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TR200101025T2 - Dopamin D3 reseptörleri modülatörleri olarak kullanılabilecek tetrahidrobenzazepin türevleri (Antipsikotik maddeler ) - Google Patents

Dopamin D3 reseptörleri modülatörleri olarak kullanılabilecek tetrahidrobenzazepin türevleri (Antipsikotik maddeler )

Info

Publication number
TR200101025T2
TR200101025T2 TR2001/01025T TR200101025T TR200101025T2 TR 200101025 T2 TR200101025 T2 TR 200101025T2 TR 2001/01025 T TR2001/01025 T TR 2001/01025T TR 200101025 T TR200101025 T TR 200101025T TR 200101025 T2 TR200101025 T2 TR 200101025T2
Authority
TR
Turkey
Prior art keywords
optionally substituted
dopamine
group
modulators
receptors
Prior art date
Application number
TR2001/01025T
Other languages
English (en)
Inventor
Stewart Hadley Michael
Norbert Johnson Christopher
James Macdonald Gregor
Stemp Geoffrey
Kuok Keong Vong Antonio
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9821976.9A external-priority patent/GB9821976D0/en
Priority claimed from GBGB9824340.5A external-priority patent/GB9824340D0/en
Priority claimed from GBGB9910711.2A external-priority patent/GB9910711D0/en
Priority claimed from GBGB9918032.5A external-priority patent/GB9918032D0/en
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of TR200101025T2 publication Critical patent/TR200101025T2/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Gynecology & Obstetrics (AREA)
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  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

R2'nin bir hidrojen atomu veya C1-4alkil grubu; q'nun 1 veya 2: A'nin, AR'nin tercihe göre ikameli bir fenil halkasi veya tercihe göre ikameli 5-veya 6- elementli bir aromatik heterosiklik halka; veya tercihe göre ikameli bir bisiklik halka sistemi oldugu bir formül (a), (b), (c) veya (d) grubu; Ar1 ve Ar2'nin ayri ayri tercihe göre ikameli bir fenil halkasi veya tercihe göre ikameli bir 5-6-veya 6-elementli bir aromatik heterosiklik halka; Y'nin bir bag, -NHCO-, -CONH-, -CH2-, veya Y'in O, S, SO2 veya CO ve m ile n'nin, m+n=0 veya 1 olacak sekilde 0 veya 1 oldugu -(CH2)mY1(CH2)n-, oldugu; ancak, A'nin bir formül (a) grubu olmasi durumunda AR'de bulunan karboksamid bölümüne dogru olan bir ikamenin mutlaka bir hidrojen veya bir metoksi grubu oldugu; r ve s'nin ayri ayri, r+s=1-4 arasi bir tam sayi olacagi sekilde 0 ila 3 arasi bir tam sayi; V'nin bir bag, O veya S, oldugu formül (1) bilesimleri ve tuzlari. Formül (I) bilesimleri ile tuzlarinin dopamin...DEVAMI VAR
TR2001/01025T 1998-10-08 1999-10-06 Dopamin D3 reseptörleri modülatörleri olarak kullanılabilecek tetrahidrobenzazepin türevleri (Antipsikotik maddeler ) TR200101025T2 (tr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9821976.9A GB9821976D0 (en) 1998-10-08 1998-10-08 Compounds
GBGB9824340.5A GB9824340D0 (en) 1998-11-06 1998-11-06 Compounds
GBGB9910711.2A GB9910711D0 (en) 1999-05-07 1999-05-07 Compounds
GBGB9918032.5A GB9918032D0 (en) 1999-07-30 1999-07-30 Compounds

Publications (1)

Publication Number Publication Date
TR200101025T2 true TR200101025T2 (tr) 2001-09-21

Family

ID=27451837

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Application Number Title Priority Date Filing Date
TR2001/01025T TR200101025T2 (tr) 1998-10-08 1999-10-06 Dopamin D3 reseptörleri modülatörleri olarak kullanılabilecek tetrahidrobenzazepin türevleri (Antipsikotik maddeler )

Country Status (30)

Country Link
US (1) US6605607B1 (tr)
EP (1) EP1119563B1 (tr)
JP (1) JP2002527433A (tr)
KR (1) KR20010085898A (tr)
CN (1) CN1329609A (tr)
AP (1) AP2001002114A0 (tr)
AR (1) AR023681A1 (tr)
AT (1) ATE316969T1 (tr)
AU (1) AU761018B2 (tr)
BG (1) BG105467A (tr)
BR (1) BR9914370A (tr)
CA (1) CA2346689A1 (tr)
CO (1) CO5140073A1 (tr)
CZ (1) CZ20011270A3 (tr)
DE (1) DE69929704T2 (tr)
EA (1) EA200100428A1 (tr)
ES (1) ES2255311T3 (tr)
HK (1) HK1038745A1 (tr)
HU (1) HUP0104280A3 (tr)
ID (1) ID28385A (tr)
IL (1) IL142388A0 (tr)
MA (1) MA26696A1 (tr)
NO (1) NO20011745L (tr)
NZ (1) NZ511018A (tr)
OA (1) OA11663A (tr)
PE (1) PE20001088A1 (tr)
PL (1) PL347237A1 (tr)
SK (1) SK4782001A3 (tr)
TR (1) TR200101025T2 (tr)
WO (1) WO2000021951A1 (tr)

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OA11663A (en) 2004-12-08
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