TW200302094A - 3 - (imidazolyl) -2- alkoxypropanoic acids - Google Patents

3 - (imidazolyl) -2- alkoxypropanoic acids Download PDF

Info

Publication number: TW200302094A
Authority: TW; Taiwan
Prior art keywords: compound; group; hydrogen; formula; optionally substituted
Prior art date: 2002-01-22

Application number

TW092100889A

Other languages

English (en)

Chinese (zh)

Inventor

Charlotte Moira Norfor Allerton

David John Bull

Mark Edward Bunnage

Robert John Maguire

John Steele

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-22

Filing date

2003-01-16

Publication date

2003-08-01

2002-01-22 Priority claimed from GB0201389A external-priority patent/GB0201389D0/en

2002-01-29 Priority claimed from GB0202027A external-priority patent/GB0202027D0/en

2003-01-16 Application filed by Pfizer filed Critical Pfizer

2003-08-01 Publication of TW200302094A publication Critical patent/TW200302094A/zh

Links

239000002253 acid Substances 0.000 title description 19
125000002883 imidazolyl group Chemical group 0.000 title description 10
150000007513 acids Chemical class 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 393
-1 Aromatic heterocycle Chemical group 0.000 claims abstract description 79
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 79
239000001257 hydrogen Substances 0.000 claims abstract description 77
238000011282 treatment Methods 0.000 claims abstract description 47
125000003118 aryl group Chemical group 0.000 claims abstract description 41
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 40
125000000623 heterocyclic group Chemical group 0.000 claims abstract description 20
125000002947 alkylene group Chemical group 0.000 claims abstract description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 143
229910001868 water Inorganic materials 0.000 claims description 133
238000000034 method Methods 0.000 claims description 115
150000003839 salts Chemical class 0.000 claims description 49
125000000217 alkyl group Chemical group 0.000 claims description 47
208000007536 Thrombosis Diseases 0.000 claims description 44
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 39
229910052736 halogen Inorganic materials 0.000 claims description 39
150000002367 halogens Chemical class 0.000 claims description 39
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 38
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 37
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 35
238000004519 manufacturing process Methods 0.000 claims description 29
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 27
125000001188 haloalkyl group Chemical group 0.000 claims description 25
239000003814 drug Substances 0.000 claims description 20
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
239000000460 chlorine Substances 0.000 claims description 18
125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 17
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201000010099 disease Diseases 0.000 claims description 15
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 13
239000001301 oxygen Substances 0.000 claims description 13
229910052760 oxygen Inorganic materials 0.000 claims description 13
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 12
229910052717 sulfur Inorganic materials 0.000 claims description 12
239000011593 sulfur Substances 0.000 claims description 12
125000000753 cycloalkyl group Chemical group 0.000 claims description 11
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QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims description 9
230000008901 benefit Effects 0.000 claims description 8
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
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208000035475 disorder Diseases 0.000 claims description 4
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DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 4
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102100035792 Kininogen-1 Human genes 0.000 claims 2
150000002431 hydrogen Chemical group 0.000 claims 2
LVCATUGNENEDGZ-ZDUSSCGKSA-N (2s)-2-(2-aminoethoxy)-3-(1-phenylimidazol-4-yl)propanoic acid Chemical compound C1=NC(C[C@H](OCCN)C(O)=O)=CN1C1=CC=CC=C1 LVCATUGNENEDGZ-ZDUSSCGKSA-N 0.000 claims 1
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XOCUXOWLYLLJLV-UHFFFAOYSA-N [O].[S] Chemical compound [O].[S] XOCUXOWLYLLJLV-UHFFFAOYSA-N 0.000 claims 1
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CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 88
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JAELLLITIZHOGQ-UHFFFAOYSA-N tert-butyl propanoate Chemical compound CCC(=O)OC(C)(C)C JAELLLITIZHOGQ-UHFFFAOYSA-N 0.000 description 1
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UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

TW092100889A 2002-01-22 2003-01-16 3 - (imidazolyl) -2- alkoxypropanoic acids TW200302094A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0201389A GB0201389D0 (en)	2002-01-22	2002-01-22	3-(imidazolyl)-2-alkoxypropanoic acids
GB0202027A GB0202027D0 (en)	2002-01-29	2002-01-29	3-(imidazolyl)-2-alkoxypropanoic acids

Publications (1)

Publication Number	Publication Date
TW200302094A true TW200302094A (en)	2003-08-01

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ID=27614792

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW092100889A TW200302094A (en)	2002-01-22	2003-01-16	3 - (imidazolyl) -2- alkoxypropanoic acids

Country Status (24)

Country	Link
EP (1)	EP1467731A1 (fr)
JP (1)	JP2005520811A (fr)
KR (1)	KR20040077775A (fr)
CN (1)	CN1620291A (fr)
AP (1)	AP2004003084A0 (fr)
AR (1)	AR038197A1 (fr)
BR (1)	BR0307016A (fr)
CA (1)	CA2472238A1 (fr)
EA (1)	EA200400716A1 (fr)
EC (1)	ECSP045200A (fr)
HR (1)	HRP20040659A2 (fr)
IL (1)	IL162677A0 (fr)
IS (1)	IS7310A (fr)
MA (1)	MA27167A1 (fr)
MX (1)	MXPA04006573A (fr)
NO (1)	NO20043457L (fr)
OA (1)	OA12756A (fr)
PA (1)	PA8563501A1 (fr)
PE (1)	PE20030929A1 (fr)
PL (1)	PL371487A1 (fr)
TN (1)	TNSN04121A1 (fr)
TW (1)	TW200302094A (fr)
UY (1)	UY27615A1 (fr)
WO (1)	WO2003061652A1 (fr)

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WO2005051384A1 (fr) *	2003-11-25	2005-06-09	Pfizer Limited	Compositions pharmaceutiques stabilisees
CA2604912A1 (fr) *	2005-04-18	2006-10-26	Bayer Schering Pharma Aktiengesellschaft	Utilisation d'inhibiteurs de tafi pour ameliorer la reperfusion myocardique et faciliter la pci
JPWO2010050525A1 (ja)	2008-10-29	2012-03-29	大正製薬株式会社	ＴＡＦＩａ阻害活性を有する化合物
CA2745121A1 (fr) *	2008-12-05	2010-06-10	Mochida Pharmaceutical Co., Ltd.	Composes de morpholinone en tant qu'inhibiteurs de facteur ixa
US8987242B2 (en)	2008-12-05	2015-03-24	Merck Sharp & Dohme Corp.	Morpholinone compounds as factor IXA inhibitors
EP2548872B1 (fr)	2010-03-18	2016-09-28	Daiichi Sankyo Company, Limited	Dérivé d'acide cyclopropanecarboxylique
ES2643132T3 (es) *	2010-03-18	2017-11-21	Daiichi Sankyo Company, Limited	Derivado de imidazol cicloalquilo sustituido
BR112015029667A2 (pt)	2013-06-10	2017-07-25	Sanofi Sa	derivados de ureia macrocíclica como inibidores de tafia, sua preparação e seus usos como produtos farmacêuticos
US20190117624A1 (en)	2016-03-29	2019-04-25	Daiichi Sankyo Company, Limited	Therapeutic agent for inflammatory bowel diseases
CA3075892C (fr)	2017-09-14	2024-01-23	Daiichi Sankyo Company, Limited	Composes heterocycliques pour le traitement et/ou la prevention des maladies inflammatoires

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9901572D0 (sv) *	1999-05-03	1999-05-03	Astra Ab	New compounds
HRP20030103A2 (en) *	2000-08-17	2003-04-30	Pfizer	Substituted imidazoles as tafia inhibitors

2003
- 2003-01-10 IL IL16267703A patent/IL162677A0/xx unknown
- 2003-01-10 OA OA1200400190A patent/OA12756A/en unknown
- 2003-01-10 AP APAP/P/2004/003084A patent/AP2004003084A0/en unknown
- 2003-01-10 JP JP2003561596A patent/JP2005520811A/ja active Pending
- 2003-01-10 WO PCT/IB2003/000060 patent/WO2003061652A1/fr not_active Ceased
- 2003-01-10 EP EP03700059A patent/EP1467731A1/fr not_active Withdrawn
- 2003-01-10 PL PL03371487A patent/PL371487A1/xx unknown
- 2003-01-10 CN CNA03802599XA patent/CN1620291A/zh active Pending
- 2003-01-10 HR HR20040659A patent/HRP20040659A2/hr not_active Application Discontinuation
- 2003-01-10 KR KR10-2004-7011370A patent/KR20040077775A/ko not_active Ceased
- 2003-01-10 CA CA002472238A patent/CA2472238A1/fr not_active Abandoned
- 2003-01-10 EA EA200400716A patent/EA200400716A1/ru unknown
- 2003-01-10 MX MXPA04006573A patent/MXPA04006573A/es unknown
- 2003-01-10 BR BR0307016-6A patent/BR0307016A/pt not_active IP Right Cessation
- 2003-01-16 TW TW092100889A patent/TW200302094A/zh unknown
- 2003-01-17 PE PE2003000058A patent/PE20030929A1/es not_active Application Discontinuation
- 2003-01-20 UY UY27615A patent/UY27615A1/es not_active Application Discontinuation
- 2003-01-21 AR ARP030100165A patent/AR038197A1/es unknown
- 2003-01-22 PA PA20038563501A patent/PA8563501A1/es unknown
2004
- 2004-06-14 IS IS7310A patent/IS7310A/is unknown
- 2004-06-30 TN TNP2004000121A patent/TNSN04121A1/en unknown
- 2004-07-15 MA MA27786A patent/MA27167A1/fr unknown
- 2004-07-22 EC EC2004005200A patent/ECSP045200A/es unknown
- 2004-08-19 NO NO20043457A patent/NO20043457L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR0307016A (pt)	2004-11-03
UY27615A1 (es)	2003-08-29
AP2004003084A0 (en)	2004-09-30
AR038197A1 (es)	2005-01-05
EP1467731A1 (fr)	2004-10-20
ECSP045200A (es)	2004-08-27
JP2005520811A (ja)	2005-07-14
MXPA04006573A (es)	2004-10-04
IL162677A0 (en)	2005-11-20
IS7310A (is)	2004-06-14
MA27167A1 (fr)	2005-01-03
KR20040077775A (ko)	2004-09-06
CA2472238A1 (fr)	2003-07-31
EA200400716A1 (ru)	2004-12-30
PE20030929A1 (es)	2003-11-05
PL371487A1 (en)	2005-06-13
TNSN04121A1 (en)	2006-06-01
NO20043457L (no)	2004-08-19
WO2003061652A8 (fr)	2004-09-10
HRP20040659A2 (en)	2004-10-31
PA8563501A1 (es)	2004-08-31
WO2003061652A1 (fr)	2003-07-31
OA12756A (en)	2006-07-03
CN1620291A (zh)	2005-05-25

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