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TR200000278T2 - 4 okzo-3,5-dihidro-4h-piridazino[4.5-b]indol-1-asetamid türevleri, hazırlanmaları ve tedavide uygulanmaları. - Google Patents

4 okzo-3,5-dihidro-4h-piridazino[4.5-b]indol-1-asetamid türevleri, hazırlanmaları ve tedavide uygulanmaları.

Info

Publication number
TR200000278T2
TR200000278T2 TR2000/00278T TR200000278T TR200000278T2 TR 200000278 T2 TR200000278 T2 TR 200000278T2 TR 2000/00278 T TR2000/00278 T TR 2000/00278T TR 200000278 T TR200000278 T TR 200000278T TR 200000278 T2 TR200000278 T2 TR 200000278T2
Authority
TR
Turkey
Prior art keywords
treatment
group
application
pyridazino
indole
Prior art date
Application number
TR2000/00278T
Other languages
English (en)
Inventor
Evanno Yannick
Dubois Laurent
Sevrin Mireille
Marguet Frank
Froissant Jacques
Bartsch Regine
Gille Catherine
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of TR200000278T2 publication Critical patent/TR200000278T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

Genel formül (I)'e sahip bilesikler olup söz konusu formüldeki X,bir hidrojen veya halojen atomunu veya bir metil, metoksi veya fenilmetoksi grubunu simgelemekte; Y, bir hirdojen atomunu, 1 veya 2 halojen atomunu veya bir hidroksil, metoksi, nitro veya metil grubunu simgelemekte; R1, bir hidrojen atomunu veya bir (C1,C4)alkil grubunu simgelemekte; R2 veR3'ün her biri, bir hidrojen atomunu, bir (C1-C4)alkil grubunu veya bir fenilmetil grubunu simgelemekte ya da R2 ve R3, kendilerini tasiyan nitrojen atomu ile, bir azetidinil, pirolidinil, 3-etoksipirolidinil, piperidinil, morfolinil,4-metilpiperazinil veya 1.3-tiyazolidinil grubunu olusturmaktadir. Tedavide uygulama.
TR2000/00278T 1997-07-30 1998-07-28 4 okzo-3,5-dihidro-4h-piridazino[4.5-b]indol-1-asetamid türevleri, hazırlanmaları ve tedavide uygulanmaları. TR200000278T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9709692A FR2766823B1 (fr) 1997-07-30 1997-07-30 Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
TR200000278T2 true TR200000278T2 (tr) 2000-08-21

Family

ID=9509801

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00278T TR200000278T2 (tr) 1997-07-30 1998-07-28 4 okzo-3,5-dihidro-4h-piridazino[4.5-b]indol-1-asetamid türevleri, hazırlanmaları ve tedavide uygulanmaları.

Country Status (32)

Country Link
US (1) US6262045B1 (tr)
EP (1) EP1000063B1 (tr)
JP (1) JP4322421B2 (tr)
KR (1) KR100497782B1 (tr)
CN (1) CN1134440C (tr)
AR (1) AR013264A1 (tr)
AT (1) ATE226584T1 (tr)
AU (1) AU736600B2 (tr)
BG (1) BG64283B1 (tr)
BR (1) BR9811582B1 (tr)
CA (1) CA2298522C (tr)
CO (1) CO5210883A1 (tr)
CZ (1) CZ290011B6 (tr)
DE (1) DE69808921T2 (tr)
DK (1) DK1000063T3 (tr)
EE (1) EE04317B1 (tr)
ES (1) ES2186212T3 (tr)
FR (1) FR2766823B1 (tr)
HU (1) HU229430B1 (tr)
IL (1) IL133633A (tr)
NO (1) NO313963B1 (tr)
NZ (1) NZ502361A (tr)
PL (1) PL194245B1 (tr)
PT (1) PT1000063E (tr)
RU (1) RU2197490C2 (tr)
SI (1) SI1000063T1 (tr)
SK (1) SK283075B6 (tr)
TR (1) TR200000278T2 (tr)
TW (1) TW506971B (tr)
UA (1) UA57088C2 (tr)
WO (1) WO1999006406A1 (tr)
ZA (1) ZA986786B (tr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
GB0000564D0 (en) * 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
CA2588760C (en) * 2004-12-07 2014-05-13 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydropyran, pyrrolidine and tetrahydrothiophene derivatives
EP1895982A2 (en) * 2005-05-05 2008-03-12 Sanofi-Aventis U.S. LLC Stable nanoparticle formulations
SI1926476T1 (sl) * 2005-08-29 2013-07-31 Sanofi-Aventis U.S. Llc Amorfne trdne disperzije 7-kloro-N,N,5-trimetil-4-okso-3-fenil-3,5- dihidro-4H-piridazino/4,5-b/indol-1-acetamida
ZA200801890B (en) * 2005-08-29 2009-11-25 Sanofi Aventis Us Llc Novel crystalline form of a pyridazino (4, 5-B) indole derivative
CA2623026A1 (en) * 2005-09-23 2007-04-05 Schering Corporation Fused tetracyclic mglur1 antagonists as therapeutic agents
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
EP2364315A1 (en) * 2008-08-18 2011-09-14 Sanofi-Aventis U.S. LLC Process for preparing polymorph of 7-chloro-n, n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4h-pyridazin0[4,5-b]indole-1-acetamide
EP2181717A1 (en) 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
FI94531C (fi) * 1990-03-13 1995-09-25 Ime Intermed Enterpris Sa Menetelmä farmaseuttisesti aktiivisen 1,3,4,6,7,8-heksahydro-2H-pyrimido-(1,2-a)-pyrimidiinijohdannaisen valmistamiseksi
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
US5756501A (en) * 1995-12-13 1998-05-26 American Home Products Corporation Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr) 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
HU229430B1 (en) 2013-12-30
BR9811582B1 (pt) 2010-10-19
EE04317B1 (et) 2004-06-15
BR9811582A (pt) 2000-09-26
IL133633A0 (en) 2001-04-30
ATE226584T1 (de) 2002-11-15
US6262045B1 (en) 2001-07-17
NO20000462D0 (no) 2000-01-28
DE69808921T2 (de) 2003-07-03
PL338445A1 (en) 2000-11-06
CN1265108A (zh) 2000-08-30
KR20010022356A (ko) 2001-03-15
CN1134440C (zh) 2004-01-14
HUP0002650A2 (hu) 2001-01-29
FR2766823A1 (fr) 1999-02-05
RU2197490C2 (ru) 2003-01-27
EP1000063A1 (fr) 2000-05-17
WO1999006406A1 (fr) 1999-02-11
CZ290011B6 (cs) 2002-05-15
NO20000462L (no) 2000-03-29
SK283075B6 (sk) 2003-02-04
CZ2000320A3 (cs) 2000-05-17
EE200000056A (et) 2000-10-16
CA2298522C (en) 2008-07-15
DK1000063T3 (da) 2003-02-24
PT1000063E (pt) 2003-03-31
DE69808921D1 (de) 2002-11-28
HUP0002650A3 (en) 2002-09-30
JP4322421B2 (ja) 2009-09-02
AR013264A1 (es) 2000-12-13
SI1000063T1 (en) 2003-04-30
HK1028027A1 (en) 2001-02-02
BG64283B1 (bg) 2004-08-31
ES2186212T3 (es) 2003-05-01
ZA986786B (en) 1999-02-02
NO313963B1 (no) 2003-01-06
AU736600B2 (en) 2001-08-02
KR100497782B1 (ko) 2005-06-27
TW506971B (en) 2002-10-21
CA2298522A1 (en) 1999-02-11
FR2766823B1 (fr) 1999-10-08
UA57088C2 (uk) 2003-06-16
BG104096A (en) 2000-08-31
IL133633A (en) 2004-02-08
JP2001512122A (ja) 2001-08-21
EP1000063B1 (fr) 2002-10-23
AU8983298A (en) 1999-02-22
NZ502361A (en) 2001-06-29
CO5210883A1 (es) 2002-10-30
PL194245B1 (pl) 2007-05-31
SK1292000A3 (en) 2000-08-14

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