UA83133C2 - Proline derivatives and their use as dipeptidyl peptidase iv inhibitors, pharmaceutical composition based thereon - Google Patents
Proline derivatives and their use as dipeptidyl peptidase iv inhibitors, pharmaceutical composition based thereonInfo
- Publication number
- UA83133C2 UA83133C2 UAA200611856A UAA200611856A UA83133C2 UA 83133 C2 UA83133 C2 UA 83133C2 UA A200611856 A UAA200611856 A UA A200611856A UA A200611856 A UAA200611856 A UA A200611856A UA 83133 C2 UA83133 C2 UA 83133C2
- Authority
- UA
- Ukraine
- Prior art keywords
- inhibitors
- pharmaceutical composition
- composition based
- dipeptidyl peptidase
- proline derivatives
- Prior art date
Links
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003147 proline derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 206010054044 Diabetic microangiopathy Diseases 0.000 abstract 1
- 201000009101 diabetic angiopathy Diseases 0.000 abstract 1
- 208000033679 diabetic kidney disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Abstract
The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein Rl, R2, R3, НЕТ, n, Q, X, Y, and Z are as described herein; compositions thereof; and uses thereof in treating diabetic complications including diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, and the like.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57030004P | 2004-05-12 | 2004-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA83133C2 true UA83133C2 (en) | 2008-06-10 |
Family
ID=38077110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200611856A UA83133C2 (en) | 2004-05-12 | 2005-04-29 | Proline derivatives and their use as dipeptidyl peptidase iv inhibitors, pharmaceutical composition based thereon |
Country Status (5)
| Country | Link |
|---|---|
| CN (1) | CN1968949B (en) |
| HN (1) | HN2005000205A (en) |
| TN (1) | TNSN06366A1 (en) |
| UA (1) | UA83133C2 (en) |
| ZA (1) | ZA200608741B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016107832A1 (en) * | 2014-12-30 | 2016-07-07 | F. Hoffmann-La Roche Ag | Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection |
| EP3292120B1 (en) * | 2015-05-04 | 2019-06-19 | H. Hoffnabb-La Roche Ag | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections |
| CN114213504B (en) * | 2021-12-24 | 2023-05-09 | 西南医科大学 | A class of compounds with antidiabetic activity and their applications |
| CN118831080B (en) * | 2024-09-24 | 2024-11-22 | 上海交通大学医学院附属仁济医院 | Application of 5-oxyproline in preparing medicine for preventing or treating cardiomyopathy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE411285T1 (en) * | 2000-08-10 | 2008-10-15 | Mitsubishi Tanabe Pharma Corp | PROLINE DERIVATIVES AND THEIR USE AS MEDICATIONS |
| GB0115517D0 (en) * | 2001-06-25 | 2001-08-15 | Ferring Bv | Novel antidiabetic agents |
-
2005
- 2005-04-29 UA UAA200611856A patent/UA83133C2/en unknown
- 2005-04-29 CN CN2005800152588A patent/CN1968949B/en not_active Expired - Lifetime
- 2005-05-10 HN HN2005000205A patent/HN2005000205A/en unknown
-
2006
- 2006-10-19 ZA ZA200608741A patent/ZA200608741B/en unknown
- 2006-11-10 TN TNP2006000366A patent/TNSN06366A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200608741B (en) | 2008-07-30 |
| HN2005000205A (en) | 2009-10-30 |
| CN1968949B (en) | 2011-05-04 |
| TNSN06366A1 (en) | 2008-02-22 |
| CN1968949A (en) | 2007-05-23 |
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