DK2364185T3 - Disubstituerede phthalazin-hedgehog-pathway-antagonister - Google Patents

Disubstituerede phthalazin-hedgehog-pathway-antagonister

Info

Publication number: DK2364185T3
Authority: DK; Denmark
Prior art keywords: hedgehog pathway; pathway antagonists; disubstituted phthalazine; phthalazine; disubstituted
Prior art date: 2008-11-03

Application number

DK09740613.6T

Other languages

English (en)

Inventor

Jolie Anne Bastian

Philip Arthur Hipskind

Daniel Jon Sall

Takako Wilson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-03

Filing date

2009-10-22

Publication date

2013-06-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2364185(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-10-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2013-06-03 Application granted granted Critical

2013-06-03 Publication of DK2364185T3 publication Critical patent/DK2364185T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK09740613.6T 2008-11-03 2009-10-22 Disubstituerede phthalazin-hedgehog-pathway-antagonister DK2364185T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11070308P	2008-11-03	2008-11-03
PCT/US2009/061573 WO2010062507A1 (en)	2008-11-03	2009-10-22	Disubstituted phthalazine hedgehog pathway antagonists

Publications (1)

Publication Number	Publication Date
DK2364185T3 true DK2364185T3 (da)	2013-06-03

Family

ID=41566219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09740613.6T DK2364185T3 (da)	2008-11-03	2009-10-22	Disubstituerede phthalazin-hedgehog-pathway-antagonister

Country Status (29)

Country	Link
US (1)	US8404687B2 (da)
EP (1)	EP2364185B1 (da)
JP (1)	JP2012507535A (da)
KR (1)	KR101335746B1 (da)
CN (1)	CN102202737B (da)
AU (1)	AU2009320251C1 (da)
BR (1)	BRPI0921437A2 (da)
CA (1)	CA2742539C (da)
CL (1)	CL2011000979A1 (da)
CO (1)	CO6382123A2 (da)
CR (1)	CR20110202A (da)
CY (1)	CY1114023T1 (da)
DK (1)	DK2364185T3 (da)
EA (1)	EA018931B1 (da)
EC (1)	ECSP11011021A (da)
ES (1)	ES2418479T3 (da)
HR (1)	HRP20130527T1 (da)
IL (1)	IL211841A0 (da)
MA (1)	MA32726B1 (da)
MX (1)	MX2011004683A (da)
NZ (1)	NZ591945A (da)
PE (1)	PE20110433A1 (da)
PL (1)	PL2364185T3 (da)
PT (1)	PT2364185E (da)
SI (1)	SI2364185T1 (da)
TN (1)	TN2011000166A1 (da)
UA (1)	UA102115C2 (da)
WO (1)	WO2010062507A1 (da)
ZA (1)	ZA201102448B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20090188A1 (es) *	2007-03-15	2009-03-20	Novartis Ag	Compuestos heterociclicos como moduladores de la senda de hedgehog
UA102250C2 (ru)	2008-04-29	2013-06-25	Эли Лилли Энд Компани	Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en)	2008-07-18	2010-02-18	Novartis Ag	Organic Compounds as Smo Inhibitors
KR101335770B1 (ko)	2008-11-17	2013-12-12	일라이 릴리 앤드 캄파니	사치환된 피리다진 헷지호그 경로 길항제
EP2358698B1 (en)	2008-11-17	2012-09-05	Eli Lilly and Company	Tetrasubstituted pyridazine as hedgehog pathway antagonists
AR077014A1 (es)	2009-06-19	2011-07-27	Lilly Co Eli	Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US9814703B2 (en)	2013-11-14	2017-11-14	The Board Of Trustees Of The Leland Stanford Junior University	Methods for treating cancer by activation of BMP signaling
CN105985320B (zh) *	2015-02-11	2018-10-26	复旦大学	苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) *	2015-02-11	2018-10-26	复旦大学	吡唑酞嗪化合物及其制备方法和用途
CN105985319B (zh) *	2015-02-11	2019-02-26	复旦大学	芳基酞嗪化合物及其制备方法和用途
CN116349204A (zh)	2020-10-13	2023-06-27	奋进生物医药公司	治疗纤维化的方法
WO2024064245A1 (en) *	2022-09-23	2024-03-28	Merck Sharp & Dohme Llc	Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
US12447148B2 (en)	2024-03-05	2025-10-21	Endeavor Biomedicines, Inc.	Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1293565A (en)	1969-05-03	1972-10-18	Aspro Nicholas Ltd	Aminophthalazines and pharmaceutical compositions thereof
WO1998014431A1 (en) *	1996-10-01	1998-04-09	Kyowa Hakko Kogyo Co., Ltd.	Nitrogenous heterocyclic compounds
ES2162235T3 (es)	1996-01-15	2001-12-16	Janssen Pharmaceutica Nv	Piridazinaminas inhibidoras de la angiogenesis.
US6432970B2 (en)	1998-04-09	2002-08-13	Johns Hopkins University School Of Medicine	Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
WO1999052534A1 (en)	1998-04-09	1999-10-21	Johns Hopkins University School Of Medicine	Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
AU780358B2 (en)	1999-06-08	2005-03-17	Lorantis Limited	Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
ATE404200T1 (de)	2002-04-22	2008-08-15	Univ Johns Hopkins Med	Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
AU2003265853A1 (en)	2002-08-29	2004-03-19	Curis, Inc.	Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) *	2003-09-29	2005-04-14	The Johns Hopkins University	Hedgehog pathway antagonists
TW200533356A (en)	2004-02-24	2005-10-16	Mitsubishi Pharma Corp	Fused pyridazine derivatives
CA2564996A1 (en)	2004-05-08	2006-01-12	Taeyoung Yoon	3-aryl-5,6-disubstituted pyridazines
KR20160058972A (ko) *	2004-09-02	2016-05-25	제넨테크, 인크.	헤지호그 신호전달에 대한 피리딜 억제제
EP1900731A1 (de)	2006-09-07	2008-03-19	Bayer Schering Pharma Aktiengesellschaft	N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
PE20090188A1 (es)	2007-03-15	2009-03-20	Novartis Ag	Compuestos heterociclicos como moduladores de la senda de hedgehog
ES2505091T3 (es)	2007-06-25	2014-10-09	Amgen Inc.	Compuestos, composiciones y métodos de uso de ftalazina
WO2009035568A1 (en)	2007-09-07	2009-03-19	Amgen Inc.	Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
UA102250C2 (ru)	2008-04-29	2013-06-25	Эли Лилли Энд Компани	Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en)	2008-07-18	2010-02-18	Novartis Ag	Organic Compounds as Smo Inhibitors
EP2358698B1 (en)	2008-11-17	2012-09-05	Eli Lilly and Company	Tetrasubstituted pyridazine as hedgehog pathway antagonists
KR101335770B1 (ko)	2008-11-17	2013-12-12	일라이 릴리 앤드 캄파니	사치환된 피리다진 헷지호그 경로 길항제
AR077014A1 (es)	2009-06-19	2011-07-27	Lilly Co Eli	Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

2009
- 2009-10-22 CN CN200980143394.3A patent/CN102202737B/zh not_active Expired - Fee Related
- 2009-10-22 BR BRPI0921437A patent/BRPI0921437A2/pt not_active IP Right Cessation
- 2009-10-22 PL PL09740613T patent/PL2364185T3/pl unknown
- 2009-10-22 EP EP09740613.6A patent/EP2364185B1/en active Active
- 2009-10-22 CA CA2742539A patent/CA2742539C/en not_active Expired - Fee Related
- 2009-10-22 AU AU2009320251A patent/AU2009320251C1/en not_active Ceased
- 2009-10-22 JP JP2011534624A patent/JP2012507535A/ja active Pending
- 2009-10-22 ES ES09740613T patent/ES2418479T3/es active Active
- 2009-10-22 PE PE2011000937A patent/PE20110433A1/es not_active Application Discontinuation
- 2009-10-22 HR HRP20130527AT patent/HRP20130527T1/hr unknown
- 2009-10-22 UA UAA201105364A patent/UA102115C2/ru unknown
- 2009-10-22 MX MX2011004683A patent/MX2011004683A/es active IP Right Grant
- 2009-10-22 NZ NZ591945A patent/NZ591945A/xx not_active IP Right Cessation
- 2009-10-22 WO PCT/US2009/061573 patent/WO2010062507A1/en not_active Ceased
- 2009-10-22 SI SI200930625T patent/SI2364185T1/sl unknown
- 2009-10-22 PT PT97406136T patent/PT2364185E/pt unknown
- 2009-10-22 US US13/122,212 patent/US8404687B2/en not_active Expired - Fee Related
- 2009-10-22 DK DK09740613.6T patent/DK2364185T3/da active
- 2009-10-22 KR KR1020117010063A patent/KR101335746B1/ko not_active Expired - Fee Related
- 2009-10-22 EA EA201170640A patent/EA018931B1/ru not_active IP Right Cessation
2011
- 2011-03-21 IL IL211841A patent/IL211841A0/en unknown
- 2011-04-01 ZA ZA2011/02448A patent/ZA201102448B/en unknown
- 2011-04-07 TN TN2011000166A patent/TN2011000166A1/fr unknown
- 2011-04-15 CR CR20110202A patent/CR20110202A/es not_active Application Discontinuation
- 2011-04-22 MA MA33790A patent/MA32726B1/fr unknown
- 2011-05-02 EC EC2011011021A patent/ECSP11011021A/es unknown
- 2011-05-02 CL CL2011000979A patent/CL2011000979A1/es unknown
- 2011-05-11 CO CO11058054A patent/CO6382123A2/es active IP Right Grant
2013
- 2013-06-05 CY CY20131100447T patent/CY1114023T1/el unknown

Also Published As

Publication number	Publication date
HK1159010A1 (en)	2012-07-27
PL2364185T3 (pl)	2013-10-31
SI2364185T1 (sl)	2013-07-31
US8404687B2 (en)	2013-03-26
EA201170640A1 (ru)	2011-12-30
ES2418479T3 (es)	2013-08-14
CO6382123A2 (es)	2012-02-15
CA2742539C (en)	2014-05-06
AU2009320251A1 (en)	2010-06-03
ECSP11011021A (es)	2011-06-30
AU2009320251B2 (en)	2013-01-24
BRPI0921437A2 (pt)	2018-10-30
CN102202737B (zh)	2014-03-26
EA018931B1 (ru)	2013-11-29
HRP20130527T1 (en)	2013-07-31
US20110190304A1 (en)	2011-08-04
AU2009320251C1 (en)	2013-08-15
KR101335746B1 (ko)	2013-12-12
CN102202737A (zh)	2011-09-28
JP2012507535A (ja)	2012-03-29
IL211841A0 (en)	2011-06-30
EP2364185B1 (en)	2013-05-22
CY1114023T1 (el)	2016-07-27
PE20110433A1 (es)	2011-07-09
CR20110202A (es)	2011-06-09
TN2011000166A1 (en)	2012-12-17
NZ591945A (en)	2012-10-26
MX2011004683A (es)	2011-06-20
PT2364185E (pt)	2013-07-24
WO2010062507A1 (en)	2010-06-03
UA102115C2 (ru)	2013-06-10
KR20110066212A (ko)	2011-06-16
CA2742539A1 (en)	2010-06-03
EP2364185A1 (en)	2011-09-14
ZA201102448B (en)	2012-09-26
CL2011000979A1 (es)	2011-10-07
MA32726B1 (fr)	2011-10-02

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EP2280264A4 (en)	2016-04-20	STANDARD AGENTS
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