TW201836611A - 含有他氟前列素及檸檬酸酯之緩釋劑 - Google Patents

含有他氟前列素及檸檬酸酯之緩釋劑 Download PDF

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Publication number: TW201836611A
Authority: TW; Taiwan
Prior art keywords: sustained; citrate; tafluprost; release agent; trialkyl
Prior art date: 2016-12-26

Application number

TW106145532A

Other languages

English (en)

Chinese (zh)

Inventor

宮崎達也

眞崎賢治

高橋恭平

山田和人

Original Assignee

日商參天製藥股份有限公司

日商旭硝子股份有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-12-26

Filing date

2017-12-25

Publication date

2018-10-16

2017-12-25 Application filed by 日商參天製藥股份有限公司, 日商旭硝子股份有限公司 filed Critical 日商參天製藥股份有限公司

2018-10-16 Publication of TW201836611A publication Critical patent/TW201836611A/zh

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HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000010352 sodium erythorbate Nutrition 0.000 description 1
239000004320 sodium erythorbate Substances 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
235000011008 sodium phosphates Nutrition 0.000 description 1
229940001482 sodium sulfite Drugs 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
239000001433 sodium tartrate Substances 0.000 description 1
229960002167 sodium tartrate Drugs 0.000 description 1
235000011004 sodium tartrates Nutrition 0.000 description 1
239000004328 sodium tetraborate Substances 0.000 description 1
RBWSWDPRDBEWCR-RKJRWTFHSA-N sodium;(2r)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethanolate Chemical compound [Na+].[O-]C[C@@H](O)[C@H]1OC(=O)C(O)=C1O RBWSWDPRDBEWCR-RKJRWTFHSA-N 0.000 description 1
239000012453 solvate Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
235000019337 sorbitan trioleate Nutrition 0.000 description 1
229960000391 sorbitan trioleate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
150000003900 succinic acid esters Chemical class 0.000 description 1
229940013883 sucrose octaacetate Drugs 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
238000010998 test method Methods 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
229940042585 tocopherol acetate Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000007680 β-tocopherol Nutrition 0.000 description 1
239000011590 β-tocopherol Substances 0.000 description 1
239000002478 γ-tocopherol Substances 0.000 description 1
QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
239000002446 δ-tocopherol Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Ophthalmology & Optometry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dispersion Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

TW106145532A 2016-12-26 2017-12-25 含有他氟前列素及檸檬酸酯之緩釋劑 TW201836611A (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2016251626A JP2020059652A (ja)	2016-12-26	2016-12-26	タフルプロストとクエン酸エステルとを含有するデポ剤
JPJP2016-251626		2016-12-26

Publications (1)

Publication Number	Publication Date
TW201836611A true TW201836611A (zh)	2018-10-16

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TW106145532A TW201836611A (zh)	2016-12-26	2017-12-25	含有他氟前列素及檸檬酸酯之緩釋劑

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Country	Link
JP (1)	JP2020059652A (fr)
TW (1)	TW201836611A (fr)
WO (1)	WO2018123945A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20230103591A1 (en)	2020-03-30	2023-04-06	Nitto Denko Corporation	Conductive composition, biomedical electrode, and biomedical sensor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6960346B2 (en) *	2002-05-09	2005-11-01	University Of Tennessee Research Foundation	Vehicles for delivery of biologically active substances
EP2127638A1 (fr) *	2008-05-30	2009-12-02	Santen Pharmaceutical Co., Ltd	Procédé et composition pour traiter l'hypertension oculaire et le glaucome
ES2902951T3 (es) *	2013-05-24	2022-03-30	Icon Bioscience Inc	Uso de dexametasona de liberación sostenida en la inflamación después de cirugía de cataratas
HK1249443A1 (en) *	2015-07-01	2018-11-02	Santen Pharmaceutical Co., Ltd	Depot preparation containing citric acid ester

2016
- 2016-12-26 JP JP2016251626A patent/JP2020059652A/ja active Pending
2017
- 2017-12-25 WO PCT/JP2017/046379 patent/WO2018123945A1/fr not_active Ceased
- 2017-12-25 TW TW106145532A patent/TW201836611A/zh unknown

Also Published As

Publication number	Publication date
WO2018123945A1 (fr)	2018-07-05
JP2020059652A (ja)	2020-04-16

Publication	Publication Date	Title
JP6955604B2 (ja)	2021-10-27	徐放性医薬組成物
JP6872322B2 (ja)	2021-05-19	クエン酸エステルを含有するデポ剤
JP6934581B2 (ja)	2021-09-15	エピナスチン又はその塩を含有する水性医薬組成物
WO2018033854A1 (fr)	2018-02-22	Composition ophtalmique et procédé de traitement de l'hypertension oculaire et du glaucome
KR20160060656A (ko)	2016-05-30	폴리에틸렌글리콜 함유 조성물
MD3593788T2 (ro)	2021-03-31	Compoziții oftalmice care conțin un azot care eliberează prostamidă
TWI794140B (zh)	2023-03-01	含有吡啶基胺基乙酸化合物之預防及/或治療劑
TW201836611A (zh)	2018-10-16	含有他氟前列素及檸檬酸酯之緩釋劑
JP6474913B2 (ja)	2019-02-27	外用剤
JP6963651B2 (ja)	2021-11-10	エピナスチン又はその塩を含有する水性組成物
TWI677346B (zh)	2019-11-21	含有多肽之醫藥組成物
KR102901189B1 (ko)	2025-12-16	피리딜아미노아세트산 화합물을 함유하는 의약 제제
HK1246167A1 (en)	2018-09-07	Depot preparation containing citric acid ester
HK1246167B (zh)	2022-07-08	含有柠檬酸酯的贮库制剂