|
PL218692B1
(pl)
|
2002-01-22 |
2015-01-30 |
Warner Lambert Co |
Podstawiony 2-(pirydyn-2-yloamino)pirydo[2,3-d]pirymidyn-7-on oraz jego zastosowanie do leczenia zaburzenia lub stanu spowodowanego nieprawidłową proliferacją komórek
|
|
CA2561516A1
(en)
*
|
2004-03-30 |
2005-10-13 |
Pfizer Products Inc. |
Combinations of signal transduction inhibitors
|
|
JP5480503B2
(ja)
*
|
2005-10-07 |
2014-04-23 |
エクセリクシス, インク. |
PI3Kαのピリドピリミジノン型阻害剤
|
|
HRP20130902T1
(hr)
*
|
2005-10-07 |
2013-11-08 |
Exelixis Inc. |
PIRIDOPIRIMIDINONSKI INHIBITORI PI3Kalfa
|
|
EP2069344A2
(en)
|
2006-09-08 |
2009-06-17 |
Pfizer Products Inc. |
Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
|
|
HRP20110621T2
(hr)
|
2006-09-15 |
2013-12-06 |
Pfizer Products Inc. |
SPOJEVI PIRIDO[2,3-d]PIRIMIDINONA I NJIHOVA UPOTREBA KAO INHIBITORI PI3
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
AU2007333791A1
(en)
*
|
2006-12-14 |
2008-06-26 |
Panacea Pharmaceuticals, Inc. |
Methods of neuroprotection by cyclin-dependent kinase inhibition
|
|
WO2009061345A2
(en)
*
|
2007-11-07 |
2009-05-14 |
Cornell Research Foundation, Inc. |
Targeting cdk4 and cdk6 in cancer therapy
|
|
MX2010006457A
(es)
|
2007-12-19 |
2010-07-05 |
Amgen Inc |
Compuestos fusionados de piridina, pirimidina y triazina como inhibidores de ciclo celular.
|
|
JP5530422B2
(ja)
*
|
2008-04-07 |
2014-06-25 |
アムジエン・インコーポレーテツド |
細胞周期阻害薬としてのgem−二置換およびスピロ環式アミノピリジン/ピリミジン
|
|
EP2341911A4
(en)
*
|
2008-10-01 |
2012-10-24 |
Univ North Carolina |
HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE INHIBITORS OF KINASES DEPENDENT ON CYCLINES 4/6
|
|
WO2010051127A2
(en)
*
|
2008-10-01 |
2010-05-06 |
The University Of North Carolina At Chapel Hill |
Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors
|
|
JO2885B1
(en)
|
2008-12-22 |
2015-03-15 |
ايلي ليلي اند كومباني |
Protein kinase inhibitors
|
|
MY160737A
(en)
|
2009-04-03 |
2017-03-15 |
Hoffmann La Roche |
Propane-i-sulfonic acid {3- [5-(4-chloro-phenyl) -1h -pyrrolo [2, 3-b] pyridine-3-carbonyl] -2,4 difluoro-phenyl} - amide compositions and uses thereof
|
|
AU2010248886A1
(en)
|
2009-05-13 |
2011-12-01 |
The University Of North Carolina At Chapel Hill |
Cyclin dependent kinase inhibitors and methods of use
|
|
SG10201407129SA
(en)
|
2009-11-06 |
2014-12-30 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
PH12012501361A1
(en)
|
2009-12-31 |
2012-10-22 |
Centro Nac De Investigaciones Oncologicas Cnio |
Tricyclic compounds for use as kinase inhibitors
|
|
TWI619713B
(zh)
|
2010-04-21 |
2018-04-01 |
普雷辛肯公司 |
用於激酶調節的化合物和方法及其適應症
|
|
US8691830B2
(en)
|
2010-10-25 |
2014-04-08 |
G1 Therapeutics, Inc. |
CDK inhibitors
|
|
WO2012068381A2
(en)
*
|
2010-11-17 |
2012-05-24 |
The University Of North Carolina At Chapel Hill |
Protection of renal tissues from schema through inhibition of the proliferative kisses cdk4 and cdk6
|
|
WO2012098387A1
(en)
|
2011-01-18 |
2012-07-26 |
Centro Nacional De Investigaciones Oncológicas (Cnio) |
6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
|
|
CN103517710B
(zh)
|
2011-02-07 |
2017-05-31 |
普莱希科公司 |
用于激酶调节的化合物
|
|
CN103703000B
(zh)
|
2011-03-23 |
2015-11-25 |
安姆根有限公司 |
Cdk4/6和flt3的稠合三环双重抑制剂
|
|
WO2012173694A1
(en)
*
|
2011-06-17 |
2012-12-20 |
Fluidic, Inc. |
Ionic liquid containing sulfonate ions
|
|
AU2013239816B2
(en)
|
2012-03-29 |
2017-08-24 |
G1 Therapeutics, Inc. |
Lactam kinase inhibitors
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
EP3431475B1
(en)
*
|
2013-02-21 |
2021-04-07 |
Pfizer Inc |
Solid forms of a selective cdk4/6 inhibitor
|
|
US20160024084A1
(en)
*
|
2013-03-15 |
2016-01-28 |
Concert Pharmaceuticals, Inc. |
Deuterated palbociclib
|
|
HK1222766A1
(zh)
|
2013-03-15 |
2017-07-14 |
G1治疗公司 |
高效的抗赘生剂和抗增生剂
|
|
RS59790B1
(sr)
|
2013-03-15 |
2020-02-28 |
G1 Therapeutics Inc |
Privremena zaštita normalnih ćelija tokom hemoterapije
|
|
WO2014203129A1
(en)
|
2013-06-19 |
2014-12-24 |
Olema Pharmaceuticals, Inc. |
Combinations of benzopyran compounds, compositions and uses thereof
|
|
US20150297606A1
(en)
|
2014-04-17 |
2015-10-22 |
G1 Therapeutics, Inc. |
Tricyclic Lactams for Use in the Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
|
|
EP3172214B1
(en)
*
|
2014-07-26 |
2020-05-13 |
Sunshine Lake Pharma Co., Ltd. |
2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
|
|
WO2016016769A1
(en)
*
|
2014-07-31 |
2016-02-04 |
Sun Pharmaceutical Industries Limited |
A process for the preparation of palbociclib
|
|
EP3180007A1
(en)
*
|
2014-08-14 |
2017-06-21 |
Sun Pharmaceutical Industries Ltd |
Crystalline forms of palbociclib
|
|
WO2016040858A1
(en)
|
2014-09-12 |
2016-03-17 |
G1 Therapeutics, Inc. |
Combinations and dosing regimes to treat rb-positive tumors
|
|
WO2016040848A1
(en)
|
2014-09-12 |
2016-03-17 |
G1 Therapeutics, Inc. |
Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
|
|
WO2016066420A1
(en)
*
|
2014-10-29 |
2016-05-06 |
Sandoz Ag |
Crystalline forms of palbociclib monohydrochloride
|
|
CN105622638B
(zh)
*
|
2014-10-29 |
2018-10-02 |
广州必贝特医药技术有限公司 |
嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
|
|
CN105616419A
(zh)
*
|
2014-11-07 |
2016-06-01 |
江苏豪森药业集团有限公司 |
含有细胞周期蛋白抑制剂固体分散体的药物组合物及其制备方法
|
|
CN105616418A
(zh)
*
|
2014-11-07 |
2016-06-01 |
江苏豪森药业集团有限公司 |
含有细胞周期蛋白抑制剂的药物制剂及其制备方法
|
|
ES2941897T3
(es)
|
2014-11-12 |
2023-05-26 |
Seagen Inc |
Compuestos que interaccionan con glicanos y procedimientos de uso
|
|
WO2016090257A1
(en)
*
|
2014-12-05 |
2016-06-09 |
Crystal Pharmatech Inc. |
Salts and crystalline forms of 6-acetyl-8-cyclopentyl-5-methyl-2((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d] pyrimidin-7(8h)-one (palbociclib)
|
|
WO2016092442A1
(en)
*
|
2014-12-08 |
2016-06-16 |
Sun Pharmaceutical Industries Limited |
Processes for the preparation of crystalline forms of palbociclib acetate
|
|
CN105732615B
(zh)
*
|
2014-12-31 |
2018-05-01 |
山东轩竹医药科技有限公司 |
Cdk激酶抑制剂
|
|
CA2974021A1
(en)
*
|
2015-02-03 |
2016-08-11 |
Jiangsu Hengrui Medicine Co., Ltd. |
Hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor, crystalline form thereof and preparation method therefor
|
|
CZ201589A3
(cs)
|
2015-02-11 |
2016-08-24 |
Zentiva, K.S. |
Pevné formy soli Palbociclibu
|
|
AR104068A1
(es)
|
2015-03-26 |
2017-06-21 |
Hoffmann La Roche |
Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
|
|
EP3078663A1
(en)
|
2015-04-09 |
2016-10-12 |
Sandoz Ag |
Modified particles of palbociclib
|
|
WO2016156070A1
(en)
|
2015-04-02 |
2016-10-06 |
Sandoz Ag |
Modified particles of palbociclib
|
|
CN104910149A
(zh)
*
|
2015-04-28 |
2015-09-16 |
上海百奇医药科技有限公司 |
一种Palbociclib制备方法
|
|
CN106117199A
(zh)
*
|
2015-05-04 |
2016-11-16 |
江苏恒瑞医药股份有限公司 |
一种细胞周期蛋白依赖性激酶抑制剂的二羟乙基磺酸盐、其结晶形式及其制备方法
|
|
LT3305785T
(lt)
*
|
2015-05-29 |
2021-11-10 |
Teijin Pharma Limited |
Pirido[3,4-d]pirimidino dariniai ir jų farmaciniu požiūriu priimtinos druskos
|
|
RU2686840C1
(ru)
*
|
2015-06-04 |
2019-05-06 |
Пфайзер Инк. |
Твёрдые лекарственные формы палбоциклиба
|
|
CN106317053A
(zh)
*
|
2015-06-29 |
2017-01-11 |
北大方正集团有限公司 |
一种帕博昔布晶型a的制备方法
|
|
WO2017021111A1
(en)
*
|
2015-08-05 |
2017-02-09 |
Ratiopharm Gmbh |
New crystalline form and acetic acid adducts of palbociclib
|
|
CN105085517B
(zh)
*
|
2015-08-06 |
2016-11-23 |
天津华洛康生物科技有限公司 |
一种结晶型帕博西尼游离碱水合物及其制备方法
|
|
CN106474129A
(zh)
*
|
2015-09-01 |
2017-03-08 |
上海方楠生物科技有限公司 |
一种帕博西林或其药学上可接受的盐与药用辅料的组合物及其制备方法
|
|
HU230962B1
(hu)
|
2015-10-28 |
2019-06-28 |
Egis Gyógyszergyár Zrt. |
Palbociclib sók
|
|
AU2016353153B2
(en)
|
2015-11-12 |
2023-11-23 |
Seagen Inc. |
Glycan-interacting compounds and methods of use
|
|
CN105418603A
(zh)
*
|
2015-11-17 |
2016-03-23 |
重庆莱美药业股份有限公司 |
一种高纯度帕布昔利布及其反应中间体的制备方法
|
|
CN106800554A
(zh)
*
|
2015-11-26 |
2017-06-06 |
上海科胜药物研发有限公司 |
一种帕博西尼二盐酸盐的晶型及其制备方法
|
|
CN106800553A
(zh)
*
|
2015-11-26 |
2017-06-06 |
上海科胜药物研发有限公司 |
一种帕博西尼二羟乙基磺酸盐的晶型
|
|
CN105541832A
(zh)
*
|
2015-12-15 |
2016-05-04 |
南京艾德凯腾生物医药有限责任公司 |
一种羟乙基磺酸盐帕布昔利布的制备方法
|
|
WO2017130219A1
(en)
|
2016-01-25 |
2017-08-03 |
Mylan Laboratories Limited |
Amorphous solid dispersion of palbociclib
|
|
WO2017145054A1
(en)
|
2016-02-24 |
2017-08-31 |
Lupin Limited |
Modified particles of crystalline palbociclib free base and process for the preparation thereof
|
|
CN107137409A
(zh)
*
|
2016-03-01 |
2017-09-08 |
江苏恒瑞医药股份有限公司 |
一种cdk4/6抑制剂与雌激素受体拮抗剂联合在制备治疗乳腺癌的药物中的用途
|
|
CN107137408A
(zh)
*
|
2016-03-01 |
2017-09-08 |
江苏恒瑞医药股份有限公司 |
一种cdk4/6抑制剂与芳香化酶抑制剂联合在制备治疗乳腺癌的药物中的用途
|
|
US10449195B2
(en)
|
2016-03-29 |
2019-10-22 |
Shenzhen Pharmacin Co., Ltd. |
Pharmaceutical formulation of palbociclib and a preparation method thereof
|
|
WO2017172734A1
(en)
*
|
2016-03-29 |
2017-10-05 |
Mayo Foundation For Medical Education And Research |
Treating cancer metastasis
|
|
WO2018001270A1
(en)
*
|
2016-06-30 |
2018-01-04 |
Noratech Pharmaceuticals, Inc. |
Palbociclib prodrugs and composition thereof
|
|
WO2018005863A1
(en)
|
2016-07-01 |
2018-01-04 |
G1 Therapeutics, Inc. |
Pyrimidine-based compounds for the treatment of cancer
|
|
EP3481825A1
(en)
|
2016-07-07 |
2019-05-15 |
Plantex Ltd. |
Solid state forms of palbociclib dimesylate
|
|
MA45920B1
(fr)
|
2016-08-15 |
2021-08-31 |
Pfizer |
Inhibiteurs de pyridopyrimidinone cdk2/4/6
|
|
WO2018065999A1
(en)
|
2016-10-07 |
2018-04-12 |
Mylan Laboratories Limited |
Novel polymorph of an intermediate for palbociclib synthesis
|
|
BR112019005526A2
(pt)
|
2016-10-20 |
2019-06-18 |
Pfizer |
agentes antiproliferativos para tratamento de pah
|
|
WO2018073574A1
(en)
|
2016-10-20 |
2018-04-26 |
Cipla Limited |
Polymorphic forms of palbociclib
|
|
US20190275049A1
(en)
|
2016-11-16 |
2019-09-12 |
Pfizer Inc. |
Combination of an EGFR T790M Inhibitor and a CDK Inhibitor for the Treatment of Non-Small Cell Lung Cancer
|
|
WO2018094143A1
(en)
|
2016-11-17 |
2018-05-24 |
Siamab Therapeutics, Inc. |
Glycan-interacting compounds and methods of use
|
|
NZ752990A
(en)
*
|
2016-11-28 |
2025-08-29 |
Teijin Pharma Ltd |
Crystal of pyrido[3, 4-d]pyrimidine derivative or solvate thereof
|
|
CA3048057A1
(en)
|
2017-01-06 |
2018-07-12 |
G1 Therapeutics, Inc. |
Combination therapy for the treatment of cancer
|
|
SG11201907889YA
(en)
|
2017-03-03 |
2019-09-27 |
Seattle Genetics Inc |
Glycan-interacting compounds and methods of use
|
|
US20200054560A1
(en)
*
|
2017-04-21 |
2020-02-20 |
Alnova Pharmaceuticals, Ltd. |
Palbociclib compositions and methods thereof
|
|
MX392531B
(es)
|
2017-06-29 |
2025-03-24 |
G1 Therapeutics Inc |
Formas morficas de g1t38 y metodos de preparacion de las mismas.
|
|
EA202090402A1
(ru)
|
2017-07-28 |
2020-05-19 |
Синтон Б.В. |
Фармацевтическая композиция, содержащая пальбоциклиб
|
|
MX2020007959A
(es)
|
2018-01-29 |
2020-09-18 |
Beta Pharma Inc |
Derivados de 2h-indazol e inhibidores de cdk4 y cdk6 y sus usos terapeuticos.
|
|
EP3749654B1
(en)
|
2018-02-06 |
2025-04-23 |
The Board of Trustees of the University of Illinois |
Substituted benzothiophene analogs as selective estrogen receptor degraders
|
|
JP2021514975A
(ja)
|
2018-02-27 |
2021-06-17 |
ファイザー・インク |
サイクリン依存性キナーゼ阻害剤およびbet−ブロモドメイン阻害剤の組合せ
|
|
EP4309656A3
(en)
|
2018-05-14 |
2024-02-28 |
Pfizer Inc. |
Oral solution formulation
|
|
AU2019310335A1
(en)
|
2018-07-23 |
2021-02-11 |
F. Hoffmann-La Roche Ag |
Methods of treating cancer with PI3K inhibitor, GDC-0077
|
|
WO2020041770A1
(en)
|
2018-08-24 |
2020-02-27 |
G1 Therapeutics, Inc. |
Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one
|
|
JP6952747B2
(ja)
|
2018-09-18 |
2021-10-20 |
ファイザー・インク |
がん処置のためのTGFβ阻害剤およびCDK阻害剤の組合せ
|
|
JP2022504388A
(ja)
|
2018-10-08 |
2022-01-13 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
Pi3kアルファ阻害剤およびメトホルミンを用いたがんの処置方法
|
|
US11424484B2
(en)
|
2019-01-24 |
2022-08-23 |
Octet Scientific, Inc. |
Zinc battery electrolyte additive
|
|
WO2020157709A1
(en)
|
2019-02-01 |
2020-08-06 |
Pfizer Inc. |
Combination of a cdk inhibitor and a pim inhibitor
|
|
WO2020240360A1
(en)
|
2019-05-24 |
2020-12-03 |
Pfizer Inc. |
Combination therapies using cdk inhibitors
|
|
JP2022534889A
(ja)
|
2019-05-24 |
2022-08-04 |
ファイザー・インコーポレイテッド |
Cdk阻害剤を使用した組合せ療法
|
|
CN112094272A
(zh)
|
2019-06-18 |
2020-12-18 |
北京睿熙生物科技有限公司 |
Cdk激酶抑制剂
|
|
CN110143948B
(zh)
*
|
2019-06-21 |
2021-05-14 |
上海博悦生物科技有限公司 |
Cdk4/6抑制剂、其药物组合物、制备方法及应用
|
|
MX2022002415A
(es)
|
2019-08-26 |
2022-03-22 |
Arvinas Operations Inc |
Metodos de tratamiento del cancer de mama con derivados de tetrahidronaftaleno como degradadores del receptor de estrogenos.
|
|
IL293347A
(en)
|
2019-12-03 |
2022-07-01 |
Genentech Inc |
Combination therapies for treatment of breast cancer
|
|
TW202146017A
(zh)
|
2020-03-05 |
2021-12-16 |
美商輝瑞股份有限公司 |
間變性淋巴瘤激酶抑制劑及周期蛋白依賴型激酶抑制劑之組合
|
|
US10988479B1
(en)
|
2020-06-15 |
2021-04-27 |
G1 Therapeutics, Inc. |
Morphic forms of trilaciclib and methods of manufacture thereof
|
|
PT4181920T
(pt)
|
2020-07-15 |
2025-11-04 |
Ctxt Pty Ltd |
Inibidor de kat6 e combinações para o tratamento do cancro da mama
|
|
CA3189632A1
(en)
|
2020-07-20 |
2022-01-27 |
Pfizer Inc. |
Combination therapy
|
|
CN114246841B
(zh)
*
|
2020-09-24 |
2024-02-02 |
南京济群医药科技股份有限公司 |
一种羟乙磺酸哌柏西利的组合物及药物
|
|
CN114306245A
(zh)
|
2020-09-29 |
2022-04-12 |
深圳市药欣生物科技有限公司 |
无定形固体分散体的药物组合物及其制备方法
|
|
WO2022091001A1
(en)
|
2020-10-29 |
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|
|
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|
|
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|
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|
|
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|
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|
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|
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|
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|
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