UA81000C2 - THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS - Google Patents

THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS Download PDF

Info

Publication number: UA81000C2
Authority: UA; Ukraine
Prior art keywords: carbonitrile; amino; methoxyphenyl; dichloro; pyridine
Prior art date: 2002-11-25

Application number

UAA200506270A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-25

Filing date

2003-11-14

Publication date

2007-11-26

2003-11-14 Application filed by Wyeth Corp filed Critical Wyeth Corp

2007-11-26 Publication of UA81000C2 publication Critical patent/UA81000C2/uk

Links

229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
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208000001132 Osteoporosis Diseases 0.000 claims abstract description 6
206010052779 Transplant rejections Diseases 0.000 claims abstract description 5
206010039073 rheumatoid arthritis Diseases 0.000 claims abstract description 5
208000023275 Autoimmune disease Diseases 0.000 claims abstract description 4
208000030761 polycystic kidney disease Diseases 0.000 claims abstract description 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 451
125000001072 heteroaryl group Chemical group 0.000 claims description 145
125000003118 aryl group Chemical group 0.000 claims description 130
125000004432 carbon atom Chemical group C* 0.000 claims description 114
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 101
125000000217 alkyl group Chemical group 0.000 claims description 82
-1 2,4-dichlorophenoxy Chemical group 0.000 claims description 80
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238000006243 chemical reaction Methods 0.000 claims description 47
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125000004433 nitrogen atom Chemical group N* 0.000 claims description 31
125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 30
125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 29
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 29
125000001424 substituent group Chemical group 0.000 claims description 27
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125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 25
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GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 16
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208000035475 disorder Diseases 0.000 claims description 16
125000005842 heteroatom Chemical group 0.000 claims description 16
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 16
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125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 15
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 15
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230000001575 pathological effect Effects 0.000 claims description 15
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 15
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ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 4
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125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
239000000460 chlorine Substances 0.000 claims description 4
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239000003937 drug carrier Substances 0.000 claims description 4
229910052731 fluorine Inorganic materials 0.000 claims description 4
239000011737 fluorine Substances 0.000 claims description 4
125000001153 fluoro group Chemical group F* 0.000 claims description 4
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 4
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239000005711 Benzoic acid Substances 0.000 claims description 3
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125000004093 cyano group Chemical group *C#N 0.000 claims description 3
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125000003107 substituted aryl group Chemical group 0.000 claims description 3
150000003573 thiols Chemical class 0.000 claims description 3
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239000008194 pharmaceutical composition Substances 0.000 claims description 2
238000004651 near-field scanning optical microscopy Methods 0.000 claims 2
WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 claims 1
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208000006011 Stroke Diseases 0.000 abstract description 5
230000008569 process Effects 0.000 abstract description 5
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 312
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239000000203 mixture Substances 0.000 description 193
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 159
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238000000921 elemental analysis Methods 0.000 description 76
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238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 66
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

UAA200506270A 2002-11-25 2003-11-14 THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS UA81000C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42886202P	2002-11-25	2002-11-25
PCT/US2003/036206 WO2004048386A2 (fr)	2002-11-25	2003-11-14	Thieno[3,2-b]pyridine-6-carbonitriles et thieno[2,3-b]pyridine-5-carbonitriles en tant qu'inhibiteurs de proteine kinase

Publications (1)

Publication Number	Publication Date
UA81000C2 true UA81000C2 (en)	2007-11-26

Family

ID=32393469

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200506270A UA81000C2 (en)	2002-11-25	2003-11-14	THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS

Country Status (20)

Country	Link
US (1)	US6987116B2 (fr)
EP (1)	EP1565474A2 (fr)
JP (1)	JP2006509760A (fr)
KR (1)	KR20050086770A (fr)
CN (1)	CN1714092A (fr)
AR (1)	AR042087A1 (fr)
AU (1)	AU2003290802A1 (fr)
BR (1)	BR0316534A (fr)
CA (1)	CA2502614A1 (fr)
CL (1)	CL2003002287A1 (fr)
EC (1)	ECSP055802A (fr)
MX (1)	MXPA05004744A (fr)
NI (1)	NI200500089A (fr)
NO (1)	NO20051928L (fr)
NZ (1)	NZ540104A (fr)
RU (1)	RU2005120018A (fr)
TW (1)	TW200412950A (fr)
UA (1)	UA81000C2 (fr)
WO (1)	WO2004048386A2 (fr)
ZA (1)	ZA200504238B (fr)

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US7276519B2 (en) *	2002-11-25	2007-10-02	Wyeth	Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
FR2862647B1 (fr) *	2003-11-25	2008-07-04	Aventis Pharma Sa	Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
US7459562B2 (en)	2004-04-23	2008-12-02	Bristol-Myers Squibb Company	Monocyclic heterocycles as kinase inhibitors
TW200538453A (en)	2004-04-26	2005-12-01	Bristol Myers Squibb Co	Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en)	2004-06-28	2008-10-21	Bristol-Myers Squibb Company	Fused heterocyclic kinase inhibitors
US20050288290A1 (en)	2004-06-28	2005-12-29	Borzilleri Robert M	Fused heterocyclic kinase inhibitors
US7432373B2 (en)	2004-06-28	2008-10-07	Bristol-Meyers Squibb Company	Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
CN101031570B (zh) *	2004-07-30	2012-09-05	梅特希尔基因公司	Vegf受体和hgf受体信号的抑制剂
GB0423653D0 (en) *	2004-10-25	2004-11-24	Piramed Ltd	Pharmaceutical compounds
KR101378716B1 (ko) *	2005-05-20	2014-04-10	메틸진 인코포레이티드	Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제
NZ563774A (en)	2005-05-20	2010-04-30	Methylgene Inc	Inhibitors of VEGF receptor and HGF receptor signaling
WO2007035428A1 (fr)	2005-09-15	2007-03-29	Bristol-Myers Squibb Company	Inhibiteurs de la kinase met
PE20070619A1 (es) *	2005-09-27	2007-07-02	Wyeth Corp	TIENO(2,3-b)PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINAS QUINASA
US7547782B2 (en)	2005-09-30	2009-06-16	Bristol-Myers Squibb Company	Met kinase inhibitors
AR059246A1 (es) *	2006-01-30	2008-03-19	Array Biopharma Inc	Compuestos heterobiciclicos de tiofeno y metodos de uso
GB0601962D0 (en) *	2006-01-31	2006-03-15	Ucb Sa	Therapeutic agents
US20100210596A1 (en) *	2006-02-01	2010-08-19	Bluestone Jeffrey A	Use of aminopyrimidine compounds in the treatment of immune disorders
AU2007212756A1 (en) *	2006-02-08	2007-08-16	Wyeth	Preparation of 7-alkenyl-3 quinolinecarbonitriles via a palladium mediated coupling reaction
JP2009539878A (ja) *	2006-06-08	2009-11-19	アレイバイオファーマ、インコーポレイテッド	キノリン化合物および使用方法
CA2660963A1 (fr) *	2006-08-21	2008-02-28	Genentech, Inc.	Composes aza-benzothiophenyle et leurs procedes d'utilisation
WO2008024725A1 (fr) *	2006-08-21	2008-02-28	Genentech, Inc.	Composés aza-benzofuranyle et leurs procédés d'utilisation
TW200821318A (en) *	2006-09-26	2008-05-16	Wyeth Corp	Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles
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NO20051928D0 (no)	2005-04-20
ZA200504238B (en)	2009-09-30
US6987116B2 (en)	2006-01-17
BR0316534A (pt)	2005-10-04
KR20050086770A (ko)	2005-08-30
CN1714092A (zh)	2005-12-28
NO20051928L (no)	2005-08-19
US20040138251A1 (en)	2004-07-15
CL2003002287A1 (es)	2005-01-14
TW200412950A (en)	2004-08-01
EP1565474A2 (fr)	2005-08-24
AR042087A1 (es)	2005-06-08
JP2006509760A (ja)	2006-03-23
WO2004048386A9 (fr)	2005-07-14
CA2502614A1 (fr)	2004-06-10
NI200500089A (es)	2006-01-11
RU2005120018A (ru)	2006-05-10
WO2004048386A3 (fr)	2004-10-07
WO2004048386A2 (fr)	2004-06-10
AU2003290802A1 (en)	2004-06-18
MXPA05004744A (es)	2005-08-03
NZ540104A (en)	2007-05-31
ECSP055802A (es)	2005-08-11

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