TN2011000294A1 - Arylcyclopropylacetamide derivatives useful as glucokinase activators - Google Patents
Arylcyclopropylacetamide derivatives useful as glucokinase activatorsInfo
- Publication number
- TN2011000294A1 TN2011000294A1 TN2011000294A TN2011000294A TN2011000294A1 TN 2011000294 A1 TN2011000294 A1 TN 2011000294A1 TN 2011000294 A TN2011000294 A TN 2011000294A TN 2011000294 A TN2011000294 A TN 2011000294A TN 2011000294 A1 TN2011000294 A1 TN 2011000294A1
- Authority
- TN
- Tunisia
- Prior art keywords
- derivatives useful
- glucokinase activators
- arylcyclopropylacetamide
- arylcyclopropylacetamide derivatives
- glucokinase
- Prior art date
Links
- 102000030595 Glucokinase Human genes 0.000 title 1
- 108010021582 Glucokinase Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A compound of formula (A) ; and pharmaceutical compositions for the treatment of diabetes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08380341 | 2008-12-19 | ||
| PCT/US2009/067603 WO2010080333A1 (en) | 2008-12-19 | 2009-12-11 | Arylcyclopropylacetamide derivatives useful as glucokinase activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2011000294A1 true TN2011000294A1 (en) | 2012-12-17 |
Family
ID=40545955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TN2011000294A TN2011000294A1 (en) | 2008-12-19 | 2011-06-09 | Arylcyclopropylacetamide derivatives useful as glucokinase activators |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US8063079B2 (en) |
| EP (1) | EP2379517B1 (en) |
| JP (1) | JP5497064B2 (en) |
| KR (1) | KR101290437B1 (en) |
| CN (1) | CN102256952B (en) |
| AR (1) | AR074470A1 (en) |
| AU (1) | AU2009335931B2 (en) |
| BR (1) | BRPI0923183B1 (en) |
| CA (1) | CA2746746C (en) |
| CO (1) | CO6382120A2 (en) |
| CR (1) | CR20110342A (en) |
| DK (1) | DK2379517T3 (en) |
| DO (1) | DOP2011000197A (en) |
| EA (1) | EA019055B1 (en) |
| EC (1) | ECSP11011150A (en) |
| ES (1) | ES2435242T3 (en) |
| HR (1) | HRP20130983T1 (en) |
| IL (1) | IL213210A (en) |
| JO (1) | JO2979B1 (en) |
| MA (1) | MA32902B1 (en) |
| MX (1) | MX2011006434A (en) |
| MY (1) | MY180567A (en) |
| NZ (1) | NZ592930A (en) |
| PA (1) | PA8851901A1 (en) |
| PE (1) | PE20120339A1 (en) |
| PL (1) | PL2379517T3 (en) |
| PT (1) | PT2379517E (en) |
| SG (1) | SG172256A1 (en) |
| SI (1) | SI2379517T1 (en) |
| TN (1) | TN2011000294A1 (en) |
| TW (1) | TWI395748B (en) |
| UA (1) | UA104742C2 (en) |
| WO (1) | WO2010080333A1 (en) |
| ZA (1) | ZA201103944B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011123572A1 (en) | 2010-03-31 | 2011-10-06 | The Scripps Research Institute | Reprogramming cells |
| WO2015075942A1 (en) * | 2013-11-22 | 2015-05-28 | 国立大学法人 東京大学 | Carrier for drug delivery and conjugate, composition containing same, and method for administering same |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176915C (en) | 2000-05-03 | 2004-11-24 | 霍夫曼-拉罗奇有限公司 | Inulin Kinase Activator of Alkynylphenyl Aromatic Heterocycle |
| KR100548901B1 (en) | 2000-05-08 | 2006-02-02 | 에프. 호프만-라 로슈 아게 | Substituted phenylacetamides and their use as glucokinase activators |
| PT1283830E (en) | 2000-05-08 | 2008-08-18 | Hoffmann La Roche | Para-amine substituted phenylamide glucokinase activators |
| PE20040801A1 (en) * | 2002-12-12 | 2004-11-25 | Hoffmann La Roche | PYRAZINE AND PYRIDINE 5-SUBSTITUTED DERIVATIVES AS GLUCOKINASE ACTIVATORS |
| ES2362656T3 (en) | 2003-01-06 | 2011-07-11 | Eli Lilly And Company | ARILCICLOPROPILACETAMIDES REPLACED AS GLUCOQUINASE ACTIVATORS. |
| PL378117A1 (en) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
| WO2004072066A1 (en) | 2003-02-11 | 2004-08-26 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
| AU2004215514B2 (en) * | 2003-02-26 | 2010-03-04 | Msd K.K. | Heteroarylcarbamoylbenzene derivative |
| JP2007533722A (en) | 2004-04-21 | 2007-11-22 | プロシディオン・リミテッド | Tri (cyclo) substituted amide compounds |
| CA2576407A1 (en) | 2004-08-12 | 2006-02-16 | Prosidion Limited | Substituted phenylacetamides and their use as glucokinase activators |
| MX2007006420A (en) * | 2004-12-03 | 2007-07-19 | Novo Nordisk As | Heteroaromatic glucokinase activators. |
| KR20080028382A (en) * | 2005-07-01 | 2008-03-31 | 노파르티스 아게 | Combination of renin inhibitors and insulin secretagogues or insulin sensitizers |
| AR057661A1 (en) | 2005-07-11 | 2007-12-12 | Tanabe Seiyaku Co | A DERIVATIVE OF OXIMA AND ITS PREPARATIONS |
| US20100160286A1 (en) * | 2005-08-09 | 2010-06-24 | Astrazeneca Uk Limited Ab | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
| JP2009514836A (en) | 2005-11-03 | 2009-04-09 | プロシディオン・リミテッド | Tricyclo-substituted amide |
| BRPI0618062A2 (en) | 2005-11-03 | 2011-08-16 | Prosidion Ltd | compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt thereof, and process for the preparation of a compound |
| US20080293741A1 (en) | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
| AU2007278261A1 (en) * | 2006-07-24 | 2008-01-31 | F. Hoffmann-La Roche Ag | Pyrazoles as glucokinase activators |
| EP2105435A4 (en) * | 2007-01-10 | 2011-06-15 | Mitsubishi Tanabe Pharma Corp | Hydrazone derivatives |
| RU2565070C2 (en) | 2008-04-28 | 2015-10-20 | Киорин Фармасьютикал Ко., Лтд. | Cyclopentylacrylamide derivative |
-
2009
- 2009-11-12 UA UAA201107562A patent/UA104742C2/en unknown
- 2009-12-03 PA PA20098851901A patent/PA8851901A1/en unknown
- 2009-12-03 AR ARP090104672A patent/AR074470A1/en active IP Right Grant
- 2009-12-04 TW TW098141556A patent/TWI395748B/en active
- 2009-12-06 JO JO2009467A patent/JO2979B1/en active
- 2009-12-11 EA EA201170845A patent/EA019055B1/en not_active IP Right Cessation
- 2009-12-11 US US12/635,758 patent/US8063079B2/en active Active
- 2009-12-11 PE PE2011001220A patent/PE20120339A1/en active IP Right Grant
- 2009-12-11 SG SG2011044823A patent/SG172256A1/en unknown
- 2009-12-11 BR BRPI0923183-8A patent/BRPI0923183B1/en not_active IP Right Cessation
- 2009-12-11 HR HRP20130983AT patent/HRP20130983T1/en unknown
- 2009-12-11 WO PCT/US2009/067603 patent/WO2010080333A1/en not_active Ceased
- 2009-12-11 DK DK09768316.3T patent/DK2379517T3/en active
- 2009-12-11 EP EP09768316.3A patent/EP2379517B1/en active Active
- 2009-12-11 JP JP2011542276A patent/JP5497064B2/en active Active
- 2009-12-11 MX MX2011006434A patent/MX2011006434A/en active IP Right Grant
- 2009-12-11 SI SI200930713T patent/SI2379517T1/en unknown
- 2009-12-11 CN CN200980150686XA patent/CN102256952B/en active Active
- 2009-12-11 AU AU2009335931A patent/AU2009335931B2/en not_active Ceased
- 2009-12-11 PT PT97683163T patent/PT2379517E/en unknown
- 2009-12-11 MY MYPI2011002765A patent/MY180567A/en unknown
- 2009-12-11 NZ NZ592930A patent/NZ592930A/en not_active IP Right Cessation
- 2009-12-11 PL PL09768316T patent/PL2379517T3/en unknown
- 2009-12-11 ES ES09768316T patent/ES2435242T3/en active Active
- 2009-12-11 KR KR1020117014073A patent/KR101290437B1/en not_active Expired - Fee Related
- 2009-12-11 CA CA2746746A patent/CA2746746C/en active Active
-
2011
- 2011-05-27 ZA ZA2011/03944A patent/ZA201103944B/en unknown
- 2011-05-30 IL IL213210A patent/IL213210A/en active IP Right Grant
- 2011-06-09 TN TN2011000294A patent/TN2011000294A1/en unknown
- 2011-06-14 MA MA33945A patent/MA32902B1/en unknown
- 2011-06-17 EC EC2011011150A patent/ECSP11011150A/en unknown
- 2011-06-17 DO DO2011000197A patent/DOP2011000197A/en unknown
- 2011-06-17 CR CR20110342A patent/CR20110342A/en unknown
- 2011-06-23 CO CO11079303A patent/CO6382120A2/en active IP Right Grant
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