TN2015000200A1 - 6-((s)-1-{1-[5-{2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}-ethyl) - 3h-1,3-benzothiazol - 2 - one as a tarp- gamma 8 dependent ampa receptor antagonist - Google Patents

6-((s)-1-{1-[5-{2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}-ethyl) - 3h-1,3-benzothiazol - 2 - one as a tarp- gamma 8 dependent ampa receptor antagonist

Info

Publication number: TN2015000200A1
Authority: TN; Tunisia
Prior art keywords: tarp; receptor antagonist; benzothiazol; pyrazol; pyridin
Prior art date: 2012-11-27

Application number

TNP2015000200A

Other languages

English (en)

Inventor

Jon Kevin Reel

Warren Jaye Porter

Jeffrey Michael Witkin

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-11-27

Filing date

2015-05-22

Publication date

2016-10-03

2015-05-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2016-10-03 Publication of TN2015000200A1 publication Critical patent/TN2015000200A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TNP2015000200A 2012-11-27 2015-05-22 6-((s)-1-{1-[5-{2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}-ethyl) - 3h-1,3-benzothiazol - 2 - one as a tarp- gamma 8 dependent ampa receptor antagonist TN2015000200A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201261730273P	2012-11-27	2012-11-27
PCT/US2013/070885 WO2014085153A1 (fr)	2012-11-27	2013-11-20	6-((s)-1-{1-[5-(2-hydroxy-éthoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}- éthyl)-3h-1,3-benzothiazol-2-one utilisable en tant qu'antagoniste du récepteur ampa dépendant de tarp-gamma

Publications (1)

Publication Number	Publication Date
TN2015000200A1 true TN2015000200A1 (en)	2016-10-03

Family

ID=49753484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2015000200A TN2015000200A1 (en)	2012-11-27	2015-05-22	6-((s)-1-{1-[5-{2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}-ethyl) - 3h-1,3-benzothiazol - 2 - one as a tarp- gamma 8 dependent ampa receptor antagonist

Country Status (35)

Country	Link
US (1)	US8765960B2 (fr)
EP (1)	EP2925754B1 (fr)
JP (1)	JP6246227B2 (fr)
KR (1)	KR101693133B1 (fr)
CN (1)	CN104797578B (fr)
AP (1)	AP2015008489A0 (fr)
AR (1)	AR093527A1 (fr)
AU (1)	AU2013352594B2 (fr)
BR (1)	BR112015011200A2 (fr)
CA (1)	CA2889243C (fr)
CL (1)	CL2015001419A1 (fr)
CR (1)	CR20150267A (fr)
CY (1)	CY1118657T1 (fr)
DK (1)	DK2925754T3 (fr)
DO (1)	DOP2015000113A (fr)
EA (1)	EA026686B1 (fr)
ES (1)	ES2618260T3 (fr)
HR (1)	HRP20170274T1 (fr)
HU (1)	HUE033447T2 (fr)
IL (1)	IL238831B (fr)
JO (1)	JO3225B1 (fr)
MA (1)	MA38126B1 (fr)
MX (1)	MX356478B (fr)
MY (1)	MY177721A (fr)
PE (1)	PE20151728A1 (fr)
PH (1)	PH12015501154B1 (fr)
PL (1)	PL2925754T3 (fr)
PT (1)	PT2925754T (fr)
SG (1)	SG11201504164VA (fr)
SI (1)	SI2925754T1 (fr)
TN (1)	TN2015000200A1 (fr)
TW (2)	TWI618705B (fr)
UA (1)	UA114345C2 (fr)
WO (1)	WO2014085153A1 (fr)
ZA (1)	ZA201503733B (fr)

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TW201609719A (zh) *	2014-05-28	2016-03-16	美國禮來大藥廠	作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物
AU2016256413B2 (en)	2015-04-29	2020-10-08	Janssen Pharmaceutica Nv	Indolone compounds and their use as AMPA receptor modulators
MX373652B (es)	2015-04-29	2020-04-02	Janssen Pharmaceutica Nv	Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa.
MX378389B (es) *	2015-04-29	2025-03-10	Janssen Pharmaceutica Nv	Compuestos de bencimidazolona y benzotiazolona y su uso como moduladores del receptor ampa.
WO2016176460A1 (fr)	2015-04-29	2016-11-03	Janssen Pharmaceutica Nv	Azabenzimidazoles et leur utilisation en tant que modulateurs des récepteurs ampa
WO2018080917A1 (fr) *	2016-10-26	2018-05-03	Janssen Pharmaceutica Nv	Composés de pyridine bicyclique fusionnés et leur utilisation comme modulateurs des récepteurs ampa
RU2650523C1 (ru) *	2017-07-24	2018-04-16	федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ)	Производное пиридоксина для лечения эпилепсии
RU2703286C1 (ru) *	2019-06-18	2019-10-16	федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ)	Соли (5-гидрокси-3,4-бис(гидроксиметил)-6-метилпиридин-2-ил)метансульфокислоты и способ их получения

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MY132385A (en) *	1995-08-31	2007-10-31	Novartis Ag	2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives
JP2000281676A (ja) *	1999-01-25	2000-10-10	Yamanouchi Pharmaceut Co Ltd	Ａｍｐａ拮抗化合物の新規製造法
ES2320973T3 (es) *	2000-06-12	2009-06-01	EISAI R&D MANAGEMENT CO., LTD.	Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos.
US8995993B2 (en) *	2000-10-11	2015-03-31	Gogo Llc	System for managing mobile internet protocol addresses in an airborne wireless cellular network
CA2589678A1 (fr) *	2004-12-17	2006-06-22	Eli Lilly And Company	Nouveaux antagonistes de recepteur mch
WO2007076161A2 (fr)	2005-12-27	2007-07-05	Myriad Genetics, Inc	Composés ayant une activité thérapeutique
TW200817385A (en) *	2006-07-04	2008-04-16	Organon Nv	Heterocyclic derivatives
WO2010041162A1 (fr) *	2008-10-08	2010-04-15	Pfizer Inc.	Tétrahydrofuranylsulfonamides destinés à être utilisés en tant que modulateurs d'ampa dans le traitement de troubles du snc
HRP20150355T1 (hr) *	2009-01-12	2015-06-19	Pfizer Limited	Sulfonamidni derivati
WO2011153192A2 (fr) *	2010-06-01	2011-12-08	Angion Biomedica Corp.	Inhibiteurs des cytochromes p450 et leurs utilisations
WO2012137982A2 (fr) *	2011-04-05	2012-10-11	Takeda Pharmaceutical Company Limited	Dérivé de sulfonamide et son utilisation
TW201609719A (zh)	2014-05-28	2016-03-16	美國禮來大藥廠	作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物

2013
- 2013-11-17 JO JOP/2013/0331A patent/JO3225B1/ar active
- 2013-11-18 AR ARP130104242A patent/AR093527A1/es unknown
- 2013-11-18 TW TW102141949A patent/TWI618705B/zh not_active IP Right Cessation
- 2013-11-18 TW TW106144388A patent/TW201825484A/zh unknown
- 2013-11-20 AP AP2015008489A patent/AP2015008489A0/xx unknown
- 2013-11-20 HR HRP20170274TT patent/HRP20170274T1/hr unknown
- 2013-11-20 KR KR1020157013470A patent/KR101693133B1/ko active Active
- 2013-11-20 HU HUE13802786A patent/HUE033447T2/en unknown
- 2013-11-20 PE PE2015000694A patent/PE20151728A1/es active IP Right Grant
- 2013-11-20 US US14/084,683 patent/US8765960B2/en active Active
- 2013-11-20 EA EA201590823A patent/EA026686B1/ru not_active IP Right Cessation
- 2013-11-20 CA CA2889243A patent/CA2889243C/fr active Active
- 2013-11-20 PT PT138027867T patent/PT2925754T/pt unknown
- 2013-11-20 ES ES13802786.7T patent/ES2618260T3/es active Active
- 2013-11-20 CN CN201380061495.2A patent/CN104797578B/zh active Active
- 2013-11-20 WO PCT/US2013/070885 patent/WO2014085153A1/fr not_active Ceased
- 2013-11-20 BR BR112015011200A patent/BR112015011200A2/pt not_active IP Right Cessation
- 2013-11-20 AU AU2013352594A patent/AU2013352594B2/en active Active
- 2013-11-20 EP EP13802786.7A patent/EP2925754B1/fr active Active
- 2013-11-20 SI SI201330464A patent/SI2925754T1/sl unknown
- 2013-11-20 SG SG11201504164VA patent/SG11201504164VA/en unknown
- 2013-11-20 JP JP2015545099A patent/JP6246227B2/ja active Active
- 2013-11-20 MA MA38126A patent/MA38126B1/fr unknown
- 2013-11-20 MY MYPI2015701544A patent/MY177721A/en unknown
- 2013-11-20 DK DK13802786.7T patent/DK2925754T3/en active
- 2013-11-20 MX MX2015006697A patent/MX356478B/es active IP Right Grant
- 2013-11-20 PL PL13802786T patent/PL2925754T3/pl unknown
- 2013-11-20 UA UAA201504865A patent/UA114345C2/uk unknown
2015
- 2015-05-14 IL IL238831A patent/IL238831B/en not_active IP Right Cessation
- 2015-05-14 DO DO2015000113A patent/DOP2015000113A/es unknown
- 2015-05-20 CR CR20150267A patent/CR20150267A/es unknown
- 2015-05-22 TN TNP2015000200A patent/TN2015000200A1/fr unknown
- 2015-05-25 PH PH12015501154A patent/PH12015501154B1/en unknown
- 2015-05-26 CL CL2015001419A patent/CL2015001419A1/es unknown
- 2015-05-26 ZA ZA2015/03733A patent/ZA201503733B/en unknown
2017
- 2017-02-24 CY CY20171100252T patent/CY1118657T1/el unknown

Also Published As

Publication number	Publication date
KR101693133B1 (ko)	2017-01-04
US20140148441A1 (en)	2014-05-29
PE20151728A1 (es)	2015-12-02
IL238831B (en)	2018-08-30
AR093527A1 (es)	2015-06-10
AU2013352594A1 (en)	2015-06-04
PL2925754T3 (pl)	2017-07-31
EA201590823A1 (ru)	2015-08-31
SG11201504164VA (en)	2015-07-30
CR20150267A (es)	2015-09-16
TWI618705B (zh)	2018-03-21
TW201825484A (zh)	2018-07-16
CN104797578A (zh)	2015-07-22
CN104797578B (zh)	2016-11-23
MX356478B (es)	2018-05-30
TW201434834A (zh)	2014-09-16
WO2014085153A8 (fr)	2014-07-31
KR20150070401A (ko)	2015-06-24
PT2925754T (pt)	2017-02-27
IL238831A0 (en)	2015-06-30
CA2889243A1 (fr)	2014-06-05
US8765960B2 (en)	2014-07-01
PH12015501154A1 (en)	2015-08-10
JO3225B1 (ar)	2018-03-08
SI2925754T1 (sl)	2017-02-28
DOP2015000113A (es)	2015-06-15
ZA201503733B (en)	2017-09-27
HUE033447T2 (en)	2017-11-28
CL2015001419A1 (es)	2015-10-02
JP6246227B2 (ja)	2017-12-13
UA114345C2 (uk)	2017-05-25
ES2618260T3 (es)	2017-06-21
AP2015008489A0 (en)	2015-05-31
CY1118657T1 (el)	2017-07-12
HK1209116A1 (en)	2016-03-24
MX2015006697A (es)	2015-08-05
MY177721A (en)	2020-09-23
PH12015501154B1 (en)	2018-05-30
HRP20170274T1 (hr)	2017-04-07
WO2014085153A1 (fr)	2014-06-05
AU2013352594B2 (en)	2016-02-18
CA2889243C (fr)	2017-06-13
JP2016501219A (ja)	2016-01-18
MA38126A1 (fr)	2017-03-31
BR112015011200A2 (pt)	2017-07-11
EP2925754B1 (fr)	2016-12-28
EA026686B1 (ru)	2017-05-31
EP2925754A1 (fr)	2015-10-07
DK2925754T3 (en)	2017-02-20
MA38126B1 (fr)	2017-11-30

Publication	Publication Date	Title
TN2015000200A1 (en)	2016-10-03	6-((s)-1-{1-[5-{2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}-ethyl) - 3h-1,3-benzothiazol - 2 - one as a tarp- gamma 8 dependent ampa receptor antagonist
PH12019502072A1 (en)	2020-07-13	Sustained release dosage forms for a jak1 inhibitor
PH12014502169A1 (en)	2014-12-10	N-cyclylamides as nematicides
SI2432472T1 (sl)	2019-11-29	3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
CL2014000534A1 (es)	2014-08-22	Procesos para preparar {1-{1-[3-fluoro-2-(trifluorometil)isonicotinoil]piperidin-4-il}-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo y compuestos intermediarios, inhibidores de jak; y compuesto intermediario (3-fluoro-2-(trifluorometil)piridin-4-il)(1,4-dioxa-8-azaspiro[4,5]decan-8-il)metanona.
PH12013500870A1 (en)	2013-06-03	Heterocyclic compounds and uses thereof
MX352927B (es)	2017-12-14	Derivados de 1h-pirrolo [2,3-b] piridina y su uso como inhibidores de quinasa.
MX2013012652A (es)	2014-05-27	Derivados de n-[(1h-pirazol-1-il)aril]-1h-indol o 1h-indazol-3-carboxamida, su preparacion y su uso como antagonistas p2y12.
GB201101517D0 (en)	2011-03-16	Receptor antagonists
MX2010008713A (es)	2010-09-09	Derivados de 5,6-bisaril-2-piridina-carboxamida, su preparacion y su aplicacion en terapeutica como antagonistas de los receptores de la urotensina ii.
PH12014501415A1 (en)	2014-09-22	Heterocyclic amide derivatives as p2x7 receptor antagonists
NZ629795A (en)	2016-06-24	4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
TN2014000519A1 (en)	2016-03-30	Pyrimidinone derivatives as antimalarial agents
MX2015005312A (es)	2015-11-16	Derivados de 1h-indazol-3-carboxamida y uso de los mismos como antagonistas de p2y12.
IN2014CN00834A (fr)	2015-04-03
PH12014501760B1 (en)	2014-11-10	Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro[5.5]undecanes
HK1192546A1 (zh)	2014-08-22	6-(哌啶-4-基氧基)-2h-异喹啉-1-酮盐酸盐的结晶性溶剂化物