TN2011000294A1 - Arylcyclopropylacetamide derivatives useful as glucokinase activators - Google Patents

Arylcyclopropylacetamide derivatives useful as glucokinase activators

Info

Publication number: TN2011000294A1
Authority: TN; Tunisia
Prior art keywords: derivatives useful; glucokinase activators; arylcyclopropylacetamide; arylcyclopropylacetamide derivatives; glucokinase
Prior art date: 2008-12-19

Application number

TN2011000294A

Other languages

English (en)

Inventor

Francisco Javier Agejas-Chicharro

Melendo Ana Belen Bueno

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-19

Filing date

2011-06-09

Publication date

2012-12-17

2011-06-09 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2012-12-17 Publication of TN2011000294A1 publication Critical patent/TN2011000294A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

TN2011000294A 2008-12-19 2011-06-09 Arylcyclopropylacetamide derivatives useful as glucokinase activators TN2011000294A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08380341		2008-12-19
PCT/US2009/067603 WO2010080333A1 (fr)	2008-12-19	2009-12-11	Dérivés d'arylcyclopropylacétamide utiles en tant qu'activateurs de glucokinase

Publications (1)

Publication Number	Publication Date
TN2011000294A1 true TN2011000294A1 (en)	2012-12-17

Family

ID=40545955

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TN2011000294A TN2011000294A1 (en)	2008-12-19	2011-06-09	Arylcyclopropylacetamide derivatives useful as glucokinase activators

Country Status (34)

Country	Link
US (1)	US8063079B2 (fr)
EP (1)	EP2379517B1 (fr)
JP (1)	JP5497064B2 (fr)
KR (1)	KR101290437B1 (fr)
CN (1)	CN102256952B (fr)
AR (1)	AR074470A1 (fr)
AU (1)	AU2009335931B2 (fr)
BR (1)	BRPI0923183B1 (fr)
CA (1)	CA2746746C (fr)
CO (1)	CO6382120A2 (fr)
CR (1)	CR20110342A (fr)
DK (1)	DK2379517T3 (fr)
DO (1)	DOP2011000197A (fr)
EA (1)	EA019055B1 (fr)
EC (1)	ECSP11011150A (fr)
ES (1)	ES2435242T3 (fr)
HR (1)	HRP20130983T1 (fr)
IL (1)	IL213210A (fr)
JO (1)	JO2979B1 (fr)
MA (1)	MA32902B1 (fr)
MX (1)	MX2011006434A (fr)
MY (1)	MY180567A (fr)
NZ (1)	NZ592930A (fr)
PA (1)	PA8851901A1 (fr)
PE (1)	PE20120339A1 (fr)
PL (1)	PL2379517T3 (fr)
PT (1)	PT2379517E (fr)
SG (1)	SG172256A1 (fr)
SI (1)	SI2379517T1 (fr)
TN (1)	TN2011000294A1 (fr)
TW (1)	TWI395748B (fr)
UA (1)	UA104742C2 (fr)
WO (1)	WO2010080333A1 (fr)
ZA (1)	ZA201103944B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2800498C (fr)	2010-03-31	2021-11-16	The Scripps Research Institute	Nouvelle programmation de cellules
EP3072506B1 (fr)	2013-11-22	2022-04-20	The University of Tokyo	Vecteur d'apport de médicament et conjugué, composition le contenant, et son procédé d'administration

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6388071B2 (en)	2000-05-03	2002-05-14	Hoffmann-La Roche Inc.	Alkynyl phenyl heteroaromatic glucokinase activators
EP1282611B1 (fr)	2000-05-08	2004-10-20	F. Hoffmann-La Roche Ag	Phenylacetamides substitues et leur utilisation en tant qu'activateurs de la glucokinase
ATE398611T1 (de)	2000-05-08	2008-07-15	Hoffmann La Roche	Para-amin substituierte phenylamid glukokinase activatoren
US7132425B2 (en) *	2002-12-12	2006-11-07	Hoffmann-La Roche Inc.	5-substituted-six-membered heteroaromatic glucokinase activators
EP1585739B1 (fr)	2003-01-06	2011-04-20	Eli Lilly And Company	Arylcyclopropylacetamides substitues servant d'activateurs de glucokinase
EP1594863A1 (fr)	2003-02-11	2005-11-16	Prosidion Limited	Composes d'amide a substitution tri(cyclo), activateurs de la glucokinase
PL378117A1 (pl)	2003-02-11	2006-03-06	Prosidion Limited	Tricyklopodstawione związki amidowe
EP1600442B1 (fr) *	2003-02-26	2018-01-17	Msd K.K.	Derives d'heteroarylcarbamoylbenzene
EA012204B1 (ru)	2004-04-21	2009-08-28	Прозидион Лимитед	Три(цикло)замещённые амидные соединения
CN101035767A (zh)	2004-08-12	2007-09-12	普洛希典有限公司	被取代的苯乙酰胺及其作为葡糖激酶激活剂的用途
MX2007006420A (es) *	2004-12-03	2007-07-19	Novo Nordisk As	Activadores heteroaromaticos de glucocinasa.
EP1907004A2 (fr) *	2005-07-01	2008-04-09	Novartis AG	Combinaison d'un inhibiteur de rénine et d'un promoteur de sécretion d'insulin ou un sensibilisateur d'insulin organiques
CN101218237B (zh)	2005-07-11	2012-03-28	田边三菱制药株式会社	肟衍生物及其制备方法
US20100160286A1 (en) *	2005-08-09	2010-06-24	Astrazeneca Uk Limited Ab	Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes
US20080293741A1 (en) *	2005-11-03	2008-11-27	Matthew Colin Thor Fyfe	Tricyclo Substituted Amides as Glucokinase Modulators
BRPI0618062A2 (pt)	2005-11-03	2011-08-16	Prosidion Ltd	composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
AU2006310475A1 (en)	2005-11-03	2007-05-10	Prosidion Ltd	Tricyclo substituted amides
CA2657566A1 (fr) *	2006-07-24	2008-01-31	F. Hoffmann-La Roche Ag	Pyrazoles comme activateurs de glucokinase
US8314247B2 (en) *	2007-01-10	2012-11-20	Mitsubishi Tanabe Pharma Corporation	Hydrazone derivative
CA2722733C (fr)	2008-04-28	2016-02-23	Kyorin Pharmaceutical Co., Ltd.	Derive de cyclopentylacrylamide

2009
- 2009-11-12 UA UAA201107562A patent/UA104742C2/uk unknown
- 2009-12-03 PA PA20098851901A patent/PA8851901A1/es unknown
- 2009-12-03 AR ARP090104672A patent/AR074470A1/es active IP Right Grant
- 2009-12-04 TW TW098141556A patent/TWI395748B/zh active
- 2009-12-06 JO JO2009467A patent/JO2979B1/en active
- 2009-12-11 ES ES09768316T patent/ES2435242T3/es active Active
- 2009-12-11 PE PE2011001220A patent/PE20120339A1/es active IP Right Grant
- 2009-12-11 DK DK09768316.3T patent/DK2379517T3/da active
- 2009-12-11 EP EP09768316.3A patent/EP2379517B1/fr active Active
- 2009-12-11 EA EA201170845A patent/EA019055B1/ru not_active IP Right Cessation
- 2009-12-11 HR HRP20130983AT patent/HRP20130983T1/hr unknown
- 2009-12-11 SG SG2011044823A patent/SG172256A1/en unknown
- 2009-12-11 NZ NZ592930A patent/NZ592930A/xx not_active IP Right Cessation
- 2009-12-11 PT PT97683163T patent/PT2379517E/pt unknown
- 2009-12-11 MY MYPI2011002765A patent/MY180567A/en unknown
- 2009-12-11 US US12/635,758 patent/US8063079B2/en active Active
- 2009-12-11 SI SI200930713T patent/SI2379517T1/sl unknown
- 2009-12-11 MX MX2011006434A patent/MX2011006434A/es active IP Right Grant
- 2009-12-11 BR BRPI0923183-8A patent/BRPI0923183B1/pt not_active IP Right Cessation
- 2009-12-11 KR KR1020117014073A patent/KR101290437B1/ko not_active Expired - Fee Related
- 2009-12-11 CN CN200980150686XA patent/CN102256952B/zh active Active
- 2009-12-11 WO PCT/US2009/067603 patent/WO2010080333A1/fr not_active Ceased
- 2009-12-11 CA CA2746746A patent/CA2746746C/fr active Active
- 2009-12-11 PL PL09768316T patent/PL2379517T3/pl unknown
- 2009-12-11 JP JP2011542276A patent/JP5497064B2/ja active Active
- 2009-12-11 AU AU2009335931A patent/AU2009335931B2/en not_active Ceased
2011
- 2011-05-27 ZA ZA2011/03944A patent/ZA201103944B/en unknown
- 2011-05-30 IL IL213210A patent/IL213210A/en active IP Right Grant
- 2011-06-09 TN TN2011000294A patent/TN2011000294A1/fr unknown
- 2011-06-14 MA MA33945A patent/MA32902B1/fr unknown
- 2011-06-17 DO DO2011000197A patent/DOP2011000197A/es unknown
- 2011-06-17 CR CR20110342A patent/CR20110342A/es unknown
- 2011-06-17 EC EC2011011150A patent/ECSP11011150A/es unknown
- 2011-06-23 CO CO11079303A patent/CO6382120A2/es active IP Right Grant

Also Published As

Publication number	Publication date
PA8851901A1 (es)	2010-07-27
SG172256A1 (en)	2011-07-28
AR074470A1 (es)	2011-01-19
HRP20130983T1 (hr)	2013-11-22
KR20110086751A (ko)	2011-07-29
BRPI0923183B1 (pt)	2019-03-19
CA2746746C (fr)	2013-09-24
CR20110342A (es)	2011-09-14
TWI395748B (zh)	2013-05-11
EP2379517A1 (fr)	2011-10-26
EP2379517B1 (fr)	2013-08-28
CA2746746A1 (fr)	2010-07-15
MY180567A (en)	2020-12-02
CN102256952A (zh)	2011-11-23
PL2379517T3 (pl)	2014-01-31
IL213210A0 (en)	2011-07-31
JP2012512874A (ja)	2012-06-07
JP5497064B2 (ja)	2014-05-21
KR101290437B1 (ko)	2013-07-29
PT2379517E (pt)	2013-11-21
EA019055B1 (ru)	2013-12-30
ES2435242T3 (es)	2013-12-17
CO6382120A2 (es)	2012-02-15
AU2009335931A1 (en)	2011-07-07
CN102256952B (zh)	2013-12-11
BRPI0923183A8 (pt)	2017-09-12
AU2009335931B2 (en)	2012-05-31
MA32902B1 (fr)	2011-12-01
PE20120339A1 (es)	2012-04-16
SI2379517T1 (sl)	2013-10-30
WO2010080333A1 (fr)	2010-07-15
IL213210A (en)	2015-03-31
TW201029999A (en)	2010-08-16
US20100160395A1 (en)	2010-06-24
DK2379517T3 (da)	2013-09-30
UA104742C2 (uk)	2014-03-11
BRPI0923183A2 (pt)	2016-02-16
NZ592930A (en)	2013-01-25
US8063079B2 (en)	2011-11-22
MX2011006434A (es)	2011-07-19
JO2979B1 (en)	2016-03-15
DOP2011000197A (es)	2011-09-15
ECSP11011150A (es)	2011-07-29
ZA201103944B (en)	2012-11-28
EA201170845A1 (ru)	2011-12-30

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