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TR200603871T2 - Aspartil proteaz inhibitörleri. - Google Patents

Aspartil proteaz inhibitörleri.

Info

Publication number
TR200603871T2
TR200603871T2 TR2006/03871T TR200603871T TR200603871T2 TR 200603871 T2 TR200603871 T2 TR 200603871T2 TR 2006/03871 T TR2006/03871 T TR 2006/03871T TR 200603871 T TR200603871 T TR 200603871T TR 200603871 T2 TR200603871 T2 TR 200603871T2
Authority
TR
Turkey
Prior art keywords
hiv
present
aspartyl protease
compounds
relates
Prior art date
Application number
TR2006/03871T
Other languages
English (en)
Inventor
Robin Hale Michael
Tung Roger
Price Stephen
David Wilkes Robin
Carl Schairer Wayne
Nicholas Jarvis Ashley
Spaltenstein Andrew
Steven Furfine Eric
Samano Vicente
Kaldor Istvan
Franklin Miller John
Stephen Brieger Michael
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of TR200603871T2 publication Critical patent/TR200603871T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Bu buluş, aspartil proteaz inhibitörleri olan yeni bir sülfonamidler sınıfı ile ilgilidir. Bu buluşbir şıkkında, spesifik yapısal ve fizikokimyasal özelliklere sahip olması ile tanımlanan yeni bir HIV aspartil proteaz inhibitörleri sınıfı ile ilgilidir. Bu buluş ayrıca, bu bileşikleri ihtiva eden farmasötik terkiplerle ilgilidir. Bu buluşa ait bileşikler ve terkipler, HIV-1 ve HIV-2 proteaz aktıvitesını inhibe etmek için özellikle uygundurlar ve bunun sonucu olarak, HIV-1 ve HIV-2 virüslerine karşı, yararlı bir şekilde anti virütik maddeler olarak kullanılabilirler. Bu buluş ayrıca, bu buluşa ait bileşikleri kullanarak HIV aspartil proteaz aktivıtesinı inhibe etmek için yöntemler ve bileşikleri, anti-HIV aktivitesi açısından taramak için yöntemlerle de ilgilidir.
TR2006/03871T 1999-06-11 2000-06-08 Aspartil proteaz inhibitörleri. TR200603871T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13907099P 1999-06-11 1999-06-11
US19021100P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
TR200603871T2 true TR200603871T2 (tr) 2007-01-22

Family

ID=26836833

Family Applications (3)

Application Number Title Priority Date Filing Date
TR2006/03871T TR200603871T2 (tr) 1999-06-11 2000-06-08 Aspartil proteaz inhibitörleri.
TR2002/00407T TR200200407T2 (tr) 1999-06-11 2000-06-08 Aspartil proteaz inhibitörleri
TR2002/02528T TR200202528T2 (tr) 1999-06-11 2000-06-08 Aspartil proteaz inhibitörleri

Family Applications After (2)

Application Number Title Priority Date Filing Date
TR2002/00407T TR200200407T2 (tr) 1999-06-11 2000-06-08 Aspartil proteaz inhibitörleri
TR2002/02528T TR200202528T2 (tr) 1999-06-11 2000-06-08 Aspartil proteaz inhibitörleri

Country Status (31)

Country Link
EP (2) EP1194404B1 (tr)
JP (2) JP4503896B2 (tr)
KR (1) KR100762188B1 (tr)
CN (2) CN100516034C (tr)
AR (1) AR031520A1 (tr)
AT (2) ATE534622T1 (tr)
AU (1) AU779994B2 (tr)
BR (1) BR0011745A (tr)
CA (1) CA2380858C (tr)
CO (1) CO5160337A1 (tr)
CY (1) CY1112632T1 (tr)
CZ (1) CZ303052B6 (tr)
DE (1) DE60027722T2 (tr)
DK (2) DK1686113T3 (tr)
ES (2) ES2375823T3 (tr)
HK (1) HK1046899B (tr)
HU (1) HUP0300385A3 (tr)
IL (3) IL146918A0 (tr)
MX (1) MXPA01012808A (tr)
MY (1) MY137777A (tr)
NO (1) NO323951B1 (tr)
NZ (1) NZ516003A (tr)
PE (1) PE20010230A1 (tr)
PL (1) PL210227B1 (tr)
PT (2) PT1194404E (tr)
SI (1) SI1194404T1 (tr)
TN (1) TNSN00129A1 (tr)
TR (3) TR200603871T2 (tr)
TW (3) TWI318116B (tr)
WO (1) WO2000076961A1 (tr)
ZA (1) ZA200110177B (tr)

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Also Published As

Publication number Publication date
KR100762188B1 (ko) 2007-10-04
NO323951B1 (no) 2007-07-23
TNSN00129A1 (fr) 2005-11-10
EP1194404A1 (en) 2002-04-10
HUP0300385A2 (hu) 2003-07-28
AR031520A1 (es) 2003-09-24
MY137777A (en) 2009-03-31
ZA200110177B (en) 2003-01-13
KR20020033642A (ko) 2002-05-07
NZ516003A (en) 2004-02-27
PT1686113E (pt) 2012-02-20
PT1194404E (pt) 2006-08-31
WO2000076961A1 (en) 2000-12-21
IL202633A (en) 2013-02-28
TW593248B (en) 2004-06-21
DK1686113T3 (da) 2012-02-20
TR200200407T2 (tr) 2002-08-21
CN100516034C (zh) 2009-07-22
CA2380858A1 (en) 2000-12-21
ES2263478T3 (es) 2006-12-16
ATE325091T1 (de) 2006-06-15
JP2003502309A (ja) 2003-01-21
HK1046899B (en) 2007-03-02
AU779994B2 (en) 2005-02-24
MXPA01012808A (es) 2002-07-22
IL146918A0 (en) 2002-08-14
HK1046899A1 (en) 2003-01-30
JP2009046493A (ja) 2009-03-05
DE60027722T2 (de) 2007-04-26
CO5160337A1 (es) 2002-05-30
TW200804252A (en) 2008-01-16
TR200202528T2 (tr) 2003-02-21
IL202633A0 (en) 2010-06-30
JP4503896B2 (ja) 2010-07-14
PE20010230A1 (es) 2001-03-15
CZ20014431A3 (cs) 2002-06-12
IL146918A (en) 2010-06-16
AU5600600A (en) 2001-01-02
HUP0300385A3 (en) 2007-05-29
CA2380858C (en) 2011-12-06
PL352830A1 (en) 2003-09-08
TWI318116B (en) 2009-12-11
DE60027722D1 (en) 2006-06-08
BR0011745A (pt) 2002-03-19
PL210227B1 (pl) 2011-12-30
EP1686113B1 (en) 2011-11-23
EP1686113A1 (en) 2006-08-02
TW200425891A (en) 2004-12-01
TWI299000B (en) 2008-07-21
DK1194404T3 (da) 2006-09-04
NO20016034L (no) 2002-01-18
NO20016034D0 (no) 2001-12-10
CZ303052B6 (cs) 2012-03-14
CY1112632T1 (el) 2016-02-10
ES2375823T3 (es) 2012-03-06
ATE534622T1 (de) 2011-12-15
EP1194404B1 (en) 2006-05-03
CN1361765A (zh) 2002-07-31
SI1194404T1 (sl) 2006-10-31
CN101245058A (zh) 2008-08-20

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