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UA89040C2 - Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds - Google Patents

Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds

Info

Publication number
UA89040C2
UA89040C2 UAA200610843A UAA200610843A UA89040C2 UA 89040 C2 UA89040 C2 UA 89040C2 UA A200610843 A UAA200610843 A UA A200610843A UA A200610843 A UAA200610843 A UA A200610843A UA 89040 C2 UA89040 C2 UA 89040C2
Authority
UA
Ukraine
Prior art keywords
compounds
glucopyranosyl
drugs containing
benzol derivatives
substituted benzol
Prior art date
Application number
UAA200610843A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Франк Химмельсбах
Маттиас Экхардт
Петер Айкельманн
Эдвард Леон Барсумиан
Лео Томас
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of UA89040C2 publication Critical patent/UA89040C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to glucopy-ranosyl-substituted benzol derivatives of general formula (I), wherein rests Rto Rand R, R, Rare such as defined in the claim 1, including the tautomers, stereoisomers, mixtures and the salts thereof. The inventive compounds are useful for treating metabolic diseases.(І)
UAA200610843A 2004-03-16 2005-03-11 Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds UA89040C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004012676A DE102004012676A1 (en) 2004-03-16 2004-03-16 New glucopyranosyl-substituted benzene derivatives are sodium-dependent glucose cotransporter inhibitors, useful for treating e.g. metabolic disorders (type 1 and type 2 diabetes mellitus or metabolic acidosis)

Publications (1)

Publication Number Publication Date
UA89040C2 true UA89040C2 (en) 2009-12-25

Family

ID=35044978

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200610843A UA89040C2 (en) 2004-03-16 2005-03-11 Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds

Country Status (4)

Country Link
CN (1) CN1930141A (en)
DE (1) DE102004012676A1 (en)
UA (1) UA89040C2 (en)
ZA (1) ZA200605511B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
ES2466672T3 (en) * 2007-04-02 2014-06-10 Theracos, Inc. Benzyl glycoside derivatives and methods of use
CN103254119B (en) * 2007-07-10 2016-07-06 莱西肯医药有限公司 Inhibitor of sodium glucose co-transporter 2 white 2 and usage thereof
JP4809931B2 (en) 2007-08-23 2011-11-09 セラコス・インコーポレイテッド Benzylbenzene derivatives and methods of use thereof
CN101503399B (en) * 2008-02-04 2012-06-27 白鹭医药技术（上海）有限公司 C-aryl glucoside SGLT2 inhibitor
MX2011002166A (en) * 2008-08-28 2011-04-07 Pfizer Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives.
EP2395983B1 (en) * 2009-02-13 2020-04-08 Boehringer Ingelheim International GmbH Pharmaceutical composition comprisng a sglt2 inhibitor, a dpp-iv inhibitor and optionally a further antidiabetic agent and uses thereof
KR20110126614A (en) * 2009-02-13 2011-11-23 베링거 인겔하임 인터내셔날 게엠베하 Pharmaceutical compositions comprising glucopyranosyl diphenylmethane derivatives, their pharmaceutical dosage forms, methods for their preparation and their use for improved sugar control in patients
EP2483286B1 (en) * 2009-09-30 2016-07-13 Boehringer Ingelheim International GmbH Method for the preparation of a crystalline form of 1-chloro-4-(beta-d-glucopyranos-1-yl)-2-(4-((s)-tetrahydrofuran-3-yloxy)benzyl)benzene
SI2486029T1 (en) 2009-09-30 2015-10-30 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
IN2012DN03299A (en) * 2009-10-14 2015-10-23 Janssen Pharmaceutica Nv
US20120283169A1 (en) * 2010-11-08 2012-11-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
JP6105489B2 (en) * 2011-02-18 2017-03-29 シャンハイ インリ ファーマシューティカル カンパニー リミティド Aryl glucoside compounds, their preparation and use
ES2719656T3 (en) * 2011-06-01 2019-07-11 Green Cross Corp Novel diphenylmethane derivatives as SGLT2 inhibitors
US9562029B2 (en) 2011-06-25 2017-02-07 Xuanzhu Pharma Co., Ltd. C-glycoside derivatives
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
CN104045513A (en) * 2013-03-14 2014-09-17 爱康药业有限公司 4-substituted-1-chloro-2-(4-fluorobenzyl)benzene, its preparation method and application as intermediate in preparation of anti-type II diabetes drugs
CA2812519A1 (en) * 2013-04-05 2014-10-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
TR201901110T4 (en) 2013-04-05 2019-02-21 Boehringer Ingelheim Int Therapeutic uses of empagliflozin.
US20140303097A1 (en) 2013-04-05 2014-10-09 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US11813275B2 (en) 2013-04-05 2023-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
CN113181161A (en) 2013-04-18 2021-07-30 勃林格殷格翰国际有限公司 Pharmaceutical compositions, methods of treatment and uses thereof
US9394329B2 (en) * 2013-09-27 2016-07-19 Sunshine Lake Pharma Co., Ltd. Glucopyranosyl derivatives and their uses in medicine
US9315438B2 (en) 2014-01-03 2016-04-19 Xuanzhu Pharma Co., Ltd Optically pure benzyl-4-chlorophenyl-C-glucoside derivative
MA46742A (en) 2016-11-10 2019-09-18 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITION, METHODS OF TREATMENT AND THEIR USES
EP3649142A4 (en) * 2017-07-04 2021-09-01 Intocell, Inc. JOINTS WITH SPLITABLE LINKER AND USES THEREOF
CN108610385A (en) * 2018-04-23 2018-10-02 中国科学院成都生物研究所 A kind of medicinal usage of white 1 inhibitor of sodium glucose co-transporter 2
CN110117300A (en) * 2018-04-23 2019-08-13 中国科学院成都生物研究所 Medicinal usage comprising white 1 inhibitor of sodium glucose co-transporter 2
CN115991702B (en) * 2021-12-09 2024-02-02 珠海市藤栢医药有限公司 Aryl C-glucoside derivative, preparation method and application thereof
WO2023104201A1 (en) * 2021-12-09 2023-06-15 珠海市藤栢医药有限公司 Aryl c-glucoside derivative, preparation method therefor and use thereof
CN117186035A (en) * 2023-09-07 2023-12-08 安徽美诺华药物化学有限公司 A kind of synthesis process of empagliflozin intermediate

Also Published As

Publication number Publication date
CN1930141A (en) 2007-03-14
ZA200605511B (en) 2007-11-28
DE102004012676A1 (en) 2005-10-06

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