TWI372620B - Treatment of autoimmune diseases - Google Patents

Treatment of autoimmune diseases

Info

Publication number: TWI372620B
Authority: TW; Taiwan
Prior art keywords: autoimmune diseases; treatment; neuritis; uveitis; invention describes
Prior art date: 2005-09-09

Application number

TW099117063A

Other languages

English (en)

Other versions

TW201034659A (en

Inventor

Rainer Albert

Nigel Graham Cooke

Barbara Nuesslein-Hildesheim

Sven Weiler

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-09

Filing date

2006-09-08

Publication date

2012-09-21

2006-09-08 Application filed by Novartis Ag filed Critical Novartis Ag

2010-10-01 Publication of TW201034659A publication Critical patent/TW201034659A/zh

2012-09-21 Application granted granted Critical

2012-09-21 Publication of TWI372620B publication Critical patent/TWI372620B/zh

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Immunology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

TW099117063A 2005-09-09 2006-09-08 Treatment of autoimmune diseases TWI372620B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71599005P	2005-09-09	2005-09-09

Publications (2)

Publication Number	Publication Date
TW201034659A TW201034659A (en)	2010-10-01
TWI372620B true TWI372620B (en)	2012-09-21

Family

ID=37056992

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
TW095133326A TWI376223B (en)	2005-09-09	2006-09-08	Treatment of autoimmune diseases
TW099117063A TWI372620B (en)	2005-09-09	2006-09-08	Treatment of autoimmune diseases

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
TW095133326A TWI376223B (en)	2005-09-09	2006-09-08	Treatment of autoimmune diseases

Country Status (28)

Country	Link
US (1)	US20080200438A1 (zh)
EP (2)	EP1926483B1 (zh)
JP (4)	JP5244598B2 (zh)
KR (3)	KR20140117704A (zh)
CN (1)	CN101257899B (zh)
AT (1)	ATE489948T1 (zh)
AU (2)	AU2006289100B2 (zh)
BR (1)	BRPI0615906A2 (zh)
CA (2)	CA2620554C (zh)
CY (1)	CY1111285T1 (zh)
DE (1)	DE602006018629D1 (zh)
DK (2)	DK1926483T3 (zh)
ES (2)	ES2357426T3 (zh)
IL (2)	IL189665A (zh)
JO (1)	JO2655B1 (zh)
MA (1)	MA29787B1 (zh)
MX (1)	MX2008003170A (zh)
NO (1)	NO20081727L (zh)
NZ (2)	NZ588372A (zh)
PL (2)	PL1926483T3 (zh)
PT (2)	PT2295049E (zh)
RU (2)	RU2493840C2 (zh)
SG (1)	SG165364A1 (zh)
SI (2)	SI1926483T1 (zh)
TN (1)	TNSN08103A1 (zh)
TW (2)	TWI376223B (zh)
WO (1)	WO2007028821A2 (zh)
ZA (1)	ZA200801694B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1772145E (pt) *	2004-07-16	2011-05-27	Kyorin Seiyaku Kk	Processo de utiliza??o eficaz de um medicamento e processo respeitante ? preven??o de efeitos secund?rios
BRPI0516337A (pt)	2004-10-12	2008-04-29	Kyorin Seiyaku Kk	processo para a produção de 2- amino-2-[4-(3-benziloxifeniltio) -2- (clorofenil} etil] - 1,3 - hidrocloreto de propanediol e hidratos dos mesmos e produtos intermerdiários para a produção dos mesmos
PL1932522T3 (pl) *	2005-10-07	2012-09-28	Kyorin Seiyaku Kk	Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu
TWI389683B (zh) *	2006-02-06	2013-03-21	Kyorin Seiyaku Kk	A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
EP2053038B1 (en) *	2006-08-08	2016-10-05	Kyorin Pharmaceutical Co., Ltd.	Amino alcohol derivative and immunosuppressive agent having same as an active ingredient
EP2058317B1 (en) *	2006-08-08	2013-10-16	Kyorin Pharmaceutical Co., Ltd.	Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient
WO2008099781A1 (ja) *	2007-02-13	2008-08-21	Kyorin Pharmaceutical Co., Ltd.	アミノアルコール誘導体を有効成分とする脱髄性疾患の治療剤又は予防剤
WO2009099174A1 (ja)	2008-02-07	2009-08-13	Kyorin Pharmaceutical Co., Ltd.	アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤
TW201000109A (en) *	2008-05-20	2010-01-01	Kyorin Seiyaku Kk	Agent for induction/maintenance of remission
EA019808B1 (ru) *	2008-08-18	2014-06-30	Новартис Аг	Производные аминоспиртов, предназначенные для лечения демиелинизирующих периферических невропатий
NZ603999A (en) *	2010-05-06	2014-06-27	Novartis Ag	Treatment of autoimmune diseases
EP2566473B1 (en) *	2010-05-06	2016-01-06	Novartis AG	Dosage regimen of diaryl sulfide derivatives

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5141421A (en) *	1991-12-17	1992-08-25	Carrier Corporation	Nested coupling mechanism for scroll machines
DE4428835A1 (de) *	1994-08-01	1996-02-08	Schering Ag	Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
SI0990440T1 (sl) *	1997-02-27	2009-04-30	Novartis Ag	Farmacevtski sestavek, ki obsega 2-amino-2-(2-(4-oktilfenil)etil)propan-1,3-diol, lecitin in saharid
WO2003029184A1 (en)	2001-09-27	2003-04-10	Kyorin Pharmaceutical Co., Ltd.	Diaryl ether derivative, addition salt thereof, and immunosuppressant
CN1329372C (zh) *	2001-09-27	2007-08-01	杏林制药株式会社	二芳基硫醚衍生物及其加成盐和免疫抑制剂
KR101003877B1 (ko) *	2002-09-19	2010-12-30	교린 세이야꾸 가부시키 가이샤	아미노알코올 유도체와 그 부가염 및 면역 억제제
CN102526079B (zh) *	2002-09-24	2014-06-18	诺华股份有限公司	治疗脱髓鞘疾病的鞘氨醇-1-磷酸受体激动剂
CA2499977A1 (en) *	2002-09-28	2004-04-08	Mcneil-Ppc, Inc.	Edible solid composition and dosage form
EP1602660B1 (en)	2003-02-18	2011-04-06	Kyorin Pharmaceutical Co., Ltd.	Aminophosphonic acid derivatives, addition salts thereof and s1p receptor modulators
EP2008650A3 (en) *	2003-04-08	2011-04-27	Novartis AG	Solid oral composition comprising a S 1 P receptor agonist and a sugar alcohol
WO2005014525A2 (en) *	2003-08-12	2005-02-17	Mitsubishi Pharma Corporation	Bi-aryl compound having immunosuppressive activity
BRPI0413151A (pt) *	2003-08-28	2006-10-03	Novartis Ag	derivados de amino propanol
PT1772145E (pt) *	2004-07-16	2011-05-27	Kyorin Seiyaku Kk	Processo de utiliza??o eficaz de um medicamento e processo respeitante ? preven??o de efeitos secund?rios
CN102600472A (zh) *	2004-11-29	2012-07-25	诺瓦提斯公司	S1p受体激动剂的剂量方案
GB0504544D0 (en) *	2005-03-04	2005-04-13	Novartis Ag	Organic compounds

2006
- 2006-09-07 MX MX2008003170A patent/MX2008003170A/es active IP Right Grant
- 2006-09-07 JP JP2008529636A patent/JP5244598B2/ja active Active
- 2006-09-07 JO JO2006298A patent/JO2655B1/en active
- 2006-09-07 KR KR1020147026128A patent/KR20140117704A/ko not_active Ceased
- 2006-09-07 WO PCT/EP2006/066150 patent/WO2007028821A2/en not_active Ceased
- 2006-09-07 SI SI200630937T patent/SI1926483T1/sl unknown
- 2006-09-07 PL PL06793341T patent/PL1926483T3/pl unknown
- 2006-09-07 EP EP06793341A patent/EP1926483B1/en active Active
- 2006-09-07 NZ NZ588372A patent/NZ588372A/en not_active IP Right Cessation
- 2006-09-07 DE DE602006018629T patent/DE602006018629D1/de active Active
- 2006-09-07 CN CN2006800328984A patent/CN101257899B/zh not_active Expired - Fee Related
- 2006-09-07 CA CA2620554A patent/CA2620554C/en not_active Expired - Fee Related
- 2006-09-07 DK DK06793341.6T patent/DK1926483T3/da active
- 2006-09-07 CA CA2820510A patent/CA2820510A1/en not_active Abandoned
- 2006-09-07 DK DK10174280.7T patent/DK2295049T3/en active
- 2006-09-07 BR BRPI0615906-0A patent/BRPI0615906A2/pt not_active IP Right Cessation
- 2006-09-07 NZ NZ566137A patent/NZ566137A/en not_active IP Right Cessation
- 2006-09-07 EP EP10174280.7A patent/EP2295049B1/en not_active Not-in-force
- 2006-09-07 SI SI200631889T patent/SI2295049T1/sl unknown
- 2006-09-07 ES ES06793341T patent/ES2357426T3/es active Active
- 2006-09-07 PT PT10174280T patent/PT2295049E/pt unknown
- 2006-09-07 ES ES10174280.7T patent/ES2529724T3/es active Active
- 2006-09-07 AU AU2006289100A patent/AU2006289100B2/en not_active Ceased
- 2006-09-07 SG SG201006580-3A patent/SG165364A1/en unknown
- 2006-09-07 PT PT06793341T patent/PT1926483E/pt unknown
- 2006-09-07 RU RU2011111117/15A patent/RU2493840C2/ru not_active IP Right Cessation
- 2006-09-07 KR KR1020147001496A patent/KR101476591B1/ko not_active Expired - Fee Related
- 2006-09-07 RU RU2008113187/15A patent/RU2424795C2/ru not_active IP Right Cessation
- 2006-09-07 PL PL10174280T patent/PL2295049T3/pl unknown
- 2006-09-07 AT AT06793341T patent/ATE489948T1/de active
- 2006-09-07 US US12/065,096 patent/US20080200438A1/en not_active Abandoned
- 2006-09-08 TW TW095133326A patent/TWI376223B/zh active
- 2006-09-08 TW TW099117063A patent/TWI372620B/zh not_active IP Right Cessation
2008
- 2008-02-21 ZA ZA200801694A patent/ZA200801694B/xx unknown
- 2008-02-21 IL IL189665A patent/IL189665A/en not_active IP Right Cessation
- 2008-03-06 TN TNP2008000103A patent/TNSN08103A1/en unknown
- 2008-03-17 MA MA30758A patent/MA29787B1/fr unknown
- 2008-04-07 NO NO20081727A patent/NO20081727L/no not_active Application Discontinuation
- 2008-04-08 KR KR1020087008413A patent/KR101476451B1/ko not_active Expired - Fee Related
2010
- 2010-09-21 AU AU2010224355A patent/AU2010224355B2/en not_active Ceased
2011
- 2011-03-01 CY CY20111100242T patent/CY1111285T1/el unknown
2012
- 2012-10-17 JP JP2012230044A patent/JP6077265B2/ja not_active Expired - Fee Related
2014
- 2014-06-23 IL IL233328A patent/IL233328A0/en unknown
- 2014-09-29 JP JP2014199069A patent/JP2015025002A/ja not_active Withdrawn
2016
- 2016-09-30 JP JP2016193400A patent/JP2017019854A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
IL189665A0 (en)	2008-06-05
HK1149906A1 (zh)	2011-10-21
DK2295049T3 (en)	2015-02-23
JP5244598B2 (ja)	2013-07-24
KR20140019033A (ko)	2014-02-13
JP2017019854A (ja)	2017-01-26
WO2007028821A2 (en)	2007-03-15
BRPI0615906A2 (pt)	2011-05-31
CA2620554A1 (en)	2007-03-15
CN101257899A (zh)	2008-09-03
PL2295049T3 (pl)	2015-04-30
JP2015025002A (ja)	2015-02-05
DK1926483T3 (da)	2011-03-14
DE602006018629D1 (de)	2011-01-13
JP2009507810A (ja)	2009-02-26
RU2011111117A (ru)	2012-09-27
TNSN08103A1 (en)	2009-07-14
NZ566137A (en)	2011-05-27
RU2493840C2 (ru)	2013-09-27
JP6077265B2 (ja)	2017-02-08
IL189665A (en)	2014-07-31
KR20080046231A (ko)	2008-05-26
AU2006289100B2 (en)	2010-07-22
KR20140117704A (ko)	2014-10-07
NZ588372A (en)	2012-03-30
ES2357426T3 (es)	2011-04-26
NO20081727L (no)	2008-06-06
MA29787B1 (fr)	2008-09-01
TW200803829A (en)	2008-01-16
JP2013010802A (ja)	2013-01-17
AU2010224355B2 (en)	2012-03-29
ATE489948T1 (de)	2010-12-15
KR101476591B1 (ko)	2014-12-24
US20080200438A1 (en)	2008-08-21
KR101476451B1 (ko)	2014-12-24
ES2529724T3 (es)	2015-02-25
RU2424795C2 (ru)	2011-07-27
MX2008003170A (es)	2008-03-18
CN101257899B (zh)	2012-10-03
PT2295049E (pt)	2015-03-02
IL233328A0 (en)	2014-08-31
SI2295049T1 (sl)	2015-03-31
ZA200801694B (en)	2009-09-30
WO2007028821A3 (en)	2007-05-03
RU2008113187A (ru)	2009-10-20
EP2295049B1 (en)	2014-11-26
AU2010224355A1 (en)	2010-10-14
JO2655B1 (en)	2012-06-17
PL1926483T3 (pl)	2011-05-31
PT1926483E (pt)	2011-03-03
EP1926483B1 (en)	2010-12-01
CA2620554C (en)	2013-12-17
CY1111285T1 (el)	2015-08-05
SI1926483T1 (sl)	2011-04-29
EP1926483A2 (en)	2008-06-04
SG165364A1 (en)	2010-10-28
TWI376223B (en)	2012-11-11
AU2006289100A1 (en)	2007-03-15
CA2820510A1 (en)	2007-03-15
TW201034659A (en)	2010-10-01
EP2295049A1 (en)	2011-03-16

Publication	Publication Date	Title
IL233328A0 (en)	2014-08-31	Treatment of autoimmune diseases
TW200509892A (en)	2005-03-16	Novel aminobenzophenone compounds
WO2005032471A3 (en)	2005-07-07	Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
WO2007022470A3 (en)	2007-06-14	Methods and compositions for treating neurological disease
WO2006058868A8 (de)	2007-01-18	Substituierte pteridine zur behandlung von entzündlichen erkrankungen
TW200806325A (en)	2008-02-01	Therapeutic uses of inhibitors of RTP801
WO2005051914A8 (en)	2005-08-11	Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
MX2011012015A (es)	2012-04-30	Tratamiento de deterioro cognitivo leve y enfermedad de alzheimer.
PL1910338T3 (pl)	2011-02-28	Związki heterotetracykliczne jako mimetyki TPO
WO2006058867A3 (de)	2006-10-26	Substituierte pteridine zur behandlung von entzündlichen erkrankungen
UA90698C2 (en)	2010-05-25	Triazole substituted aminobenzophenone compounds
TW200635597A (en)	2006-10-16	Substituted pteridines for the treatment of inflammatory diseases
WO2006078576A3 (en)	2006-10-05	Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
MX2008002166A (es)	2008-04-22	Compuestos y composiciones como mimeticos de trombopoietina (tpo).
BR0306855A (pt)	2005-04-05	Método para o tratamento de distúrbios cognitivos
WO2007058862A3 (en)	2007-10-11	Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
TW200633711A (en)	2006-10-01	Substituted pteridines for the treatment of inflammatory diseases
IL181713A0 (en)	2008-03-20	Use of il-17f for the treatment and/or prevention of neurological diseases
WO2007019080A3 (en)	2008-01-17	Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease
TW200603791A (en)	2006-02-01	Compounds and compositions as cathepsin S inhibitors
CY1116051T1 (el)	2017-02-08	Θεραπεια αυτοανοσων ασθενειων
TW200628453A (en)	2006-08-16	Triazole substituted aminobenzophenone compounds
BRPI0402756A (pt)	2006-02-21	método para o tratamento de distúrbios cognitivos
MX2007003281A (es)	2007-05-18	N-etilhidroxietilamina util en el tratamiento de afecciones del sistema nervioso central.

Legal Events

Date	Code	Title	Description
2016-06-21	MM4A	Annulment or lapse of patent due to non-payment of fees