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UA35557C2 - Похідні 1,2,4-оксадіазолілфеноксіалкілізоксазолу, що мають противірусну активність та фармацевтична композиція на їх основі - Google Patents

Похідні 1,2,4-оксадіазолілфеноксіалкілізоксазолу, що мають противірусну активність та фармацевтична композиція на їх основі

Info

Publication number
UA35557C2
UA35557C2 UA93003099A UA93003099A UA35557C2 UA 35557 C2 UA35557 C2 UA 35557C2 UA 93003099 A UA93003099 A UA 93003099A UA 93003099 A UA93003099 A UA 93003099A UA 35557 C2 UA35557 C2 UA 35557C2
Authority
UA
Ukraine
Prior art keywords
oxadiazolyl
antiviral activity
phenoxyalkylisoxazole
derivatives
alkoxy
Prior art date
Application number
UA93003099A
Other languages
English (en)
Russian (ru)
Inventor
Домінік Діана Гай
Доминик Диана Гай
Джон Нітц Теодор
Джон Нитц Теодор
Original Assignee
Санофі Сінтелабо
Санофи Синтелабо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофі Сінтелабо, Санофи Синтелабо filed Critical Санофі Сінтелабо
Publication of UA35557C2 publication Critical patent/UA35557C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,2,4-оксадіазолілфеноксиалкілізоксазоли загальної формули (I): , (I) де R1 являє собою алкіл, алкокси, гідрокси, циклоалкіл, гідроксиалкіл, алкоксиалкіл або гідроксиалкокси, Y є алкіленом, що містить від 3 до 9 атомів вуглецю, R2 і R3 незалежно є воднем, алкілом, алкокси, галоїдом, трифторметилом або нітрогрупою, R4 є алкокси, гідрокси, галоїдметилом, дигалоїдметилом, тригалоїдметилом, циклоалкілом, алкоксикарбонілом, гідроксиалкілом, алкоксиалкілом, алканкарбонилоксиалкілом, ціано, 2,2,2-трифторетилом, 4-метилфенилсульфонілоксиметилом, групою Q або C(O) Q, де Q є аміно, алкіламіно, диалкіламіно, або їх фармацевтично прийнятні аддитивні кислотні солі, що мають противірусну активність.
UA93003099A 1992-04-15 1993-06-15 Похідні 1,2,4-оксадіазолілфеноксіалкілізоксазолу, що мають противірусну активність та фармацевтична композиція на їх основі UA35557C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/869,287 US5349068A (en) 1992-04-15 1992-04-15 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (1)

Publication Number Publication Date
UA35557C2 true UA35557C2 (uk) 2001-04-16

Family

ID=25353269

Family Applications (1)

Application Number Title Priority Date Filing Date
UA93003099A UA35557C2 (uk) 1992-04-15 1993-06-15 Похідні 1,2,4-оксадіазолілфеноксіалкілізоксазолу, що мають противірусну активність та фармацевтична композиція на їх основі

Country Status (26)

Country Link
US (3) US5349068A (uk)
EP (1) EP0566199B1 (uk)
JP (1) JP3103845B2 (uk)
KR (1) KR100314158B1 (uk)
AT (1) ATE189958T1 (uk)
AU (1) AU666528B2 (uk)
CA (1) CA2094012C (uk)
CZ (1) CZ285845B6 (uk)
DE (1) DE69327913T2 (uk)
DK (1) DK0566199T3 (uk)
ES (1) ES2143487T3 (uk)
FI (1) FI112229B (uk)
GR (1) GR3033486T3 (uk)
HU (2) HU220606B1 (uk)
IL (1) IL105372A (uk)
MX (1) MX9302169A (uk)
MY (1) MY110191A (uk)
NO (1) NO302700B1 (uk)
NZ (1) NZ247411A (uk)
PH (1) PH30454A (uk)
PT (1) PT566199E (uk)
RU (1) RU2114112C1 (uk)
SG (1) SG50663A1 (uk)
SK (1) SK279786B6 (uk)
TW (1) TW239140B (uk)
UA (1) UA35557C2 (uk)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) * 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
EP1406632A4 (en) * 2001-06-08 2009-11-04 Cytovia Inc SUBSTITUTED 3-ARYL-5-ARYL-1,2,4-OXADIAZOLE AND ANALOGUE AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCTORS AND THEIR USE
US7129359B2 (en) * 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
CA2459375A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
WO2003020271A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
ES2372915T3 (es) * 2001-12-07 2012-01-27 Ana Maria Sandino Neomicina para el aumento de la sobrevivencia de animales acuáticos expuestos a ipnv.
AU2003215246A1 (en) * 2002-02-14 2003-09-04 Viropharma Incorporated Methods of reducing rhinovirus contagion and related compositions
EP1581213A4 (en) * 2002-12-18 2008-11-19 Cytovia Inc 3,5-DISUBSTITUTED 1,2,4-OXADIAZOLE AND ANALOGUE TO ACTIVATE CASPASE AND INTRODUCTION OF APOPTOSIS AND THEIR USE
US7259174B2 (en) * 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds
EP1819329A2 (en) * 2004-08-04 2007-08-22 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
JP2009526063A (ja) * 2006-02-09 2009-07-16 シェーリング コーポレイション 医薬製剤
CA2641605A1 (en) * 2006-02-09 2007-08-23 Schering Corporation Pharmaceutical formulations
EP1981545A2 (en) * 2006-02-09 2008-10-22 Schering Corporation Pharmaceutical formulations
RU2469032C2 (ru) 2006-12-13 2012-12-10 Ф.Хоффманн-Ля Рош Аг Производные 2-(пиперидин-4-ил)-4-фенокси- или фениламинопиримидина в качестве ненуклеозидных ингибиторов обратной транскриптазы
KR101031584B1 (ko) * 2009-04-21 2011-04-27 파인오토시스템(주) 전면부가 개폐되는 차량용 적외선 조사장치
CN103102348B (zh) * 2011-11-14 2016-06-08 上海交通大学 噁二唑类化合物及其制备方法、药物组合物及其用途
MY200452A (en) * 2018-08-21 2023-12-27 Kyorin Seiyaku Kk Bicyclic heteroaromatic ring derivative
WO2021062189A1 (en) * 2019-09-27 2021-04-01 Collaborations Pharmaceuticals, Inc. Isoxazole-3-carboxamide derivatives and their use for treatment of diseases caused by virus infection
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
CA1299176C (en) * 1985-07-02 1992-04-21 Guy Dominic Diana Process for preparing isoxazole and furan derivatives
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
AU666528B2 (en) 1996-02-15
SG50663A1 (en) 1998-07-20
IL105372A0 (en) 1993-08-18
HU9301084D0 (en) 1993-06-28
CZ285845B6 (cs) 1999-11-17
MX9302169A (es) 1993-10-01
NZ247411A (en) 1994-06-27
ATE189958T1 (de) 2000-03-15
US5349068A (en) 1994-09-20
GR3033486T3 (en) 2000-09-29
US5464848A (en) 1995-11-07
CA2094012A1 (en) 1993-10-16
KR930021637A (ko) 1993-11-22
EP0566199B1 (en) 2000-03-01
KR100314158B1 (ko) 2002-02-19
MY110191A (en) 1998-02-28
FI931707L (fi) 1993-10-16
SK279786B6 (sk) 1999-03-12
US5643929A (en) 1997-07-01
JPH0649066A (ja) 1994-02-22
IL105372A (en) 1998-12-27
FI112229B (fi) 2003-11-14
DE69327913D1 (de) 2000-04-06
DE69327913T2 (de) 2000-10-12
PT566199E (pt) 2000-09-29
CZ59793A3 (en) 1994-02-16
CA2094012C (en) 2001-08-21
HUT65574A (en) 1994-07-28
TW239140B (uk) 1995-01-21
PH30454A (en) 1997-05-28
HU211320A9 (en) 1995-11-28
NO931366L (no) 1993-10-18
AU3688193A (en) 1993-10-21
FI931707A0 (fi) 1993-04-15
SK35393A3 (en) 1994-06-08
NO931366D0 (no) 1993-04-14
JP3103845B2 (ja) 2000-10-30
ES2143487T3 (es) 2000-05-16
NO302700B1 (no) 1998-04-14
EP0566199A1 (en) 1993-10-20
RU2114112C1 (ru) 1998-06-27
DK0566199T3 (da) 2000-06-19
HU220606B1 (hu) 2002-03-28

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