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UA95438C2 - Биспецифические антитела, которые замещают функциональные белки - Google Patents

Биспецифические антитела, которые замещают функциональные белки

Info

Publication number
UA95438C2
UA95438C2 UAA200604899A UAA200604899A UA95438C2 UA 95438 C2 UA95438 C2 UA 95438C2 UA A200604899 A UAA200604899 A UA A200604899A UA A200604899 A UAA200604899 A UA A200604899A UA 95438 C2 UA95438 C2 UA 95438C2
Authority
UA
Ukraine
Prior art keywords
blood coagulation
coagulation factor
substituting
bispecific antibodies
functional proteins
Prior art date
Application number
UAA200604899A
Other languages
English (en)
Ukrainian (uk)
Inventor
Кунихиро Хаттори
Тецуо Коджима
Таро Мийазаки
Тецухиро Соеда
Original Assignee
Чугей Сейяку Кабусики Кайся
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Чугей Сейяку Кабусики Кайся filed Critical Чугей Сейяку Кабусики Кайся
Publication of UA95438C2 publication Critical patent/UA95438C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Изобретение относится к биспецифическим антителам, которые распознают как протеолитический фермент, так и субстрат, и функционально замещают фактор свертывания крови VIII/активированный фактор свертывания крови VIII, которые связываются как с фактором свертывания крови IX/активированным фактором свертывания крови IX, так и с фактором свертывания крови X, и усиливают ферментативную реакцию. Изобретение также относится к композиции, которая содержит данное антитело и способам лечения или профилактики кровотечения с использованием данного антитела.
UAA200604899A 2003-10-10 2004-10-08 Биспецифические антитела, которые замещают функциональные белки UA95438C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2003/013062 WO2005035753A1 (ja) 2003-10-10 2003-10-10 機能蛋白質を代替する二重特異性抗体

Publications (1)

Publication Number Publication Date
UA95438C2 true UA95438C2 (ru) 2011-08-10

Family

ID=34430861

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200604899A UA95438C2 (ru) 2003-10-10 2004-10-08 Биспецифические антитела, которые замещают функциональные белки

Country Status (20)

Country Link
US (1) US8062635B2 (ru)
EP (3) EP2289944A3 (ru)
KR (2) KR101361437B1 (ru)
CN (1) CN1890369B (ru)
AT (1) ATE518952T1 (ru)
AU (2) AU2003271174A1 (ru)
BR (1) BRPI0415230B1 (ru)
CA (1) CA2541671C (ru)
DK (2) DK3085783T3 (ru)
ES (1) ES2370250T3 (ru)
IL (1) IL174794A (ru)
MX (1) MXPA06003831A (ru)
NO (2) NO345624B1 (ru)
NZ (1) NZ546509A (ru)
PL (1) PL3085783T3 (ru)
RU (1) RU2339696C2 (ru)
SI (1) SI3085783T1 (ru)
TW (1) TW200514790A (ru)
UA (1) UA95438C2 (ru)
WO (2) WO2005035753A1 (ru)

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