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NI200500089A - TIENO [3,2-b] PIRIDIN-6-CARBONITRILOS Y TIENO [2,3-b] PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINA CINASAS - Google Patents

TIENO [3,2-b] PIRIDIN-6-CARBONITRILOS Y TIENO [2,3-b] PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINA CINASAS

Info

Publication number
NI200500089A
NI200500089A NI200500089A NI200500089A NI200500089A NI 200500089 A NI200500089 A NI 200500089A NI 200500089 A NI200500089 A NI 200500089A NI 200500089 A NI200500089 A NI 200500089A NI 200500089 A NI200500089 A NI 200500089A
Authority
NI
Nicaragua
Prior art keywords
carbonitrils
piridin
inhibitors
protein kinases
compounds
Prior art date
Application number
NI200500089A
Other languages
English (en)
Inventor
Diane Harris Boschelli
Nan Zhang
Sosa Ana Carolina Barrios
Harris Durutlic
Biqi Wu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NI200500089A publication Critical patent/NI200500089A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invención proporciona compuestos de las fórmulas (1a) - (1f), en donde: X, R1 y R2 se definen anteriormente en la especificación, los cuales son útiles en el tratamiento del cáncer, apoplejía, osteoporosis, enfermedad de riñón poliquístico, enfermedad autoinmune, artritis reumatoide y rechazo de trasplantes y un procedimiento para producir los compuestos.
NI200500089A 2002-11-25 2005-04-26 TIENO [3,2-b] PIRIDIN-6-CARBONITRILOS Y TIENO [2,3-b] PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINA CINASAS NI200500089A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42886202P 2002-11-25 2002-11-25

Publications (1)

Publication Number Publication Date
NI200500089A true NI200500089A (es) 2006-01-11

Family

ID=32393469

Family Applications (1)

Application Number Title Priority Date Filing Date
NI200500089A NI200500089A (es) 2002-11-25 2005-04-26 TIENO [3,2-b] PIRIDIN-6-CARBONITRILOS Y TIENO [2,3-b] PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINA CINASAS

Country Status (20)

Country Link
US (1) US6987116B2 (es)
EP (1) EP1565474A2 (es)
JP (1) JP2006509760A (es)
KR (1) KR20050086770A (es)
CN (1) CN1714092A (es)
AR (1) AR042087A1 (es)
AU (1) AU2003290802A1 (es)
BR (1) BR0316534A (es)
CA (1) CA2502614A1 (es)
CL (1) CL2003002287A1 (es)
EC (1) ECSP055802A (es)
MX (1) MXPA05004744A (es)
NI (1) NI200500089A (es)
NO (1) NO20051928L (es)
NZ (1) NZ540104A (es)
RU (1) RU2005120018A (es)
TW (1) TW200412950A (es)
UA (1) UA81000C2 (es)
WO (1) WO2004048386A2 (es)
ZA (1) ZA200504238B (es)

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US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
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KR20100137495A (ko) * 2008-03-05 2010-12-30 메틸진 인코포레이티드 단백질 티로신 키나아제 활성의 억제제
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Also Published As

Publication number Publication date
CA2502614A1 (en) 2004-06-10
ZA200504238B (en) 2009-09-30
US20040138251A1 (en) 2004-07-15
CN1714092A (zh) 2005-12-28
US6987116B2 (en) 2006-01-17
NZ540104A (en) 2007-05-31
MXPA05004744A (es) 2005-08-03
EP1565474A2 (en) 2005-08-24
UA81000C2 (en) 2007-11-26
ECSP055802A (es) 2005-08-11
NO20051928L (no) 2005-08-19
TW200412950A (en) 2004-08-01
NO20051928D0 (no) 2005-04-20
WO2004048386A3 (en) 2004-10-07
AU2003290802A1 (en) 2004-06-18
BR0316534A (pt) 2005-10-04
CL2003002287A1 (es) 2005-01-14
JP2006509760A (ja) 2006-03-23
WO2004048386A2 (en) 2004-06-10
KR20050086770A (ko) 2005-08-30
AR042087A1 (es) 2005-06-08
WO2004048386A9 (en) 2005-07-14
RU2005120018A (ru) 2006-05-10

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