[go: up one dir, main page]

TR200400611T4 - Sitalopramın preparasyon metodu - Google Patents

Sitalopramın preparasyon metodu

Info

Publication number
TR200400611T4
TR200400611T4 TR2004/00611T TR200400611T TR200400611T4 TR 200400611 T4 TR200400611 T4 TR 200400611T4 TR 2004/00611 T TR2004/00611 T TR 2004/00611T TR 200400611 T TR200400611 T TR 200400611T TR 200400611 T4 TR200400611 T4 TR 200400611T4
Authority
TR
Turkey
Prior art keywords
group
cyano
converting
cor
alkyl
Prior art date
Application number
TR2004/00611T
Other languages
English (en)
Inventor
Petersen Hans
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Publication of TR200400611T4 publication Critical patent/TR200400611T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Bulus, herhangi bir sirayla, Y'nin bir siyano grubu veya bir siyano grubuna dönüstürülebilen bir grup oldugu, R'nin hidrojen, -O-R1, NH2, NHCH3 veya -N(CH3)2(R1, hidrojen, alkil, alkenil, alkinil ve istege göre alkille ikame edilen aril veya aralkilden seçilir) oldugu bir formül (III) bilesiginin, i) -CH=CH-COR formülünün yan zincirinde çifli bag indirgemesine tabi tutulmasini; ii) -COR grubunun veya bunun indirgenmis bir formunun, bir dimetilaminemetil grubuna dönüstürülmesini; ve iii) Y'nin siyano olmamasi durumunda Y grubunun bir siyano grubuna dönüstürülmesini; bunu takiben sitalopram bazinin veya bunun farmasötik açidan kabul gören asit ilaveli bir tuzunun izole edilmesini kapsayan bir preparasyon metodu ile ilgilidir.
TR2004/00611T 2000-03-14 2001-03-09 Sitalopramın preparasyon metodu TR200400611T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200000415 2000-03-14

Publications (1)

Publication Number Publication Date
TR200400611T4 true TR200400611T4 (tr) 2004-04-21

Family

ID=8159331

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2004/00611T TR200400611T4 (tr) 2000-03-14 2001-03-09 Sitalopramın preparasyon metodu
TR2002/02155T TR200202155T2 (tr) 2000-03-14 2001-03-09 Sitalopramin preparasyon metodu

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2002/02155T TR200202155T2 (tr) 2000-03-14 2001-03-09 Sitalopramin preparasyon metodu

Country Status (26)

Country Link
US (1) US6806376B2 (tr)
EP (1) EP1265882B1 (tr)
JP (1) JP2003527386A (tr)
KR (1) KR20020080476A (tr)
CN (1) CN1418205A (tr)
AT (1) ATE257832T1 (tr)
AU (1) AU2001239213A1 (tr)
BG (1) BG107051A (tr)
BR (1) BR0109268A (tr)
CA (1) CA2402557A1 (tr)
DE (1) DE60101786T2 (tr)
DK (1) DK1265882T3 (tr)
EA (1) EA005094B1 (tr)
ES (1) ES2214400T3 (tr)
HR (1) HRP20020740A2 (tr)
HU (1) HUP0300178A2 (tr)
IL (1) IL151488A0 (tr)
IS (1) IS6527A (tr)
MX (1) MXPA02008653A (tr)
NO (1) NO20024198D0 (tr)
PL (1) PL360107A1 (tr)
PT (1) PT1265882E (tr)
SK (1) SK14512002A3 (tr)
TR (2) TR200400611T4 (tr)
WO (1) WO2001068630A1 (tr)
ZA (1) ZA200206897B (tr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1142926C (zh) * 1999-04-14 2004-03-24 H·隆德贝克有限公司 制备西酞普兰的方法
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
MXPA02008684A (es) * 2000-03-13 2003-02-24 Lundbeck & Co As H Alquilacion gradual de 1-(4-fluorofenil)-1,3-dihidroisobenzofuranos 5-substituidos.
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (tr) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
KR100357975B1 (ko) 1997-07-08 2002-10-25 하. 룬트벡 아크티에 셀스카브 시탈로프램의 제조방법
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (en) 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
DK1123284T3 (da) 1998-10-20 2003-04-28 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
JP2002533450A (ja) 1998-12-23 2002-10-08 ハー・ルンドベック・アクチエゼルスカベット ５−シアノフタリドの製造方法
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
CN1142926C (zh) 1999-04-14 2004-03-24 H·隆德贝克有限公司 制备西酞普兰的方法
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
TR200101874T1 (tr) 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
JP2003519136A (ja) 1999-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
PL197821B1 (pl) 2000-01-14 2008-04-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
ES2159271B1 (es) 2000-03-16 2002-05-01 Lundbeck & Co As H Metodo para la preparacion de 5-ciano-1-(4-fluorofenil)-1,3-dihidroisobenzofuranos
AU2001272368A1 (en) 2000-07-06 2002-01-21 H. Lundbeck, A/S Method for the preparation of citalopram
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
DE60100016T2 (de) 2000-12-28 2003-04-17 H. Lundbeck A/S, Valby Verfahren zur herstellung von reinem citalopram

Also Published As

Publication number Publication date
HRP20020740A2 (en) 2004-12-31
ATE257832T1 (de) 2004-01-15
ES2214400T3 (es) 2004-09-16
DK1265882T3 (da) 2004-06-01
NO20024198L (no) 2002-09-03
US20030050484A1 (en) 2003-03-13
PT1265882E (pt) 2004-06-30
DE60101786D1 (de) 2004-02-19
CA2402557A1 (en) 2001-09-20
WO2001068630A1 (en) 2001-09-20
EP1265882A1 (en) 2002-12-18
EA005094B1 (ru) 2004-10-28
DE60101786T2 (de) 2004-07-15
BG107051A (en) 2003-05-30
TR200202155T2 (tr) 2002-12-23
IL151488A0 (en) 2003-04-10
BR0109268A (pt) 2002-12-03
HUP0300178A2 (en) 2003-05-28
PL360107A1 (en) 2004-09-06
SK14512002A3 (sk) 2003-03-04
US6806376B2 (en) 2004-10-19
JP2003527386A (ja) 2003-09-16
AU2001239213A1 (en) 2001-09-24
KR20020080476A (ko) 2002-10-23
IS6527A (is) 2002-08-27
NO20024198D0 (no) 2002-09-03
EA200200970A1 (ru) 2003-02-27
EP1265882B1 (en) 2004-01-14
CN1418205A (zh) 2003-05-14
MXPA02008653A (es) 2003-02-24
ZA200206897B (en) 2003-08-28

Similar Documents

Publication Publication Date Title
TR200200099T2 (tr) Th2 farklılaşma inhibitörleri
CY1120189T1 (el) Λιπιδια, συμπλοκα λιπιδιων και χρηση εξ' αυτων
DK1325910T3 (da) Aliphatiske nitrogenholdige femleddede ringforbindelser
CY1106522T1 (el) Ετepοκυκλικη ενωση και αντικαρκινικο μεσο που πepιεχει την ιδια ως δραστικο συστατικο
ATE448226T1 (de) Aza heterocyclische derivate und ihre therapeutische verwendung
TR200102237T2 (tr) N²-fenil amidin türevleri.
EA200200942A1 (ru) Фармацевтические композиции, содержащие производные 3-аминоазетидина, новые производные и способ их получения
TR200102957T2 (tr) Sitalopram hazırlanması için metod.
MXPA04006322A (es) Derivados de 6-fluorobiciclo[3.1.0]hexano.
TR200400611T4 (tr) Sitalopramın preparasyon metodu
TR200400857T4 (tr) Yeni galantamın türevleri ve analogları
SE0000933D0 (sv) Method of producing 6-substituted (S)-nicotine derivatives and intermediate compounds
EP1189900A4 (en) HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES FOR USE AS MELATONERGIC AGENTS
ATE407930T1 (de) Synthese zyklischerverbindungen
HUP9701080A2 (hu) Virusellenes hatású vegyületet és hidroximsavszármazékot tartalmazó gyógyszerkészítmény
EP1813270A4 (en) PROTEIN INHIBITORS OF THE HSP90 FAMILY
BRPI0411664A (pt) composição oral antiplaca aquosa estável
TW200407325A (en) Novel interleukin-1β converting enzyme inhibitors
DE60101784D1 (de) Synthese von wasserlöslischem 9-dihydroplacitaxel derivate aus 9-dihydro-13-acetylbacchatin iii
ATE151750T1 (de) 3-(indol-3-yl) propensäurderivate, die als nmda- antagonisten nützlich sind
NO20020291L (no) Terapeutiske og profylaktiske midler for neoplasmer
DE60003561D1 (de) 2,3-benzodiazepinderivate
NZ524330A (en) Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same
MXPA03008727A (es) Procedimiento para la preparacion de derivados de imidazol tetrasubstituidos y estructuras cristalinas novedosas de los mismos.
CY1110529T1 (el) Παρασκευη ν-υποκατεστημενων 2,7-διαλκυλο-4-υδροξυ-5-αμινο-8-αρυλοοκτανοϋλαμιδιων