
WO2007012972A2 (en) 2007-02-01
AU2006273692B2 (en) 2012-11-22
TNSN08020A1 (en) 2009-07-14
DK1746097T3 (da) 2010-05-25
TW200740812A (en) 2007-11-01
EA200800374A1 (ru) 2008-08-29
PE20100718A1 (es) 2010-10-20
ECSP078062A (es) 2008-01-23
WO2007012972A3 (en) 2007-04-05
CA2615700A1 (en) 2007-02-01
KR101286796B1 (ko) 2013-07-17
ZA200800542B (en) 2010-02-24
MX2008000902A (es) 2008-03-26
DOP2006000175A (es) 2007-03-31
CY1109964T1 (el) 2014-09-10
CR9663A (es) 2008-02-21
AU2006273692B8 (en) 2012-12-13
PT1746097E (pt) 2010-04-15
AU2006273692A8 (en) 2012-12-13
ES2339676T3 (es) 2010-05-24
DE602005018911D1 (de) 2010-03-04
MY148617A (en) 2013-05-15
JP2013063987A (ja) 2013-04-11
EP1746097A1 (en) 2007-01-24
CA2615700C (en) 2013-06-18
US8163768B2 (en) 2012-04-24
EP1910366A2 (en) 2008-04-16
CN101243087A (zh) 2008-08-13
KR20080026658A (ko) 2008-03-25
PL1746097T3 (pl) 2010-06-30
EP1910366B1 (en) 2011-08-24
PE20070212A1 (es) 2007-03-21
EP1746097B1 (en) 2010-01-13
EA016815B1 (ru) 2012-07-30
IL188861A0 (en) 2008-04-13
NZ592766A (en) 2012-12-21
SI1746097T1 (sl) 2010-05-31
AU2006273692A1 (en) 2007-02-01
US20080261969A1 (en) 2008-10-23
MA29634B1 (fr) 2008-07-01
HN2008000088A (es) 2011-05-31
NO20080831L (no) 2008-04-03
RS51351B (sr) 2011-02-28
JP2009501778A (ja) 2009-01-22
CN101243087B (zh) 2013-07-24
TWI386411B (zh) 2013-02-21

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