TN2009000253A1 - Solid dispersion of a neurokinin antagonist - Google Patents

Solid dispersion of a neurokinin antagonist

Info

Publication number: TN2009000253A1
Authority: TN; Tunisia
Prior art keywords: solid dispersion; neurokinin antagonist; functional; disorders; bistrifluoromethyl
Prior art date: 2006-12-22

Application number

TNP2009000253A

Other languages

English (en)

Inventor

Anke Diederich

Carsten Timpe

Angelika Ries

Isabel Ottinger

Irene Mueller

Michael Herbig

Helmut Schuetz

Jay Parthiban Lankshman

Oskar Kalb

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-22

Filing date

2009-06-19

Publication date

2010-10-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37762542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2009000253(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-06-19 Application filed by Novartis Ag filed Critical Novartis Ag

2010-10-18 Publication of TN2009000253A1 publication Critical patent/TN2009000253A1/fr

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Dispersion Chemistry (AREA)
Nutrition Science (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TNP2009000253A 2006-12-22 2009-06-19 Solid dispersion of a neurokinin antagonist TN2009000253A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06126964A EP1938804A1 (fr)	2006-12-22	2006-12-22	Préparation pharmaceutique comprenant un antagoniste de neurokinine
PCT/EP2007/011293 WO2008077591A2 (fr)	2006-12-22	2007-12-20	Dispersion solide d'un antagoniste de la neurokinine

Publications (1)

Publication Number	Publication Date
TN2009000253A1 true TN2009000253A1 (en)	2010-10-18

Family

ID=37762542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2009000253A TN2009000253A1 (en)	2006-12-22	2009-06-19	Solid dispersion of a neurokinin antagonist

Country Status (25)

Country	Link
US (1)	US20100015225A1 (fr)
EP (2)	EP1938804A1 (fr)
JP (1)	JP2010513356A (fr)
KR (1)	KR20090092288A (fr)
CN (1)	CN101541309A (fr)
AR (1)	AR064622A1 (fr)
AU (1)	AU2007338359B2 (fr)
BR (1)	BRPI0720937A2 (fr)
CA (1)	CA2672402A1 (fr)
CL (1)	CL2007003767A1 (fr)
CO (1)	CO6180497A2 (fr)
EA (1)	EA200900827A1 (fr)
EC (1)	ECSP099450A (fr)
GT (1)	GT200900173A (fr)
IL (1)	IL198780A0 (fr)
MA (1)	MA31004B1 (fr)
MX (1)	MX2009006747A (fr)
MY (1)	MY145919A (fr)
NO (1)	NO20092722L (fr)
NZ (1)	NZ576987A (fr)
PE (1)	PE20081848A1 (fr)
TN (1)	TN2009000253A1 (fr)
TW (1)	TW200848056A (fr)
WO (1)	WO2008077591A2 (fr)
ZA (1)	ZA200903271B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI398433B (zh) *	2006-02-10	2013-06-11	Dow Agrosciences Llc	殺蟲性之ｎ-取代（６-鹵烷基吡啶-３-基）烷基磺醯亞胺
JPWO2010092925A1 (ja) *	2009-02-12	2012-08-16	あすか製薬株式会社	固体分散体とその医薬組成物、並びにそれらの製造方法
CN102395358A (zh) *	2009-02-24	2012-03-28	诺瓦提斯公司	Nk受体拮抗剂的用途
US8263119B2 (en) *	2010-12-01	2012-09-11	Shire Llc	Capsule formulations containing lanthanum compounds
RS60569B1 (sr)	2012-01-06	2020-08-31	Lundbeck La Jolla Research Center Inc	Jedinjenja karbamata i postupci njihovog pravljenja i upotrebe
CN107529758B (zh) *	2015-03-10	2021-01-26	盐野义制药公司	固体分散体
CN107849021A (zh)	2015-05-11	2018-03-27	阿比德治疗公司	治疗炎症或神经性疼痛的方法
EP3307246A1 (fr)	2015-06-09	2018-04-18	Capsugel Belgium NV	Formulations pour obtenir une dissolution rapide d'un médicament à partir de dispersions séchées par pulvérisation dans des capsules
EP3541807B1 (fr)	2016-11-16	2021-09-29	H. Lundbeck A/S	Une forme cristalline d'un inhibiteur de magl
TN2019000148A1 (en)	2016-11-16	2020-10-05	Abide Therapeutics Inc	Pharmaceutical formulations
JP2023523219A (ja)	2020-04-21	2023-06-02	ハー・ルンドベック・アクチエゼルスカベット	モノアシルグリセロールリパーゼ阻害剤の合成
CN111904960A (zh) *	2020-05-19	2020-11-10	合肥合源药业有限公司	一种固体分散体及药用组合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3622677A (en) *	1969-07-07	1971-11-23	Staley Mfg Co A E	Compressed tablets containing compacted starch as binder-disintegrant ingredient
JPH054919A (ja) *	1990-07-25	1993-01-14	Sankyo Co Ltd	チアゾリジン誘導体の固体分散体
MY132550A (en) *	1996-08-22	2007-10-31	Novartis Ag	Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
WO1999022738A1 (fr) *	1997-11-03	1999-05-14	Janssen Pharmaceutica N.V.	Compositions d'hypolipemiants
HRP20000707B1 (en) *	1998-03-26	2005-06-30	Fujisawa Pharmaceutical Co.	Sustained release preparations
AR028253A1 (es) *	2000-03-16	2003-04-30	Pfizer Prod Inc	Inhibidores de la glucogeno fosforilasa
JP2004131393A (ja) *	2002-10-08	2004-04-30	Kowa Co	易溶出性製剤
GB2394417A (en) *	2002-10-24	2004-04-28	Novartis Ag	Solid dispersion comprising a piperidine substance P antagonist and a carrier
EP1686985A2 (fr) *	2003-10-27	2006-08-09	Novartis AG	Utilisation d'antagonistes de la neurokinine dans le traitement de l'enuresie
GB0402679D0 (en) *	2004-02-06	2004-03-10	Novartis Ag	Organic compounds
KR100627687B1 (ko) *	2005-04-20	2006-09-25	주식회사 씨티씨바이오	시부트라민 유리염기 함유 조성물 및 이의 제조방법
EP1871346A4 (fr) *	2005-04-20	2012-07-18	Ctc Bio Inc	Composition pharmaceutique contenant une base exempte de sibutramine et son procede de conception

2006
- 2006-12-22 EP EP06126964A patent/EP1938804A1/fr not_active Ceased
2007
- 2007-12-20 WO PCT/EP2007/011293 patent/WO2008077591A2/fr not_active Ceased
- 2007-12-20 MY MYPI20092111A patent/MY145919A/en unknown
- 2007-12-20 MX MX2009006747A patent/MX2009006747A/es not_active Application Discontinuation
- 2007-12-20 BR BRPI0720937-1A patent/BRPI0720937A2/pt not_active IP Right Cessation
- 2007-12-20 US US12/520,312 patent/US20100015225A1/en not_active Abandoned
- 2007-12-20 AU AU2007338359A patent/AU2007338359B2/en not_active Ceased
- 2007-12-20 JP JP2009541897A patent/JP2010513356A/ja active Pending
- 2007-12-20 CA CA002672402A patent/CA2672402A1/fr not_active Abandoned
- 2007-12-20 KR KR1020097012819A patent/KR20090092288A/ko not_active Withdrawn
- 2007-12-20 AR ARP070105788A patent/AR064622A1/es not_active Application Discontinuation
- 2007-12-20 NZ NZ576987A patent/NZ576987A/en not_active IP Right Cessation
- 2007-12-20 EA EA200900827A patent/EA200900827A1/ru unknown
- 2007-12-20 EP EP07857016A patent/EP2117511A2/fr not_active Withdrawn
- 2007-12-20 CN CNA2007800435054A patent/CN101541309A/zh active Pending
- 2007-12-21 TW TW096149580A patent/TW200848056A/zh unknown
- 2007-12-21 CL CL200703767A patent/CL2007003767A1/es unknown
2008
- 2008-01-02 PE PE2008000080A patent/PE20081848A1/es not_active Application Discontinuation
2009
- 2009-05-12 ZA ZA200903271A patent/ZA200903271B/xx unknown
- 2009-05-14 IL IL198780A patent/IL198780A0/en unknown
- 2009-06-17 CO CO09062883A patent/CO6180497A2/es not_active Application Discontinuation
- 2009-06-17 MA MA32008A patent/MA31004B1/fr unknown
- 2009-06-19 TN TNP2009000253A patent/TN2009000253A1/fr unknown
- 2009-06-19 GT GT200900173A patent/GT200900173A/es unknown
- 2009-06-22 EC EC2009009450A patent/ECSP099450A/es unknown
- 2009-07-17 NO NO20092722A patent/NO20092722L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EA200900827A1 (ru)	2009-12-30
EP1938804A1 (fr)	2008-07-02
CN101541309A (zh)	2009-09-23
GT200900173A (es)	2010-06-24
AR064622A1 (es)	2009-04-15
PE20081848A1 (es)	2009-01-19
MX2009006747A (es)	2009-06-30
TW200848056A (en)	2008-12-16
WO2008077591A2 (fr)	2008-07-03
US20100015225A1 (en)	2010-01-21
CA2672402A1 (fr)	2008-07-03
NO20092722L (no)	2009-07-21
AU2007338359A1 (en)	2008-07-03
EP2117511A2 (fr)	2009-11-18
ZA200903271B (en)	2010-04-28
BRPI0720937A2 (pt)	2014-03-11
MA31004B1 (fr)	2009-12-01
IL198780A0 (en)	2010-02-17
MY145919A (en)	2012-05-15
AU2007338359B2 (en)	2011-04-28
WO2008077591A3 (fr)	2009-04-09
CO6180497A2 (es)	2010-07-19
NZ576987A (en)	2011-10-28
ECSP099450A (es)	2009-07-31
KR20090092288A (ko)	2009-08-31
JP2010513356A (ja)	2010-04-30
CL2007003767A1 (es)	2008-07-18

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