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TNSN96085A1 - Amides therapeutiques et compositions les contenant - Google Patents

Amides therapeutiques et compositions les contenant

Info

Publication number
TNSN96085A1
TNSN96085A1 TNTNSN96085A TNSN96085A TNSN96085A1 TN SN96085 A1 TNSN96085 A1 TN SN96085A1 TN TNSN96085 A TNTNSN96085 A TN TNSN96085A TN SN96085 A TNSN96085 A TN SN96085A TN SN96085 A1 TNSN96085 A1 TN SN96085A1
Authority
TN
Tunisia
Prior art keywords
compositions containing
amides
therapeutic amides
therapeutic
apolipoprotein
Prior art date
Application number
TNTNSN96085A
Other languages
English (en)
Inventor
Chang George
H Dorff Peter
J Quallich George
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB1995/000448 external-priority patent/WO1996040640A1/fr
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN96085A1 publication Critical patent/TNSN96085A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES DE FORMULE (I) : DANS LAQUELLE X, Y et Z REPRESENTENT DIVERS SUBSTITUANTS. ELLE CONCERNE EGALEMENT UNE COMPOSITION PHARMACEUTIQUE RENFERMANT UN TEL COMPOSE. APPLICATION : UTILISATION DANS LA DIMINUTION DE LA SECRETION D'APOLIPOPROTEINE B ET DANS LE TRAITEMENT D'AFFECTIONS, TELLES QUE L'ATHEROSCLEROSE.
TNTNSN96085A 1995-06-07 1996-06-06 Amides therapeutiques et compositions les contenant TNSN96085A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1995/000448 WO1996040640A1 (fr) 1995-06-07 1995-06-07 DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B)

Publications (1)

Publication Number Publication Date
TNSN96085A1 true TNSN96085A1 (fr) 2005-03-15

Family

ID=11004342

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN96085A TNSN96085A1 (fr) 1995-06-07 1996-06-06 Amides therapeutiques et compositions les contenant

Country Status (20)

Country Link
US (1) US5919795A (fr)
KR (1) KR100225713B1 (fr)
AR (1) AR003424A1 (fr)
AT (1) ATE233734T1 (fr)
AU (1) AU703493B2 (fr)
BG (1) BG62442B1 (fr)
CO (1) CO4440626A1 (fr)
DE (1) DE69529849T2 (fr)
DK (1) DK0832069T3 (fr)
DZ (1) DZ2045A1 (fr)
IL (3) IL135375A (fr)
MA (1) MA23895A1 (fr)
MX (1) MX9709914A (fr)
OA (1) OA10363A (fr)
RO (1) RO116897B1 (fr)
RU (1) RU2141478C1 (fr)
TN (1) TNSN96085A1 (fr)
TR (1) TR199600481A2 (fr)
TW (1) TW476756B (fr)
YU (1) YU35296A (fr)

Families Citing this family (40)

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ES2180935T3 (es) * 1996-04-30 2003-02-16 Pfizer Procedimientos e intermedios para preparar (2-(2h-(1,2,4)triazol-3-ilmetil)-1,2,3,4-tetrahidroisoquinolin-6-il)amida del acido 4'-trifluorometilbifenil-2-carboxilico.
JP2959765B2 (ja) 1997-12-12 1999-10-06 日本たばこ産業株式会社 ３−ピペリジル−４−オキソキナゾリン誘導体及びそれを含有してなる医薬組成物
CA2325358C (fr) 1999-11-10 2005-08-02 Pfizer Products Inc. Amides de l'acide 7-¬(4'-trifluoromethylbiphenyl-2-carbonyl)amino|-quinoleine-3-carboxylique et methodes pour inhiber la secretion d'apolipoproteine b
ATE295836T1 (de) * 2000-01-18 2005-06-15 Novartis Pharma Gmbh Carboxamide und ihre verwendung als inhibitoren des mikrosomalen triglycerid-transfer-proteins und der apolipoprotein b (apo b) sekretion
DE10023484A1 (de) * 2000-05-09 2001-11-22 Schering Ag Anthranylamide und deren Verwendung als Arzneimittel
JO2654B1 (en) * 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
US6953671B2 (en) * 2001-02-23 2005-10-11 The Trustees Of Columbia University In The City Of New York Plasma phospholipid transfer protein (PLTP) deficiency represents an anti-atherogenic state and PLTP inhibitor has anti-atherosclerosis action
DE60228447D1 (de) 2001-06-28 2008-10-02 Pfizer Prod Inc Triamidsubstituierte indole, benzofurane und benzothiophene als inhibitoren des mikrosomalen triglyceridtransferproteins (mtp) und/oder der sekretion von apolipoprotein b (apo b)
US7012077B2 (en) * 2001-12-20 2006-03-14 Hoffmann-La Roche Inc. Substituted cyclohexane derivatives
NZ535366A (en) * 2002-03-13 2007-07-27 Univ Tennessee Res Foundation Substituted tetrahydroisoquinoline compounds, methods of making, and their use
KR20060109926A (ko) 2003-11-19 2006-10-23 메타베이시스 테라퓨틱스, 인크. 새로운 인-함유 갑상선 호르몬 모방약들
WO2005051945A1 (fr) * 2003-11-20 2005-06-09 Eli Lilly And Company Composes heterocycliques utilises comme modulateurs des recepteurs actives proliferateurs du peroxysome (ppar), utiles dans le traitement et/ou la prevention de troubles modules par un ppar
EP1716137A1 (fr) * 2004-02-04 2006-11-02 Pfizer Products Incorporated Composes de quinoline substitues
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
JP2006249022A (ja) 2005-03-11 2006-09-21 Sumitomo Chemical Co Ltd ４−（２−メチルフェニル）ベンゾトリフルオライドの製造方法
ES2430319T3 (es) * 2005-04-19 2013-11-20 Surface Logix, Inc. Inhibidores de la secreción de la proteína microsomal de transferencia de triglicéridos y de la apo-B
WO2006129193A2 (fr) * 2005-05-27 2006-12-07 Pfizer Products Inc. Polytherapie pour le traitement de l'obesite ou le maintien du poids apres une perte ponderale
JP5198430B2 (ja) 2006-04-03 2013-05-15 サンタリス ファーマ アー／エス ａｎｔｉｍｉＲＮＡアンチセンスオリゴヌクレオチドを含む医薬組成物
EA201100812A1 (ru) * 2006-04-03 2012-06-29 Сантарис Фарма А/С Фармацевтическая композиция
GB0619176D0 (en) * 2006-09-29 2006-11-08 Lectus Therapeutics Ltd Ion channel modulators & uses thereof
EP2076597A2 (fr) * 2006-10-09 2009-07-08 Santaris Pharma A/S Composés antagonistes de l'arn pour la modulation de pcsk9
WO2008045564A2 (fr) * 2006-10-12 2008-04-17 Epix Delaware, Inc. Composés de carboxamide et leur utilisation
DK2149605T3 (da) * 2007-03-22 2013-09-30 Santaris Pharma As Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
WO2008113830A1 (fr) * 2007-03-22 2008-09-25 Santaris Pharma A/S Composés arn antagonistes pour l'inhibition de l'expression de l'apo-b100
AU2008292091A1 (en) * 2007-08-30 2009-03-05 Santaris Pharma A/S RNA antagonist compounds for the modulation of FABP4/aP2
DK2623599T3 (en) * 2007-10-04 2019-04-08 Roche Innovation Ct Copenhagen As Micromirers
CA2708364A1 (fr) 2007-12-11 2009-06-18 Efrat Ben-Zeev Composes a base de carboxamide et leur utilisation en tant qu'agonistes du recepteur des chimiokines
WO2009109665A1 (fr) * 2008-03-07 2009-09-11 Santaris Pharma A/S Compositions pharmaceutiques pour le traitement de maladies associées aux microarn
WO2010012667A1 (fr) 2008-08-01 2010-02-04 Santaris Pharma A/S Modulation à médiation par micro-arn de facteurs stimulateurs de colonies
EP2356094A1 (fr) * 2008-10-29 2011-08-17 F. Hoffmann-La Roche AG Nouveaux dérivés d'amides phényliques ou d'amides pyridyliques et leur utilisation en tant agonistes de gpbar1
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
EP2421970B1 (fr) * 2009-04-24 2016-09-07 Roche Innovation Center Copenhagen A/S Compositions pharmaceutiques pour le traitement de patients souffrant du vhc ne réagissant pas aux interférons
WO2010127212A1 (fr) * 2009-04-30 2010-11-04 Forest Laboratories Holdings Limited Inhibiteurs de l'acétyl-coa carboxylase
WO2010127208A1 (fr) * 2009-04-30 2010-11-04 Forest Laboratories Holdings Limited Inhibiteurs de l'acétyl-coa carboxylase
EP2456870A1 (fr) 2009-07-21 2012-05-30 Santaris Pharma A/S Oligomères anti-sens ciblant pcsk9
CA2817093A1 (fr) * 2010-11-15 2012-05-24 Abbvie Inc. Inhibiteurs de nampt
WO2014207232A1 (fr) 2013-06-27 2014-12-31 Santaris Pharma A/S Oligomères antisens et conjugués ciblant pcsk9
US12453728B1 (en) 2024-08-08 2025-10-28 Redux Therapeutics, Llc Compositions comprising inhibitors of microsomal triglyceride transfer protein and Apo-B secretion

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US3905982A (en) * 1973-07-23 1975-09-16 Searle & Co 1-Aryl-n-dialkylaminoalkyl-3,4-dihydro-2(1H)-isoquinolinecarboxamides and related compounds
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CA1248536A (fr) * 1982-09-10 1989-01-10 Wellcome Foundation Limited (The) Derives d'acide benzoique
DK8386A (da) * 1986-01-15 1987-07-09 Tpo Pharmachim Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme
DE3734385A1 (de) * 1987-10-10 1989-04-20 Hoechst Ag Verwendung der (alpha)-modifikation von cis-naphthoylen-bis-benzimidazol zum pigmentieren von polyolefinen
GB9127306D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicyclic compounds and pharmaceutical compositions containing them
YU23499A (sh) * 1996-11-27 2001-07-10 Pfizer Inc. Inhibitorski amidi apo-b-sekrecije/mtp-a

Also Published As

Publication number Publication date
TW476756B (en) 2002-02-21
IL135377A0 (en) 2001-05-20
KR100225713B1 (ko) 1999-10-15
RU2141478C1 (ru) 1999-11-20
AU5478496A (en) 1996-12-19
RO116897B1 (ro) 2001-07-30
CO4440626A1 (es) 1997-05-07
DK0832069T3 (da) 2003-04-22
US5919795A (en) 1999-07-06
IL135376A0 (en) 2001-05-20
AU703493B2 (en) 1999-03-25
BG100637A (bg) 1997-03-31
DZ2045A1 (fr) 2002-07-21
KR970003589A (ko) 1997-01-28
YU35296A (sh) 1999-06-15
MX9709914A (es) 1998-03-31
IL135375A (en) 2001-07-24
DE69529849T2 (de) 2003-09-04
IL135375A0 (en) 2001-05-20
AR003424A1 (es) 1998-08-05
OA10363A (en) 2001-11-15
MA23895A1 (fr) 1996-12-31
IL135376A (en) 2001-05-20
ATE233734T1 (de) 2003-03-15
TR199600481A2 (tr) 1996-12-21
BG62442B1 (bg) 1999-11-30
DE69529849D1 (de) 2003-04-10
IL135377A (en) 2001-05-20

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