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MX374555B - Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos. - Google Patents

Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos.

Info

Publication number
MX374555B
MX374555B MX2017016619A MX2017016619A MX374555B MX 374555 B MX374555 B MX 374555B MX 2017016619 A MX2017016619 A MX 2017016619A MX 2017016619 A MX2017016619 A MX 2017016619A MX 374555 B MX374555 B MX 374555B
Authority
MX
Mexico
Prior art keywords
btk
inhibitors
tyrosine kinase
pyrimidine derivatives
bruton tyrosine
Prior art date
Application number
MX2017016619A
Other languages
English (en)
Other versions
MX2017016619A (es
Inventor
Hui Qiu
Lesley Liu-Bujalski
richard d Caldwell
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2017016619A publication Critical patent/MX2017016619A/es
Publication of MX374555B publication Critical patent/MX374555B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

La presente invención se relaciona a compuestos de pirimidina y composiciones farmacéuticamente aceptables de los mismos, útiles como inhibidores de BTK. (ver Fórmula).
MX2017016619A 2015-07-09 2016-07-08 Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos. MX374555B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562190350P 2015-07-09 2015-07-09
PCT/US2016/041438 WO2017007987A1 (en) 2015-07-09 2016-07-08 Pyrimidine derivatives as btk inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
MX2017016619A MX2017016619A (es) 2018-05-15
MX374555B true MX374555B (es) 2025-03-04

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MX2017016619A MX374555B (es) 2015-07-09 2016-07-08 Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos.

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Country Link
US (2) US10045985B2 (es)
EP (1) EP3319960B1 (es)
JP (1) JP6853234B2 (es)
KR (1) KR20180041119A (es)
CN (1) CN108137559B (es)
AU (2) AU2016290950A1 (es)
BR (1) BR112017028549A2 (es)
CA (1) CA2989651A1 (es)
ES (1) ES2854703T3 (es)
IL (1) IL256610B (es)
MX (1) MX374555B (es)
RU (1) RU2743040C2 (es)
WO (1) WO2017007987A1 (es)
ZA (1) ZA201708568B (es)

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TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
AU2017382360B2 (en) * 2016-12-23 2022-07-28 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use
CN108610295B (zh) * 2018-04-04 2023-01-10 大连医科大学附属第一医院 嘧啶类化合物，组合物及其在治疗淋巴瘤白血病中的用途
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
CN120157654B (zh) * 2025-03-07 2025-11-14 辽宁大学 含取代苯胺结构的卤代嘧啶类化合物及其制备方法和应用

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