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TN2013000462A1 - Positive allosteric modulators of nicotinic acetylcholine receptor - Google Patents

Positive allosteric modulators of nicotinic acetylcholine receptor

Info

Publication number
TN2013000462A1
TN2013000462A1 TNP2013000462A TN2013000462A TN2013000462A1 TN 2013000462 A1 TN2013000462 A1 TN 2013000462A1 TN P2013000462 A TNP2013000462 A TN P2013000462A TN 2013000462 A TN2013000462 A TN 2013000462A TN 2013000462 A1 TN2013000462 A1 TN 2013000462A1
Authority
TN
Tunisia
Prior art keywords
nicotinic acetylcholine
positive allosteric
allosteric modulators
acetylcholine receptor
compounds
Prior art date
Application number
TNP2013000462A
Other languages
English (en)
Inventor
Jørgen Eskildsen
Anette Graven Sams
Ask Püschl
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/063219 external-priority patent/WO2013007621A1/fr
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of TN2013000462A1 publication Critical patent/TN2013000462A1/fr

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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TNP2013000462A 2011-07-08 2013-11-06 Positive allosteric modulators of nicotinic acetylcholine receptor TN2013000462A1 (en)

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WO2018187606A1 (fr) * 2017-04-07 2018-10-11 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center PROCÉDÉS ET COMPOSITIONS POUR MODULER LES INTERACTIONS β-AMYLOÏDE/α7-NACHR
EA202092608A1 (ru) 2018-05-01 2021-03-02 Мерк Шарп И Доум Корп. Спиропиперидиновые аллостерические модуляторы никотиновых ацетилхолиновых рецепторов
EP4404935A4 (fr) * 2021-09-21 2025-07-16 Merck Sharp & Dohme Llc Modulateurs allostériques des récepteurs nicotiniques de l'acétylcholine
US20250002448A1 (en) * 2021-09-21 2025-01-02 Merck Sharp & Dohme Llc Allosteric modulators of nicotinic acetylcholine receptors

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WO2009043784A1 (fr) 2007-10-04 2009-04-09 F. Hoffmann-La Roche Ag Dérivés de cyclopropyl aryl amides et leurs utilisations
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US8497271B2 (en) 2009-10-07 2013-07-30 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
CA2839769A1 (fr) 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Composes inhibiteurs de metalloenzymes
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JP5993472B2 (ja) 2016-09-14
US20140323523A1 (en) 2014-10-30
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US9889122B2 (en) 2018-02-13
DOP2013000304A (es) 2014-04-15
US20150231121A1 (en) 2015-08-20
US20170079967A1 (en) 2017-03-23
US9023870B2 (en) 2015-05-05
HRP20180913T1 (hr) 2018-07-27
US8765790B2 (en) 2014-07-01
US9050327B2 (en) 2015-06-09
JP2015129161A (ja) 2015-07-16
US8598213B2 (en) 2013-12-03
US9549919B2 (en) 2017-01-24
US20140044806A1 (en) 2014-02-13
PH12016500136B1 (en) 2017-02-20
PH12016500136A1 (en) 2017-02-20
US20140010897A1 (en) 2014-01-09
MA35407B1 (fr) 2014-09-01
US20130012530A1 (en) 2013-01-10
US20140010898A1 (en) 2014-01-09

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