TN2011000166A1 - Disubstituted phthalazine hedgehog pathway antagonists - Google Patents

Disubstituted phthalazine hedgehog pathway antagonists

Info

Publication number: TN2011000166A1
Authority: TN; Tunisia
Prior art keywords: hedgehog pathway; pathway antagonists; disubstituted phthalazine; phthalazine hedgehog; disubstituted
Prior art date: 2008-11-03

Application number

TN2011000166A

Other languages

English (en)

Inventor

Jolie Anne Bastian

Philip Arthur Hipskind

Daniel Jon Sall

Takako Wilson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-03

Filing date

2011-04-07

Publication date

2012-12-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2011000166(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-04-07 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2012-12-17 Publication of TN2011000166A1 publication Critical patent/TN2011000166A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TN2011000166A 2008-11-03 2011-04-07 Disubstituted phthalazine hedgehog pathway antagonists TN2011000166A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11070308P	2008-11-03	2008-11-03
PCT/US2009/061573 WO2010062507A1 (fr)	2008-11-03	2009-10-22	Antagonistes phtalazine disubstituée de la voie de signalisation hedgehog

Publications (1)

Publication Number	Publication Date
TN2011000166A1 true TN2011000166A1 (en)	2012-12-17

Family

ID=41566219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TN2011000166A TN2011000166A1 (en)	2008-11-03	2011-04-07	Disubstituted phthalazine hedgehog pathway antagonists

Country Status (29)

Country	Link
US (1)	US8404687B2 (fr)
EP (1)	EP2364185B1 (fr)
JP (1)	JP2012507535A (fr)
KR (1)	KR101335746B1 (fr)
CN (1)	CN102202737B (fr)
AU (1)	AU2009320251C1 (fr)
BR (1)	BRPI0921437A2 (fr)
CA (1)	CA2742539C (fr)
CL (1)	CL2011000979A1 (fr)
CO (1)	CO6382123A2 (fr)
CR (1)	CR20110202A (fr)
CY (1)	CY1114023T1 (fr)
DK (1)	DK2364185T3 (fr)
EA (1)	EA018931B1 (fr)
EC (1)	ECSP11011021A (fr)
ES (1)	ES2418479T3 (fr)
HR (1)	HRP20130527T1 (fr)
IL (1)	IL211841A0 (fr)
MA (1)	MA32726B1 (fr)
MX (1)	MX2011004683A (fr)
NZ (1)	NZ591945A (fr)
PE (1)	PE20110433A1 (fr)
PL (1)	PL2364185T3 (fr)
PT (1)	PT2364185E (fr)
SI (1)	SI2364185T1 (fr)
TN (1)	TN2011000166A1 (fr)
UA (1)	UA102115C2 (fr)
WO (1)	WO2010062507A1 (fr)
ZA (1)	ZA201102448B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2008225766B2 (en) *	2007-03-15	2012-06-07	Novartis Ag	Organic compounds and their uses
AU2009241561B2 (en)	2008-04-29	2013-05-16	Eli Lilly And Company	Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en)	2008-07-18	2010-02-18	Novartis Ag	Organic Compounds as Smo Inhibitors
ES2446307T3 (es)	2008-11-17	2014-03-07	Eli Lilly And Company	Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog
CN102216285B (zh)	2008-11-17	2014-08-13	伊莱利利公司	四取代的哒嗪hedgehog途径拮抗剂
AR077014A1 (es)	2009-06-19	2011-07-27	Lilly Co Eli	Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US9814703B2 (en)	2013-11-14	2017-11-14	The Board Of Trustees Of The Leland Stanford Junior University	Methods for treating cancer by activation of BMP signaling
CN105985319B (zh) *	2015-02-11	2019-02-26	复旦大学	芳基酞嗪化合物及其制备方法和用途
CN105985320B (zh) *	2015-02-11	2018-10-26	复旦大学	苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) *	2015-02-11	2018-10-26	复旦大学	吡唑酞嗪化合物及其制备方法和用途
EP4229828A4 (fr)	2020-10-13	2024-08-28	Endeavor Biomedicines, Inc.	Méthodes de traitement de la fibrose
AU2023347443A1 (en) *	2022-09-23	2025-04-03	Merck Sharp & Dohme Llc	Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
WO2025188802A1 (fr)	2024-03-05	2025-09-12	Endeavor Biomedicines, Inc.	Méthodes d'amélioration de la fonction pulmonaire

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1293565A (en)	1969-05-03	1972-10-18	Aspro Nicholas Ltd	Aminophthalazines and pharmaceutical compositions thereof
ES2162235T3 (es)	1996-01-15	2001-12-16	Janssen Pharmaceutica Nv	Piridazinaminas inhibidoras de la angiogenesis.
JP4073961B2 (ja) *	1996-10-01	2008-04-09	協和醗酵工業株式会社	含窒素複素環化合物
JP5067986B2 (ja)	1998-04-09	2012-11-07	ジョンズホプキンズユニヴァーシティースクールオブメディシン	ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用
US6432970B2 (en)	1998-04-09	2002-08-13	Johns Hopkins University School Of Medicine	Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
ATE283700T1 (de)	1999-06-08	2004-12-15	Lorantis Ltd	Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges
DE60322869D1 (de)	2002-04-22	2008-09-25	Univ Johns Hopkins	Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
AU2003265853A1 (en)	2002-08-29	2004-03-19	Curis, Inc.	Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (fr) *	2003-09-29	2005-04-14	The Johns Hopkins University	Antagonistes de la voie hedgehog
WO2005080378A1 (fr)	2004-02-24	2005-09-01	Mitsubishi Pharma Corporation	Dérivés de pyridazine fondue
US8338591B2 (en)	2004-05-08	2012-12-25	Novartis International Pharmaceutical Ltd.	3-aryl-5,6-disubstituted pyridazines
KR20130083488A (ko) *	2004-09-02	2013-07-22	제넨테크, 인크.	헤지호그 신호전달에 대한 피리딜 억제제
EP1900731A1 (fr)	2006-09-07	2008-03-19	Bayer Schering Pharma Aktiengesellschaft	N-(1-Phthalazin-1-yl-piperidin-4-yl)-amides comme modulateurs du récepteur EP2
AU2008225766B2 (en) *	2007-03-15	2012-06-07	Novartis Ag	Organic compounds and their uses
AU2008269128B2 (en)	2007-06-25	2012-08-02	Amgen Inc.	Phthalazine compounds, compositions and methods of use
CA2697682A1 (fr)	2007-09-07	2009-03-19	Amgen Inc.	Pyridazines annelees destinees au traitement de tumeurs induites par une signalisation hedgehog inadaptee
AU2009241561B2 (en)	2008-04-29	2013-05-16	Eli Lilly And Company	Disubstituted phthalazine hedgehog pathway antagonists
US20100041663A1 (en)	2008-07-18	2010-02-18	Novartis Ag	Organic Compounds as Smo Inhibitors
CN102216285B (zh)	2008-11-17	2014-08-13	伊莱利利公司	四取代的哒嗪hedgehog途径拮抗剂
ES2446307T3 (es)	2008-11-17	2014-03-07	Eli Lilly And Company	Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog
AR077014A1 (es)	2009-06-19	2011-07-27	Lilly Co Eli	Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

2009
- 2009-10-22 HR HRP20130527AT patent/HRP20130527T1/hr unknown
- 2009-10-22 WO PCT/US2009/061573 patent/WO2010062507A1/fr not_active Ceased
- 2009-10-22 DK DK09740613.6T patent/DK2364185T3/da active
- 2009-10-22 PL PL09740613T patent/PL2364185T3/pl unknown
- 2009-10-22 EA EA201170640A patent/EA018931B1/ru not_active IP Right Cessation
- 2009-10-22 NZ NZ591945A patent/NZ591945A/xx not_active IP Right Cessation
- 2009-10-22 PT PT97406136T patent/PT2364185E/pt unknown
- 2009-10-22 PE PE2011000937A patent/PE20110433A1/es not_active Application Discontinuation
- 2009-10-22 EP EP09740613.6A patent/EP2364185B1/fr active Active
- 2009-10-22 JP JP2011534624A patent/JP2012507535A/ja active Pending
- 2009-10-22 US US13/122,212 patent/US8404687B2/en not_active Expired - Fee Related
- 2009-10-22 KR KR1020117010063A patent/KR101335746B1/ko not_active Expired - Fee Related
- 2009-10-22 UA UAA201105364A patent/UA102115C2/ru unknown
- 2009-10-22 BR BRPI0921437A patent/BRPI0921437A2/pt not_active IP Right Cessation
- 2009-10-22 ES ES09740613T patent/ES2418479T3/es active Active
- 2009-10-22 MX MX2011004683A patent/MX2011004683A/es active IP Right Grant
- 2009-10-22 CA CA2742539A patent/CA2742539C/fr not_active Expired - Fee Related
- 2009-10-22 CN CN200980143394.3A patent/CN102202737B/zh not_active Expired - Fee Related
- 2009-10-22 SI SI200930625T patent/SI2364185T1/sl unknown
- 2009-10-22 AU AU2009320251A patent/AU2009320251C1/en not_active Ceased
2011
- 2011-03-21 IL IL211841A patent/IL211841A0/en unknown
- 2011-04-01 ZA ZA2011/02448A patent/ZA201102448B/en unknown
- 2011-04-07 TN TN2011000166A patent/TN2011000166A1/fr unknown
- 2011-04-15 CR CR20110202A patent/CR20110202A/es not_active Application Discontinuation
- 2011-04-22 MA MA33790A patent/MA32726B1/fr unknown
- 2011-05-02 CL CL2011000979A patent/CL2011000979A1/es unknown
- 2011-05-02 EC EC2011011021A patent/ECSP11011021A/es unknown
- 2011-05-11 CO CO11058054A patent/CO6382123A2/es active IP Right Grant
2013
- 2013-06-05 CY CY20131100447T patent/CY1114023T1/el unknown

Also Published As

Publication number	Publication date
ZA201102448B (en)	2012-09-26
ECSP11011021A (es)	2011-06-30
MA32726B1 (fr)	2011-10-02
EA201170640A1 (ru)	2011-12-30
CR20110202A (es)	2011-06-09
HRP20130527T1 (en)	2013-07-31
CL2011000979A1 (es)	2011-10-07
BRPI0921437A2 (pt)	2018-10-30
PE20110433A1 (es)	2011-07-09
JP2012507535A (ja)	2012-03-29
CN102202737A (zh)	2011-09-28
CY1114023T1 (el)	2016-07-27
NZ591945A (en)	2012-10-26
SI2364185T1 (sl)	2013-07-31
US8404687B2 (en)	2013-03-26
CA2742539A1 (fr)	2010-06-03
KR101335746B1 (ko)	2013-12-12
AU2009320251B2 (en)	2013-01-24
EP2364185B1 (fr)	2013-05-22
AU2009320251A1 (en)	2010-06-03
UA102115C2 (ru)	2013-06-10
MX2011004683A (es)	2011-06-20
US20110190304A1 (en)	2011-08-04
CN102202737B (zh)	2014-03-26
CO6382123A2 (es)	2012-02-15
KR20110066212A (ko)	2011-06-16
IL211841A0 (en)	2011-06-30
CA2742539C (fr)	2014-05-06
PT2364185E (pt)	2013-07-24
DK2364185T3 (da)	2013-06-03
EP2364185A1 (fr)	2011-09-14
EA018931B1 (ru)	2013-11-29
ES2418479T3 (es)	2013-08-14
WO2010062507A1 (fr)	2010-06-03
AU2009320251C1 (en)	2013-08-15
HK1159010A1 (en)	2012-07-27
PL2364185T3 (pl)	2013-10-31

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