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TN2015000355A1 - Derives de pyrrolo [2, 3-d] pyrimidine servant d'inhibiteurs de kinases de type janus (jak) - Google Patents

Derives de pyrrolo [2, 3-d] pyrimidine servant d'inhibiteurs de kinases de type janus (jak)

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Publication number
TN2015000355A1
TN2015000355A1 TN2015000355A TN2015000355A TN2015000355A1 TN 2015000355 A1 TN2015000355 A1 TN 2015000355A1 TN 2015000355 A TN2015000355 A TN 2015000355A TN 2015000355 A TN2015000355 A TN 2015000355A TN 2015000355 A1 TN2015000355 A1 TN 2015000355A1
Authority
TN
Tunisia
Prior art keywords
jak
pyrrolo
kinase inhibitors
janus
pyrimidine derivatives
Prior art date
Application number
TN2015000355A
Other languages
English (en)
Inventor
Matthew Frank Brown
Ashley Edward Fenwick
Mark Edward Flanagan
Andrea Gonzales
Timothy Allan Johnson
Neelu Kaila
Mark J Mitton-Fry
Joseph Walter Strohbach
Ruth E Tenbrink
John David Trzupek
Rayomand Jal Unwalla
Michael L Vazquez
D Parikh Mihir
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TN2015000355A1 publication Critical patent/TN2015000355A1/fr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member

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Abstract

Il est décrit dans le présent mémoire des dérivés de pyrrolo (2,3 -d) pyramide, leur utilisation comme inhibiteurs de kinase janus (JAK) et des compositions pharmaceutiques les contenant
TN2015000355A 2013-02-22 2015-08-18 Derives de pyrrolo [2, 3-d] pyrimidine servant d'inhibiteurs de kinases de type janus (jak) TN2015000355A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767947P 2013-02-22 2013-02-22
PCT/IB2014/058889 WO2014128591A1 (fr) 2013-02-22 2014-02-11 Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak)

Publications (1)

Publication Number Publication Date
TN2015000355A1 true TN2015000355A1 (fr) 2017-01-03

Family

ID=50151346

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2015000355A TN2015000355A1 (fr) 2013-02-22 2015-08-18 Derives de pyrrolo [2, 3-d] pyrimidine servant d'inhibiteurs de kinases de type janus (jak)

Country Status (47)

Country Link
US (3) US9035074B2 (fr)
EP (2) EP3290421B1 (fr)
JP (2) JP6145179B2 (fr)
KR (1) KR101787858B1 (fr)
CN (2) CN107089985B (fr)
AP (1) AP2015008664A0 (fr)
AR (1) AR094857A1 (fr)
AU (1) AU2014220357B2 (fr)
BR (1) BR112015019634B1 (fr)
CA (1) CA2900703C (fr)
CL (1) CL2015002303A1 (fr)
CR (1) CR20150395A (fr)
CU (1) CU24275B1 (fr)
CY (3) CY1119502T1 (fr)
DK (2) DK3290421T3 (fr)
DO (1) DOP2015000206A (fr)
EA (1) EA027879B1 (fr)
ES (2) ES2713052T3 (fr)
FR (1) FR22C1006I2 (fr)
GE (1) GEP201606600B (fr)
HR (2) HRP20171599T2 (fr)
HU (3) HUE041778T2 (fr)
IL (1) IL240132B (fr)
LT (3) LT3290421T (fr)
LU (1) LUC00261I2 (fr)
MA (1) MA38347A1 (fr)
MD (1) MD4735C1 (fr)
ME (2) ME03301B (fr)
MX (1) MX374338B (fr)
MY (1) MY177476A (fr)
NL (1) NL301155I2 (fr)
NO (2) NO3052752T3 (fr)
NZ (1) NZ710411A (fr)
PE (1) PE20151764A1 (fr)
PH (1) PH12015501779A1 (fr)
PL (2) PL3290421T3 (fr)
PT (2) PT3290421T (fr)
RS (2) RS56503B1 (fr)
SG (1) SG11201505816UA (fr)
SI (2) SI3290421T1 (fr)
TN (1) TN2015000355A1 (fr)
TR (1) TR201902525T4 (fr)
TW (1) TWI507408B (fr)
UA (1) UA111804C2 (fr)
UY (1) UY35337A (fr)
WO (1) WO2014128591A1 (fr)
ZA (1) ZA201505454B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3311666T3 (da) 2010-08-18 2021-06-28 Biosplice Therapeutics Inc Diketoner og hydroxyketoner som aktivatorer af catenin-signalvejen
ES2797376T3 (es) 2013-01-24 2020-12-02 Palvella Therapeutics Inc Composiciones para la administración transdérmica de inhibidores de mTOR
CA2901671C (fr) 2013-02-22 2021-07-13 Samumed, Llc .gamma.-dicetones en tant qu'activateurs de la voie de signalisation wnt/.beta.-catenine
PL3290421T3 (pl) 2013-02-22 2019-05-31 Pfizer Kombinacja pochodnych pirolo [2,3d]pirymidyny z jednym lub więcej dodatkowymi środkami jako inhibitory kinaz janusowych (JAK)
ES2750655T3 (es) * 2014-08-12 2020-03-26 Pfizer Derivados de pirrolo[2,3-d]pirimidina útiles para inhibir la Janus cinasa
RU2727039C2 (ru) 2014-08-20 2020-07-17 СЭМЬЮМЕД, ЭлЭлСи Гамма-дикетоны для лечения и профилактики старения кожи и морщин
CA2983481C (fr) * 2015-05-29 2020-04-14 Wuxi Fortune Pharmaceutical Co., Ltd Inhibiteur de la janus kinase
US12365689B2 (en) 2015-10-16 2025-07-22 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11780848B2 (en) 2015-10-16 2023-10-10 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
CA3002220C (fr) 2015-10-16 2021-07-20 Abbvie Inc. Procede de preparation de (3s,4r)-3-ethyl-4-(3h-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide et de ses formes a l'etat solide
CN106831779B (zh) * 2015-11-28 2019-07-19 南昌弘益药业有限公司 一类jak激酶抑制剂的新化合物
US10973913B2 (en) 2016-02-16 2021-04-13 Washington University JAK inhibitors and uses thereof
WO2018129364A1 (fr) 2017-01-06 2018-07-12 Palvella Therapeutics Llc Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
CN108794480A (zh) * 2017-04-28 2018-11-13 天津药物研究院有限公司 吡咯并嘧啶类化合物、其制备方法和用途
PE20251292A1 (es) 2018-03-08 2025-05-14 Incyte Corp Compuestos diolicos de aminopirazina como inhibidores de pi3k-gamma
WO2020010073A1 (fr) 2018-07-02 2020-01-09 Palvella Therapeutics, Inc. Compositions anhydres d'inhibiteurs de mtor et méthodes d'utilisation
WO2020010003A1 (fr) 2018-07-02 2020-01-09 Incyte Corporation DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ
TWI709562B (zh) 2018-07-06 2020-11-11 美商輝瑞股份有限公司 吡咯并〔２，３-ｄ〕嘧啶化合物的製造方法與中間產物及其用途
AU2019375412A1 (en) * 2018-11-05 2021-06-03 Avista Pharma Solutions, Inc. Chemical compounds
AU2019426113B2 (en) * 2019-01-30 2022-06-16 Felicamed Biotechnology Co., Ltd. JAK inhibitor and preparation method therefor
TWI820301B (zh) 2019-02-15 2023-11-01 美商輝瑞股份有限公司 結晶型嘧啶基－３，８－二氮雜雙環〔３．２．１〕辛烷基甲酮化合物及其用途
EP3939979A4 (fr) 2019-03-14 2022-04-06 Shanghai Synergy Pharmaceutical Sciences Co., Ltd Inhibiteur de kinase jak, son procédé de préparation et ses applications dans le domaine de la médecine
EP3989975A4 (fr) * 2019-06-27 2023-09-27 Glenmark Life Sciences Limited Procédé pour la préparation d'abrocitinib
WO2021048736A1 (fr) * 2019-09-11 2021-03-18 Pfizer Inc. Traitement de l'hidradénite avec des inhibiteurs de jak
AU2020356575A1 (en) 2019-09-27 2022-04-14 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
JP2023519738A (ja) 2020-04-04 2023-05-12 ファイザー・インク コロナウイルス疾患２０１９を処置する方法
CN113637018A (zh) 2020-04-27 2021-11-12 苏州晶云药物科技股份有限公司 磺酰胺类化合物的晶型及其制备方法
US20230174645A1 (en) 2020-05-13 2023-06-08 Disc Medicine, Inc. Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
US20230219963A1 (en) * 2020-05-28 2023-07-13 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives
TW202227434A (zh) * 2020-09-08 2022-07-16 瑞士商葛德瑪控股公司 新穎jak抑制劑化合物、其合成方法及其用途
CN116917285A (zh) * 2020-09-11 2023-10-20 高德美控股有限公司 新型jak抑制剂化合物、其合成方法及其用途
IL304874A (en) 2021-02-02 2023-10-01 Pfizer Dosing regime for treatment of chronic hand eczema
KR20230019801A (ko) * 2021-08-02 2023-02-09 한국화학연구원 신규한 피롤로 피리미딘 유도체 화합물, 이의 제조방법, 및 이를 유효성분으로 포함하는 대사성 간질환의 예방 또는 치료용 약학적 조성물
CN118255769A (zh) * 2022-12-28 2024-06-28 格格巫（珠海）生物科技有限公司 一种立体异构体的制备方法及中间体
ES2993658B2 (es) 2023-06-27 2025-07-02 Moehs Iberica Sl (3-(metil(7h-pirrolo[2,3-d]pirimidin-4-il)amino)ciclobutilo)carbamato de bencilo o una sal del mismo, procedimiento para su preparacion y su uso en la sintesis de abrocitinib
WO2025008772A2 (fr) 2023-07-06 2025-01-09 Pfizer Ireland Pharmaceuticals Procédé de fabrication amélioré et intermédiaires pour un composé pyrrolo[2,3-d]pyrimidine et leur utilisation
ES3040374A1 (es) 2024-04-30 2025-10-30 Moehs Iberica Sl Cocristales de N-{cis-3-[metil(7H-pirrolo[2,3-d]pirimidin-4-il)amino]ciclobutil}propano-1-sulfonamida

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037980A (en) 1955-08-18 1962-06-05 Burroughs Wellcome Co Pyrrolopyrimidine vasodilators and method of making them
ES2128544T3 (es) 1992-12-17 1999-05-16 Pfizer Pirrolopirimidinas como antagonistas del crf.
JPH06329675A (ja) 1993-05-20 1994-11-29 Teijin Ltd ４―置換アルキルアミノ―ピロロ［２，３―ｄ］ピリミジン誘導体
JPH06329674A (ja) 1993-05-20 1994-11-29 Teijin Ltd ４―置換シクロヘキシルアミノ―ピロロ［２，３―ｄ］ピリミジン
JPH08134068A (ja) 1994-11-02 1996-05-28 Teijin Ltd ４―置換アルキルアミノ―ピロロ［２，３―ｄ］ピリミジン誘導体
US6051578A (en) 1996-02-12 2000-04-18 Pfizer Inc. Pyrazolopyrimidines for treatment of CNS disorders
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
HUP0102574A3 (en) 1998-06-19 2002-01-28 Pfizer Prod Inc Pyrrolo[2,3-d]pyrimidine compounds
CZ27399A3 (cs) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
EP1040831A3 (fr) 1999-04-02 2003-05-02 Pfizer Products Inc. Utilisation d'antagonistes du facteur de libération de la corticotropine pour la prévention de la mort subite
CA2371271A1 (fr) 1999-04-30 2000-11-09 Neurogen Corporation Derives 9h-pyrimido[4,5-b]indoles: ligands specifiques de crf1
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
RS51574B (sr) 1999-12-10 2011-08-31 Pfizer Products Inc. JEDINJENJA PIROLO (2,3-d) PIRIMIDINA
IL150594A0 (en) 2000-01-07 2003-02-12 Ustav Ex Botan Adademie Ved Ce Purine derivatives, process for their preparation and use
DE60118917T2 (de) 2000-06-26 2006-11-30 Pfizer Products Inc., Groton PYRROLO[2,3-d]PYRIMIDIN-VERBINDUNGEN ALS IMMUNOSUPPRESSIVE WIRKSTOFFE '
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
AU2002360436A1 (en) 2001-11-30 2003-06-17 Osi Pharmaceuticals, Inc. 2-aryl pyrrologpyrimidines for a1 and a3 receptors
US20030139427A1 (en) 2002-08-23 2003-07-24 Osi Pharmaceuticals Inc. Bicyclic pyrimidinyl derivatives and methods of use thereof
AU2003299901A1 (en) 2002-10-04 2004-05-04 Merck And Co., Inc. Thrombin inhibitors
WO2004046112A2 (fr) 2002-11-21 2004-06-03 Pfizer Products Inc. Derives de 3-amino-piperadine et leurs procedes de preparation
AR054416A1 (es) 2004-12-22 2007-06-27 Incyte Corp Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
PT1913000E (pt) * 2005-07-29 2012-02-28 Pfizer Prod Inc Derivados de pirrolo[2,3-d]pirimidina, suas substâncias intermédias e processo de síntese
JP2007091649A (ja) 2005-09-29 2007-04-12 Taisho Pharmaceut Co Ltd ピリミジン誘導体及びその使用に関連する治療方法
GB0526246D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
BRPI0709699A2 (pt) 2006-03-29 2011-07-26 Foldrx Pharmaceuticals Inc inibiÇço da toxidez da alfa-sinucleina
US20080194557A1 (en) 2007-01-18 2008-08-14 Joseph Barbosa Methods and compositions for the treatment of pain, inflammation and cancer
US20080200458A1 (en) 2007-01-18 2008-08-21 Joseph Barbosa Methods and compositions for the treatment of body composition disorders
CN101917999A (zh) 2007-11-07 2010-12-15 弗尔德里克斯制药股份有限公司 蛋白质运输的调节
JP2011503046A (ja) 2007-11-08 2011-01-27 ファイザー・インク シクロブチルカルボン酸誘導体
US8946239B2 (en) 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
ME01269B (me) 2008-08-20 2013-06-20 Zoetis Services Llc Jedinjenja pirolo (2,3-d) pirimidina
CN102159548A (zh) 2008-09-18 2011-08-17 辉瑞有限公司 在治疗中有用的酰胺化合物
PE20121077A1 (es) * 2009-10-15 2012-08-10 Pfizer Compuestos de pirrolo[2,3-d]pirimidina
CN108774237A (zh) 2009-12-01 2018-11-09 Abbvie 公司 新的三环化合物
EP2513114B1 (fr) 2009-12-18 2014-04-02 Pfizer Inc. Composés de pyrrolo[2,3-d]pyrimidine
AR079984A1 (es) 2010-01-12 2012-03-07 Hoffmann La Roche Compuestos heterociclicos triciclicos, composiciones y su uso en el tratamiento de enfermedades mediadas por la inhibicion de jak1
CN102781431B (zh) 2010-02-24 2014-08-27 硕腾有限责任公司 兽医组合物
EP2593425B1 (fr) 2010-07-16 2018-10-17 Agios Pharmaceuticals, Inc. Compositions thérapeutiquement actives et méthode d'utilisation correspondante
WO2012009649A1 (fr) 2010-07-16 2012-01-19 Anderson Gaweco Inhibiteurs mif et leurs utilisations
MX2013006251A (es) 2010-12-03 2013-10-01 Epizyme Inc Compuestos de purina y 7 - deazapurina substituidos como moduladores de enzimas epigeneticas.
US8987307B2 (en) 2011-03-03 2015-03-24 Hoffmann-La Roche Inc. 3-amino-pyridines as GPBAR1 agonists
KR20140041519A (ko) 2011-06-07 2014-04-04 다이닛본 스미토모 세이야꾸 가부시끼가이샤 인다졸-유도체 및 피롤로피리딘-유도체 및 그의 약제학적 용도
JP2013010719A (ja) 2011-06-30 2013-01-17 Dainippon Sumitomo Pharma Co Ltd ベンズイミダゾロンおよびオキシインドール誘導体ならびにそれらの医薬用途
PL2796460T3 (pl) * 2011-12-21 2018-12-31 Jiangsu Hengrui Medicine Co. Ltd. Sześcioczłonowa pirolowa heteroarylowa pochodna pierścieniowa, sposób jej otrzymywania i zastosowania medyczne
US20140018361A1 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
CA2878867C (fr) 2012-07-20 2018-01-09 Zoetis Llc Regime posologique destine a des inhibiteurs de la janus kinase (jak)
JP2014133739A (ja) 2012-12-12 2014-07-24 Dainippon Sumitomo Pharma Co Ltd インダゾール誘導体またはピロロピリジン誘導体からなる医薬
PL3290421T3 (pl) 2013-02-22 2019-05-31 Pfizer Kombinacja pochodnych pirolo [2,3d]pirymidyny z jednym lub więcej dodatkowymi środkami jako inhibitory kinaz janusowych (JAK)
ES2750655T3 (es) 2014-08-12 2020-03-26 Pfizer Derivados de pirrolo[2,3-d]pirimidina útiles para inhibir la Janus cinasa

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