TWI504407B - 癌疫苗組合物 - Google Patents

癌疫苗組合物 Download PDF

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Publication number: TWI504407B
Authority: TW; Taiwan
Prior art keywords: peptide; hla; cells; positive; cancer
Prior art date: 2007-12-05

Application number

TW102139047A

Other languages

English (en)

Chinese (zh)

Other versions

TW201406390A (zh

Inventor

Haruo Sugiyama

Original Assignee

Int Inst Cancer Immunology Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-05

Filing date

2008-12-05

Publication date

2015-10-21

2008-12-05 Application filed by Int Inst Cancer Immunology Inc filed Critical Int Inst Cancer Immunology Inc

2014-02-16 Publication of TW201406390A publication Critical patent/TW201406390A/zh

2015-10-21 Application granted granted Critical

2015-10-21 Publication of TWI504407B publication Critical patent/TWI504407B/zh

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TW102139047A 2007-12-05 2008-12-05 癌疫苗組合物 TWI504407B (zh)

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CN (3)	CN103394079B (ja)
AU (1)	AU2008332278C1 (ja)
CA (3)	CA2881594C (ja)
ES (2)	ES2989864T3 (ja)
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RU (3)	RU2010127298A (ja)
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7612162B2 (en)	2004-09-21	2009-11-03	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response
EP1951281B1 (en)	2005-10-17	2015-04-15	Sloan Kettering Institute For Cancer Research	Wt1 hla class ii-binding peptides and compositions and methods comprising same
EP3117836A1 (en)	2006-04-10	2017-01-18	Sloan Kettering Institute For Cancer Research	Immunogenic wt-1 peptides and uses thereof
RU2010127298A (ru) *	2007-12-05	2012-01-10	Интернешнл Инститьют Оф Кэнсер Иммунолоджи, Инк. (Jp)	Вакцинная композиция против злокачественной опухоли
AU2011293522B2 (en) *	2010-08-24	2015-03-19	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Interleukin-13 receptor alpha 2 peptide-based brain cancer vaccines
SG10201602159VA (en) *	2011-02-11	2016-04-28	Sloan Kettering Inst Cancer	Hla-restricted, peptide-specific antigen binding proteins
AU2012276908A1 (en) *	2011-06-28	2014-02-20	International Institute Of Cancer Immunology, Inc.	Receptor gene for peptide cancer antigen-specific T cell
RU2633068C2 (ru)	2011-09-14	2017-10-11	Интернешнл Инститьют Оф Кэнсер Иммунолоджи, Инк.	Способ измерения антитела против wt1
SG10201608552WA (en) *	2011-10-28	2016-12-29	Oncotherapy Science Inc	Topk Peptides And Vaccines Including The Same
EP2802347B1 (en)	2012-01-13	2019-01-09	Memorial Sloan Kettering Cancer Center	Immunogenic wt-1 peptides and methods of use thereof
ES2655031T3 (es)	2012-07-02	2018-02-16	Sumitomo Dainippon Pharma Co., Ltd.	Preparación transdérmica de péptido antigénico del cáncer
CA2884366A1 (en) *	2012-09-12	2014-03-20	International Institute Of Cancer Immunology, Inc.	Antigen-specific helper t-cell receptor genes
MX364732B (es) *	2012-12-13	2019-05-06	Univ Pennsylvania	Vacuna contra el tumor de wilms 1.
US10815273B2 (en)	2013-01-15	2020-10-27	Memorial Sloan Kettering Cancer Center	Immunogenic WT-1 peptides and methods of use thereof
SI2945647T1 (sl)	2013-01-15	2021-01-29	Memorial Sloan Kettering Cancer Center	Imunogeni peptidi WT-1 in postopki za uporabo le-teh
KR102045029B1 (ko) *	2013-02-05	2019-11-14	닛토덴코 가부시키가이샤	점막 투여용 ｗｔ1 펩티드 암 백신 조성물
RU2685933C2 (ru) *	2013-02-05	2019-04-23	Нитто Денко Корпорейшн	Композиция противораковой вакцины, содержащая пептид wt1, для трансдермального введения
IN2014CH00393A (ja) *	2013-02-05	2015-04-03	Nitto Denko Corp
RU2687144C2 (ru) *	2013-02-05	2019-05-07	Нитто Денко Корпорейшн	Композиция противораковой вакцины, содержащей пептид wt1, для трансдермального введения
ES2694328T3 (es) *	2013-03-12	2018-12-19	Sumitomo Dainippon Pharma Co., Ltd.	Composición acuosa líquida
WO2014157692A1 (ja)	2013-03-29	2014-10-02	大日本住友製薬株式会社	Ｗｔ１抗原ペプチドコンジュゲートワクチン
WO2014157704A1 (ja)	2013-03-29	2014-10-02	大日本住友製薬株式会社	Ｅｒａｐ１によるトリミング機能をきっかけとしたコンジュゲートワクチン
CA2912514A1 (en) *	2013-05-13	2014-11-20	International Institute Of Cancer Immunology, Inc.	Method for predicting clinical effect of immunotherapy
WO2015077717A1 (en)	2013-11-25	2015-05-28	The Broad Institute Inc.	Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
US11725237B2 (en)	2013-12-05	2023-08-15	The Broad Institute Inc.	Polymorphic gene typing and somatic change detection using sequencing data
JP7060324B2 (ja)	2013-12-20	2022-04-26	ザ・ブロード・インスティテュート・インコーポレイテッド	ネオ抗原ワクチンによる併用療法
WO2015129790A1 (ja) *	2014-02-26	2015-09-03	株式会社バイオイミュランス	Ｗｔ１抗原性ポリペプチド、及び該ポリペプチドを含む抗腫瘍剤
EP3231438B1 (en) *	2014-12-11	2020-06-17	International Institute of Cancer Immunology, Inc.	Wt1 immunotherapy for intraocular angiogenic disease
US10993997B2 (en)	2014-12-19	2021-05-04	The Broad Institute, Inc.	Methods for profiling the t cell repertoire
US10975442B2 (en)	2014-12-19	2021-04-13	Massachusetts Institute Of Technology	Molecular biomarkers for cancer immunotherapy
JP6028253B2 (ja) *	2015-01-28	2016-11-16	学校法人北里研究所	癌細胞の検出方法及び癌細胞検出キット
CN107530557A (zh)	2015-03-20	2018-01-02	宾夕法尼亚大学理事会	Isg15和其作为佐剂的用途
CA3005896C (en)	2015-11-20	2025-09-23	Memorial Sloan Kettering Cancer Center	METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BY MEANS OF THE COMBINATION OF A WT1 PEPTIDE AND A CHECKPOINT INHIBITOR
US20190025314A1 (en)	2016-01-11	2019-01-24	Janette Dixon	Methods for determining tumour phenotypes
WO2018101309A1 (ja)	2016-11-30	2018-06-07	大日本住友製薬株式会社	Ｗｔ１ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ
JP7393752B2 (ja)	2018-10-05	2023-12-07	株式会社癌免疫研究所	良性腫瘍の予防または治療薬
TWI875736B (zh)	2019-02-28	2025-03-11	日商住友製藥股份有限公司	選擇可期待用於治療或預防癌之醫藥組合物之效果之對象之方法
KR102215578B1 (ko) *	2019-03-28	2021-02-15	한국과학기술연구원	인간 백혈구 항원에 특이적으로 결합하는 펩타이드 및 이의 용도
CN116134131A (zh)	2019-12-31	2023-05-16	伊利克斯根治疗公司	核酸和蛋白质向细胞和组织的基于温度的瞬时递送
CA3182959A1 (en)	2020-05-12	2021-11-18	Sumitomo Pharma Co., Ltd.	Pharmaceutical composition for treating cancer
KR20250158315A (ko)	2024-04-30	2025-11-06	한림대학교 산학협력단	골육종용 암백신 항원단백질 및 이를 포함하는 암백신 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1640458A1 (en) *	2003-06-27	2006-03-29	Haruo Sugiyama	Method of selecting patients suitable for wt1 vaccine
CN1762490A (zh) *	1998-07-31	2006-04-26	杉山治夫	基于癌抑制基因wt1的产物的癌抗原
TWI455721B (zh) *	2007-12-05	2014-10-11	Int Inst Cancer Immunology Inc	癌疫苗組合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3904260B2 (ja)	1995-06-01	2007-04-11	岸本忠三	ウイルムス腫瘍遺伝子（ｗｔ１）に対するアンチセンスオリゴヌクレオチド誘導体を含んで成る白血病細胞増殖阻害剤
JP4789095B2 (ja)	1997-07-16	2011-10-05	治夫杉山	ウイルムス腫瘍遺伝子（ｗｔ１）に対する発現阻害物質を含んで成る固形腫瘍治療剤
EP1103561B1 (en) *	1998-07-28	2006-04-19	Green Peptide Co., Ltd.	Hla-a2 restraint tumor antigen peptide originating in sart-1
HK1039782B (en) *	1998-09-30	2008-11-14	Corixa Corporation	Compositions and methods for wt1 specific immunotherapy
US7115272B1 (en) *	1998-09-30	2006-10-03	Corixa Corporation	Compositions and methods for WT1 specific immunotherapy
GB9823897D0 (en) *	1998-11-02	1998-12-30	Imp College Innovations Ltd	Immunotherapeutic methods and molecules
JP3728439B2 (ja)	2001-03-22	2005-12-21	治夫杉山	Ｗｔ１改変ペプチド
JP4365784B2 (ja)	2002-06-12	2009-11-18	株式会社癌免疫研究所	Ｈｌａ−ａ２４拘束性癌抗原ペプチド
US7772188B2 (en) *	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
ES2402184T5 (es)	2003-12-01	2016-10-25	Sloan-Kettering Institute For Cancer Research	Análogos de péptidos de unión a HLA sintéticos y sus usos
JP2006045287A (ja)	2004-08-02	2006-02-16	Inax Corp	弾性接着剤及びタイル張り壁面
WO2007016466A2 (en)	2005-07-29	2007-02-08	Sloan-Kettering Institute For Cancer Research	Single wall nanotube constructs and uses therefor

2008
- 2008-12-05 RU RU2010127298/15A patent/RU2010127298A/ru not_active Application Discontinuation
- 2008-12-05 CN CN201310241647.9A patent/CN103394079B/zh active Active
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- 2008-12-05 EP EP18156472.5A patent/EP3384926B1/en active Active
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2013
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1762490A (zh) *	1998-07-31	2006-04-26	杉山治夫	基于癌抑制基因wt1的产物的癌抗原
EP1640458A1 (en) *	2003-06-27	2006-03-29	Haruo Sugiyama	Method of selecting patients suitable for wt1 vaccine
TWI455721B (zh) *	2007-12-05	2014-10-11	Int Inst Cancer Immunology Inc	癌疫苗組合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Brett Trost et al." Strength in numbers: achieving greater accuracy in MHC-I binding prediction by combining the results from multiple prediction tools", Immunome Research 2007, 3:5. *
Tanigaki N et al." HLA-A2-binding peptides cross-react not only within the A2 subgroup but also with other HLA-A-locus allelic products", Hum Immunol. 1994 Mar;39(3):155-62. *

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EP3384926B1 (en)	2024-10-09
AU2008332278B2 (en)	2013-06-13
KR101592855B1 (ko)	2016-02-12
US10426822B2 (en)	2019-10-01
CA2940962C (en)	2018-07-24
AU2008332278A1 (en)	2009-06-11
EP2228072A4 (en)	2012-03-14
JPWO2009072610A1 (ja)	2011-04-28
US20170232089A1 (en)	2017-08-17
CA2881594A1 (en)	2009-06-11
JP2013241417A (ja)	2013-12-05
JP5921494B2 (ja)	2016-05-24
TW201406390A (zh)	2014-02-16
EP3384926A1 (en)	2018-10-10
US20110070251A1 (en)	2011-03-24
AU2008332278C1 (en)	2013-10-03
CN103394079A (zh)	2013-11-20
JP5478260B2 (ja)	2014-04-23
CA2706907C (en)	2016-10-18
CA2940962A1 (en)	2009-06-11
US20160367649A1 (en)	2016-12-22
US20140023670A1 (en)	2014-01-23
ES2989864T3 (es)	2024-11-28
EP2228072A1 (en)	2010-09-15
KR20100090710A (ko)	2010-08-16
TWI455721B (zh)	2014-10-11
US9119801B2 (en)	2015-09-01
RU2010127298A (ru)	2012-01-10
RU2013141920A (ru)	2015-03-20
ES2679127T3 (es)	2018-08-22
JP2016166223A (ja)	2016-09-15
CN101888852A (zh)	2010-11-17
KR20150055091A (ko)	2015-05-20
US11707512B2 (en)	2023-07-25
RU2682726C9 (ru)	2019-08-15
RU2721574C2 (ru)	2020-05-20
CA2881594C (en)	2016-04-12
RU2682726C2 (ru)	2019-03-22
CN101888852B (zh)	2017-02-08
WO2009072610A1 (ja)	2009-06-11
CN105903006A (zh)	2016-08-31
KR101610664B1 (ko)	2016-04-08
EP2228072B1 (en)	2018-06-13
US8557779B2 (en)	2013-10-15
TW200930402A (en)	2009-07-16
CA2706907A1 (en)	2009-06-11
US20190388529A1 (en)	2019-12-26
MX2010006070A (es)	2010-12-06
JP6435286B2 (ja)	2018-12-05
RU2013141923A (ru)	2015-03-20
CN103394079B (zh)	2017-03-01

Publication	Publication Date	Title
TWI504407B (zh)	2015-10-21	癌疫苗組合物
HK1143552B (en)	2019-05-17	Cancer vaccine composition
HK1143552A (en)	2011-01-07	Cancer vaccine composition
HK1261028B (en)	2025-04-25	Cancer vaccine composition
HK1261028A1 (en)	2019-12-27	Cancer vaccine composition