[go: up one dir, main page]

TR199902199T2 - Siklosporin tatbiki için hidrofilik ikili sistemler. - Google Patents

Siklosporin tatbiki için hidrofilik ikili sistemler.

Info

Publication number
TR199902199T2
TR199902199T2 TR1999/02199T TR9902199T TR199902199T2 TR 199902199 T2 TR199902199 T2 TR 199902199T2 TR 1999/02199 T TR1999/02199 T TR 1999/02199T TR 9902199 T TR9902199 T TR 9902199T TR 199902199 T2 TR199902199 T2 TR 199902199T2
Authority
TR
Turkey
Prior art keywords
binary systems
hydrophilic
cyclosporine administration
hydrophilic binary
cyclosporine
Prior art date
Application number
TR1999/02199T
Other languages
English (en)
Inventor
A. Al-Razzak Laman
Pericleous Constantinides Panayiotis
Kaul Dilip
M. Lipari John
L. Mcchesney-Harris Lisa
Y. Abdullah Bashar
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of TR199902199T2 publication Critical patent/TR199902199T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Ikili farmasötik kompozisyonlar olup, (i) bir siklosporin bilesigi, (ii) bir hidrofilik faz ve (iii) bir yüzey etkin madde ihtiva etmekte, bir lipofilik faza ihtiyaç olmadan etkin bilesenin bioavailabilitesini üçlü kompozisyonlara muadil temin etmektedir.
TR1999/02199T 1997-03-12 1998-03-12 Siklosporin tatbiki için hidrofilik ikili sistemler. TR199902199T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81637597A 1997-03-12 1997-03-12

Publications (1)

Publication Number Publication Date
TR199902199T2 true TR199902199T2 (tr) 2002-06-21

Family

ID=25220436

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02199T TR199902199T2 (tr) 1997-03-12 1998-03-12 Siklosporin tatbiki için hidrofilik ikili sistemler.

Country Status (24)

Country Link
US (1) US6008192A (tr)
EP (1) EP0969856B1 (tr)
JP (2) JP4718653B2 (tr)
KR (1) KR100966245B1 (tr)
CN (1) CN1309414C (tr)
AT (1) ATE286403T1 (tr)
AU (1) AU6461898A (tr)
BG (1) BG64669B1 (tr)
BR (1) BR9808656A (tr)
CA (1) CA2284000C (tr)
CZ (1) CZ301382B6 (tr)
DE (1) DE69828496T2 (tr)
DK (1) DK0969856T3 (tr)
ES (1) ES2236891T3 (tr)
HU (1) HU228855B1 (tr)
IL (2) IL131609A0 (tr)
NO (1) NO994266L (tr)
NZ (1) NZ337316A (tr)
PL (1) PL193414B1 (tr)
PT (1) PT969856E (tr)
SI (1) SI0969856T1 (tr)
SK (1) SK282714B6 (tr)
TR (1) TR199902199T2 (tr)
WO (1) WO1998040094A1 (tr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
GB2355195B (en) * 1997-01-30 2001-09-12 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
IT1294205B1 (it) * 1997-07-23 1999-03-24 Farmigea Spa Procedimento per la solubilizzazione in acqua e in veicoli acquosi di sostanze farmacologicamente attive
FR2771292B1 (fr) * 1997-11-21 2000-02-18 Ethypharm Lab Prod Ethiques Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
CN1236813C (zh) 1998-12-11 2006-01-18 药品处理公司 水难溶性药物的自乳化组合物
DE19859910C2 (de) * 1998-12-23 2001-03-22 Ratiopharm Gmbh Orales Arzneimittel
ATE404172T1 (de) 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6616942B1 (en) 1999-03-29 2003-09-09 Soft Gel Technologies, Inc. Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing
US6057289A (en) * 1999-04-30 2000-05-02 Pharmasolutions, Inc. Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system
GB9912476D0 (en) * 1999-05-28 1999-07-28 Novartis Ag Organic compounds
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
GB2355656B (en) * 1999-08-17 2004-04-07 Galena As Pharmaceutical compositions for oral and topical administration
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6632671B2 (en) * 2000-02-28 2003-10-14 Genesegues, Inc. Nanoparticle encapsulation system and method
US6623734B2 (en) * 2000-06-22 2003-09-23 Soft Gel Technologies, Inc. Super absorption coenzyme Q10
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
CA2418135C (en) 2000-08-03 2011-09-20 Antares Pharma Ipl Ag Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
US6960563B2 (en) * 2001-08-31 2005-11-01 Morton Grove Pharmaceuticals, Inc. Spontaneous emulsions containing cyclosporine
PT1435910E (pt) * 2001-10-19 2009-09-07 Isotechnika Inc Novos pré-concentrados de microemulsão de análogos da ciclosporina
BR0215187A (pt) * 2001-12-20 2004-11-16 Bernard Charles Sherman Composições farmacêuticas que compreendem uma ciclosporina, um tensoativo hidrofìlico e um tensoativo lipofìlico
EP1344523A1 (en) * 2002-03-11 2003-09-17 Warner-Lambert Company Ibuprofen solution for hard gelatin capsules
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
AU2004277951B2 (en) 2003-09-29 2010-11-11 Soft Gel Technologies, Inc. Solubilized CoQ-10
US8124072B2 (en) 2003-09-29 2012-02-28 Soft Gel Technologies, Inc. Solubilized CoQ-10
PT1670433E (pt) 2003-10-10 2012-02-08 Ferring Bv Fórmula farmacológica transdérmica para a minimização de resíduos na pele
JP2005255677A (ja) * 2004-02-12 2005-09-22 Nof Corp シクロスポリン製剤
US7425340B2 (en) 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
ITMI20041245A1 (it) * 2004-06-22 2004-09-22 Ibsa Inst Biochimique Sa Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrina
JP2008518931A (ja) * 2004-10-29 2008-06-05 ノバルティス アクチエンゲゼルシャフト 自発的に分散可能な医薬組成物
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
US20070207107A1 (en) * 2006-03-03 2007-09-06 Gareth Winckle Silicone based emulsions for topical drug delivery
NZ571460A (en) 2006-04-21 2010-10-29 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
US8343541B2 (en) 2007-03-15 2013-01-01 Soft Gel Technologies, Inc. Ubiquinol and alpha lipoic acid compositions
JP5135852B2 (ja) * 2007-03-30 2013-02-06 日油株式会社 可溶化用組成物
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension
TWI474830B (en) * 2010-02-04 2015-03-01 Ophthalmic pharmaceutical composition in the dosage form of a low-irritating and translucent emulsion for the treatment of topical immunomodulator with anti-inflammatory effect of the eye or the surrounding or associated tissues thereof
CN101897949B (zh) * 2010-02-24 2016-07-06 温士顿医药股份有限公司 低刺激性透明乳化液剂型以供眼睛或眼睛周围有关组织表面免疫调节及消炎的眼用药物组合物
US20120003162A1 (en) 2010-06-30 2012-01-05 Mcneil-Ppc, Inc. Methods of Preparing Non-Alcohol Bioactive Esential Oil Mouth Rinses
US9084902B2 (en) 2010-06-30 2015-07-21 Mcneil-Ppc, Inc. Non-alchohol bioactive essential oil mouth rinses
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
WO2013082299A1 (en) 2011-11-29 2013-06-06 Als Therapy Development Institute Targeting of t-lymphocytes to treat amyotrophic lateral sclerosis
KR101211902B1 (ko) * 2012-04-30 2012-12-13 주식회사 휴온스 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물
WO2015005409A1 (ja) * 2013-07-11 2015-01-15 参天製薬株式会社 シクロスポリンａを含有する水性眼科用組成物
US20150352176A1 (en) * 2014-06-06 2015-12-10 Newport Research, Inc. Oil-free and fat-free aqueous suspensions of cyclosporin
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
CN107072963B (zh) 2014-09-03 2020-07-07 吉倪塞思公司 治疗性纳米粒子和相关的组合物、方法和系统
US20200237859A1 (en) 2019-01-25 2020-07-30 Newport Research, Inc. Aqueous suspensions of cyclosporin
US11324800B2 (en) * 2015-01-15 2022-05-10 Wellspring Ophthalmics, Inc. Aqueous suspensions of cyclosporin
WO2016170698A1 (ja) * 2015-04-24 2016-10-27 日本パーカライジング株式会社 水系表面処理剤、皮膜の製造方法及び表面処理材
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
JP2020503269A (ja) 2016-11-28 2020-01-30 リポカイン インコーポレーテッド 経口ウンデカン酸テストステロン療法
WO2019002362A1 (en) * 2017-06-28 2019-01-03 Spherium Biomed, S.L. TOPICAL COMPOSITIONS OF CYCLOSPORIN A
CA3107214A1 (en) 2018-07-20 2020-01-23 Lipocine Inc. Liver disease
KR20220063082A (ko) * 2020-11-09 2022-05-17 주식회사 스카이테라퓨틱스 고상의 물질 및 이를 포함하는 분산 조성물
WO2022098121A1 (ko) * 2020-11-09 2022-05-12 주식회사 스카이테라퓨틱스 고상의 물질 및 이를 포함하는 분산 조성물
CN116390762A (zh) * 2020-11-09 2023-07-04 思凯制药有限公司 固体环孢菌素a和包含其的分散组合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
FR2642650B1 (fr) * 1989-02-09 1994-12-09 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines
JPH037237A (ja) * 1989-03-14 1991-01-14 Sandoz Ag シクロスポリン類投与の新規用途および治療手段
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
JPH0558906A (ja) * 1991-09-06 1993-03-09 Sankyo Co Ltd シクロスポリン点眼製剤
WO1994023733A1 (de) * 1993-04-20 1994-10-27 Dr. Rentschler Arzneimittel Gmbh & Co. Neue pharmazeutische zubereitungen zur oralen verabreichung enthaltend cyclosporin
NZ247516A (en) * 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
CN1077800C (zh) * 1993-07-01 2002-01-16 韩美药品工业株式会社 环孢菌素软胶囊组合物
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
PL319898A1 (en) * 1995-08-25 1997-09-01 Sangstat Medical Corp Cyclosporines containing compositions for oral administration
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
GB2355195B (en) * 1997-01-30 2001-09-12 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A

Also Published As

Publication number Publication date
KR20000076443A (ko) 2000-12-26
ES2236891T3 (es) 2005-07-16
EP0969856B1 (en) 2005-01-05
IL131609A0 (en) 2001-01-28
NZ337316A (en) 2001-06-29
HK1026840A1 (en) 2000-12-29
BG64669B1 (bg) 2005-11-30
CZ301382B6 (cs) 2010-02-10
NO994266L (no) 1999-11-10
SK119999A3 (en) 2000-02-14
JP4718653B2 (ja) 2011-07-06
US6008192A (en) 1999-12-28
HU228855B1 (en) 2013-06-28
JP2001516351A (ja) 2001-09-25
DE69828496D1 (de) 2005-02-10
IL131609A (en) 2012-04-30
HUP0001782A2 (hu) 2000-12-28
KR100966245B1 (ko) 2010-06-28
AU6461898A (en) 1998-09-29
ATE286403T1 (de) 2005-01-15
SI0969856T1 (en) 2005-06-30
DK0969856T3 (da) 2005-05-02
CN1309414C (zh) 2007-04-11
CN1250377A (zh) 2000-04-12
SK282714B6 (sk) 2002-11-06
PL335575A1 (en) 2000-05-08
CA2284000C (en) 2012-01-03
PT969856E (pt) 2005-04-29
NO994266D0 (no) 1999-09-02
JP2011105754A (ja) 2011-06-02
PL193414B1 (pl) 2007-02-28
CZ312999A3 (cs) 2000-01-12
HUP0001782A3 (en) 2001-04-28
WO1998040094A1 (en) 1998-09-17
EP0969856A1 (en) 2000-01-12
DE69828496T2 (de) 2006-03-23
BG103790A (en) 2000-07-31
CA2284000A1 (en) 1998-09-17
BR9808656A (pt) 2000-05-23

Similar Documents

Publication Publication Date Title
TR199902199T2 (tr) Siklosporin tatbiki için hidrofilik ikili sistemler.
AU7912598A (en) Biphasic multicomponent pharmaceutical dosage forms containing substanc es able to modify the partitioning of drugs
DE69831504T2 (de) Orale verabreichungsform enthaltend einen protonenpumpeninhibitor (z.b.pantoprazole)
DE19581805T1 (de) Pharmazeutische Zusammensetzungen
IL102310A (en) Pharmaceutical compositions comprising cyclosporins
TR200002586T2 (tr) Siklosporin ya da bir makrolid içeren emülsiyon prekonsantratları
NZ337592A (en) Stabilization of acid sensitive benzimidazoles with amino/cyclodextrin combinations
ATE554750T1 (de) Hydrophobe pharmazeutische wirkstoffe enthaltende zubereitungen
ATE203411T1 (de) Lagerstabile wässrige pharmazeutische zubereitungen von g-csf
HK86593A (en) Pharmaceutical compositions containing cyclosporins
TR200100366T2 (tr) Aktif madde dağıtmaya mahsus bileşikler ve bileşimler.
CA2326485A1 (en) Anticancer compositions
ATE247981T1 (de) Proteinenthaltende pharmazeutische zubereitung
ATE450254T1 (de) Schwimmende pharmazeutische zusammensetzung mit einer aktiven phase und einer inaktiven phase
ATE293459T1 (de) Konjugate enthaltend zwei wirkstoffe
WO2001037383A3 (en) Group iii-nitride semiconductor structures with reduced phase separation
AR012627A1 (es) Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado
TH57976A (th) ส่วนประกอบอีพลีรีโนน