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TR200001992T2 - Osteoporoz tedavisinde de yararlı olan indol türevleri. - Google Patents

Osteoporoz tedavisinde de yararlı olan indol türevleri.

Info

Publication number
TR200001992T2
TR200001992T2 TR2000/01992T TR200001992T TR200001992T2 TR 200001992 T2 TR200001992 T2 TR 200001992T2 TR 2000/01992 T TR2000/01992 T TR 2000/01992T TR 200001992 T TR200001992 T TR 200001992T TR 200001992 T2 TR200001992 T2 TR 200001992T2
Authority
TR
Turkey
Prior art keywords
optionally substituted
alkyl
substituted
compound
group
Prior art date
Application number
TR2000/01992T
Other languages
English (en)
Inventor
Gagliardi Stefania
Marguerite Marie Gerard Nadler Guy
A.T. Novella Pietro
Original Assignee
Smithkline Beecham Laboratoires Pharmaceutiques
Smithkline Beecham S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Laboratoires Pharmaceutiques, Smithkline Beecham S.P.A. filed Critical Smithkline Beecham Laboratoires Pharmaceutiques
Publication of TR200001992T2 publication Critical patent/TR200001992T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A' nin, tercihe göre ikameli bir aril veya heterosiklil grubu; Ra' nin Rs ve Rt' nin bagimsiz olarak hidrojen, alkil, ikameli alkil, tercihe göre ikameli alkenil, ikameli aril, ikameli arialkil, ikameli heterosiklil veya tercihe göre ikameli heterosiklilalkil grubunu, veya Rs ile Rt' nin takildiklari nitrojenle birliktei bir heteroksiklil grubu oldugu -CO_NRsRt'yi; R1 ve R2 bagimsiz olarak hidrojen, hidroksi, amino, alkoksi, tercihe göre ikameli ariloksi, tercihe göre ikameli benziloksi, alkilamino, dialkilamino, halo, trifluorometil, trifluorometoksi, nitro, alkil, karboksi, kalbalkoksi, karbamoil, alkilkarbamoil' u , veya R1 ile R2' nin birlikte metilendioksi, karboniloksi veya karbonildiamino' yu; R3' ün hidrojen, alkanoil, alkil, aminoalkil, hidroksialkil, karboksialkil, karbalkoksialkil, karbamoil veya alkilsülfonil ve arilsülfonil' i temsil ettigi bir formül (I) bilesimi veya bir tuzu; bu bilesimi hazirlama prosesi, bu bilesimi içeren bir farmasötik terkip, DEVAMI VAR
TR2000/01992T 1997-12-24 1998-12-17 Osteoporoz tedavisinde de yararlı olan indol türevleri. TR200001992T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97403154 1997-12-24

Publications (1)

Publication Number Publication Date
TR200001992T2 true TR200001992T2 (tr) 2001-01-22

Family

ID=8229937

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01992T TR200001992T2 (tr) 1997-12-24 1998-12-17 Osteoporoz tedavisinde de yararlı olan indol türevleri.

Country Status (22)

Country Link
EP (1) EP1042316B1 (tr)
JP (1) JP4627881B2 (tr)
KR (1) KR20010033528A (tr)
CN (1) CN1208333C (tr)
AR (1) AR018032A1 (tr)
AT (1) ATE288909T1 (tr)
AU (1) AU749319B2 (tr)
BR (1) BR9814403A (tr)
CA (1) CA2315723A1 (tr)
CO (1) CO4970811A1 (tr)
DE (1) DE69828998T2 (tr)
ES (1) ES2236971T3 (tr)
HU (1) HUP0100785A3 (tr)
IL (1) IL136720A0 (tr)
NO (1) NO320272B1 (tr)
NZ (1) NZ505060A (tr)
PL (1) PL191633B1 (tr)
SA (1) SA99200109B1 (tr)
SI (1) SI1042316T1 (tr)
TR (1) TR200001992T2 (tr)
WO (1) WO1999033822A1 (tr)
ZA (1) ZA9811758B (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
GB9914825D0 (en) * 1999-06-24 1999-08-25 Smithkline Beecham Spa Novel compounds
DE60138605D1 (de) * 2000-03-31 2009-06-18 Ortho Mcneil Pharm Inc Phenyl-substituierte indole als h3 histaminrezeptorantagonisten
US6872834B2 (en) 2000-03-31 2005-03-29 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted indoles and indazoles
AU2001249679A1 (en) 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
ITMI20040875A1 (it) * 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali
US20090142832A1 (en) 2007-11-29 2009-06-04 James Dalton Indoles, Derivatives, and Analogs Thereof and Uses Therefor
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
EP3209655B1 (en) * 2014-10-24 2020-07-15 Landos Biopharma, Inc. Lanthionine synthetase c-like 2-based therapeutics
EA202091325A1 (ru) 2017-11-30 2020-08-28 Лэндос Байофарма, Инк. Способы лечения с помощью лигандов лантионин c-подобного белка 2 и подготовленных с их помощью клеток
US11117881B2 (en) 2019-12-20 2021-09-14 Landos Biopharma, Inc. Lanthionine c-like protein 2 ligands, cells prepared therewith, and therapies using same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3542827B2 (ja) * 1994-07-15 2004-07-14 帝国臓器製薬株式会社 新規な５−置換イソキサゾール−３−カルボン酸アミド誘導体
PL321263A1 (en) * 1995-01-10 1997-11-24 Smithkline Beecham Spa Derivatives of indole useful in treating osteoporosis
EP0991623A2 (en) * 1997-06-19 2000-04-12 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) * 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto

Also Published As

Publication number Publication date
ATE288909T1 (de) 2005-02-15
SA99200109B1 (ar) 2006-09-13
KR20010033528A (ko) 2001-04-25
NO20003315D0 (no) 2000-06-23
ES2236971T3 (es) 2005-07-16
HK1032953A1 (en) 2001-08-10
DE69828998T2 (de) 2006-05-04
SI1042316T1 (tr) 2005-08-31
JP4627881B2 (ja) 2011-02-09
PL341318A1 (en) 2001-04-09
NO20003315L (no) 2000-06-23
JP2003532616A (ja) 2003-11-05
DE69828998D1 (de) 2005-03-17
CN1299357A (zh) 2001-06-13
NZ505060A (en) 2002-09-27
EP1042316A1 (en) 2000-10-11
CO4970811A1 (es) 2000-11-07
NO320272B1 (no) 2005-11-14
CN1208333C (zh) 2005-06-29
CA2315723A1 (en) 1999-07-08
BR9814403A (pt) 2000-10-10
PL191633B1 (pl) 2006-06-30
HUP0100785A2 (hu) 2001-08-28
EP1042316B1 (en) 2005-02-09
ZA9811758B (en) 2000-06-22
IL136720A0 (en) 2001-06-14
HUP0100785A3 (en) 2001-09-28
AU749319B2 (en) 2002-06-20
WO1999033822A1 (en) 1999-07-08
AR018032A1 (es) 2001-10-31
AU2715499A (en) 1999-07-19

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