[go: up one dir, main page]

TN2009000085A1 - Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3 - Google Patents

Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3

Info

Publication number
TN2009000085A1
TN2009000085A1 TN2009000085A TN2009000085A TN2009000085A1 TN 2009000085 A1 TN2009000085 A1 TN 2009000085A1 TN 2009000085 A TN2009000085 A TN 2009000085A TN 2009000085 A TN2009000085 A TN 2009000085A TN 2009000085 A1 TN2009000085 A1 TN 2009000085A1
Authority
TN
Tunisia
Prior art keywords
inhibitors
pyrido
pyrimidinone derivatives
derivatives
pyrimidinone
Prior art date
Application number
TN2009000085A
Other languages
English (en)
Inventor
Hengmiao Cheng
Dilip 2Bhumralkar
Klaus Ruprecht Dress
Jacqui Elizabeth Hoffman
Mary Catherine Johnson
Robert Steven Kania
Phuong Thi Quy Le
Mitchell David Nambu
Mason Alan Pairish
Michael Bruno Plewe
Khanh Tuan Tran
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TN2009000085A1 publication Critical patent/TN2009000085A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

La présente invention concerne des dérivés de 4-méthylpyridopyrimidinone nouveaux de formule (I). leurs sels, leur synthèse, et leur utilisation comme inhibiteurs de la phosphoinositide -3- kinase alpha (PI3-ka).
TN2009000085A 2006-09-15 2009-03-13 Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3 TN2009000085A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84506506P 2006-09-15 2006-09-15
US94785207P 2007-07-03 2007-07-03
US95262807P 2007-07-30 2007-07-30
PCT/IB2007/002578 WO2008032162A1 (fr) 2006-09-15 2007-09-03 Composés de pyrido (2, 3-d) pyrimidin0ne et leur utilisation en tant qu'inhibiteurs de pi3

Publications (1)

Publication Number Publication Date
TN2009000085A1 true TN2009000085A1 (fr) 2010-08-19

Family

ID=38859750

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2009000085A TN2009000085A1 (fr) 2006-09-15 2009-03-13 Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3

Country Status (41)

Country Link
US (3) US7696213B2 (fr)
EP (1) EP2074122B9 (fr)
JP (1) JP4718637B2 (fr)
KR (1) KR101099926B1 (fr)
CN (1) CN101573358B (fr)
AP (1) AP2710A (fr)
AR (1) AR062785A1 (fr)
AT (1) ATE514695T1 (fr)
AU (1) AU2007297212B8 (fr)
BR (1) BRPI0716749B8 (fr)
CA (1) CA2663401C (fr)
CL (1) CL2007002682A1 (fr)
CR (1) CR10662A (fr)
CU (1) CU23783B7 (fr)
CY (1) CY1111911T1 (fr)
DK (1) DK2074122T5 (fr)
DO (1) DOP2009000039A (fr)
EA (1) EA016388B1 (fr)
ES (1) ES2366489T3 (fr)
GE (1) GEP20115306B (fr)
GT (1) GT200700077A (fr)
HN (1) HN2007000267A (fr)
HR (1) HRP20110621T2 (fr)
IL (1) IL197243A (fr)
MA (1) MA30709B1 (fr)
ME (1) MEP8009A (fr)
MX (1) MX2009002927A (fr)
MY (1) MY146420A (fr)
NI (1) NI200900032A (fr)
NO (1) NO342357B1 (fr)
NZ (1) NZ575167A (fr)
PE (1) PE20080670A1 (fr)
PL (1) PL2074122T3 (fr)
PT (1) PT2074122E (fr)
RS (2) RS20090104A (fr)
SI (1) SI2074122T1 (fr)
TN (1) TN2009000085A1 (fr)
TW (1) TWI334353B (fr)
UY (1) UY30588A1 (fr)
WO (1) WO2008032162A1 (fr)
ZA (1) ZA200901477B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101573358B (zh) * 2006-09-15 2012-05-30 辉瑞产品公司 吡啶并(2,3-d)嘧啶酮化合物及其作为pi3抑制剂的用途
RS52939B (sr) * 2007-04-10 2014-02-28 Exelixis Inc. Postupci za lečenje kancera upotrebom piridopirimidinonskih inhibitora pi3k alfa
BRPI0810175A2 (pt) * 2007-04-11 2014-12-30 Exelixis Inc Inibidores pirididopirinidinona de p13k alfa
WO2010006225A1 (fr) * 2008-07-11 2010-01-14 Novartis Ag Combinaison de (a) un inhibiteur de phosphoinositide 3-kinase et de (b) un modulateur de voie ras/raf/mek
US8697694B2 (en) 2008-08-20 2014-04-15 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
JP5674661B2 (ja) 2008-08-20 2015-02-25 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． エチニル置換ピリジンおよびピリミジン誘導体ならびにそれらのウイルス感染の治療における使用
US8470834B2 (en) 2008-08-20 2013-06-25 Merck Sharp & Dohme Corp. AZO-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
JP5619743B2 (ja) * 2008-08-20 2014-11-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． エテニル置換ピリジンおよびピリミジン誘導体およびウイルス感染の治療におけるそれらの使用
WO2010039740A1 (fr) * 2008-09-30 2010-04-08 Exelixis, Inc. Inhibiteurs de pyridopyrimidinone de la pi3 kinase α et de la mtor
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
AR084312A1 (es) 2010-12-16 2013-05-08 Genentech Inc Compuestos triciclicos inhibidores de la pi3k y composiciones farmaceuticas
US8664230B2 (en) * 2011-03-17 2014-03-04 The Asan Foundation Pyridopyrimidine derivatives and use thereof
TW201306842A (zh) * 2011-06-15 2013-02-16 Exelixis Inc 使用ｐｉ３ｋ／ｍｔｏｒ吡啶並嘧啶酮抑制劑及苯達莫司汀及／或利妥昔單抗治療惡性血液疾病之組合療法
AU2012333092B2 (en) 2011-08-31 2016-04-21 Novartis Ag Synergistic combinations of PI3K- and MEK-inhibitors
CN104829609B (zh) * 2014-02-11 2016-08-03 北大方正集团有限公司 取代的吡啶并嘧啶化合物及其制备方法和应用
WO2016015597A1 (fr) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. Composés utilisés comme petits molécules inhibitrices de cdk et leurs utilisations
CN105330699B (zh) * 2014-08-13 2018-12-04 山东汇睿迪生物技术有限公司 一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用
AU2015329625B2 (en) 2014-10-10 2018-04-05 Pfizer Inc. Synergistic auristatin combinations
MX376083B (es) 2015-06-04 2025-03-07 Pfizer Formas de dosificacion solidas de palbociclib.
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
CN109563088B (zh) 2016-07-06 2022-10-11 密歇根大学董事会 MEK/PI3K和mTOR/MEK/PI3K的多功能抑制剂和治疗用途
AU2017311645B2 (en) 2016-08-15 2021-05-27 Pfizer Inc. Pyridopyrimdinone CDK2/4/6 inhibitors
AU2017376766A1 (en) * 2016-12-14 2019-06-06 Tva (Abc), Llc HSP90-targeting conjugates and formulations thereof
WO2019157516A1 (fr) 2018-02-12 2019-08-15 resTORbio, Inc. Polythérapies
CN112423843B (zh) 2018-06-15 2023-11-28 詹森药业有限公司 雷帕霉素类似物和其用途
AU2019413683B2 (en) * 2018-12-28 2025-05-22 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
US20220220103A1 (en) * 2018-12-28 2022-07-14 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
US11583538B2 (en) 2019-04-08 2023-02-21 Venenum Biodesign, LLC Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
WO2021113665A1 (fr) 2019-12-05 2021-06-10 Navitor Pharmaceuticals, Inc. Analogues de la rapamycine et leurs utilisations
WO2021139775A1 (fr) * 2020-01-10 2021-07-15 江苏先声药业有限公司 Composé de pyridone et son application
WO2022075974A1 (fr) * 2020-10-06 2022-04-14 Venenum Biodesign, LLC Inhibiteurs cycliques de trex1
KR20230121758A (ko) 2020-11-18 2023-08-21 데시페라 파마슈티칼스, 엘엘씨. Gcn2 및 perk 키나제 억제제 및 그의 사용 방법
CA3238551A1 (fr) * 2021-11-18 2023-05-25 Steven FRUCHTMAN Methodes et compositions pour traitement du cancer
WO2024254511A2 (fr) 2023-06-08 2024-12-12 Nimbus Wadjet, Inc. Inhibiteurs de wrn
WO2025137599A1 (fr) * 2023-12-21 2025-06-26 Nimbus Wadjet, Inc. Inhibiteurs de wrn

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264437A (en) * 1992-03-20 1993-11-23 Syntex (U.S.A.) Inc. Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
AU711426B2 (en) 1994-11-14 1999-10-14 Warner-Lambert Company 6-aryl pyrido(2,3-d)pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation
CN1177960A (zh) * 1995-03-10 1998-04-01 圣诺菲药品有限公司 6－取代的吡唑并[3,4－d]嘧啶－4－酮及其组合物和使用方法
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5925761A (en) 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
US6498163B1 (en) 1997-02-05 2002-12-24 Warner-Lambert Company Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
EP0964864B1 (fr) 1997-02-05 2008-04-09 Warner-Lambert Company LLC Pyrido 2,3d pyrimidines et 4-aminopyrimidines en tant qu'inhibiteurs de la proliferation cellulaire
GB9904932D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
PL357634A1 (en) 2000-01-27 2004-07-26 Warner-Lambert Company Pyridopyrimidinone derivatives for treatment of neurodegenerative disease
CN1422268A (zh) 2000-03-06 2003-06-04 沃尼尔·朗伯公司 5－烷基吡啶并[2,3－d]嘧啶酪氨酸激酶抑制剂
WO2001083456A1 (fr) 2000-04-27 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derives d'heteroaryle condenses
EP1364950A4 (fr) 2001-02-26 2005-03-09 Tanabe Seiyaku Co Derive de pyridopyrimidine ou naphthyridine
US7019002B2 (en) * 2001-12-11 2006-03-28 Pharmacia & Upjohn, S.P.A. Pyridopyrimidinones derivatives as telomerase inhibitors
DE60303009T2 (de) 2002-01-22 2006-07-13 Warner-Lambert Co. Llc 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-one
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Ｇｒｋ阻害剤
ES2291630T3 (es) 2002-04-19 2008-03-01 Smithkline Beecham Corporation Nuevos compuestos.
US20040063658A1 (en) 2002-05-06 2004-04-01 Roberts Christopher Don Nucleoside derivatives for treating hepatitis C virus infection
JP2004083587A (ja) 2002-08-06 2004-03-18 Tanabe Seiyaku Co Ltd 医薬組成物
US7098332B2 (en) * 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
JP2004203751A (ja) 2002-12-24 2004-07-22 Pfizer Inc 置換６，６−ヘテロ二環式誘導体
WO2004063195A1 (fr) 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Inhibiteurs de kinases a base de pyridopyrimidine
WO2004089930A1 (fr) 2003-04-02 2004-10-21 Imclone Systems Incorporated Derives de 4- fluoroquinolone et leur utilisation comme inhibiteurs de kinase
US20070053831A1 (en) 2003-05-20 2007-03-08 Barrio Jorge R Methods for binding agents to b-amyloid plaques
SI1648889T1 (sl) 2003-07-11 2009-02-28 Warner Lambert Co Izetionatna sol selektivnega CDK4 inhibitorja
BRPI0412876A (pt) 2003-07-22 2006-10-03 Janssen Pharmaceutica Nv derivados de quinolinona como inibidores de c-fms quinase
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
BRPI0507668A (pt) 2004-02-14 2007-07-17 Irm Llc compostos e composições como inibidores de proteìna cinase
CA2555724A1 (fr) 2004-02-18 2005-09-09 Warner-Lambert Company Llc 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
CA2561516A1 (fr) 2004-03-30 2005-10-13 Pfizer Products Inc. Combinaisons d'inhibiteurs de transduction de signaux
WO2005105097A2 (fr) 2004-04-28 2005-11-10 Gpc Biotech Ag Derives de pyridopyrimidine
ES2292130T3 (es) * 2004-05-04 2008-03-01 Warner-Lambert Company Llc Pirido(2,3-d)pirimidin-7-onas pirrolil-sustituidas y derivados de las mismas como agentes terapeuticos.
BRPI0511065A (pt) 2004-06-04 2007-12-26 Pfizer Prod Inc método para tratar crescimento de célula anormal
EP1786817A1 (fr) 2004-08-26 2007-05-23 Boehringer Ingelheim International GmbH Pteridinones en tant que inhibiteurs de plk (polo like kinase)
US7608594B2 (en) 2004-11-03 2009-10-27 University Of Kansas Novobiocin analogues as anticancer agents
JP5111113B2 (ja) 2004-12-13 2012-12-26 サネシス ファーマシューティカルズ， インコーポレイテッド Ｒａｆキナーゼ阻害剤として有用なピリドピリミジノン、ジヒドロピリミドピリミジノンおよびプテリジノン
US20060142312A1 (en) 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
KR20140105621A (ko) * 2005-10-07 2014-09-01 엑셀리시스, 인코포레이티드 ＰＩ３Ｋα의 피리도피리미디논 억제제
US8247408B2 (en) * 2005-10-07 2012-08-21 Exelixis, Inc. Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer
EP1872922A1 (fr) * 2006-06-27 2008-01-02 Nederlandse Organisatie voor Toegepast-Natuuurwetenschappelijk Onderzoek TNO Procédé et dispositif de fabrication d'un article en matière plastique
ATE539752T1 (de) 2006-08-16 2012-01-15 Exelixis Inc Verwendung von pi3k- und mek-modulatoren bei der krebsbehandlung
CN101573358B (zh) 2006-09-15 2012-05-30 辉瑞产品公司 吡啶并(2,3-d)嘧啶酮化合物及其作为pi3抑制剂的用途
EA018441B1 (ru) * 2007-03-14 2013-08-30 ЭКСЕЛИКСИС ПАТЕНТ КОМПАНИ ЭлЭлСи Ингибиторы пути хеджхога
BRPI0810175A2 (pt) 2007-04-11 2014-12-30 Exelixis Inc Inibidores pirididopirinidinona de p13k alfa
WO2010039740A1 (fr) 2008-09-30 2010-04-08 Exelixis, Inc. Inhibiteurs de pyridopyrimidinone de la pi3 kinase α et de la mtor
WO2011130628A1 (fr) * 2010-04-16 2011-10-20 Curis, Inc. Traitement de cancers présentant des mutations k-ras

Also Published As

Publication number Publication date
WO2008032162A8 (fr) 2009-03-26
MEP8009A (en) 2011-12-20
MY146420A (en) 2012-08-15
HRP20110621T1 (hr) 2011-09-30
NO20091141L (no) 2009-03-31
TWI334353B (en) 2010-12-11
JP4718637B2 (ja) 2011-07-06
DOP2009000039A (es) 2015-12-15
CN101573358B (zh) 2012-05-30
GEP20115306B (fr) 2011-10-10
AU2007297212B8 (en) 2011-04-28
JP2010503653A (ja) 2010-02-04
CN101573358A (zh) 2009-11-04
HK1138589A1 (en) 2010-08-27
CA2663401C (fr) 2011-07-12
NZ575167A (en) 2010-10-29
CA2663401A1 (fr) 2008-03-20
CY1111911T1 (el) 2015-11-04
PT2074122E (pt) 2011-08-24
CU20090040A7 (es) 2011-07-11
ATE514695T1 (de) 2011-07-15
US20120309775A1 (en) 2012-12-06
EA016388B1 (ru) 2012-04-30
US7696213B2 (en) 2010-04-13
EP2074122B1 (fr) 2011-06-29
AP2009004790A0 (en) 2009-04-30
HRP20110621T2 (hr) 2013-12-06
EP2074122B9 (fr) 2013-09-11
HN2007000267A (es) 2011-02-25
PE20080670A1 (es) 2008-06-14
GT200700077A (es) 2009-08-03
IL197243A0 (en) 2009-12-24
TW200820972A (en) 2008-05-16
US8273755B2 (en) 2012-09-25
WO2008032162A1 (fr) 2008-03-20
KR101099926B1 (ko) 2011-12-28
EA200970207A1 (ru) 2009-08-28
NO342357B1 (no) 2018-05-14
MA30709B1 (fr) 2009-09-01
AR062785A1 (es) 2008-12-03
AU2007297212A1 (en) 2008-03-20
UY30588A1 (es) 2008-05-02
PL2074122T3 (pl) 2011-10-31
US20100137279A1 (en) 2010-06-03
US8633204B2 (en) 2014-01-21
EP2074122A1 (fr) 2009-07-01
ZA200901477B (en) 2010-07-28
CL2007002682A1 (es) 2008-04-04
DK2074122T5 (da) 2014-03-17
RS20090104A (sr) 2010-06-30
BRPI0716749B8 (pt) 2021-05-25
MX2009002927A (es) 2009-03-31
AP2710A (en) 2013-07-30
BRPI0716749B1 (pt) 2020-10-06
US20080090801A1 (en) 2008-04-17
BRPI0716749A2 (pt) 2014-02-18
DK2074122T3 (da) 2011-08-15
IL197243A (en) 2013-07-31
CR10662A (es) 2009-04-17
RS51927B (sr) 2012-02-29
KR20090040389A (ko) 2009-04-23
ES2366489T3 (es) 2011-10-20
ES2366489T9 (es) 2013-12-27
AU2007297212B2 (en) 2011-04-14
CU23783B7 (es) 2012-02-15
SI2074122T1 (sl) 2011-10-28
NI200900032A (es) 2010-05-14

Similar Documents

Publication Publication Date Title
TN2009000085A1 (fr) Derives de pyrido (2,3-d) pyrimidinone et leur utilisation comme inhibiteurs de pi3
TN2010000052A1 (fr) Derives de pyrazole et leur utilisation comme inhibiteurs de raf
MA33492B1 (fr) Inhibiteurs de bace
CY1118199T1 (el) Ενωσεις υποκατεστημενης πυραζολο[1,5] πυριμιδινης ως ενδιαμεσα στη συνθεση αναστολεων κινασης trk
TN2009000329A1 (fr) DERIVES DE 2-AMINO-5,7-DIHYDRO-6H-PYRROLO[3,4-d]-PYRIMIDINE SERVANT D'INHBITEURS DE HSP-90 POUR LE TRAITEMENT DU CANCER
ATE542813T1 (de) 6-substituierte 2- heterocyclylaminopyrazinverbindungen als chk-1- inhibitoren
TW200626610A (en) Analogs of 17-hydroxywortmannin as PI3K inhibitors
EA201000149A1 (ru) Производные 1-фенил-2-пиридинилалкиловых спиртов в качестве ингибиторов фосфодиэстераз
MA32351B1 (fr) Derives d'aminodihydrothiazine a titre d'inhibiteurs de bace pour le traitement de la maladie d'alzheimer
PE20120495A1 (es) 3-ciclopentilamino-2,2-difluor-propanoato de etilo como intermediario en la preparacion de pirimidodiazepinas
GEP20156282B (en) Compounds and compositions as protein kinase inhibitors
EA201001017A1 (ru) 3h-[1,2,3]триазоло[4,5-d]пиримидиновые соединения, их применение в качестве ингибиторов киназы mtor и киназы pi3 и их синтезы
EA200970156A1 (ru) Пиридизиноновые производные
EA201100580A1 (ru) Имидазопиридазинкарбонитрилы, используемые в качестве ингибиторов киназы
EA201200669A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
EA201000642A1 (ru) 2'-фтор-2'-дезокситетрагидроуридины в качестве ингибиторов цитидиндеаминазы
DE60309848D1 (de) Purinderivate als kinaseinhibitoren
EA200800760A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
EA201070480A1 (ru) Ингибиторы с-fms киназы
EP2114942A4 (fr) Nouveaux dérivés d'aminopyrimidine comme inhibiteurs de plk1
MX2009007302A (es) Derivados de purina.
MX2009000169A (es) Derivados de purinona como agonistas de hm74a.
UA83875C2 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
EA200970936A1 (ru) СОЕДИНЕНИЯ ПИРИДО[2,3-d]ПИРИМИДИН-7-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3K-АЛЬФА ДЛЯ ЛЕЧЕНИЯ РАКА
MA32776B1 (fr) Inhibiteurs de l'akt et de la p70 s6 kinase