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TW200633980A - Pyridones useful as inhibitors of kinases - Google Patents

Pyridones useful as inhibitors of kinases

Info

Publication number
TW200633980A
TW200633980A TW094144949A TW94144949A TW200633980A TW 200633980 A TW200633980 A TW 200633980A TW 094144949 A TW094144949 A TW 094144949A TW 94144949 A TW94144949 A TW 94144949A TW 200633980 A TW200633980 A TW 200633980A
Authority
TW
Taiwan
Prior art keywords
inhibitors
kinases
compounds
useful
pyridones useful
Prior art date
Application number
TW094144949A
Other languages
English (en)
Inventor
Jean-Damien Charrier
Steven Durrant
Sharn Ramaya
Juan-Miguel Jimenez
Alistair Rutherford
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of TW200633980A publication Critical patent/TW200633980A/zh

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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JP2013213046A (ja) 2013-10-17
US20060183911A1 (en) 2006-08-17
RU2423351C2 (ru) 2011-07-10
KR20070095952A (ko) 2007-10-01
US20130184259A1 (en) 2013-07-18
AU2005316540A1 (en) 2006-06-22
EP1831168A1 (en) 2007-09-12
WO2006065946A1 (en) 2006-06-22
NO20073628L (no) 2007-07-16
RU2007126832A (ru) 2009-03-27
US8101770B2 (en) 2012-01-24
MX2007007330A (es) 2007-10-04
US20120190699A1 (en) 2012-07-26
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US8338597B2 (en) 2012-12-25
CA2591413A1 (en) 2006-06-22

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