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UA90698C2 - Triazole substituted aminobenzophenone compounds - Google Patents

Triazole substituted aminobenzophenone compounds

Info

Publication number
UA90698C2
UA90698C2 UAA200707890A UAA200707890A UA90698C2 UA 90698 C2 UA90698 C2 UA 90698C2 UA A200707890 A UAA200707890 A UA A200707890A UA A200707890 A UAA200707890 A UA A200707890A UA 90698 C2 UA90698 C2 UA 90698C2
Authority
UA
Ukraine
Prior art keywords
triazole substituted
aminobenzophenone compounds
compounds
substituted aminobenzophenone
triazole
Prior art date
Application number
UAA200707890A
Other languages
English (en)
Ukrainian (uk)
Inventor
Эрик Рюттер Оттосен
Original Assignee
Лео Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лео Фарма А/С filed Critical Лео Фарма А/С
Publication of UA90698C2 publication Critical patent/UA90698C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к новым соединениям формулы (Иа) или (Иb), (Ia), (Ib)упомянутые соединения являются полезными, например, при лечении воспалительных, офтальмологических заболеваний или раковой опухоли.
UAA200707890A 2004-12-13 2005-11-28 Triazole substituted aminobenzophenone compounds UA90698C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63500004P 2004-12-13 2004-12-13

Publications (1)

Publication Number Publication Date
UA90698C2 true UA90698C2 (en) 2010-05-25

Family

ID=37715934

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200707890A UA90698C2 (en) 2004-12-13 2005-11-28 Triazole substituted aminobenzophenone compounds

Country Status (23)

Country Link
US (1) US8293772B2 (ru)
EP (1) EP1828148B1 (ru)
JP (1) JP5015005B2 (ru)
KR (1) KR101260236B1 (ru)
CN (1) CN101115728B (ru)
AR (1) AR051792A1 (ru)
AT (1) ATE455768T1 (ru)
AU (1) AU2005316034B2 (ru)
BR (1) BRPI0518993A2 (ru)
CA (1) CA2590479A1 (ru)
DE (1) DE602005019093D1 (ru)
DK (1) DK1828148T3 (ru)
ES (1) ES2341473T3 (ru)
HR (1) HRP20100225T1 (ru)
IL (1) IL183513A0 (ru)
MX (1) MX2007006739A (ru)
NO (1) NO20073574L (ru)
PL (1) PL1828148T3 (ru)
PT (1) PT1828148E (ru)
RU (1) RU2394818C2 (ru)
UA (1) UA90698C2 (ru)
WO (1) WO2006063585A1 (ru)
ZA (1) ZA200704809B (ru)

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ATE469135T1 (de) * 2002-05-30 2010-06-15 Scripps Research Inst Kupferkatalysierte ligierung von aziden und acetylenen
WO2007148074A1 (en) * 2006-06-21 2007-12-27 Hammersmith Imanet Limited Chemical methods and apparatus
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
KR100932093B1 (ko) 2006-09-27 2009-12-16 주식회사종근당 미세소관 형성 저해제로서 유용한 벤조페논 유도체
US8288367B2 (en) 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
SI2225231T1 (sl) * 2007-12-18 2011-12-30 Actelion Pharmaceuticals Ltd Derivati aminotriazola kot alx agonisti
EP2272845B1 (en) * 2008-03-26 2015-03-04 Chong Kun Dang Pharmaceutical Corp. Benzophenone thiazole derivatives useful for inhibiting formation of microtubule and method for producing the same
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
HUE060249T2 (hu) 2008-06-16 2023-02-28 Univ Tennessee Res Found Vegyületek rák kezelésére
JP5873439B2 (ja) 2009-12-22 2016-03-01 レオ ファーマ アクティーゼルスカブ ビタミンｄ類似体および溶媒と界面活性剤の混合物を含む皮膚組成物
WO2011076208A2 (en) 2009-12-22 2011-06-30 Leo Pharma A/S Calcipotriol monohydrate nanocrystals
US20130023501A1 (en) 2009-12-22 2013-01-24 Leo Pharma A/S Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
AU2010347233B2 (en) 2010-03-01 2015-06-18 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
KR101666759B1 (ko) * 2015-08-06 2016-10-18 경북대학교 산학협력단 1-벤조피란메틸-1h-1,2,3-트리아졸 유도체 및 이의 용도
CN106632285B (zh) * 2016-11-23 2019-11-01 河南师范大学 一种齐多夫定-1,2,3-三氮唑类化合物的合成方法

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* Cited by examiner, † Cited by third party
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SU1709907A3 (ru) * 1988-01-07 1992-01-30 Е.И.Дюпон Де Немур Энд Компани (Фирма) Способ получени азолов
GB9701453D0 (en) * 1997-01-24 1997-03-12 Leo Pharm Prod Ltd Aminobenzophenones
DK1202954T3 (da) 1999-07-16 2004-02-09 Leo Pharma As Nye aminobenzophenoner
PT1202957E (pt) 1999-07-16 2005-01-31 Leo Pharma As Aminobenzofenonas como inibidoras de il-1beta e tnf-alpha
PL352944A1 (en) 1999-07-16 2003-09-22 Leo Pharma Aminobenzophenones as inhibitors of il-1beta and tnf-alpha
RU2247719C2 (ru) 1999-07-16 2005-03-10 Лео Фармасьютикал Продактс Лтд.А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) Аминобензофеноны как ингибиторы il-1 бета и tnf-альфа, фармацевтическая композиция и способ лечения и/или профилактики воспалительных заболеваний
NZ516825A (en) 1999-07-16 2004-05-28 Leo Pharm Prod Ltd Aminobenzophenones as inhibitors of IL-1beta and TNF-alpha
HUP0203813A3 (en) 1999-12-06 2008-03-28 Leo Pharma As Aminobenzophenones as inhibitors of il-1betha and tnf-alpha, pharmaceutical compositions containing them and their use
RU2270194C2 (ru) 2000-05-22 2006-02-20 Лео Фарма А/С Бензофеноны как ингибиторы il-1бета и tnf-альфа, фармацевтическая композиция и способ лечения
GB0107368D0 (en) 2001-03-23 2001-05-16 Novartis Ag Organic compounds
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KR100896667B1 (ko) 2001-08-28 2009-05-14 레오 파마 에이/에스 신규한 아미노벤조페논 및 이를 포함하는 약제학적 조성물
PL377377A1 (pl) 2002-12-20 2006-02-06 Leo Pharma A/S Nowe związki aminobenzofenonu
ZA200510137B (en) * 2003-07-24 2007-04-25 Leo Pharma As Novel aminobenzophenone compounds
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Also Published As

Publication number Publication date
EP1828148A1 (en) 2007-09-05
JP2008523115A (ja) 2008-07-03
CN101115728B (zh) 2012-12-19
ATE455768T1 (de) 2010-02-15
DE602005019093D1 (de) 2010-03-11
ES2341473T3 (es) 2010-06-21
MX2007006739A (es) 2007-08-02
WO2006063585A1 (en) 2006-06-22
BRPI0518993A2 (pt) 2008-12-23
NO20073574L (no) 2007-07-10
KR20070095945A (ko) 2007-10-01
RU2394818C2 (ru) 2010-07-20
PT1828148E (pt) 2010-05-04
HRP20100225T1 (hr) 2010-07-31
AU2005316034A1 (en) 2006-06-22
US20060128766A1 (en) 2006-06-15
JP5015005B2 (ja) 2012-08-29
DK1828148T3 (da) 2010-05-17
CN101115728A (zh) 2008-01-30
RU2007126648A (ru) 2009-01-20
AR051792A1 (es) 2007-02-07
AU2005316034B2 (en) 2012-01-19
PL1828148T3 (pl) 2010-08-31
KR101260236B1 (ko) 2013-05-06
IL183513A0 (en) 2007-09-20
ZA200704809B (en) 2008-08-27
EP1828148B1 (en) 2010-01-20
US8293772B2 (en) 2012-10-23
CA2590479A1 (en) 2006-06-22

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